臺灣博碩士論文加值系統

近年來生醫微流道晶片(Bio-microfluidic chip)的發展帶來許多生醫研究與臨床醫學的突破，流速對生醫微流道的應用常有關鍵性的影響，然而目前對於微流道的流速測量大多都是透過額外的測量分析裝置，提高了操作的複雜度，如果能夠設計簡單且直觀的即時流速測量的流速計，將可解決此問題。本研究設計一雙懸壁樑結構微流速計，此流速計由兩個粗懸壁樑(Cantilever) 加上一個相對應的擋板指針(Indicator)，及兩個細懸壁樑(Cantilever) 加上一個相對應的擋板指針(Indicator)組合而成的綜合懸壁樑式微流速計。希望藉由粗懸壁樑可以適應高流速範圍，細懸壁樑可以適應低流速的高靈敏度，來優化流速計。
首先以計算流體力學方法模擬此流速計在微流道中與流速的關係，此研究結果有助於在微流道內嵌製一懸壁樑式流速計前的參考，然後利用雙光子聚合(Two-photon polymerization, TPP)技術在微流道中製造微結構，接著進行微流道流速測量實驗，最後分析實驗和模擬數據。

第一章 緒論 1
1.1研究背景 1
1.2研究目的 1
1.3研究步驟簡介 2
第二章 理論與研究背景 3
2.1實驗室晶片 3
2.2微流速計 3
2.2.1微粒子影像流速計(Microparticle Image Velocimetry) 5
2.2.2熱式流量感測器 6
2.2.3光流體流量感測器 7
2.2.4 MEMS流量感測器 8
2.2.5微流速計比較 9
2.3雙光子吸收光致聚合(TPP) 9
2.3.1雙光子吸收(two-photon absorption) 9
2.3.2光致聚合(photo-polymerization) 10
2.3.3 TPP 雙光子吸收光致聚合之優點 11
2.3.4 TPP製造技術與傳統蝕刻技術之比較 12
第三章 材料與方法 14
3.1設備介紹 14
3.2 流速計 22
3.2.1單一懸壁樑微流速計 22
3.2.2複合式雙懸壁樑微流速計 23
3.2.3 複合式雙懸壁樑微流速計特色 24
3.3 模擬 25
第四章 結果與討論 28
4.1 模擬分析 28
4.1.1單一懸壁樑微流速 28
4.1.2複合式雙懸壁樑壁樑微流速計 29
4.2 TPP 實驗結果 30
4.2.1單一懸壁樑微流速 30
4.2.2複合式雙懸樑壁樑微流速計 34
第五章 結論 37
參考文獻 38

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