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研究生:陳益偉
研究生(外文):Yi-wei Chen
論文名稱:直線型與S型流道於旋轉平台上生成微氣泡之可視化實驗
論文名稱(外文):Visualization experiments of microbubble generation on a rotating disk with straight and S-type microchannels
指導教授:陳志敏陳志敏引用關係
指導教授(外文):Jerry M. Chen
口試委員:洪子倫吳嘉哲
口試委員(外文):Tzyy-Leng HorngChia-Che Wu
口試日期:2016-07-28
學位類別:碩士
校院名稱:國立中興大學
系所名稱:機械工程學系所
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:中文
論文頁數:36
中文關鍵詞:微流道微氣泡液柱離心力
外文關鍵詞:microchannelmicrobubbleliquid plugcentrifugal force
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微氣泡的產生與應用,在微流控領域裡正逐漸被重視,尤其是可運用於生醫檢測及製藥。本研究乃是利用流道聚焦(flow-focus)之概念設計微流道,流體藉由馬達提供離心力來驅動,於聚焦處會合後將經過混和區然後往出口流。混和區的形狀有直線型及S型,旨在探討於旋轉平台上,以甘油及矽油個別做為工作流體,所產生微氣泡的機制與差異。同時藉由流場理論計算出壓力隨轉速之變化、流體密度之變化,並與可視化實驗之結果作比較。
本實驗利用微影和軟微影製做寬度200 μm、深度100 μm的流道。實驗結果發現S型混合區因為轉彎處產生流阻消耗部分的流體動量,導致連續相流速變慢,消散相突破值變低,生成比直線型混合區更長的氣泡與液柱,而且氣泡的生成範圍將需要更高的轉速。對於不同流體,甘油也因為慣性力、黏滯力及介面張力等因素影響而生成較矽油更長的氣泡與液柱;於S型混和區中,甘油的氣泡與液柱長度都較直線型長。

Generation of microbubbles in microfluidics has received increasing attention for its important applications in pharmaceutical and biomedical detection. In this study, we employ the flow-focusing concept to design microfluidics for microbubble generation on a disk driven by a DC motor. Centrifugal force produced by the rotating motion propels the continuous fluids loaded in the storage chambers toward the flow-focusing zone where air stream sucked through disperse channel can be squeezed into bubbles at micro-scales. In the present experiments, channels of both straight and S-types are used in the mixing zone positioned downstream of the flow focusing. Experimental results are also compared for the use of glycerol and silicone oil as the continuous fluids. At the same time, the pressure values at the flow-focusing zone were computed from a theoretical result for change in rotational speed and fluid density.
Microfluidics with a channel width of 200 μm and a depth of 100 μm were fabricated utilizing lithography and soft lithography techniques. The experimental results showed that the S-type channels with a greater flow resistance at the turning corners produce longer microbubbles than those of the straight channels. The liquid plugs in the S-type channels are also found longer than those in the straight channels. The use of glycerol also generate longer microbubbles and liquid plugs than those using silicone oil as the continuous fluid.

摘要 i
Abstract ii
目錄 iii
圖表目錄 v
第一章 緒論 1
1.1 研究動機 1
1.2 文獻回顧 2
1.2.1流體黏性與表面張力 2
1.2.2流道材質的親疏水性 2
1.2.3連續相與消散相流率比 3
1.2.4 流道構型與轉速 3
1.3 目的 3
1.4 論文架構 3
第二章 基礎理論與流道設計 5
2.1 離心力下的流場相關公式 5
2.2 流道結構設計 6
2.3 流道匯流聚焦處之受力 10
第三章 實驗設備 11
3.1 旋轉實驗平台 11
3.1.1 碟片旋轉平台 11
3.1.2 影像擷取系統 13
3.1.3 顯微物鏡 13
3.1.4 光源 13
3.2 晶片設計與製作 13
3.2.1實驗晶片設計與幾何尺寸 14
3.2.2晶片製作 15
3.2.3微影製作 15
3.2.4 軟微影製程 19
第四章 實驗結果 20
4.1 旋轉微流道實驗氣泡生成過程 20
4.2改變流道幾何形狀 22
4.3 改變工作流體 27
第五章 結論與未來展望 33
參考文獻 34


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