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研究生:翁怡莘
研究生(外文):Yi-SinWong
論文名稱:職業暴露於低劑量游離輻射員工與血液學變化之關係
論文名稱(外文):The relationship between workers with occupational exposure to low-dose ionizing radiation and changes in the hematological profiles
指導教授:郭浩然郭浩然引用關係
指導教授(外文):How-Ran Guo
學位類別:碩士
校院名稱:國立成功大學
系所名稱:環境醫學研究所
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:英文
論文頁數:42
中文關鍵詞:職業輻射甲狀腺荷爾蒙血液學
外文關鍵詞:occupationradiationthyroid hormonehematological profile
相關次數:
  • 被引用被引用:0
  • 點閱點閱:135
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Table of Contents

中文摘要 I
Abstract II
誌謝 (Acknowledgement) IV
Table of Contents V
List of Tables VII
List of Figures VIII
1. Introduction 1
1.1 Radiation and hematopoietic system 1
1.2 Physiology of Thyroid 1
1.3 Radiation-related hypothyroidis 1
2. Study 1: Difference of hematological changes
between health care workers whose work were near
radiation and control group 2
2.1 Methods 2
2.1.1 Patient characteristics 2
2.1.2 Statistical Analysis 3
2.2 Results 3
3. Study 2: The relationship between health care
workers with occupational exposure to low-dose
ionizing radiation and changes in thyroid
hormones 4
3.1 Methods 4
3.1.1 Patient characteristics 4
3.1.2 Statistical analysis 5
3.2 Results 5
4. Study 3: The relationship between workers of
nuclear waste deposal with occupational exposure
to low-dose ionizing radiation and changes in
thyroid hormones 6
4.1 Methods 6
4.1.1 Patient characteristics 6
4.1.2 Statistical analysis 7
4.2 Results 7
5. Discussion 8
5.1. Occupational exposure to radiation and
hematological change 8
5.2. Thyroid diseases in radiation exposure related
workers 9
5.3. Whether thyroid hormones change with aging 10
5.4. The relationship between radiation exposure and
hypothyroidism 11
6. Limitations 13
7. Conclusion 13
8. Reference 14


List of Tables

Table 1. Characteristics of workers with radiation-related job and workers whose work not near radiation source exposure to radiation-related job in study 1 17
Table 2. Mean value of hematological profiles in case group and control group in study 1 18
Table 3. Characteristics of workers with radiation-related job in Chia-yi Cristian Hospital in the study 2 19
Table 4. Final multivariate generalized estimating equation (GEE) analysis for change of T3 in the 326 radiation-exposure related workers in Chia-yi Cristian Hospital (Study 2) 20
Table 5. Final multivariate generalized estimating equation (GEE) analysis for change of T4 in the 326 radiation-exposure related workers in Chia-yi Cristian Hospital (Study 2) 21
Table 6. Final multivariate generalized estimating equation (GEE) analysis for change of TSH in the 326 radiation-exposure related workers in Chia-yi Cristian Hospital (Study 2) 22
Table 7. Characters of workers from nuclear waste deposal at Lanyu in the study 3 23
Table 8. Final multivariate generalized estimating equation(GEE) analysis for change of T3 in workers of nuclear waste deposal at Lanyu (Study 3) 24
Table 9. Final multivariate generalized estimating equation(GEE) analysis for change of T4 in workers of nuclear waste deposal at Lanyu (Study 3) 25
Table 10. Final multivariate generalized estimating equation(GEE) analysis for change of TSH in workers of nuclear waste deposal at Lanyu (Study 3) 26


List of Figures

Figure 1. Flowchart of study 1 27
Figure 2. Difference of hematological changes between case group and control group in study 1 28
Figure 3. Flowchart of study 2 29
Figure 4. Trend line showing the changes in mean T3 levels for overall and both gender groups in Chia-yi Cristian hospital (Study 2) 30
Figure 5. Trend line showing the changes in mean T3 levels for each type of workers in 31
Figure 6. Trend line showing the changes in mean T4 levels for overall and both gender groups in Chia-yi Cristian hospital (Study 2) 32
Figure 7. Trend line showing the changes in mean T4 levels for each type of workers in 33
Figure 8. Trend line showing the changes in mean TSH levels in overall and both gender groups in Chia-yi Cristian hospital (Study 2) 34
Figure 9. Trend line showing the changes in mean TSH levels for each type of workers in Chia-yi Cristian hospital (Study 2) 35
Figure 10. Flowchart of study 3 36
Figure 11. Trend line showing the changes in mean T3 levels for overall and each age groups in Lan-Yu nuclear waste deposal (Study 3) 37
Figure 12. Trend line showing the changes in mean T3 levels for the 2 different exposure duration groups in Lan-Yu nuclear waste deposal (Study 3) 38
Figure 13. Trend line showing the changes in mean T4 levels for overall and each age groups in Lan-Yu nuclear waste deposal (Study 3) 39
Figure 14. Trend line showing the changes in mean T4 levels for the 2 different exposure duration groups in Lan-Yu nuclear waste deposal (Study 3) 40
Figure 15. Trend line showing the changes in mean TSH levels for overall and each age groups in Lan-Yu nuclear waste deposal (Study 3) 41
Figure 16. Trend line showing the changes in mean TSH levels for the 2 different exposure duration groups in Lan-Yu nuclear waste deposal (Study 3) 42









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