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研究生:薛雯元
研究生(外文):Wen-Yuan Xue
論文名稱:在中性與未絕育犬中尿液皮質醇與肌酸酐比值在不同時間的波動性研究
論文名稱(外文):Fluctuation of urinary cortisol/creatinine ratios at different times in neutered and intact dogs
指導教授:李衛民李衛民引用關係
指導教授(外文):Wei-Ming Lee
口試委員:賴政宏吳瑞得
口試委員(外文):Cheng-Hung LaiJui-Te Wu
口試日期:2016-06-15
學位類別:碩士
校院名稱:國立中興大學
系所名稱:獸醫學系暨研究所
學門:獸醫學門
學類:獸醫學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:英文
論文頁數:43
中文關鍵詞:皮質醇肌酸酐波動性
外文關鍵詞:cortisolcreatininefluctuation
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庫興氏症被認為是犬隻最為好發的內分泌疾病之一,是由於長期曝露於不正常的高濃度血漿皮質類固醇而導致的一系列臨床症狀與體癥。而皮質醇是由腎上腺皮質所分泌的主要糖皮質激素,並主要受下視丘﹣垂體﹣腎上腺皮質軸(HPA)所調控。皮質醇經由脈衝釋放到血液中,研究顯示犬隻皮質醇的波動釋放的頻率大約為每24小時10次。由於血液中皮質醇濃度很容易受到應激而造成波動,且大約1﹣2%的游離皮質醇會固定排洩到尿液中。因此檢測尿液中皮質醇與肌酸酐的比值(UCCR)可以提供在一段時間內皮質醇分泌狀況的綜合評估避免由於應激或是波動釋所造成的血液皮質醇濃度波動的影響。因此本實驗欲探究在一天中不同時間尿液中皮質醇含量是否具有波動性以及性荷爾蒙是否會對尿液中皮質醇的濃度有所影響。本實驗選取12只健康犬隻,將其均分為兩組(n=6/組),分別為絕育中性組,以及未絕育雄性組。尿液樣本均由飼主帶回家後收集。犬隻均連續三天于8:00,12:00以及16:00帶出散步并收集中段尿液。分別檢測各個時間尿液樣本中皮質醇與肌酸酐濃度,并計算其比值。結果顯示,尿液皮質醇與肌酸酐比值在犬內和犬間均有相當大的差異,並沒有一致的每日波動,且在8:00,12:00和16:00之間均無顯著性差異。而未絕育雄性組其尿液皮質醇與肌酸酐比值在12:00與16:00顯著性高於絕育中性組,但在8:00差異不明顯。本實驗顯示犬隻尿液皮質醇與肌酸酐比值在一天中不同時間沒有顯著差異以及一致的每日波動性,未絕育公犬尿液皮質醇含量顯著性高於絕育中性犬,且檢測皮質醇肌酸酐比值的尿液樣本應于早上採集較為準確。

Cushing’s syndrome is recognized as one of the most common endocrinopathies occurring in dogs, which will cause clinical symptoms and signs due to prolonged exposure to excess corticosteroid. Cortisol is the principle glucocorticoids released by adrenal cortex and is mainly regulated by the hypothalamic-pituitary-adrenocortical axis (HPA). Besides, cortisol is released into blood as pulsation, the number of secretory pluses in dogs was reported to be around 10 in 24 hours. As plasma cortisol concentration is easily to be affected by stress, and about 1-2% cortisol is excreted in the urine unaltered. Therefore, measurement of urinary cortisol/creatinine ratio (UCCR) provides an integrated assessment of cortisol over a period of time and adjusts for fluctuations in plasma levels caused by the pulsatile release of cortisol. The aim of the study was to investigate the urinary cortisol levels in healthy neutered and intact dogs and its daily fluctuations and whether the gonadal hormones would affect the cortisol concentration in urine. Twelve healthy dogs (n=12) from private owners were distributed into 2 groups (n=6/group): Neutered group (n=6) and Intact male group (n=6). Midstream voided urine samples were taken by each owner at home for three consecutive days at 8:00, 12:00 and 16:00 every day when dogs were taken outside and walked. Cortisol and creatinine concentrations were measured and calculated for the cortisol/creatinine ratios. Results indicated that urinary cortisol/creatinine ratios (UCCRs) had considerable variations both within and among dogs, but there was no consistent time of day fluctuation and with no significant variations at 8:00, 12:00 and 16:00. In addition, UCCRs were significantly higher in intact male dogs than in the neutered ones at 12:00 and 16:00, but it was not distinct at 8:00. In conclusion, there was no consistent time of day fluctuation and significant variations at different times of UCCR in dogs. Cortisol concentration is higher in the intact male dogs than the neutered dogs. Urine sample for UCCR detection should be taken in the morning.


摘要 i
Abstract ii
List of tables v
List of figures vi
Chapter 1 Introduction 1
Chapter 2 Literature review 2
2.1 Cortisol 2
2.1.1 The regulation of adrenal gland cortisol secretion 2
2.1.2 Biosynthesis and metabolism of cortisol 3
2.1.3 Biological functions of cortisol 5
2.2 Gonadal hormones and adrenal cortisol 6
2.2.1 The regulation and secretion of sex hormone 6
2.2.2 The relationship between gonadal hormone and andrenal cortisol 9
2.3 Creatinine 11
2.3.1 Introduction of creatinine 11
2.3.2 Diagnostic use of creatinine test in clinical 11
2.4 Urine cortisol/Creatinine ratio (UCCR) 12
2.4.1 Introduction of urine cortisol/Creatinine ratio (UCCR) 12
2.4.2 The biochemical diagnosis of UCCR in hypercortisolism 12
Chapter 3 Material and methods 14
3.1 Animals 14
3.2 Experiment design 14
3.3 Urine sampling 14
3.3.1 Urine cortisol concentration measurement 14
3.3.2 Urine creatinine concentration measurement 15
3.3.3 The measurement of urinary cortisol/creatinine ratio 16
3.4 Statistical analysis 16
Chapter 4 Results 17
4.1 Fluctuation of cortisol concentration in urine 17
4.2 UCCRs between neutered and intact dogs 17
4.3 Correlation between UCCRs with cortisol, creatinine and ages 17
4.4 Urine cortisol between neutered and intact dogs 18
4.5 Urine creatinine between neutered and intact dogs 18
Chapter 5 Discussion 29
5.1 Fluctuation of cortisol concentration in urine 29
5.2 Gonadal hormones and adrenal cortisol 30
5.3 The effects of sterilization on creatinine 31
5.4 The effects of ages on adrenal cortisol 32
5.5 Conclusion 32
Reference 33


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