臺灣博碩士論文加值系統

載體的保護與控制釋放效果能增加活性物質的生物利用率，常被用作於活性物質的運輸與在體內特定部位的釋放。然而有關控制釋放的技術大部分只利用於製藥領域，因此控制釋放技術被使用在食品產業是非常值得研究的課題。
羧甲基纖維素為食品級的添加物，它可透過交聯反應形成纖維素水凝膠，其可作為吸水膨脹型之載體。然而市售的羧甲基纖維素之粘度太高並不適於載體的製作，因此本研究自行製備羧甲基纖維素，希望可製作出粘度較低之羧甲基纖維素，然而其在製備過程中常因氫氧化鈉與單氯醋酸之副反應產生，而降低其取代程度與產率。因此，本研究希望找出其最適合之酸鹼比例與條件來製作羧甲基纖維素，接著再評估其製作成纖維素水凝膠後的吸水與控制釋放效果。
結果顯示，製備羧甲基纖維素的最佳鹼酸重量比例為1：1.2並加熱反應4 hr。在吸水與控制釋放試驗中，增加高取代程度(D.S：0.567)之纖維素水凝膠中的纖維素含量(33 mg/cm3增加至48 mg/cm3)會降低其吸水率與活性物質的釋放率，在第5 min時的釋放率從49.03%降低至34.01%。高取代程度的纖維素水凝膠在酸性的檸檬酸溶液(pH 1.8)中之吸水率遠低於其在鹼性的碳酸氫鈉溶液(pH 9.0)，其在第15 min的釋放率分別為50.52%及78.73%。因此推測降低水凝膠的吸水能力會減緩其活性物質的釋放。

中文摘要 i
英文摘要 iii
目錄 v
表次 vii
圖次 viii
1. 前言 1
1.1. 纖維素 1
1.1.1. 纖維素的前處理 3
1.1.2. 纖維素的溶解與凝聚 4
1.1.3. 纖維素之應用 9
1.2. 載體的控制釋放 9
1.3. 水凝膠 12
1.4. 羧甲基纖維素與纖維素水凝膠 13
2. 研究目的 16
3. 材料與方法 17
3.1. 實驗架構 17
3.2. 羧甲基纖維素的製備 17
3.3. 羧甲基纖維素的取代程度測定 19
3.4. 羧甲基纖維素溶液之視粘度測定 19
3.5. 纖維素水凝膠薄片之製作 20
3.6. 纖維素水凝膠的吸水膨脹實驗 20
3.7. 纖維素水凝膠之控制釋放實驗 20
3.8. 統計分析方法 21
4. 結果與討論 22
4.1. 羧甲基纖維素的製備 22
4.2. 不同取代程度對羧甲基纖維素視粘度之變化 32
4.3. 加熱反應時間對水凝膠的吸水率之影響 36
4.4. 不同環境對水凝膠的吸水率之影響 44
4.5. 纖維素水凝膠的控制釋放實驗 47
5. 結論 55
6. 參考文獻 56

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