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研究生:林則安
研究生(外文):Tse-AnLin
論文名稱:合成磺酸化氫化橡膠及其血液相容性與細胞毒性之探討
論文名稱(外文):Synthesis of Sulfonated SEPS and its characteristics of hemocompatibility and cytotoxicity
指導教授:林睿哲
指導教授(外文):Jui-Che Lin
學位類別:碩士
校院名稱:國立成功大學
系所名稱:化學工程學系
學門:工程學門
學類:化學工程學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:中文
論文頁數:93
中文關鍵詞:磺酸化彈性材料氫化橡膠傷口敷料血液相容性細胞毒性
外文關鍵詞:sulfonationelastic materialshydrogenated SEPSwound dressingblood compatibilitycytotoxicity
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本實驗將利用陰離子聚合合成出SIS三嵌段共聚物,此嵌段共聚物是由苯乙烯-異戊二烯-苯乙烯所組成。而在本實驗中會於苯乙烯鏈段中混摻入不同比例之叔丁基苯乙烯,去觀察其對高分子磺酸化所造成的影響。
由於經由陰離子聚合所得到嵌段共聚物是由苯乙烯組成的硬鏈段及異戊二烯所組成的軟鏈段所構成,而在軟鏈段的部分具有雙鍵,會造成此團鏈段共聚物在高溫時容易降解,所以在本實驗中利用氫化反應使其變為poly (styrene-b-(ethylene-co-propylene)-b-styrene) (SEPS),讓上面的雙鍵消失,並且具有更佳的熱性質。
最後經由磺酸化反應,將磺酸根導入SEPS高分子中,利用磺酸根的生物相容性及親水性,結合氫化橡膠的高彈性,開發出具有保水透濕的彈性材料,並經由血液相容性評估與細胞毒性評估,確認其具有應用於醫療敷材的潛力。

In this study, SIS triblock copolymers were successfully copolymerized by anionic copolymerization. This type of triblock copolymer is the composite of styrene-isoprene-styrene. In this experiment, the hard segment of the triblock copolymer will be blended with different ratios of styrene and tert-butyl styrene, and the effects of the blending ratio on the degree of sulfonation was observed.
Because the triblock copolymer is a composite of the hard segment styrene and the soft segment isoprene, there are double bonds in the soft segment which will cause the triblock copolymer to degrade easily at high temperature. In order to overcome this issue, the SIS triblock copolymer underwent hydrogenation, which can saturate the existing double bonds, giving the resulting SEPS (styrene-ethylene-propylene-styrene) triblock copolymer better thermal properties.
After the hydrogenation, SEPS would go through sulfonattion, introducing the hydrophilic sulfonic functional groups into the SEPS triblock copolymer. The purpose of sulfonating SEPS triblock copolymers is to combine the biocompatibility and hydrophilicity of the sulfonic functional groups with the high resilience of SEPS, thus developing a new elastic material that possesses moisture retention capabilities. Finally, via the assessment of blood compatibility and cytotoxicity tests, this research can demonstrate that sulfonated SEPS exhibits great potential in being future candidates for wound dressing or in tissue engineering applications.

摘要 I
Extend abstract II
誌謝 XIII
目錄 XIV
表目錄 XVIII
圖目錄 XIX
第一章 緒論 1
1-1前言 1
1-2研究動機與目的 1
第二章 文獻回顧 3
2-1燒燙傷敷材簡介 3
2-1-1生醫材料之定義 3
2-1-2燒燙傷口復原過程 3
2-1-3燒燙傷敷材之材料 4
2-2熱塑形彈性體(Thermoplastic Elastomers) 11
2-2-1熱塑性彈性體之定義 11
2-2-2熱塑性彈性體之種類與發展 11
2-2-3熱塑性彈性體之特性 13
2-3陰離子聚合法 15
2-3-1分子量控制 17
2-3-2反應用溶劑 17
2-3-3起始劑種類與起始反應 18
2-3-4成長反應(Propagation Reactions) 23
2-3-5終止反應及鏈轉移反應(Termination and Chain Transfer Reaction) 24
2-4 SIS三嵌段共聚物 25
2-4-1 三嵌段共聚物文獻回顧 26
2-4-2 SIS之微相分離 27
2-4-3 SBS於生醫材料之應用 29
2-5血液相容性之探討 31
2-5-1血液的組成 31
2-5-2血小板的功能 31
2-5-3凝血機制探討 33
2-5-4負電性官能基表面對於血液相容性之影響 34
第三章 實驗藥品與儀器介紹 36
3-1實驗藥品 36
3-1-1 SIS三嵌段共聚物之合成 36
3-1-2 氫化SIS三嵌段共聚物 36
3-1-3氫化SIS之磺酸化 37
3-1-4血液相容性實驗 37
3-1-5細胞毒性實驗 38
3-2實驗設備與儀器 39
3-3儀器原理介紹 40
3-3-1凝膠滲透層析儀(Gel permeation chromatography, GPC) 40
3-3-2高解析核磁共振光譜儀(Nuclear magnetic resonance, NMR) 40
3-3-3霍氏轉換紅外光譜儀(Foureier transform infrared spectrometer, FTIR) 41
3-3-4掃描式電子顯微鏡(Field emission scanning electron microscope, FESEM) 42
3-3-5二氧化碳臨界點乾燥機(Supercritical CO2 dry release machine) 43
第四章 實驗步驟 44
4-1實驗流程圖 44
4-2合成SIS三嵌段共聚物 45
4-2-1實驗藥品前處理 45
4-2-2合成A—B—A團鏈共聚物 45
4-2-3製備SIS薄膜 47
4-2-4測量SIS薄膜機械性質 47
4-2-5利用GPC量測SIS之分子量 47
4-3氫化SIS三嵌段共聚物 48
4-3-1氫化步驟 48
4-3-2氫化產物去除觸媒 49
4-3-3靜態接觸角之測量(Static water contact angle measurement) 49
4-4磺酸化SEPS嵌段共聚物 50
4-4-1磺酸化步驟 50
4-4-2磺酸化程度評估 51
4-5磺酸化後材料特性分析 51
4-4-1材料吸水性(Water uptake, WU) 51
4-4-2血小板貼附實驗(In vitro platelet adhesion) 51
4-4-3細胞毒性測試(Cytotoxicity) 54
第五章 結果與討論 56
5-1合成SIS三嵌段共聚物 56
5-1-1合成SIS三嵌段共聚物之NMR結構鑑定 56
5-1-2 SIS共聚物之分子量(The molecular weight of SIS copolymers) 60
5-1-3機械性質評估 61
5-2氫化SIS三嵌段共聚物 63
5-2-1氫化SIS三嵌段共聚物之1H-NMR結構鑑定 63
5-2-2 SEPS之靜態接觸角分析(Static water contact angle analysis) 66
5-3磺酸化SEPS嵌段共聚物 68
5-3-1磺酸化SEPS嵌段共聚物之ATR-FTIR鑑定 68
5-3-2磺酸化程度之分析(Analysis of degree of sulfonation) 71
5-4磺酸化SEPS嵌段共聚物之特性分析 74
5-4-1吸水性測試(Water uptake, WU) 74
5-4-2血小板貼附實驗(In vitro patelet adhesion) 75
5-4-3細胞毒性測試(Cytotoxicity) 81
第六章 結論 83
參考文獻 84


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