王郁菁,2008。高糖誘發之氧化傷害對Hep G2細胞之影響。靜宜大學食品營養學研究所碩士論文。臺中。行政院衛生署,2011。民國101年死因統計年報。行政院衛生署。臺北。
李淑蓮,2004。亞砷酸鈉誘發人類臍靜脈內皮細胞蛋白質羰基化及硝基化之探討:二維電泳分析。中山醫學大學生化暨生物科技研究所碩士論文。臺中。
李佩珊,2007。探討鎳、砷對於腎細胞株之氧化性壓力、粒線體膜電位與細胞週期的影響。輔英科技大學醫事技術研究所碩士論文。屏東。呂鋒洲,1996。中國大陸地方病考察記:砷引起烏腳病學說的省思。健康世界250: 59-74。呂鋒洲和郭浩然,1987。烏腳病的研究與發展 (上)。健康世界 133: 36-43。
姚佩萱,2008。砷汙染地區農田土壤與稻作砷含量關係之研究。臺灣大學生物環境系統工程學研究所碩士論文。臺北。
張育維,2006。鎳、鎘、砷對於腎細胞株 (LLC-PK1) 之氧化傷害、凋亡蛋白的表現與細胞內鈣離子影響之研究。輔英科技大學醫事技術研究所碩士論文。屏東。翁義宗,2002。桑椹之抗氧化及對脂多醣所誘導RAW 264.7巨噬細胞產生PGE2及NO之影響。國立中興大學食品科學研究所碩士學位論文。臺中。Abernathy, C. O., Liu, Y. P., Longfellow, D., Aposhian, H. V., Beck, B., Fowler, B., Goyer, R., Menzer, R., Rossman, T., Thompson, C. and Waalkes, M. 1999. Arsenic: health effects, mechanisms of actions, and research issues. Environmental Health Perspectives 107: 593-597.
Abordo, E. A., Westwood, M. E. and Thornalley, P. J. 1996. Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose–derived advanced glycation endproducts. Immunology Letters 53: 7-13.
Abou-Seif, M. A. and Youssef, A. 2004. Evaluation of some biochemical changes in diabetic patients. Clinica Chimica Acta 346: 161-170.
ADA (American Diabetes Association). 2011. Standards of medical care in diabetes. Diabetes Care 34: S11-S61.
ADA (American Diabetes Association). 2012. Diagnosis and classification of Diabetes Mellitus. Diabetes Care 35: S64-S71.
Adler, A. I., Stevens, R. J., Neil, A., Stratton, I. M., Boulton, A. J. and Holman, R. R. 2002. UKPDS 59: Hyperglycemia and other potentially modifiable risk factors for peripheral vascular disease in type 2 diabetes. Diabetes Care 25: 894-899.
Aiston, S., Coghlan, M. P. and Agius, L. 2003. Inactivation of phophorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis. European Journal of Biochemistry 270: 2773-2781.
Aguirre, V., Uchida, T., Yenush, L., Davis, R. and White, M. F. 2000. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. Journal of Biological Chemistry 275: 9047-9054.
ATSDR (Agency for Toxic Substances and Disease Registry) 2005. Toxicological Profile for Arsenic (Update). U.S. Environmental Protection Agency (EPA). U.S.A.
Bae, O. N., Lim, K. M., Noh, J. Y., Chung, S. M., Kim, S. H. and Chung, J. H. 2009. Trivalent methylated arsenical-induced phosphatidylserine exposure and apoptosis in platelets may lead to increased thrombus formation. Toxicology and Applied Pharmacology 239: 144-153.
Balakumar, P. and Kaur, J. 2009. Arsenic exposure and cardiovascular disorders: An overview. Cardiovascular Toxicology 9: 169-176.
Balint, B. L. and Nagy, L. 2006. Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocrine, Metabolic and Immune Disorders-Drug Targets 6: 33-43.
Beks, P. J., Mackaay, A. J., de Neeling, J. N., de Vries, H., Bouter, L. M. and Heine, R. J. 1995. Peripheral arterial disease in relation to glycaemic level in an elderly Caucasian population: The Hoorn study. Diabetologia 38: 86–96.
Bissen, M. and Frimmel, F. H. 2003. Arsenic-A review. Part I: Occurrence, toxicity, speciation, mobility. Acta Hydrochimica et Hydrobiologica 31: 9-18.
Biswas, D., Banerjee, M., Sen, G., Das, J. K., Banerje, A., Sau, T. J., Pandit, S., Giri A. K. and Biswas, T. 2008. Mechanism of erythrocyte death in human population exposed to arsenic through drinking water. Toxicology and Applied Pharmacology 230: 57-66.
Boquist, L., Boquis, S. and Ericsson, I. 1988. Structure beta cell changes and transient hyperglymia in mice treated with compounds including inhibited critic acid cycle enzyme activity. Diabetes 37: 89-98.
Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complic- ations. Nature 414: 813-820.
Casteels. K. and Mathieu, C. 2003. Diabetic ketoacidosis. Reviews in Endocrine and Metabolic Disorders 4: 159-166.
Centeno, J. A., Mullick, F. G., Martinez, L., Page, N. P., Gibb, H., Longfellow, D., Thompson, C. and Ladich, E. R. 2002. Pathology related to chronic arsenic exposure. Environmental Health Perspectives 110: 883-886.
Chang, C. C., Ho, S. C., Tsai, S. S. and Yang, C. Y. 2004. Ischemic heart disease mortality reduction in an arseniasisendemic area in southwestern Taiwan after a switch in the tapwater supply system. Journal of Toxicology and Environmental Health: Part A 67: 1353-1361.
Chao, J. I., Hsu, S. H. and Tsou, T. C. 2006. Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway. Toxicological Sciences 90: 73-86.
Chen, H. and Tappel, A. L. 1995. Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo. Free Radical Biology and Medicine 18: 949-953.
Chen, K. P. and Wu, H. Y. 1962. Epidemiologic studies on balckfoot disease in Taiwan, China 4. A study of source of drinking water in relation to the disease. Journal of the Formasan Medical Association 61: 611-618.
Chen, C. J., Hsueh, Y. M., Lai, M. S., Shyu, M. P., Chen, S. Y., Wu, M. M., Kuo, T. L. and Tai, T. Y. 1995. Increased prevalence of hypertension and long-term arsenic exposure. Hypertension 25: 53-60.
Chen, F., Demers, L. M., Vallyathan, V., Ding, M., Lu, Y., Castranova, V. and Shi X. 1999. Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages. Journal of Biological Chemistry 274: 20307-20312.
Chen, Z., Peng, I. C., Cui, X., Li, Y. S., Chien, S. and Shyy, J. J. 2010. Shear stress, SIRT1, and vascular homeostasis. Proceedings of the National Academy of Sciences 107: 10268-10273.
Chen, Y., Graziano, J. H., Parvez, F., Liu, M., Slavkovich, V., Kalra, T., Argos, M., Islam, T., Ahmed, A., Rakibuz-Zaman, M., Hasan, R., Sarwar, G., Levy, D., van Geen, A. and Ahsan, H. 2011. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: Prospective cohort study. British Medical Journal 342: d2431.
Chiou, H. Y., Hsueh, Y. M., Liaw, K. F., Horng, S. F., Chiang, M. H., Pu, Y. S., Lin, J. S., Huang, C. H. and Chen, C. J. 1995. Incidence of internal cancers and ingested inorganic arsenic: A seven-follow-up study in Taiwan. Cancer Research 55: 1296-1300.
Chou, C. T., Lin, W. F., Kong, Z. L., Chen, S. Y. and Hwang, D. F. 2013. Taurine prevented cell cycle arrest and restored neurotrophic gene expression in arsenite-treated SH-SY5Y cells. Amino acids 45: 811-819.
Chun, Y. S., Kim, M. S. and Park, J. W. 2002. Oxygen-dependent and independent regulation of HIF-1alpha. Journal of Korean Medical Science 17: 581-588.
Craven, P. A., Studer, R. K. and DeRubertis, F. R. 1994. Impaired nitric oxide -dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response. Journal of Clinical Investigation 93: 311-320.
Cui, Y., Xu, X., Bi, H., Zhu, Q., Wu, J., Xia, X., Ren, Q. and Ho, P. C. 2006. Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: The role of reactive oxygen species in diabetic retinopathy. Experimental Eye Research 83: 807-816.
Davey, J. C., Bodwell, J. E., Gosse, J. A. and Hamilton, J. W. 2007. Arsenic as an endocrine disruptor: Effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicological Sciences 98: 75-86.
Degenhardt, T. P., Thorpe, S. R. and Baynes, J. W. 1998. Chemical modification of protein by methylglyoxal. Cell and Molecular Biology 44: 1139-1145.
Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N. and Leverve, X. 2005. Metformin prevents high-glucose–induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 54: 2179-2187.
Diaz, Z., Colombo, M., Mann, K. K., Su, H., Smith, K. N., Bohle, D. S., Schipper, H. M. and Miller, W. H. Jr. 2005. Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines. Blood 105: 1237-1245.
Drobn#westeur034#, Z., Walton, F. S., Paul, D. S., Xing, W., Thomas, D. J. and St#westeur062#blo, M. 2010. Metabolism of arsenic in human liver: the role of membrane transporters. Archives of Toxicology 84: 3-16.
El-Demerdash, F. M., Yousef, M. I. and Radwan, F. M. 2009. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food and Chemical Toxicology 47: 249-254.
Esta#westeur050#, M. C., Calvi#westeur050#o, E., de Blas, E., Boyano-Ad#westeur034#nez, M. D. C., Mena, M. L., G#westeur052#mez-G#westeur052#mez, M., Rial, E. and Aller, P. 2012. 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: Involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. Biochemical Pharmacology 84: 1604-1616.
Engel, R. H. and Evens, A. M. 2006. Oxidative stress and apoptosis: A new treatment paradigm in cancer. Frontiers in Bioscience 11: 300-312.
Evans, J. L., Goldfine, I. D., Maddux, B. A. and Grodsky, G. M. 2003. Are oxidative stress- activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 52: 1-8.
Faraci, F. M. and Didson, S. P. 2004. Vascular protection: Superoxide dismutase isoforms in the vessel wall. Arteriosclerosis, Thrombosis, and Vascular Biology 24: 1367-1373.
Flora, S. J., Bhadauria, S., Kannan, G. M. and Singh, N. 2007. Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: A review. Journal of Environmental Biology 28: 333-347.
Flora, S. J. 2011. Arsenic-induced oxidative stress and its reversibility. Free Radical Biology and Medicine, 51: 257-281.
Frayn, K. N., Fielding, B. A. and Karpe, F. 2005. Adipose tissue fatty acid meta- bolism and cardiovascular disease. Current Opinion in Lipidology 16: 409-415.
Fu, J., Woods, C. G., Yehuda-Shnaidman, E., Zhang, Q., Wong, V. and Collins, S. 2010. Low-level arsenic impairs glucose- stimulated insulin secretion in pancreatic β-cells: involvement of cellular adaptive response to oxidative stress. Environmental Health Perspectives 118: 864-870.
Fujita, H., Omori, S., Ishikura, K., Hida, M. and Awazu, M. 2004. ERK and p38 mediate high-glucose-induced hypertrophy and TGF-β expression in renal tubular cells. American Journal of Physiology-Renal Physiology 286: F120-F126.
Gennari, A., Cortese, E., Boveri, M., Casado, J. and Prieto, P. 2003. Sensitive endpoints for evaluating cadmium-induced acute toxicity in LLC-PK1 cells. Toxicology 183: 211-220.
Giardino, I., Edelstein, D. and Brownlee, M. 1994. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alter basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes. Journal of Clinical Investigation 94: 110-117.
Gimbrone, M. A., Topper, J. N., Nagel, T., Anderson, K. R. and Garcia-Carde#westeur050#a, G. 2000. Endothelial dysfunction, hemodynamic forces, and atherogenesis. Atherosclerosis V: The Fifth Saratoga Conference 902: 230-240.
Gray, S. G. and De Meytes, P. 2005. Role of histone and transcription factor acetylation in diabetes pathogenesis. Diabetes/Metabolism Research and Reviews 21: 416-433.
Gregus, Z., Fekete, T., Hal#westeur034#szi, E. and Klaassen, C. D. 1996. Does hepatic ATP depletion impair glycine conjugation in vivo? Drug Metabolism and Disposition 24: 1347-1354.
Hansson, G. K. 2005. Inflammation, atherosclerosis, and coronary artery disease. The New England Journal of Medicine 352: 1685-1695.
Harris, G. K. and Shi, X. 2003. Signaling by carcinogenic metals and metal-induced reactive oxygen species. Mutation Research 533: 183-200.
Hawkins, M., Barzilai, N., Liu, R., Hu, M., Chen, W. and Rossetti, L. 1997. Role of the glucosamine pathway in fat-induced insulin resistance. Journal of Clinical Investigation 99: 2173-2182.
He, X., Chen, M. G., Lin, G. X. and Ma, Q. 2006. Arsenic induces NAD(P)H-quinone Oxidoreductase I by disrupting the Nrf2•Keap1•Cul3 complex and recruiting Nrf2•Maf to the antioxidant response element enhancer. Journal of Biological Chemistry 281: 23620-23631.
Henke, B. R. and Sparks, S. M. 2006. Glycogen phosporylase inhibitors. Mini Reviews in Medicinal Chemistry 6: 845-857.
Hetz, C. 2012. The unfolded protein response: Controlling cell fate decisions under ER stress and beyond. Nature Reviews Molecular Cell Biology 13: 89-102.
Hiatt, W. R., Hoag, S. and Hamman, R. F. 1995. Effect of diagnostic criteria on the prevalence of peripheral arterial disease The San Luis Valley diabetes study. Circulation 91: 1472-1479.
Hill, D. S., Wlodarczyk, B. J. and Finnell, R. H. 2008. Reproductive consequences of oral arsenate exposure during pregnancy in a mouse model. Birth Defects Research Part B: Developmental and Reproductive Toxicology 83: 40-47
Ho, F. M., Liu, S. H., Liau, C. S., Huang, P. J. and Lin-Shiau, S. Y. 2000. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH2-terminal kinase and caspase-3. Circulation 101: 2618-2624.
Ho, F. M., Lin, W. W., Chen, B. C., Chao, C. M., Yang, C. R., Lin, L. Y., Lai, C. C., Liu, S. H. and Liau, C. S. 2006. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cell Signal 18: 391-399.
Hou, N., Torii, S., Saito, N., Hosaka, M. and Takeuchi, T. 2008. Reactive oxygen species-mediated pancreatic β-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases. Endocrinology 149: 1654-1665.
Huang, X. F. and Chen, J. Z. 2009. Obesity, the PI3K/AKt signal pathway and colon cancer. Obesity Reviews 10: 610-616.
Hughes, M. F., Beck, B. D., Chen, Y., Lewis, A. S., &; Thomas, D. J. 2011. Arsenic exposure and toxicology: A historical perspective. Toxicological Sciences 123: 305-332.
Hyun Park, W., Hee Cho, Y., Won Jung, C., Oh Park, J., Kim, K., Hyuck Im, Y., Lee, M. H., Kang, W. K. and Park, K. 2003. Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis. Biochemical and Biophysical Research Communications 300: 230-235.
Ishii, H., Jirousek, M. R., Koya, D., Takagi, C., Xia, F., Clermont, A., Bursell, S. E., Kern, T. S., Ballas, L. M., Heath, W. F., Stramm, L. E., Feener, E. P. and King, G. L. 1996. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272: 728-731.
Jomova, K. and Valko, M. 2011. Advances in metal-induced oxidative stress and human disease. Toxicology 283: 65-87.
Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C. J. and Valko, M. 2011. Arsenic: Toxicity, oxidative stress and human disease. Journal of Applied Toxicology 31: 95-107.
Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T. A., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y. and Hori, M. 2004. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nature Medicine 10: 1128-1132.
Kanikarla-Marie, P. and Jain, S. K. 2014. l-Cysteine supplementation reduces high-glucose and ketone-induced adhesion of monocytes to endothelial cells by inhibiting ROS. Molecular and cellular biochemistry 391: 251-256.
Kannel, W. B. and McGee, D. L. 1985. Update on some epidemiologic features of intermittent claudication: The Framingham study. Journal of the American Geriatrics Society 33: 13-18.
Kawashima, S. 2004. The two faces of endothelial nitric oxide synthase in the pathophysiology of atherosclerosis. Endothelium 11: 99-107.
Kenneth, O. 2001. Peripheral arterial disease. The Lancet 358: 1257-1264.
Kim, C. and Vaziri, N. D. 2005. Hypertension promotes integrin expression and reactive oxygen species generation by circulating leukocytes. Kidney International 67: 1462-1470.
Kim, I., Xu, W. and Reed, J. C. 2008. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nature Reviews Drug Discovery 7: 1013-1030.
Kim, I., Moon, S. O., Kim, S. H., Kim, H. J., Koh, Y. S., Koh, G. Y. 2001. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (icam‐1), vascular cell adhesion molecule 1 (vcam‐1), and e‐selectin through nuclear factor‐kappa b activation in endothelial cells. Journal of Biological Chemistry 276: 7614‐7620.
Klaassen, C., Watkins, J. and Casarett, D. 2003. Casarett and Doull's Essentials of Toxicology. pp. 512. McGraw-Hill, New York, U.S.A.
Kobayashi, M. and Yamamoto, M. 2006. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Advances in Enzyme Regulation 46: 113-140.
Kolm-Litty, V., Sauer, U., Nerlich, A., Lehmann, R. and Schleicher, E. D. 1998. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. Journal of Clinical Investigation 101: 160-169.
Koya, D. and King, G. L. 1998. Protein kinase C activation and the development of diabetic complications. Diabetes 47: 859-866.
Kumagai, Y. and Sumi, D. 2007. Arsenic: signal transduction, transcription factor, and biotransformation involved in cellular response and toxicity. Annual Review of Pharmacology and Toxicology 47: 243-262.
Koya, D., Jirousek, M. R., Lin, Y. W., Ishii, H., Kuboki, K. and King, G. L. 1997. Characteriz-ation of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. Journal of Clinical Investigation 100: 115-126.
Lagathu, C., Bastard, J. P., Auclair, M., Maachi, M., Capeau, J. and Caron, M. 2003. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochemical and Biophysical Research Communications 311: 372-379.
Lai, M. S., Hsueh, Y. M., Chen, C. J., Shyu, M. P., Chen, S. Y., Kuo, T.L., Wu, M. M. and Tai, T. Y. 1994. Ingested inorganic arsenic and prevalence of diabetes mellitus. American Journal of Epidemiology 139: 484-492.
Li, Y., Huang, T. T., Charlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., Wallace, D. C. and Epstein, C. J. 1995. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nature Genetics 11: 376-381.
Lii, C. K., Lin, A. H., Lee, S. L., Chen, H. W. and Wang, T. S. 2010. Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environmental Toxicology 26: 459-471.
Li, J. X., Shen, Y. Q., Cai, B. Z., Zhao, J., Bai, X., Lu, Y. J. and Li, X. Q. 2010. Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. Molecular Biology Reports 37: 1569-1576.
Liu, Y., Guyton, K. Z., Gorospe, M., Xu, Q., Lee, J. C. and Holbrook, N. J. 1996. Differential activation of ERK, JNK/SAPK and P3/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radical Biology and Medicine 21: 771-781.
Liu, S. X., Athar, M., Lippai, I., Waldren, C. and Hei, T. K. 2000. Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity. Proceedings of the National Academy of Science of the United States of America 98: 1643-1648.
Liu, S. X., Athar, M., Lippai, I., Waldren, C. and Hei, T. K. 2001. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proceedings of the National Academy of Sciences 98: 1643-1648.
Liu, G., Sun, Y., Li, Z., Song, T., Wang, H., Zhang, Y. and Ge, Z. 2008. Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease. Biochemical and Biophysical Research Communications 370: 651-656.
Lu, T. H., Su, C. C., Chen, Y. W., Yang, C. Y., Wu, C. C., Hung, D. Z., Chen, C. H., Cheng, P. W., Liu, S. H. and Huang, C. F. 2011. Arsenic induces pancreatic β-cell apoptosis via the oxidative stress-regulated mitochondria-dependent and endoplasmic reticulum stress-triggered signaling pathways. Toxicology Letters 201: 15-26.
Lu, T, H., Tseng, T. J., Su, C. C., Tang, F. C., Yen, C. C., Liu, Y. Y., Yang, C. Y., Wu, C. C., Chen, K. L., Hung, D. Z. and Chen, Y. W. 2014. Arsenic induces reactive oxygen species-caused neuronal cell apoptosis through JNK/ERK-mediated mitochondria-dependent and GRP 78/CHOP-regulated pathways. Toxicology letters 224: 130-140.
Luther, M., Lepantalo, M., Alback, A. and Matzke, S. 1996. Amputation rates as a measure of vascular surgical results. British Journal of Surgery 83: 241-244.
Maddux, B. A., See, W., Lawrence, J. C., Jr., Goldfine, A. L., Goldfine, I. D. and Evans, J. L. 2001. Protection against oxidative stress-induced insulin resistance in rat 16 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes 50: 404-410.
Maiese, K., Morhan, S. D. and Chong, Z. Z. 2007. Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Current Neurovascular Research 4: 63-71.
Marshall, S., Bacote, V. and Traxinger, R. R. 1991. Discovery of a metabolic pathway mediating glucoseinduced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. Journal of Biological Chemistry 266: 4706-4712.
Marso, S. and Hiatt, R. 2006. Peripheral arterial disease in patients with diabetes. Journal of the American College of Cardiology 47: 921-929.
Maritim, A. C., Sanders, R. A. and Watkins, 3. J. 2003. Diabetes, oxidative stress, and antioxidants: A review. Journal of Biochemical and Molecular Toxicology 17: 24-38.
Mateos, R., Goya, L. and Bravo, L. 2004. Determination of malondialdehyde by liquid chromatography as the 2, 4-dinitrophenylhydrazone derivative: a marker for oxidative stress in cell cultures of human hepatoma HepG2. Journal of Chromatography B 805: 33-39.
May, J. M. 1985. The inhibition of hexose transport by permeant and impermerant sulfhydryl agents in rat adipocytes. Journal of Biological Chemistry 260: 462-467.
Menzel, D. B., Ross, M., Oddo, S. V., Bergstrom, P., Greene, H. and Roth, R.N. 1994. A physicologically based pharmacokinetic model for ingested arsenic. Environmental Geochemistry and Health 16: 209-218.
Meyer, A.S. and Isaksen, A. 1995. Application of enzymes as food antioxidants. Trends in Food Science &; Technology 6: 300-304.
Moser, C. C., Farid, T. A., Chobot, S. E. and Dutton, P. L. 2006. Electron tunneling chains of mitochondria. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1757: 1096-1109.
Mueller, C. F., Laude, K., McNally, J. S. and Harrison, D. G. 2005. Redox mechanisms in blood vessels. Arteriosclerosis, Thrombosis, and Vascular Biology 2: 274-278.
Murakami, H. and Nurse, P. 2000. DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts. The Biochem. Journal 349: 1-12.
Nakagawa, Y., Akao, Y., Morikawa, H., Hirata, I., Katsu, K., Naoe, T., Ohishi, N. and Yagi, K. 2002. Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. Life Sciences 70: 2253-2269.
Partridge, M. A., Huang, S. X., Hernandez-Rosa, E., Davidson, M. M. and Hei, T. K. 2007. Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: Implications for genotoxic mechanisms in mammalian cells. Cancer Research 67: 5239-5247.
Pieper, G. M. and Riaz-ul-Haq, J. 1997. Activation of nuclear factor-kappa B in cultured endothelial cells by increased glucose concentration: Prevention by calphostin C. Journal of Cardiovascular Pharmacology 30: 528-532.
Puri, S. C. and Mullen, K. 1980. Multiple comparisons. In Hall, G. K. Applied Statistics for Food and Agriculture Scientists., pp. 146-162. Medical Publishers, Boston, U.S.A.
Rahman, M. and Axelson, O. 1995. Diabetes mellitus and arsenic exposure: A second look at case-control data from a Swedish copper smelter. Occupational and Environmental Medicine 52: 773-774.
Rahman, M., Tondel, M., Ahmad, S. A. and Axelson, O. 1998. Diabetes mellitus associated with arsenic exposure in Bangladesh. American Journal of Epidemiology 148: 198-203.
Rahman, M. M., Chowdhury, U. K., Mukherjee, S. C., Mondal, B. K., Paul, K., Lodh, D., Biswas, B. K., Chanda, C. R., Basu, G. K., Saha, K. C., Roy, S., Das, R., Palit, S. K., Quamruzzaman, Q. and Chakraborti, D. 2001. Chronic arsenic toxicity in Bangladesh and West Bengal, India--A review and commentary. Journal of Toxicology - Clinical Toxicology 39: 683-700.
Ramanathan, K., Anusuyadevi, M., Shila, S. and Panneerselvam, C. 2005. Ascorbic acid and alpha-tocopherol as potent modulators of apoptosis on arsenic induced toxicity in rats. Toxicology Letters 156: 297-306.
Rawal, A., Muddeshwar, M. and Biswas, S. 2004. Effect of Rubia cordifolia, Fagonia cretica linn, and Tinospora cordifolia on free radical generation and lipid peroxidation during oxygen-glucose deprivation in rat hippocampal slices. Biochemical and Biophysical Research Communications 324: 588-596.
Rein, P., Beer, S., Saely, C. H., Vonbank, A. and Drexel, H. 2009. Prevalence of impaired glucose metabolism in individuals with peripheral arterial disease. International Journal of Cardiology 144: 243-244.
Robbins, S. L., Cotran, R. S., Kumar, V. and Collins T. 1999. Pocket Companion to Pathologic Basic of Disease, Sixth edition. pp. 798, Elsevier Pte Ltd., Singapore.
Robertson, R. P. 2004. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells diabetes. Journal of Biological Chemistry 279: 42351-42354.
Roberts, C. K., Vaziri, N. D. and Barnard, R. J. 2002. Effect of diet and exercise intervention on blood pressure, oxidative stress and nitric oxide availability. Circulation 106: 2530-2532.
Ron, D. and Walter, P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews Molecular Cell Biology 8: 519-529.
Rotter, V., Nagaev, I. and Smith, U. 2003. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. Journal of Biological Chemistry 278: 45777-45784.
Sakul, A., Cumaoğlu, A., Aydin, E., Ari, N., Dilsiz, N. and Karasu, C. 2013. Age- and diabetes-induced regulation of oxidative protein modification in rat brain and peripheral tissues: consequences of treatment with antioxidant pyridoindole Experimental Gerontology 48: 476-484.
Saltiel, A. R. and Kahn, C. R. 2001. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414: 799-806.
Santra, A., Chowdhury, A., Ghatak, S., Biswas, A. and Dhali, G. K. 2007. Arsenic induces apoptosis in mouse liver is mitochondria dependent and is abrogated by N-acetylcysteine. Toxicology and Applied Pharmacology 220: 146-155.
Samikkannu, T., Chen, C. H., Yih, L. H., Wang, A. S., Lin, S. Y., Chen, T. C. and Jan, K. Y. 2003. Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity. Chemistry Research Toxicology 16: 409-414.
Schmidt, A. M., Hori, O., Chen, J. X., Li, J. F., Crandall, J., Zhang, J., Cao, R., Yan, S. D., Brett, J. and Stern, D. 1995. Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice: A potential mechanism for the accelerated vasculopathy of diabetes. Journal of Clinical Investigation 96: 1395-1403.
Sen, C. K. 2001. Antioxidant and redox regulation of cellular signaling: Introduction. Medicine and Science in Sports and Exercise 33: 368-370.
Sharp, P. C., Liu, W. H., Yue, K. K., McMaster, D., Catherwood, M. A., McGinty, A. M. and Trimble E. R. 1998. Glucose-induced oxidative stress in vascular contractile cells: Comparison od aortic smooth muscle cells and retinal pericytes. Diabetes 47: 801-809.
Shi, H., Shi, X. and Liu, K. J. 2004. Oxidative mechanism of arsenic toxicity and carcinogenesis. Molecular and Cellular Biochemistry 255: 67-78.
Shi, Y., Wei, Y., Qu, S., Wang, Y., Li, Y. and Li, R. 2010. Arsenic induces apoptosis of human umbilical vein endothelial cells through mitochondrial pathways. Cardiovascular Toxicology 10: 153-160.
Shishehbor, M. H., Aviles, R. J., Brennan, M. L., Fu, X., Goormastic, M., Pearce, G. L., Gokce, N., Keaney, J. F. Jr, Penn, M. S., Sprecher, D. L., Vita, J. A. and Hazen, S. L. 2003. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. Jama 289: 1675-1680.
Simeonova, P. P. and Luster, M. I. 2004. Arsenic and atherosclerosis. Toxicology and Applied Pharmacology 198: 444-449.
Soliman, G. Z. 2008. Blood lipid peroxidation (superoxide dismutase, malondialdehyde, glutathione) levels in Egyptian type 2 diabetic patients. Singapore Medical Journal 49: 129-136.
Stamler, J. S., Lamas, S. and Fang, F. C. 2001. Nitrosylation. The prototypic redox- based signaling mechanism. Cell 106: 675-683.
Studer, R. K., Craven, P. A. and DeRubertis, F. R. 1993. Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium. Diabetes 42: 118-126.
Sumbayev, V. V. and Yasinska, I. M. 2005. Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species. Archives of Biochemistry and Biophysics 436: 406-412.
Szegezdi, E., Logue, S. E., Gorman, A. M. and Samali, A. 2006. Mediators of endoplasmic reticulum stress‐induced apoptosis. EMBO Reports 7: 880-885.
Tang, C. H., Chiu, Y. C., Huang, C. F., Chen, Y. W. and Chen, P. C. 2009. Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress. Toxicology and Applied Pharmacology 241: 173-181.
Thannickal, V. J. and Fanburg, B. L. 2000. Reactive oxygen species in cell signaling. American Journal of Physiology 279: L1005-L1028.
Thornalley, P. J. 1990. The glyoxalase system: New developments towards functional characterization of a metabolic pathway fundamental to biological life. Biochemical Journal 269: 1-11.
Tiedge, M., Lortz, S., Drinkgern, J. and Lenzen, S. 1997. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46: 1733-1742.
Tseng, W. P. 1989. Blackfoot disease in Taiwan: A 30-year follow-up study. Angiology 40: 547-558.
Tseng, C. H. 2002. An overview on peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan. Angiology 53: 529-537
Walters, D. P., Gatling, W., Mullee, M. A. and Hill, R. D. 1992. The prevalence, detection, and epidemiological correlates of peripheral vascular disease: A comparison of diabetic and non-diabetic subjects in an English community. Diabetic Medicine 9: 710-715.
Tseng, C. H., Tai, T. Y., Chong, C. K., Tseng, C. P., Lai, M. S., Lin, B. J., Chiou, H. Y., Hsueh, Y. M., Hsu, K. H. and Chen, C. J. 2000. Long-term arsenic exposure and non-insulin-depend incidence of ent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan. Environmental Health Perspectives 108: 847-851.
Wang, L., Kou, M. C., Weng, C. Y., Hu, L. W., Wang, Y. J. and Wu, M. J. 2012. Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: Roles of ROS, NF-κB, and MAPK pathways. Archives of Toxicology 86: 879-896.
Wang, L., Son, Y. O., Ding, S., Wang, X., Hitron, J. A., Budhraja, A., Lee, J. C., Lin, Q., Poyil, P., Zhang, Z., Luo, J. and Shi, X. 2013. Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway. Toxicological Sciences 130: 269-280.
Wells-knecht, K. J. 1995. Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in autoxidative modification of proteins by glucose. Biochemistry 34: 3702-3709.
Weng, C. Y., Chiou, S. Y., Wang, L., Kou, M. C., Wang, Y. J. and M. J. 2014. Arsenic trioxide induces unfolded protein response in vascular endothelial cells. Archives of Toxicology 88: 213-226.
WHO (World Health Organization). 1999. Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation. Part 1: Diagnosis and classification of diabetes mellitus. Geneva: World Health Organization; Available from: http://www.who.int/diabetes/currentpublica- tions/en/. Accessed in june 7, 2006.
WHO (World Health Organizatuon). 2011. The Top 10 Cause of Death. http:// who.int/mediacentre/factsheets/fs310/en/index.html.
Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27: 1047-1053.
Woo, S. H., Park, M. J. An, S., Lee, H. C., Jin, H. O., Lee, S. J., Gwak, H. S., Park, I. C., Hong, S. I. and Rhee, C. H. 2005. Diarsenic and tetraarsenic oxide inhibit cell cycle progression and bFGF- and VEGF-induced proliferation of human endothelial cells. Journal of Cellular Biochemistry 95: 120-130.
Wu, M. M., Kuo, T. L., Hwang, Y. H. and Chen, C. J. 1989. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. American Journal of Epidemiology 130: 1123-1132.
Wu, Q., Wang, J. H., Fennessy, F., Redmond, H. P. and Bouchier-Hayes, D. 1999. Taurine prevents high-glucose-induced human vascular endothelial cell apoptosis. American Journal of Physiology-Cell Physiology 277: C1229-C1238.
Vahter, M. 1983. Metabolism of arsenic. In: Fowler, B. A. (Ed.) Biological and Environmental Effects of Arsenic. pp. 171-198. Elseviar, Amsterdam, Nederland.
Vaziri, N. D. 2008. Causal link between oxidative stress, inflammation, and hypertension. Iranian Journal of Kidney Diseases 2: 1-10.
Velazquez, E., Winocour, P. H., Kesteven, P., Albert, K. G. M. M. and Laker, M. F. 1991. Relation of lipid peroxides to macrovascular disease in type 2 diabetes. Diabetic Medicine 8: 752-758.
Vlassara, H. 1988. Cachectin/TNF and IL-1 induced by glucose-modified proteins: Role in normal tissue remodeling. Science 240: 1546-1548.
Yen, Y. P., Tsai, K. S., Chen, Y. W., Huang, C. F., Yang, R. S. and Liu, S. H. 2012. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Archives of Toxicology 86: 923-933.
Yu, C., Chen, Y., Cline, G.W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., Atcheson, B., White, M. F., Kraegen, E. W. and Shulman, G. I. 2002. Mechnism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phopsphatidylinosi- tol-3-kinase activity in muscle. Journal of Biological Chemistry 277: 50230-50236.
Zakharyan, R. A., Tsaprailis, G., Growdhury, U. K., Hernandez, A. and Aposhian, H. V. 2005. Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase. Chemical Research in Toxicology 18: 1287-1295.