跳到主要內容

臺灣博碩士論文加值系統

(3.236.124.56) 您好!臺灣時間:2021/07/31 05:07
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果 :::

詳目顯示

我願授權國圖
: 
twitterline
研究生:陳倩儀
研究生(外文):Chien-Yi Chen
論文名稱:探討發炎性反應在新生兒疾病扮演的角色及其臨床啟示
論文名稱(外文):Exploring the Role of Inflammatory Reaction in Neonatal Disease and Its Clinical Implication
指導教授:謝武勳謝武勳引用關係符文美符文美引用關係
口試委員:張美惠曹伯年王煇雄穆淑琪
口試日期:2015-06-03
學位類別:博士
校院名稱:國立臺灣大學
系所名稱:臨床醫學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2015
畢業學年度:103
語文別:英文
論文頁數:172
中文關鍵詞:發炎反應新生兒腦部損傷B型肝炎疫苗早產兒缺氧前置處理額葉損傷大腦執行功能
外文關鍵詞:Neuroinflammationhepatitis B vaccinepretermperinatal brain injuryhypoxic preconditioningfrontal brain injury
相關次數:
  • 被引用被引用:0
  • 點閱點閱:90
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
近年新生兒研究及照護的進步大幅改善新生兒死亡率,進一步的研究大多專注在預防及早期治療早產及各式新生兒併發症,其中發炎性反應已被證實與早產、子宮內感染及新生兒腦部損傷等有很強的關聯性,本論文將探討發炎性反應在新生兒疾病扮演的角色並運用在改善臨床照護與預防層面。
周產期窒息造成的缺氧缺血腦病變是新生兒最常見腦部傷害的主因之一,常會造成永久性的神經後遺症,除低溫治療外,目前仍無臨床有效的藥物治療方式;有許多證據指出,在腦部缺氧時,不僅會對神經直接造成損傷,同時也會引發發炎反應,包括腦部微小膠細胞及星形膠細胞的活化、血液中性球及單核球的活化,以及發炎性細胞激素和活性氧物質等的釋放,進而加重其傷害程度,雖然有一些機制及分子已經被證實與缺氧前置處理的保護效果相關,但是發炎反應所扮演的角色卻未曾被提及,我們利用新生鼠腦部缺氧缺血的動物模式,以及細胞培養的體外研究方式,發現缺氧前置處理可藉由抑制微小膠細胞及星形膠細胞的活化,並抑制進一步的發炎反應的機制,來達到神經保護的效果,由此內生性抗發炎反應的神經保護作用研究可以了解,適當的使用具有抗發炎效果的藥物,對腦部缺氧造成的神經損傷可能會有治療效果。
因周產期窒息或其他原因造成腦損傷的新生兒,即使沒有發生腦性麻痺或智能障礙等嚴重神經後遺症,仍有很高的風險發生神經發展障礙,例如認知發展異常,情緒管理異常,學習障礙或過動兒等,造成長期的問題,其中大腦執行功能的異常為造成神經發展障礙的主要因素之一;已經有很多證據指出,執行功能的發展,與大腦額葉的成熟有緊密的相關性,而大腦額葉在兒童腦部發展中,是最晚完成髓鞘化並達成熟的區域,任何早期的腦部損傷,即使較為輕微,都有可能對這較不成熟的區域造成損傷,進而引起長期神經發展障礙,然而針對兒童及新生兒大腦額葉傷害的動物模式卻了解甚少,對其相關機制的探討亦較少被報告,因此我們發展一個新的單側局部前額葉腦部損傷的兒童動物模式,此局部損傷會引起明顯的局部發炎反應,在另外兩組小時候遭受過額葉損傷的老鼠,分別在成長到青春期和成年期後再測試其行為模式發現,此局部額葉損傷對焦慮表現,社交能力,空間學習和記憶並不會造成長期影響,然而在兩組的運動功能及學習對比於對照組有明顯的障礙,此結果與同側大腦額葉皮質體積的減少相吻合;此動物模式將有助於我們進一步研究新生兒疾病或治療對額葉損傷的影響,並可以藉由行為測試來驗證其長期功能的影響,對於進一步抗發炎藥物對新生兒腦部傷害的神經保護作用探討,有很大的幫助。
B型肝炎是台灣子宮內及周產期感染最常見的問題之一,只要能在新生兒時期進行早期預防措施即可有效降低感染率並減少慢性B型肝炎帶來的併發症,台灣自1984年開始實施全面新生兒接種B型肝炎疫苗計畫,於出生24 小時內、一個月及六個月大時各施打一劑B肝疫苗,不但使感染率明顯下降,同時也減少兒童猛爆性肝炎及肝癌的發生率;然而出生體重不足2000克的早產兒若是在出生時就施打第一劑B型肝炎疫苗,其後的追蹤發現並不能產生有效的血中保護抗體濃度,因此目前台大的早產兒B型肝炎疫苗注射是在體重滿2000或2200克時施打第一劑疫苗,這根據體重的策略與美國小兒科醫學會建議於體重滿2000克或一個月大時再施打第一劑建議更為延遲,雖然在臨床上更為方便執行,因為很多早產兒在一個月大時仍不夠穩定足以施打疫苗,然而此施打策略可能會有增加感染風險的疑慮。因此我們以台大醫院155位2至13歲之極低體重早產兒(出生體重低於1500克)為對象,評估目前延遲施打B型肝炎疫苗政策下之預防成效;我們發現所有的研究個案的B肝表面抗原(HBsAg)及核心抗體(anti-HBc)皆為陰性,儘管接受第一劑B肝疫苗的平均年齡大於55天大,且大多數(94%)遲於美國小兒科醫學會建議的30天大,沒有任何研究個案感染B型肝炎;其中有26位嬰兒的媽媽為B肝帶原者,產婦B肝帶原率在此研究中約為16.8%,與一般發生率相當,雖然並沒有給予美國小兒科醫學會建議於剛出生時給予第零劑B肝疫苗,沒有個案因而被感染。本研究成果顯示目前的早產兒B肝疫苗延遲施打政策並不會增加感染風險,且為臨床上可行的政策。

Numerous reports have identified the association between infection, inflammation, preterm birth and perinatal tissue injury. Exploring of the role of inflammatory reaction in neonatal diseases may further improve neonatal care and outcome. Firstly, we examine the role of inflammatory response in perinatal brain injury. By using the well-established Rice–Vannucci model of hypoxia-ischemia (HI) injury in p7 neonatal rat and primary glial culture and microglial cell line BV-2, we demonstrated that hypoxic preconditioning induced significant neuroprotection, possibly through suppression of glial activation and subsequent inflammatory responses after HI insults. Induction of endogenous anti-inflammatory response may be beneficial to protect neuron from HI-induced brain damage. These results further address the importance of anti-inflammatory strategies in preventing neonatal brain injury.
Perinatal brain injury increase the risk of cognitive and executive deficit in infants, and the development of executive function is related to the maturation of the frontal lobe, particularly the prefrontal cortex. Despite the clinical significance of injuries localized to this region during brain development, the mechanisms underlying secondary damage and long-term recovery are poorly understood. Here, we have characterized the first model of unilateral focal traumatic injury to the developing frontal lobe with local inflammatory response, and determine the long-term functional consequences in adolescence and adulthood. In both cohorts, brain-injured mice showed normal levels of anxiety, sociability, spatial learning and memory, but were deficits in motor function and motor learning, coincident with a reduction in ipsilateral cortical brain volumes. Based on consistent findings of region-specific cellular vulnerability, coupled with evidence of a clinically relevant motor impairment, the new model of unilateral frontal brain injury to the developing brain may be of use in the future investigation.
Secondly, we studied the Hepatitis B virus (HBV) immunization policy for preterm infants. HBV infection is one of the major intrauterine and perinatal infections in Taiwan. Perinatal transmission from infectious mother to infant is an important route for HBV infection, and passive and active immunization starting at birth is an extremely important preventive measure. All infants in Taiwan receive three doses of HBV vaccine, at birth and at 1 and 6 months of age, but preterm infants with birth weights less than 2,000 g delayed the first dose until their weight of 2,000–2,200 g has been reached, regardless of chronological age. This weight-based policy is different from the recommendation from American Academy of Pediatrics (AAP), which the first dose is given as early as 30 days of chronologic age. Thus we conducted a retrospective cross-sectional study to evaluate the efficacy and immunogenicity of hepatitis B vaccinations in preterm infants.
There were 155 very low birth weight preterm infants was recruited at age 2 to 13 years, and all of them were HBsAg and anti-HBc negative. The low prevalence of HBsAg (0%) is comparable to that of children born at term after universal vaccination began in Taiwan (0.9%), and is much lower than the rate among children born before the vaccination program began (10%). Although the children in our study received their first dose of vaccine at a mean age >55 days, with the majority (94%) starting the first dose after 30 days, which is much later than the current AAP recommendation, none of the children was seropositive for HBsAg or anti-HBc. The maternal HBV carrier rate in the present preterm population was approximately 16.8%, which is in accordance with that of the general population. Although we did not use the birth dose of hepatitis B vaccine as part of immunoprophylaxis in infants born to carrier mothers during study periods, none of the 26 infants was infected. This observation demonstrates that our weight-based policy of hepatitis B vaccination in preterm infants, in comparison to the age-based policy, did not increase the risk of HBV infection in an endemic area.

第一章 緒論 .....9
第二章 研究材料與方法.....39
第三章 Suppression of glia activation by hypoxic preconditioning.....62
第四章 Frontal traumatic brain injury : a new murine model.....79
第五章 Hepatitis B vaccination in preterm infants.....120
第六章 展望..... 132
參考文獻 .....142
附錄 .....167

American Academy of Pediatrics Committee on Infectious Diseases. Update on timing of hepatitis B vaccination for premature infants and for children with lapsed immunization. Pediatrics. 1994 Sep; 94(3): 403-404.
Aarnoudse-Moens, C. S., Weisglas-Kuperus, N., van Goudoever, J. B. and Oosterlaan, J. Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics. 2009 Aug; 124(2): 717-728.
Adams-Chapman, I. Neurodevelopmental outcome of the late preterm infant. Clin Perinatol. 2006 Dec; 33(4): 947-964; abstract xi.
Adelson, P. D., Dixon, C. E. and Kochanek, P. M. Long-term dysfunction following diffuse traumatic brain injury in the immature rat. J Neurotrauma. 2000 Apr; 17(4): 273-282.
Adelson, P. D., Dixon, C. E., Robichaud, P. and Kochanek, P. M. Motor and cognitive functional deficits following diffuse traumatic brain injury in the immature rat. J Neurotrauma. 1997 Feb; 14(2): 99-108.
Adelson, P. D., Fellows-Mayle, W., Kochanek, P. M. and Dixon, C. E. Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat. Childs Nerv Syst. 2013 29(1): 43-53.
Ajao, D. O., Pop, V., Kamper, J. E., Adami, A., Rudobeck, E., Huang, L., Vlkolinsky, R., Hartman, R. E., Ashwal, S., Obenaus, A. and Badaut, J. Traumatic Brain Injury in Young Rats Leads to Progressive Behavioral Deficits Coincident with Altered Tissue Properties in Adulthood. Journal of Neurotrauma. 2012 29: 2060-2074.
Alter, M. J. Epidemiology of hepatitis B in Europe and worldwide. J Hepatol. 2003 39 Suppl 1: S64-69.
Anderson, P. Assessment and development of executive function (EF) during childhood. Child neuropsychology. 2002 Jun; 8(2): 71-82.
Anderson, S. W., Damasio, H., Tranel, D. and Damasio, A. R. Long-term sequelae of prefrontal cortex damage acquired in early childhood. Dev Neuropsychol. 2000 18(3): 281-296.
Anderson, V., Godfrey, C., Rosenfeld, J. V. and Catroppa, C. Predictors of cognitive function and recovery 10 years after traumatic brain injury in young children. Pediatrics. 2012 Feb; 129(2): e254-261.
Anderson, V., Jacobs, R. and Harvey, A. S. Prefrontal lesions and attentional skills in childhood. Journal of the International Neuropsychological Society : JINS. 2005 11(7): 817-831.
Andine, P., Thordstein, M., Kjellmer, I., Nordborg, C., Thiringer, K., Wennberg, E. and Hagberg, H. Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia. J Neurosci Methods. 1990 Dec; 35(3): 253-260.
Andre, F. E. and Zuckerman, A. J. Review: protective efficacy of hepatitis B vaccines in neonates. J Med Virol. 1994 Oct; 44(2): 144-151.
Assad, S. and Francis, A. Over a decade of experience with a yeast recombinant hepatitis B vaccine. Vaccine. 1999 Aug 20; 18(1-2): 57-67.
Barker, L. F. and Murray, R. Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis--associated antigen. Am J Med Sci. 1972 Jan; 263(1): 27-33.
Barkley, R. A. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997 Jan; 121(1): 65-94.
Basford, J. R., Chou, L. S., Kaufman, K. R., Brey, R. H., Walker, A., Malec, J. F., Moessner, A. M. and Brown, A. W. An assessment of gait and balance deficits after traumatic brain injury. Archives of Physical Medicine and Rehabilitation. 2003 84(3): 343-349.
Beasley, R. P., Hwang, L. Y., Lee, G. C., Lan, C. C., Roan, C. H., Huang, F. Y. and Chen, C. L. Prevention of perinatally transmitted hepatitis B virus infections with hepatitis B virus infections with hepatitis B immune globulin and hepatitis B vaccine. Lancet. 1983 Nov 12; 2(8359): 1099-1102.
Beasley, R. P., Hwang, L. Y., Lin, C. C., Leu, M. L., Stevens, C. E., Szmuness, W. and Chen, K. P. Incidence of hepatitis B virus infections in preschool children in Taiwan. J Infect Dis. 1982 Aug; 146(2): 198-204.
Beasley, R. P., Hwang, L. Y., Lin, C. C., Stevens, C. E., Wang, K. Y., Sun, T. S., Hsieh, F. J. and Szmuness, W. Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Initial report of a randomised double-blind placebo-controlled trial. Lancet. 1981 Aug 22; 2(8243): 388-393.
Beasley, R. P., Stevens, C. E., Shiao, I. S. and Meng, H. C. Evidence against breast-feeding as a mechanism for vertical transmission of hepatitis B. Lancet. 1975 Oct 18; 2(7938): 740-741.
Bergeron, M., Gidday, J. M., Yu, A. Y., Semenza, G. L., Ferriero, D. M. and Sharp, F. R. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol. 2000 Sep; 48(3): 285-296.
Bernaudin, M., Nedelec, A. S., Divoux, D., MacKenzie, E. T., Petit, E. and Schumann-Bard, P. Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J Cereb Blood Flow Metab. 2002 Apr; 22(4): 393-403.
Bhutta, A. T., Cleves, M. A., Casey, P. H., Cradock, M. M. and Anand, K. J. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA. 2002 Aug 14; 288(6): 728-737.
Bortolotti, F., Cadrobbi, P., Crivellaro, C., Guido, M., Rugge, M., Noventa, F., Calzia, R. and Realdi, G. Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterology. 1990 Sep; 99(3): 805-810.
Boxall, E. H., Sira, J., Standish, R. A., Davies, P., Sleight, E., Dhillon, A. P., Scheuer, P. J. and Kelly, D. A. Natural history of hepatitis B in perinatally infected carriers. Arch Dis Child Fetal Neonatal Ed. 2004 Sep; 89(5): F456-460.
Bravo, T. P., Matchett, G. A., Jadhav, V., Martin, R. D., Jourdain, A., Colohan, A., Zhang, J. H. and Tang, J. Role of histamine in brain protection in surgical brain injury in mice. Brain Res. 2008 Apr 18; 1205: 100-107.
Britton, P., Lu, X. C., Laskosky, M. S. and Tortella, F. C. Dextromethorphan protects against cerebral injury following transient, but not permanent, focal ischemia in rats. Life Sci. 1997 60(20): 1729-1740.
Broderick, A. and Jonas, M. M. Management of hepatitis B in children. Clin Liver Dis. 2004 May; 8(2): 387-401.
Brooks, S. P. and Dunnett, S. B. Tests to assess motor phenotype in mice: a user''s guide. Nature Reviews Neuroscience. 2009 10: 519-529.
Brucklacher, R. M., Vannucci, R. C. and Vannucci, S. J. HP increases brain glycogen and delays energy depletion from HI in the immature rat. Dev Neurosci. 2002 24(5): 411-417.
Buhimschi, C. S., Dulay, A. T., Abdel-Razeq, S., Zhao, G., Lee, S., Hodgson, E. J., Bhandari, V. and Buhimschi, I. A. Fetal inflammatory response in women with proteomic biomarkers characteristic of intra-amniotic inflammation and preterm birth. BJOG. 2009 Jan; 116(2): 257-267.
Buki, A. and Povlishock, J. T. All roads lead to disconnection? - Traumatic axonal injury revisited. Acta Neurochir (Wein). 2006 148: 181-194.
Burk, R. D., Hwang, L. Y., Ho, G. Y., Shafritz, D. A. and Beasley, R. P. Outcome of perinatal hepatitis B virus exposure is dependent on maternal virus load. J Infect Dis. 1994 Dec; 170(6): 1418-1423.
Butterfield, C. R., Shockley, M., San Miguel, G. and Rosa, C. Routine screening for hepatitis B in an obstetric population. Obstet Gynecol. 1990 Jul; 76(1): 25-27.
Catroppa, C., Anderson, V., Morse, S., Haritou, F. and Rosenfeld, J. Outcome and predictors of functional recovery 5 years following pediatric traumatic brain injury (TBI). Journal of Pediatric Psychology. 2008 33(7): 707-718.
Cestari, V., Lucidi, A., Pieroni, L. and Rossi-Arnaud, C. Memory for object location: a span study in children. Canadian Journal of Experimental Psychology. 2007 61(1): 13-20.
Chang, M. H. Chronic hepatitis virus infection in children. J Gastroenterol Hepatol. 1998 May; 13(5): 541-548.
Chang, M. H. Decreasing incidence of hepatocellular carcinoma among children following universal hepatitis B immunization. Liver Int. 2003 Oct; 23(5): 309-314.
Chang, M. H. Hepatitis B virus infection. Semin Fetal Neonatal Med. 2007 Jun; 12(3): 160-167.
Chang, M. H., Chen, C. J., Lai, M. S., Hsu, H. M., Wu, T. C., Kong, M. S., Liang, D. C., Shau, W. Y. and Chen, D. S. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group. N Engl J Med. 1997 Jun 26; 336(26): 1855-1859.
Chang, M. H., Chen, T. H., Hsu, H. M., Wu, T. C., Kong, M. S., Liang, D. C., Ni, Y. H., Chen, C. J. and Chen, D. S. Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems. Clin Cancer Res. 2005 Nov 1; 11(21): 7953-7957.
Chang, M. H., Hsu, H. Y., Huang, L. M., Lee, P. I., Lin, H. H. and Lee, C. Y. The role of transplacental hepatitis B core antibody in the mother-to-infant transmission of hepatitis B virus. J Hepatol. 1996 Jun; 24(6): 674-679.
Chang, M. H., Lee, C. Y., Chen, D. S., Hsu, H. C. and Lai, M. Y. Fulminant hepatitis in children in Taiwan: the important role of hepatitis B virus. J Pediatr. 1987 Jul; 111(1): 34-39.
Chang, M. H., Shau, W. Y., Chen, C. J., Wu, T. C., Kong, M. S., Liang, D. C., Hsu, H. M., Chen, H. L., Hsu, H. Y. and Chen, D. S. Hepatitis B vaccination and hepatocellular carcinoma rates in boys and girls. Jama. 2000 Dec 20; 284(23): 3040-3042.
Chang, M. H., Sung, J. L., Lee, C. Y., Chen, C. J., Chen, J. S., Hsu, H. Y., Lee, P. I. and Chen, D. S. Factors affecting clearance of hepatitis B e antigen in hepatitis B surface antigen carrier children. J Pediatr. 1989 Sep; 115(3): 385-390.
Chau, V., McFadden, D. E., Poskitt, K. J. and Miller, S. P. Chorioamnionitis in the pathogenesis of brain injury in preterm infants. Clin Perinatol. 2014 Mar; 41(1): 83-103.
Chawla, A., Repa, J. J., Evans, R. M. and Mangelsdorf, D. J. Nuclear receptors and lipid physiology: opening the X-files. Science. 2001 Nov 30; 294(5548): 1866-1870.
Chen, C. J., Wang, L. Y. and Yu, M. W. Epidemiology of hepatitis B virus infection in the Asia-Pacific region. J Gastroenterol Hepatol. 2000 May; 15 Suppl: E3-6.
Chen, D. S., Hsu, N. H., Sung, J. L., Hsu, T. C., Hsu, S. T., Kuo, Y. T., Lo, K. J. and Shih, Y. T. A mass vaccination program in Taiwan against hepatitis B virus infection in infants of hepatitis B surface antigen-carrier mothers. Jama. 1987 May 15; 257(19): 2597-2603.
Chen, H. L., Chang, C. J., Kong, M. S., Huang, F. C., Lee, H. C., Lin, C. C., Liu, C. C., Lee, I. H., Wu, T. C., Wu, S. F., Ni, Y. H., Hsu, H. Y., Chen, D. S. and Chang, M. H. Pediatric fulminant hepatic failure in endemic areas of hepatitis B infection: 15 years after universal hepatitis B vaccination. Hepatology. 2004 Jan; 39(1): 58-63.
Chen, H. L., Chang, M. H., Ni, Y. H., Hsu, H. Y., Lee, P. I., Lee, C. Y. and Chen, D. S. Seroepidemiology of hepatitis B virus infection in children: Ten years of mass vaccination in Taiwan. Jama. 1996 Sep 18; 276(11): 906-908.
Claus, C. P., Tsuru-Aoyagi, K., Adwanikar, H., Walker, B., Manvelyan, H., Whetstone, W. and Noble-Haeusslein, L. J. Age is a determinant of leukocyte infiltration and loss of cortical volume after traumatic brain injury. Dev Neurosci. 2010 32(5-6): 454-465.
Dammann, O. and Leviton, A. Intermittent or sustained systemic inflammation and the preterm brain. Pediatr Res. 2014 Mar; 75(3): 376-380.
Dammann, O. and O''Shea, T. M. Cytokines and perinatal brain damage. Clin Perinatol. 2008 Dec; 35(4): 643-663, v.
de Martino, M., Appendino, C., Resti, M., Rossi, M. E., Muccioli, A. T. and Vierucci, A. Should hepatitis B surface antigen positive mothers breast feed? Arch Dis Child. 1985 Oct; 60(10): 972-974.
Dehmer, T., Heneka, M. T., Sastre, M., Dichgans, J. and Schulz, J. B. Protection by pioglitazone in the MPTP model of Parkinson''s disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem. 2004 Jan; 88(2): 494-501.
del Canho, R., Grosheide, P. M., Schalm, S. W., de Vries, R. R. and Heijtink, R. A. Failure of neonatal hepatitis B vaccination: the role of HBV-DNA levels in hepatitis B carrier mothers and HLA antigens in neonates. J Hepatol. 1994 Apr; 20(4): 483-486.
Depino, A. M. and Gross, C. Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice. Behavioral Brain Research. 2007 177(2): 254-260.
Diab, A., Deng, C., Smith, J. D., Hussain, R. Z., Phanavanh, B., Lovett-Racke, A. E., Drew, P. D. and Racke, M. K. Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2002 Mar 1; 168(5): 2508-2515.
Diseases, A. A. o. P. C. o. I. (2006). Red Book : Report of the Committee on Infectious Diseases / Committe on Infectious Diseases, American Academy of Pediatrics, Elk Village, IL : American Academy of Pediatrics.
du Plessis, A. J. and Volpe, J. J. Perinatal brain injury in the preterm and term newborn. Curr Opin Neurol. 2002 Apr; 15(2): 151-157.
Duvoisin, R. M., Villasana, L., Davis, M. J., Winder, D. G. and Raber, J. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav Brain Res. 2011 Aug 1; 221(1): 50-54.
Eslinger, P. J. and Biddle, K. R. Adolescent neuropsychological development after early right prefrontal cortex damage. Dev Neuropsychol. 2000 18(3): 297-329.
Fan, P., Yamauchi, T., Noble, L. J. and Ferriero, D. M. Age-dependent differences in glutathione peroxidase activity after traumatic brain injury. J Neurotrauma. 2003 May; 20(5): 437-445.
Favrais, G., van de Looij, Y., Fleiss, B., Ramanantsoa, N., Bonnin, P., Stoltenburg-Didinger, G., Lacaud, A., Saliba, E., Dammann, O., Gallego, J., Sizonenko, S., Hagberg, H., Lelievre, V. and Gressens, P. Systemic inflammation disrupts the developmental program of white matter. Ann Neurol. 2011 Oct; 70(4): 550-565.
Feinstein, D. L., Galea, E., Gavrilyuk, V., Brosnan, C. F., Whitacre, C. C., Dumitrescu-Ozimek, L., Landreth, G. E., Pershadsingh, H. A., Weinberg, G. and Heneka, M. T. Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis. Ann Neurol. 2002 Jun; 51(6): 694-702.
Feng, Y., Rhodes, P. G. and Bhatt, A. J. HP provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemic model. Brain Res. 2010 Apr 14; 1325: 1-9.
Ferriero, D. M. Neonatal brain injury. N Engl J Med. 2004 Nov 4; 351(19): 1985-1995.
File, S. E. Factors controlling measures of anxiety and responses to novelty in the mouse. Behav Brain Res. 2001 Nov 1; 125(1-2): 151-157.
Fitzsimons, D., Francois, G., Hall, A., McMahon, B., Meheus, A., Zanetti, A., Duval, B., Jilg, W., Bocher, W. O., Lu, S. N., Akarca, U., Lavanchy, D., Goldstein, S., Banatvala, J. and Damme, P. V. Long-term efficacy of hepatitis B vaccine, booster policy, and impact of hepatitis B virus mutants. Vaccine. 2005 Jul 14; 23(32): 4158-4166.
Ganem, D. and Prince, A. M. Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med. 2004 Mar 11; 350(11): 1118-1129.
George, C. P., Goldberg, M. P., Choi, D. W. and Steinberg, G. K. Dextromethorphan reduces neocortical ischemic neuronal damage in vivo. Brain Res. 1988 Feb 9; 440(2): 375-379.
Gidday, J. M. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 2006 Jun; 7(6): 437-448.
Gidday, J. M., Fitzgibbons, J. C., Shah, A. R. and Park, T. S. Neuroprotection from ischemic brain injury by HP in the neonatal rat. Neurosci Lett. 1994 Feb 28; 168(1-2): 221-224.
Gidday, J. M., Shah, A. R., Maceren, R. G., Wang, Q., Pelligrino, D. A., Holtzman, D. M. and Park, T. S. Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of HP. J Cereb Blood Flow Metab. 1999 Mar; 19(3): 331-340.
Gilles, F. H., Averill, D. R., Jr. and Kerr, C. S. Neonatal endotoxin encephalopathy. Ann Neurol. 1977 Jul; 2(1): 49-56.
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., 3rd, Herman, D. H., Clasen, L. S., Toga, A. W., Rapoport, J. L. and Thompson, P. M. Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 8174-8179.
Goldman, P. S. Functional recovery after lesions of the nervous systems. 3. Developmental processes in neural plasticity. Recovery of function after CNS lesions in infant monkeys. Neurosciences Research Program Bulletin. 1974 12(2): 217-222.
Gomez, R., Romero, R., Ghezzi, F., Yoon, B. H., Mazor, M. and Berry, S. M. The fetal inflammatory response syndrome. Am J Obstet Gynecol. 1998 Jul; 179(1): 194-202.
Hack, M., Youngstrom, E. A., Cartar, L., Schluchter, M., Taylor, H. G., Flannery, D., Klein, N. and Borawski, E. Behavioral outcomes and evidence of psychopathology among very low birth weight infants at age 20 years. Pediatrics. 2004 Oct; 114(4): 932-940.
Hagberg, H., Gressens, P. and Mallard, C. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann Neurol. 2012 Apr; 71(4): 444-457.
Hagberg, H., Mallard, C., Ferriero, D. M., Vannucci, S. J., Levison, S. W., Vexler, Z. S. and Gressens, P. The role of inflammation in perinatal brain injury. Nat Rev Neurol. 2015 Apr; 11(4): 192-208.
Hamm, R. J., Dixon, C. E., Gbadebo, D. M., Singha, A. K., Jenkins, L. W., Lyeth, B. G. and Hayes, R. L. Cognitive deficits following traumatic brain injury produced by controlled cortical impact. J Neurotrauma. 1992 Spring; 9(1): 11-20.
Harvey, J. M., O''Callaghan, M. J. and Mohay, H. Executive function of children with extremely low birthweight: a case control study. Dev Med Child Neurol. 1999 May; 41(5): 292-297.
Hedtjarn, M., Mallard, C. and Hagberg, H. Inflammatory gene profiling in the developing mouse brain after HI. J Cereb Blood Flow Metab. 2004 Dec; 24(12): 1333-1351.
Heneka, M. T., Landreth, G. E. and Feinstein, D. L. Role for peroxisome proliferator-activated receptor-gamma in Alzheimer''s disease. Ann Neurol. 2001 Feb; 49(2): 276.
Hill, J. B., Sheffield, J. S., Kim, M. J., Alexander, J. M., Sercely, B. and Wendel, G. D. Risk of hepatitis B transmission in breast-fed infants of chronic hepatitis B carriers. Obstet Gynecol. 2002 Jun; 99(6): 1049-1052.
Hoane, M. R., Lasley, L. A. and Akstulewicz, S. L. Middle age increases tissue vulnerability and impairs sensorimotor and cognitive recovery following traumatic brain injury in the rat. Behav Brain Res. 2004 Aug 12; 153(1): 189-197.
Hsu, H. C., Wu, M. Z., Chang, M. H., Su, I. J. and Chen, D. S. Childhood hepatocellular carcinoma develops exclusively in hepatitis B surface antigen carriers in three decades in Taiwan. Report of 51 cases strongly associated with rapid development of liver cirrhosis. J Hepatol. 1987 Dec; 5(3): 260-267.
Hsu, H. M., Chen, D. S., Chuang, C. H., Lu, J. C., Jwo, D. M., Lee, C. C., Lu, H. C., Cheng, S. H., Wang, Y. F., Wang, C. Y. and et al. Efficacy of a mass hepatitis B vaccination program in Taiwan. Studies on 3464 infants of hepatitis B surface antigen-carrier mothers. Jama. 1988 Oct 21; 260(15): 2231-2235.
Hsu, H. M., Lu, C. F., Lee, S. C., Lin, S. R. and Chen, D. S. Seroepidemiologic survey for hepatitis B virus infection in Taiwan: the effect of hepatitis B mass immunization. J Infect Dis. 1999 Feb; 179(2): 367-370.
Hsu, H. Y., Chang, M. H., Hsieh, K. H., Lee, C. Y., Lin, H. H., Hwang, L. H., Chen, P. J. and Chen, D. S. Cellular immune response to HBcAg in mother-to-infant transmission of hepatitis B virus. Hepatology. 1992 May; 15(5): 770-776.
Hsu, H. Y., Chang, M. H., Ni, Y. H. and Chen, H. L. Survey of hepatitis B surface variant infection in children 15 years after a nationwide vaccination programme in Taiwan. Gut. 2004 Oct; 53(10): 1499-1503.
Hsu, H. Y., Chang, M. H., Ni, Y. H., Lin, H. H., Wang, S. M. and Chen, D. S. Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis. Hepatology. 1997 Sep; 26(3): 786-791.
Hu, P., Fan, J., Xu, P., Zhou, S., Zhang, L., Tian, Y. and Wang, K. Attention network impairments in patients with focal frontal or parietal lesions. Neurosci Lett. 2013 Feb 8; 534: 177-181.
Huang, F. Y., Lee, P. I., Lee, C. Y., Huang, L. M., Chang, L. Y. and Liu, S. C. Hepatitis B vaccination in preterm infants. Arch Dis Child Fetal Neonatal Ed. 1997 Sep; 77(2): F135-138.
Huizinga, M., Dolan, C. V. and van der Molen, M. W. Age-related change in executive function: developmental trends and a latent variable analysis. Neuropsychologia. 2006 44(11): 2017-2036.
Ip, H. M., Lelie, P. N., Wong, V. C., Kuhns, M. C. and Reesink, H. W. Prevention of hepatitis B virus carrier state in infants according to maternal serum levels of HBV DNA. Lancet. 1989 Feb 25; 1(8635): 406-410.
Ivacko, J. A., Sun, R. and Silverstein, F. S. Hypoxic-ischemic brain injury induces an acute microglial reaction in perinatal rats. Pediatr Res. 1996 Jan; 39(1): 39-47.
Jacobs, R., Harvey, A. S. and Anderson, V. Executive function following focal frontal lobe lesions: impact of timing of lesion on outcome. Cortex. 2007 Aug; 43(6): 792-805.
Jacobs, R., Harvey, A. S. and Anderson, V. Are executive skills primarily mediated by the prefrontal cortex in childhood? Examination of focal brain lesions in childhood. Cortex. 2011 Jul-Aug; 47(7): 808-824.
Jadhav, V., Matchett, G., Hsu, F. P. and Zhang, J. H. Inhibition of Src tyrosine kinase and effect on outcomes in a new in vivo model of surgically induced brain injury. J Neurosurg. 2007 Apr; 106(4): 680-686.
Johnson, V. E., Stewart, W. and Smith, D. H. Axonal pathology in traumatic brain injury. Exp Neurol. 2012 Jan 20.
Kaidanovich-Beilin, O., Lipina, T., Vukobradovic, I., Roder, J. and Woodgett, J. R. Assessment of social interaction behaviors. J Vis Exp. 2011 (48).
Kalpakidou, A. K., Allin, M. P., Walshe, M., Giampietro, V., Nam, K. W., McGuire, P., Rifkin, L., Murray, R. M. and Nosarti, C. Neonatal brain injury and neuroanatomy of memory processing following very preterm birth in adulthood: an fMRI study. PloS one. 2012 7(4): e34858.
Kao, J. H., Hsu, H. M., Shau, W. Y., Chang, M. H. and Chen, D. S. Universal hepatitis B vaccination and the decreased mortality from fulminant hepatitis in infants in Taiwan. J Pediatr. 2001 Sep; 139(3): 349-352.
Karthigesu, V. D., Allison, L. M., Ferguson, M. and Howard, C. R. A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg "a" determinant. J Med Virol. 1999 Aug; 58(4): 346-352.
Karver, C. L., Wade, S. L., Cassedy, A., Taylor, H. G., Stancin, T., Yeates, K. O. and Walz, N. C. Age at injury and long-term behavior problems after traumatic brain injury in young children. Rehabil Psychol. 2012 Aug; 57(3): 256-265.
Katz-Leurer, M., Rotem, H., Lewitus, H., Keren, O. and Meyer, S. Relationship between balance abilities and gait characteristics in children with post-traumatic brain injury. Brain Inj. 2008 Feb; 22(2): 153-159.
Kaukola, T., Satyaraj, E., Patel, D. D., Tchernev, V. T., Grimwade, B. G., Kingsmore, S. F., Koskela, P., Tammela, O., Vainionpaa, L., Pihko, H., Aarimaa, T. and Hallman, M. Cerebral palsy is characterized by protein mediators in cord serum. Ann Neurol. 2004 Feb; 55(2): 186-194.
Kaur, C., Rathnasamy, G. and Ling, E. A. Roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina. Journal of neuroimmune pharmacology. 2013 Mar; 8(1): 66-78.
Kesler, K., Nasenbeny, J., Wainwright, R., McMahon, B. and Bulkow, L. Immune responses of prematurely born infants to hepatitis B vaccination: results through three years of age. Pediatr Infect Dis J. 1998 Feb; 17(2): 116-119.
Khalak, R., Pichichero, M. E. and D''Angio, C. T. Three-year follow-up of vaccine response in extremely preterm infants. Pediatrics. 1998 Apr; 101(4 Pt 1): 597-603.
Kiaei, M., Kipiani, K., Chen, J., Calingasan, N. Y. and Beal, M. F. Peroxisome proliferator-activated receptor-gamma agonist extends survival in transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol. 2005 Feb; 191(2): 331-336.
Kielian, T. and Drew, P. D. Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation. J Neurosci Res. 2003 Feb 1; 71(3): 315-325.
Kilbourne, M., Kuehn, R., Tosun, C., Caridi, J., Keledjian, K., Bochicchio, G., Scalea, T., Gerzanich, V. and Simard, J. M. Novel model of frontal impact closed head injury in the rat. J Neurotrauma. 2009 Dec; 26(12): 2233-2243.
Kim, S. C., Chung, E. K., Hodinka, R. L., DeMaio, J., West, D. J., Jawad, A. F. and Watson, B. Immunogenicity of hepatitis B vaccine in preterm infants. Pediatrics. 1997 Apr; 99(4): 534-536.
Kirmani, K. I., Lofthus, G., Pichichero, M. E., Voloshen, T. and D''Angio, C. T. Seven-year follow-up of vaccine response in extremely premature infants. Pediatrics. 2002 Mar; 109(3): 498-504.
Kolb, B., Gibb, R. and Gorny, G. Cortical plasticity and the development of behavior after early frontal cortical injury. Dev Neuropsychol. 2000 18(3): 423-444.
Kolb, B., Holmes, C. and Whishaw, I. Q. Recovery from early cortical lesions in rats. III. Neonatal removal of posterior parietal cortex has greater behavioral and anatomical effects than similar removals in adulthood. Behav Brain Res. 1987 Nov-Dec; 26(2-3): 119-137.
Kolb, B. and Whishaw, I. Q. Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and neocortical thickness. Behav Neurosci. 1985 Aug; 99(4): 691-706.
Kramer, B. W. Antenatal inflammation and lung injury: prenatal origin of neonatal disease. J Perinatol. 2008 May; 28 Suppl 1: S21-27.
Kuhtz-Buschbeck, J. P., Hoppe, B., Golge, M., Dreesmann, M., Damm-Stunitz, U. and Ritz, A. Sensorimotor recovery in children after traumatic brain injury: analyses of gait, gross motor, and fine motor skills. Dev Med Child Neurol. 2003 Dec; 45(12): 821-828.
Kuhtz-Buschbeck, J. P., Stolze, H., Golge, M. and Ritz, A. Analyses of gait, reaching, and grasping in children after traumatic brain injury. Arch Phys Med Rehabil. 2003 Mar; 84(3): 424-430.
Lahra, M. M. and Jeffery, H. E. A fetal response to chorioamnionitis is associated with early survival after preterm birth. Am J Obstet Gynecol. 2004 Jan; 190(1): 147-151.
Lalonde, R. and Strazielle, C. Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice. J Neurosci Methods. 2008 Jun 15; 171(1): 48-52.
Lau, Y. L., Tam, A. Y., Ng, K. W., Tsoi, N. S., Lam, B., Lam, P. and Yeung, C. Y. Response of preterm infants to hepatitis B vaccine. J Pediatr. 1992 Dec; 121(6): 962-965.
Lavanchy, D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004 Mar; 11(2): 97-107.
Laviola, G., Macri, S., Morley-Fletcher, S. and Adriani, W. Risk-taking behavior in adolescent mice: psychobiological determinants and early epigenetic influence. Neurosci Biobehav Rev. 2003 Jan-Mar; 27(1-2): 19-31.
Lee, C., Gong, Y., Brok, J., Boxall, E. H. and Gluud, C. Effect of hepatitis B immunisation in newborn infants of mothers positive for hepatitis B surface antigen: systematic review and meta-analysis. BMJ. 2006 Feb 11; 332(7537): 328-336.
Lee, W. M. Hepatitis B virus infection. N Engl J Med. 1997 Dec 11; 337(24): 1733-1745.
Lehrke, M. and Lazar, M. A. The many faces of PPARgamma. Cell. 2005 Dec 16; 123(6): 993-999.
Lemon, R. N. and Griffiths, J. Comparing the function of the corticospinal system in different species: organizational differences for motor specialization? Muscle Nerve. 2005 Sep; 32(3): 261-279.
Levene, M. L., Kornberg, J. and Williams, T. H. The incidence and severity of post-asphyxial encephalopathy in full-term infants. Early Hum Dev. 1985 May; 11(1): 21-26.
Levin, H. S. and Hanten, G. Executive functions after traumatic brain injury in children. Pediatr Neurol. 2005 Aug; 33(2): 79-93.
Levin, H. S., Hanten, G., Zhang, L., Swank, P. R., Ewing-Cobbs, L., Dennis, M., Barnes, M. A., Max, J., Schachar, R., Chapman, S. B. and Hunter, J. V. Changes in working memory after traumatic brain injury in children. Neuropsychology. 2004 Apr; 18(2): 240-247.
Levin, H. S., Zhang, L., Dennis, M., Ewing-Cobbs, L., Schachar, R., Max, J., Landis, J. A., Roberson, G., Scheibel, R. S., Miller, D. L. and Hunter, J. V. Psychosocial outcome of TBI in children with unilateral frontal lesions. J Int Neuropsychol Soc. 2004 May; 10(3): 305-316.
Leviton, A., Gilles, F., Neff, R. and Yaney, P. Multivariate analysis of risk of perinatal telencephalic leucoencephalopathy. American journal of epidemiology. 1976 Dec; 104(6): 621-626.
Li, G., Cui, G., Tzeng, N. S., Wei, S. J., Wang, T., Block, M. L. and Hong, J. S. Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. Faseb J. 2005 Apr; 19(6): 489-496.
Lin, H. H., Chang, M. H., Chen, D. S., Sung, J. L., Hong, K. H., Young, Y. C., Yang, K. H. and Lee, T. Y. Early predictor of the efficacy of immunoprophylaxis against perinatal hepatitis B transmission: analysis of prophylaxis failure. Vaccine. 1991 Jun; 9(6): 457-460.
Lin, H. H., Kao, J. H., Hsu, H. Y., Mizokami, M., Hirano, K. and Chen, D. S. Least microtransfusion from mother to fetus in elective cesarean delivery. Obstet Gynecol. 1996 Feb; 87(2): 244-248.
Lin, H. H., Lee, T. Y., Chen, D. S., Sung, J. L., Ohto, H., Etoh, T., Kawana, T. and Mizuno, M. Transplacental leakage of HBeAg-positive maternal blood as the most likely route in causing intrauterine infection with hepatitis B virus. J Pediatr. 1987 Dec; 111(6 Pt 1): 877-881.
Lin, H. Y., Huang, C. C. and Chang, K. F. Lipopolysaccharide preconditioning reduces neuroinflammation against hypoxic ischemia and provides long-term outcome of neuroprotection in neonatal rat. Pediatr Res. 2009 Sep; 66(3): 254-259.
Lin, T. N., Cheung, W. M., Wu, J. S., Chen, J. J., Lin, H., Chen, J. J., Liou, J. Y., Shyue, S. K. and Wu, K. K. 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol. 2006 Mar; 26(3): 481-487.
Lin, Y. C., Chang, M. H., Ni, Y. H., Hsu, H. Y. and Chen, D. S. Long-term immunogenicity and efficacy of universal hepatitis B virus vaccination in Taiwan. J Infect Dis. 2003 Jan 1; 187(1): 134-138.
Linder, N., Handsher, R., German, B., Sirota, L., Bachman, M., Zinger, S., Mendelson, E. and Barzilai, A. Controlled trial of immune response of preterm infants to recombinant hepatitis B and inactivated poliovirus vaccines administered simultaneously shortly after birth. Arch Dis Child Fetal Neonatal Ed. 2000 Jul; 83(1): F24-27.
Linder, N., Vishne, T. H., Levin, E., Handsher, R., Fink-Kremer, I., Waldman, D., Levine, A., Ashkenazi, S. and Sirota, L. Hepatitis B vaccination: long-term follow-up of the immune response of preterm infants and comparison of two vaccination protocols. Infection. 2002 Jun; 30(3): 136-139.
Lindner, M. D., Plone, M. A., Cain, C. K., Frydel, B., Francis, J. M., Emerich, D. F. and Sutton, R. L. Dissociable long-term cognitive deficits after frontal versus sensorimotor cortical contusions. J Neurotrauma. 1998 Mar; 15(3): 199-216.
Liu, Y., Qin, L., Li, G., Zhang, W., An, L., Liu, B. and Hong, J. S. Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation. J Pharmacol Exp Ther. 2003 Apr; 305(1): 212-218.
Lok, A. S. Chronic hepatitis B. N Engl J Med. 2002 May 30; 346(22): 1682-1683.
Lok, A. S. and Lai, C. L. A longitudinal follow-up of asymptomatic hepatitis B surface antigen-positive Chinese children. Hepatology. 1988 Sep-Oct; 8(5): 1130-1133.
Lok, A. S. and McMahon, B. J. Chronic hepatitis B. Hepatology. 2007 Feb; 45(2): 507-539.
Losonsky, G. A., Wasserman, S. S., Stephens, I., Mahoney, F., Armstrong, P., Gumpper, K., Dulkerian, S., West, D. J. and Gewolb, I. H. Hepatitis B vaccination of premature infants: a reassessment of current recommendations for delayed immunization. Pediatrics. 1999 Feb; 103(2): E14.
Lowe, J., Duvall, S. W., MacLean, P. C., Caprihan, A., Ohls, R., Qualls, C. and Phillips, J. Comparison of structural magnetic resonance imaging and development in toddlers born very low birth weight and full-term. J Child Neurol. 2011 May; 26(5): 586-592.
Lu, D. Y., Yu, W. H., Yeh, W. L., Tang, C. H., Leung, Y. M., Wong, K. L., Chen, Y. F., Lai, C. H. and Fu, W. M. Hypoxia-induced matrix metalloproteinase-13 expression in astrocytes enhances permeability of brain endothelial cells. J Cell Physiol. 2009 Jul; 220(1): 163-173.
Luna-Medina, R., Cortes-Canteli, M., Alonso, M., Santos, A., Martinez, A. and Perez-Castillo, A. Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. J Biol Chem. 2005 Jun 3; 280(22): 21453-21462.
Luo, Y., Yin, W., Signore, A. P., Zhang, F., Hong, Z., Wang, S., Graham, S. H. and Chen, J. Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. J Neurochem. 2006 Apr; 97(2): 435-448.
Malecki, J. M., Guarin, O., Hulbert, A. and Brumback, C. L. Prevalence of hepatitis B surface antigen among women receiving prenatal care at the Palm Beach County Health Department. Am J Obstet Gynecol. 1986 Mar; 154(3): 625-626.
Mallard, C. and Hagberg, H. Inflammation-induced preconditioning in the immature brain. Semin Fetal Neonatal Med. 2007 Aug; 12(4): 280-286.
Marlow, N., Hennessy, E. M., Bracewell, M. A., Wolke, D. and Group, E. P. S. Motor and executive function at 6 years of age after extremely preterm birth. Pediatrics. 2007 Oct; 120(4): 793-804.
Martens, K. M., Vonder Haar, C., Hutsell, B. A. and Hoane, M. R. A discrimination task used as a novel method of testing decision-making behavior following traumatic brain injury. J Neurotrauma. 2012 Oct 10; 29(15): 2505-2512.
Mast, E. E., Margolis, H. S., Fiore, A. E., Brink, E. W., Goldstein, S. T., Wang, S. A., Moyer, L. A., Bell, B. P. and Alter, M. J. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep. 2005 Dec 23; 54(RR-16): 1-31.
McRae, A., Gilland, E., Bona, E. and Hagberg, H. Microglia activation after neonatal hypoxic-ischemia. Brain Res Dev Brain Res. 1995 Feb 16; 84(2): 245-252.
Meyer, U., Feldon, J. and Dammann, O. Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatr Res. 2011 May; 69(5 Pt 2): 26R-33R.
Milich, D. and Liang, T. J. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology. 2003 Nov; 38(5): 1075-1086.
Milich, D. R., Jones, J. E., Hughes, J. L., Price, J., Raney, A. K. and McLachlan, A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci U S A. 1990 Sep; 87(17): 6599-6603.
Monyer, H. and Choi, D. W. Morphinans attenuate cortical neuronal injury induced by glucose deprivation in vitro. Brain Res. 1988 Apr 12; 446(1): 144-148.
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J. and Crawley, J. N. Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav. 2004 Oct; 3(5): 287-302.
Murias, K., Brooks, B., Kirton, A. and Iaria, G. A review of cognitive outcomes in children following perinatal stroke. Dev Neuropsychol. 2014 39(2): 131-157.
Ngui, S. L., Andrews, N. J., Underhill, G. S., Heptonstall, J. and Teo, C. G. Failed postnatal immunoprophylaxis for hepatitis B: characteristics of maternal hepatitis B virus as risk factors. Clin Infect Dis. 1998 Jul; 27(1): 100-106.
Ni, Y. H., Chang, M. H., Wu, J. F., Hsu, H. Y., Chen, H. L. and Chen, D. S. Minimization of hepatitis B infection by a 25-year universal vaccination program. J Hepatol. 2012 Oct; 57(4): 730-735.
Ni, Y. H., Huang, L. M., Chang, M. H., Yen, C. J., Lu, C. Y., You, S. L., Kao, J. H., Lin, Y. C., Chen, H. L., Hsu, H. Y. and Chen, D. S. Two decades of universal hepatitis B vaccination in taiwan: impact and implication for future strategies. Gastroenterology. 2007 Apr; 132(4): 1287-1293.
Niino, M., Iwabuchi, K., Kikuchi, S., Ato, M., Morohashi, T., Ogata, A., Tashiro, K. and Onoe, K. Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma. J Neuroimmunol. 2001 May 1; 116(1): 40-48.
Onderdonk, A. B., Delaney, M. L., DuBois, A. M., Allred, E. N., Leviton, A. and Extremely Low Gestational Age Newborns Study, I. Detection of bacteria in placental tissues obtained from extremely low gestational age neonates. Am J Obstet Gynecol. 2008 Jan; 198(1): 110 e111-117.
Oni, M. B., Wilde, E. A., Bigler, E. D., McCauley, S. R., Wu, T. C., Yallampalli, R., Chu, Z., Li, X., Hunter, J. V., Vasquez, A. C. and Levin, H. S. Diffusion tensor imaging analysis of frontal lobes in pediatric traumatic brain injury. J Child Neurol. 2010 Aug; 25(8): 976-984.
Park, H. K., Seol, I. J. and Kim, K. S. Protective effect of HP on hypoxic-ischemic injured newborn rats. J Korean Med Sci. 2011 Nov; 26(11): 1495-1500.
Patel, D. M., Butler, J., Feldman, S., Graves, G. R. and Rhodes, P. G. Immunogenicity of hepatitis B vaccine in healthy very low birth weight infants. J Pediatr. 1997 Oct; 131(4): 641-643.
Pereira, M. P., Hurtado, O., Cardenas, A., Alonso-Escolano, D., Bosca, L., Vivancos, J., Nombela, F., Leza, J. C., Lorenzo, P., Lizasoain, I. and Moro, M. A. The nonthiazolidinedione PPARgamma agonist L-796,449 is neuroprotective in experimental stroke. J Neuropathol Exp Neurol. 2005 Sep; 64(9): 797-805.
Pereira, M. P., Hurtado, O., Cardenas, A., Bosca, L., Castillo, J., Davalos, A., Vivancos, J., Serena, J., Lorenzo, P., Lizasoain, I. and Moro, M. A. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. J Cereb Blood Flow Metab. 2006 Feb; 26(2): 218-229.
Perez-Pinzon, M. A., Mumford, P. L., Rosenthal, M. and Sick, T. J. Anoxic preconditioning in hippocampal slices: role of adenosine. Neuroscience. 1996 Dec; 75(3): 687-694.
Perez-Pinzon, M. A., Vitro, T. M., Dietrich, W. D. and Sick, T. J. The effect of rapid preconditioning on the microglial, astrocytic and neuronal consequences of global cerebral ischemia. Acta Neuropathol (Berl). 1999 May; 97(5): 495-501.
Poland, G. A. and Jacobson, R. M. Clinical practice: prevention of hepatitis B with the hepatitis B vaccine. N Engl J Med. 2004 Dec 30; 351(27): 2832-2838.
Poovorawan, Y., Theamboonlers, A., Vimolket, T., Sinlaparatsamee, S., Chaiear, K., Siraprapasiri, T., Khwanjaipanich, S., Owatanapanich, S., Hirsch, P. and Chunsuttiwat, S. Impact of hepatitis B immunisation as part of the EPI. Vaccine. 2000 Nov 22; 19(7-8): 943-949.
Potts, M. B., Koh, S. E., Whetstone, W. D., Walker, B. A., Yoneyama, T., Claus, C. P., Manvelyan, H. M. and Noble-Haeusslein, L. J. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx. 2006 Apr; 3(2): 143-153.
Prince, D. A. and Feeser, H. R. Dextromethorphan protects against cerebral infarction in a rat model of HI. Neurosci Lett. 1988 Mar 10; 85(3): 291-296.
Prins, M. L. and Hovda, D. A. Traumatic brain injury in the developing rat: effects of maturation on Morris water maze acquisition. J Neurotrauma. 1998 Oct; 15(10): 799-811.
Pullela, R., Raber, J., Pfankuch, T., Ferriero, D. M., Claus, C. P., Koh, S. E., Yamauchi, T., Rola, R., Fike, J. R. and Noble-Haeusslein, L. J. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Dev Neurosci. 2006 28(4-5): 396-409.
Rice, J. E., 3rd, Vannucci, R. C. and Brierley, J. B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol. 1981 Feb; 9(2): 131-141.
Rodrigues, M. C., Mello, R. R. and Fonseca, S. C. Learning difficulties in schoolchildren born with very low birth weight. Jornal de pediatria. 2006 Jan-Feb; 82(1): 6-14.
Rola, R., Raber, J., Rizk, A., Otsuka, S., VandenBerg, S. R., Morhardt, D. R. and Fike, J. R. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp Neurol. 2004 Aug; 188(2): 316-330.
Romero, R., Espinoza, J., Goncalves, L. F., Kusanovic, J. P., Friel, L. and Hassan, S. The role of inflammation and infection in preterm birth. Seminars in reproductive medicine. 2007 Jan; 25(1): 21-39.
Romero, R. and Garite, T. J. Twenty percent of very preterm neonates (23-32 weeks of gestation) are born with bacteremia caused by genital Mycoplasmas. Am J Obstet Gynecol. 2008 Jan; 198(1): 1-3.
Rosenzweig, H. L., Lessov, N. S., Henshall, D. C., Minami, M., Simon, R. P. and Stenzel-Poore, M. P. Endotoxin preconditioning prevents cellular inflammatory response during ischemic neuroprotection in mice. Stroke. 2004 Nov; 35(11): 2576-2581.
Rudebeck, P. H., Buckley, M. J., Walton, M. E. and Rushworth, M. F. A role for the macaque anterior cingulate gyrus in social valuation. Science. 2006 Sep 1; 313(5791): 1310-1312.
Rudebeck, P. H., Walton, M. E., Millette, B. H., Shirley, E., Rushworth, M. F. and Bannerman, D. M. Distinct contributions of frontal areas to emotion and social behaviour in the rat. Eur J Neurosci. 2007 Oct; 26(8): 2315-2326.
Ryan, B. C., Young, N. B., Moy, S. S. and Crawley, J. N. Olfactory cues are sufficient to elicit social approach behaviors but not social transmission of food preference in C57BL/6J mice. Behav Brain Res. 2008 Nov 21; 193(2): 235-242.
Saari, T. N. Immunization of preterm and low birth weight infants. American Academy of Pediatrics Committee on Infectious Diseases. Pediatrics. 2003 Jul; 112(1 Pt 1): 193-198.
Salchner, P., Lubec, G. and Singewald, N. Decreased social interaction in aged rats may not reflect changes in anxiety-related behaviour. Behav Brain Res. 2004 May 5; 151(1-2): 1-8.
Schlapbach, L. J., Aebischer, M., Adams, M., Natalucci, G., Bonhoeffer, J., Latzin, P., Nelle, M., Bucher, H. U., Latal, B., Swiss Neonatal, N. and Follow-Up, G. Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infants. Pediatrics. 2011 Aug; 128(2): e348-357.
Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M. and Noble-Haeusslein, L. J. Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species. Prog Neurobiol. 2013 Apr 11.
Semple, B. D., Canchola, S. A. and Noble-Haeusslein, L. Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice. J Neurotrauma. 2012 Aug 14.
Shao, Z. J., Xu, D. Z., Xu, J. Q., Li, J. H., Yan, Y. P., Men, K., Wang, X. P., Zhang, Z. Y., Jiang, Q. W. and Zhang, L. Maternal hepatitis B virus (HBV) DNA positivity and sexual intercourse are associated with HBV intrauterine transmission in China: a prospective case-control study. J Gastroenterol Hepatol. 2007 Feb; 22(2): 165-170.
Shatrov, J. G., Birch, S. C., Lam, L. T., Quinlivan, J. A., McIntyre, S. and Mendz, G. L. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol. 2010 Aug; 116(2 Pt 1): 387-392.
Shimazu, T., Inoue, I., Araki, N., Asano, Y., Sawada, M., Furuya, D., Nagoya, H. and Greenberg, J. H. A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke. 2005 Feb; 36(2): 353-359.
Shiraki, K., Yoshihara, N., Sakurai, M., Eto, T. and Kawana, T. Acute hepatitis B in infants born to carrier mother with the antibody to hepatitis B e antigen. J Pediatr. 1980 Nov; 97(5): 768-770.
Shultz, S. R., MacFabe, D. F., Foley, K. A., Taylor, R. and Cain, D. P. A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: support for an animal model of concussion. Behav Brain Res. 2011 Oct 31; 224(2): 326-335.
Siopi, E., Calabria, S., Plotkine, M., Marchand-Leroux, C. and Jafarian-Tehrani, M. Minocycline restores olfactory bulb volume and olfactory behavior after traumatic brain injury in mice. J Neurotrauma. 2012 Jan 20; 29(2): 354-361.
Slowik, M. K. and Jhaveri, R. Hepatitis B and C viruses in infants and young children. Semin Pediatr Infect Dis. 2005 Oct; 16(4): 296-305.
Spear, L. Modeling adolescent development and alcohol use in animals. Alcohol Res Health. 2000 24(2): 115-123.
Speer, C. P. Chorioamnionitis, postnatal factors and proinflammatory response in the pathogenetic sequence of bronchopulmonary dysplasia. Neonatology. 2009 95(4): 353-361.
Spencer-Smith, M. and Anderson, V. Healthy and abnormal development of the prefrontal cortex. Dev Neurorehabil. 2009 12(5): 279-297.
Spencer, C. M., Alekseyenko, O., Serysheva, E., Yuva-Paylor, L. A. and Paylor, R. Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome. Genes Brain Behav. 2005 Oct; 4(7): 420-430.
Spikeman, J. M., Timmerman, M. E., Milders, M. V., Veenstra, W. S. and van der Naalt, J. Social cognition impairments in relation to general cognitive deficits, injury severity, and prefrontal lesions in traumatic brain injury patients. J Neurotrauma. 2012 Jan 1; 29(1): 101-111.
Spreng, M., Rossier, J. and Schenk, F. Spaced training facilitates long-term retention of place navigation in adult but not in adolescent rats. Behav Brain Res. 2002 Jan 7; 128(1): 103-108.
Steinberg, G. K., George, C. P., DeLaPaz, R., Shibata, D. K. and Gross, T. Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits. Stroke. 1988 Sep; 19(9): 1112-1118.
Stetler, R. A., Leak, R. K., Gan, Y., Li, P., Zhang, F., Hu, X., Jing, Z., Chen, J., Zigmond, M. J. and Gao, Y. Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance. Prog Neurobiol. 2014 Mar; 114: 58-83.
Stevens, C. E., Beasley, R. P., Tsui, J. and Lee, W. C. Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med. 1975 Apr 10; 292(15): 771-774.
Stigger, F., Lovatel, G., Marques, M., Bertoldi, K., Moyses, F., Elsner, V., Siqueira, I. R., Achaval, M. and Marcuzzo, S. Inflammatory response and oxidative stress in developing rat brain and its consequences on motor behavior following maternal administration of LPS and perinatal anoxia. Int J Dev Neurosci. 2013 Dec; 31(8): 820-827.
Storer, P. D., Xu, J., Chavis, J. and Drew, P. D. Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. J Neuroimmunol. 2005 Apr; 161(1-2): 113-122.
Storer, P. D., Xu, J., Chavis, J. A. and Drew, P. D. Cyclopentenone prostaglandins PGA2 and 15-deoxy-delta12,14 PGJ2 suppress activation of murine microglia and astrocytes: implications for multiple sclerosis. J Neurosci Res. 2005 Apr 1; 80(1): 66-74.
Strunk, T., Inder, T., Wang, X., Burgner, D., Mallard, C. and Levy, O. Infection-induced inflammation and cerebral injury in preterm infants. The Lancet Infectious Diseases. 2014 14(8): 751-762.
Su, H. X., Xu, D. Z., Li, D., Zhang, J. X., Lu, J., Choi, B. C. and Yan, Y. P. Heterogeneity analysis of the hepatitis B virus genome in intrauterine infection. J Med Virol. 2005 Oct; 77(2): 180-187.
Sun, J. and Buys, N. Early executive function deficit in preterm children and its association with neurodevelopmental disorders in childhood: a literature review. International journal of adolescent medicine and health. 2012 24(4): 291-299.
Sundararajan, S., Gamboa, J. L., Victor, N. A., Wanderi, E. W., Lust, W. D. and Landreth, G. E. Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience. 2005 130(3): 685-696.
Suryana, E. and Jones, N. M. The effects of HP on white matter damage following hypoxic-ischaemic injury in the neonatal rat brain. Int J Dev Neurosci. 2014 Oct; 37: 69-75.
Szaflarski, J., Burtrum, D. and Silverstein, F. S. Cerebral HI stimulates cytokine gene expression in perinatal rats. Stroke. 1995 Jun; 26(6): 1093-1100.
Tahraoui, S. L., Marret, S., Bodenant, C., Leroux, P., Dommergues, M. A., Evrard, P. and Gressens, P. Central role of microglia in neonatal excitotoxic lesions of the murine periventricular white matter. Brain pathology. 2001 Jan; 11(1): 56-71.
Tang, J. R., Hsu, H. Y., Lin, H. H., Ni, Y. H. and Chang, M. H. Hepatitis B surface antigenemia at birth: a long-term follow-up study. J Pediatr. 1998 Sep; 133(3): 374-377.
Thomas, D. M. and Kuhn, D. M. MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity. Brain Res. 2005 Jul 19; 1050(1-2): 190-198.
Tong, W., Igarashi, T., Ferriero, D. M. and Noble, L. J. Traumatic brain injury in the immature mouse brain: characterization of regional vulnerability. Exp Neurol. 2002 Jul; 176(1): 105-116.
Tortella, F. C., Britton, P., Williams, A., Lu, X. C. and Newman, A. H. Neuroprotection (focal ischemia) and neurotoxicity (electroencephalographic) studies in rats with AHN649, a 3-amino analog of dextromethorphan and low-affinity N-methyl-D-aspartate antagonist. J Pharmacol Exp Ther. 1999 Oct; 291(1): 399-408.
Tran, T. T. and Martin, P. Hepatitis B: epidemiology and natural history. Clin Liver Dis. 2004 May; 8(2): 255-266.
Trendelenburg, G. and Dirnagl, U. Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia. 2005 Jun; 50(4): 307-320.
Tse, K., Siu, S. L., Yip, K. T., Chan, S. M., Que, T. L., Lui, W. Y. and Chan, P. S. Immuno-prophylaxis of babies borne to hepatitis B carrier mothers. Hong Kong Med J. 2006 Oct; 12(5): 368-374.
Tsuru-Aoyagi, K., Potts, M. B., Trivedi, A., Pfankuch, T., Raber, J., Wendland, M., Claus, C. P., Koh, S. E., Ferriero, D. and Noble-Haeusslein, L. J. Glutathione peroxidase activity modulates recovery in the injured immature brain. Ann Neurol. 2009 May; 65(5): 540-549.
Tucker, J. and McGuire, W. Epidemiology of preterm birth. BMJ. 2004 Sep 18; 329(7467): 675-678.
Van Herck, K. and Van Damme, P. Benefits of early hepatitis B immunization programs for newborns and infants. Pediatr Infect Dis J. 2008 Oct; 27(10): 861-869.
Vannucci, R. C., Towfighi, J. and Vannucci, S. J. HP and hypoxic-ischemic brain damage in the immature rat: pathologic and metabolic correlates. J Neurochem. 1998 Sep; 71(3): 1215-1220.
Volpe, J. J. (2008.). Neurology of the newborn. Philadelphia, Saunders/Elsevier.
Walker, W. C. and Pickett, T. C. Motor impairment after severe traumatic brain injury: A longitudinal multicenter study. J Rehabil Res Dev. 2007 44(7): 975-982.
Wang, C. W., Wang, L. C., Chang, M. H., Ni, Y. H., Chen, H. L., Hsu, H. Y. and Chen, D. S. Long-term follow-up of Hepatitis B Surface antibody levels in subjects receiving universal Hepatitis B vaccination in infancy in an area of hyperendemicity: correlation between radioimmunoassay and enzyme immunoassay. Clin Diagn Lab Immunol. 2005 Dec; 12(12): 1442-1447.
Wang, J. S. and Zhu, Q. R. Infection of the fetus with hepatitis B e antigen via the placenta. Lancet. 2000 Mar 18; 355(9208): 989.
Wang, Z., Zhang, J., Yang, H., Li, X., Wen, S., Guo, Y., Sun, J. and Hou, J. Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol. 2003 Nov; 71(3): 360-366.
Wen, W. H., Chang, M. H., Hsu, H. Y., Ni, Y. H. and Chen, H. L. The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection. J Pediatr. 2004 Mar; 144(3): 397-399.
Wilde, E. A., Hunter, J. V., Newsome, M. R., Scheibel, R. S., Bigler, E. D., Johnson, J. L., Fearing, M. A., Cleavinger, H. B., Li, X., Swank, P. R., Pedroza, C., Roberson, G. S., Bachevalier, J. and Levin, H. S. Frontal and temporal morphometric findings on MRI in children after moderate to severe traumatic brain injury. J Neurotrauma. 2005 Mar; 22(3): 333-344.
Wilde, E. A., Merkley, T. L., Bigler, E. D., Max, J. E., Schmidt, A. T., Ayoub, K. W., McCauley, S. R., Hunter, J. V., Hanten, G., Li, X., Chu, Z. D. and Levin, H. S. Longitudinal changes in cortical thickness in children after traumatic brain injury and their relation to behavioral regulation and emotional control. Int J Dev Neurosci. 2012 30: 267-276.
Williams, G., Galna, B., Morris, M. E. and Olver, J. Spatiotemporal deficits and kinematic classification of gait following a traumatic brain injury: a systematic review. J Head Trauma Rehabil. 2010 Sep-Oct; 25(5): 366-374.
Wright, T. L. Introduction to chronic hepatitis B infection. Am J Gastroenterol. 2006 101 Suppl 1: S1-6.
Wu, Y. W. and Colford, J. M., Jr. Chorioamnionitis as a risk factor for cerebral palsy: A meta-analysis. JAMA. 2000 Sep 20; 284(11): 1417-1424.
Xu, D. Z., Yan, Y. P., Choi, B. C., Xu, J. Q., Men, K., Zhang, J. X., Liu, Z. H. and Wang, F. S. Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study. J Med Virol. 2002 May; 67(1): 20-26.
Xu, D. Z., Yan, Y. P., Zou, S., Choi, B. C., Wang, S., Liu, P., Bai, G., Wang, X. and Shi, M. Role of placental tissues in the intrauterine transmission of hepatitis B virus. Am J Obstet Gynecol. 2001 Oct; 185(4): 981-987.
Xu, Y. Y., Yu, J. Y., Zhong, Y. W., Song, H. B., Liu, H. H., Jia, L. L., Li, S. L., Xu, J. Q. and Li, Q. Association between the frequency of class II HLA antigens and the susceptibility to intrauterine infection of hepatitis B virus. Int J Biol Sci. 2008 4(2): 111-115.
Xu, Z. Y., Duan, S. C., Margolis, H. S., Purcell, R. H., Ou-Yang, P. Y., Coleman, P. J., Zhuang, Y. L., Xu, H. F., Qian, S. G., Zhu, Q. R. and et al. Long-term efficacy of active postexposure immunization of infants for prevention of hepatitis B virus infection. United States-People''s Republic of China Study Group on Hepatitis B. J Infect Dis. 1995 Jan; 171(1): 54-60.
Yang, M. and Crawley, J. N. Simple behavioral assessment of mouse olfaction. Curr Protoc Neurosci. 2009 Jul; Chapter 8: Unit 8 24.
Yang, M., Silverman, J. L. and Crawley, J. N. Automated three-chambered social approach task for mice. Curr Protoc Neurosci. 2011 Jul; Chapter 8: Unit 8 26.
Yoneyama-Sarnecky, T., Olivas, A. D., Azari, S., Ferriero, D. M., Manvelyan, H. M. and Noble-Haeusslein, L. J. Heme oxygenase-2 modulates early pathogenesis after traumatic injury to the immature brain. Dev Neurosci. 2010 32(1): 81-90.
Yoon, B. H., Jun, J. K., Romero, R., Park, K. H., Gomez, R., Choi, J. H. and Kim, I. O. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol. 1997 Jul; 177(1): 19-26.
Yoon, B. H., Romero, R., Park, J. S., Kim, C. J., Kim, S. H., Choi, J. H. and Han, T. R. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol. 2000 Mar; 182(3): 675-681.
Zhang, N., Zhang, X., Liu, X., Wang, H., Xue, J., Yu, J., Kang, N. and Wang, X. Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice. Mediators of inflammation. 2014 2014: 370530.
Zhang, W., Wang, T., Qin, L., Gao, H. M., Wilson, B., Ali, S. F., Hong, J. S. and Liu, B. Neuroprotective effect of dextromethorphan in the MPTP Parkinson''s disease model: role of NADPH oxidase. Faseb J. 2004 Mar; 18(3): 589-591.
Zhao, Y., Patzer, A., Gohlke, P., Herdegen, T. and Culman, J. The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. Eur J Neurosci. 2005 Jul; 22(1): 278-282.
Zuckerman, A. J. Prevention of primary liver cancer by immunization. N Engl J Med. 1997 Jun 26; 336(26): 1906-1907.
Zuckerman, J. N. Review: hepatitis B immune globulin for prevention of hepatitis B infection. J Med Virol. 2007 Jul; 79(7): 919-921.

QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關論文
 
1. 王同茂、康正男、陳志一(2006)。公立大學體育館營運成本分析--臺大綜合體育館運用作業基礎成本制度研究。運動教練科學,6期,137-154頁。
2. 王建臺(1993)。學校體育設施的開放與管理。國民體育季刊,96,97-102頁。
3. 王傑賢(2004)。體育館設施服務品質之顧客滿意度研究:以「國立台灣大學綜合體育館重量訓練室」為例。體育學報,36,181-194頁。
4. 李晶(2004)。居民參與校園休閒活動社區意識之影響研究:以台北市國民中學為例。體育學報,36,195-206頁。
5. 周靈山(2000)。國立大學運動設施開放與經營管理問題探討。大專體育,48期,121-127頁。
6. 吳崇旗、周靈山(2001)。落實體育運動場館「使用者付費」關念之探討。大專體育,56期,59-63頁。
7. 洪嘉文(2001)。學校體育經營與管理之革新趨勢與發展策略。大專體育學刊,3(1),177-190頁。
8. 徐元民(2000)。多元文化時代與學校體育。國民體育季刊,29(1),頁12-18。
9. 郭慧龍(1997)。社區教育與學校運動場地設施開放。國民體育季刊,26(1),21-29頁。
10. 程紹同(1994)。運動管理法則在大專體育教學上的運用。國民體育季刊,23(3),123頁。
11. 葉公鼎(2001)。掌握時代發展學校體育運動設施經營的新契機。學校體育雙月刊,11(4),13-21頁。
12. 葉憲清(1999)。臺灣公立體育場之體育館之經營研究。體育學報,27,1-10頁。
13. 鄭志富(2002)。學校運動場舘經營與管理。學校體育雙月刊,12(3),2-4頁。
14. 蔡培村、孫國華(1998)。我國成人教育專業化的現況與展望。長榮學報,2(1),77-90頁。
 
無相關點閱論文