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研究生:房彥君
研究生(外文):Fang, Yen-Chun
論文名稱:利用肺癌小鼠模式探討當歸補血湯藉由免疫調節及抗氧化機制達到抗癌之功效
論文名稱(外文):Danggui Buxue Tang against cancer and cachexia via immunomodulation and anti-oxidative stress in the lung tumor-bearing mouse model
指導教授:吳彰哲
指導教授(外文):Wu, Chang-Jer
口試委員:廖光文詹伊琳蔡國珍
口試委員(外文):Liao, Kuang-WenChan, Yi-LinTsai, Kuo-Chen
口試日期:2016-06-15
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:食品科學系
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:中文
論文頁數:74
中文關鍵詞:當歸補血湯抗氧化免疫調節癌症
外文關鍵詞:Danggui Buxue TangAnti-oxidative stressImmunomodulationCancer
相關次數:
  • 被引用被引用:5
  • 點閱點閱:185
  • 評分評分:
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
壹、前言 1
貳、文獻回顧 2
一、 肺癌 (Lung cancer) 2
1. 肺癌流行病學 2
2. 肺癌特徵 2
3. 肺癌病理學 3
4. 癌症惡病質 (Cancer cachexia) 7
5. 肺癌治療現況與困境 8
二、 中草藥 (Chinese medicine) 8
1. 黃耆 (Astragalus membranaceus) 8
2. 當歸 (Angelica sinensis) 9
3. 當歸補血湯 (Danggui Buxue Tang) 10
三、研究動機 11
參、 實驗設計流程 12
一、 Chinese medicine screening 12
二、 In vivo 12
肆、 實驗材料與方法 14
一、 實驗材料 14
1. 實驗細胞株 14
2. 細胞培養相關試劑 14
3. 中草藥來源 14
4. 抗體 14
5. 細胞存活率試劑 15
6. 抗氧化試驗 15
7. 實驗動物 16
8. 細胞激素分析 16
9. 蛋白質萃取與西方點墨法相關試劑 16
10. 組織切片 17
11. 免疫螢光染色 17
二、 儀器設備 17
三、 實驗方法 18
1. 中草藥製備 18
2. 細胞株之保存活化與培養 18
3. 中草藥對細胞毒性測試 19
4. 中草藥抗氧化能力試驗 20
5.巨噬細胞吞噬能力試驗 23
6. 細胞激素分析 24
7. 白蛋白分析 24
8. 免疫細胞分析 24
9. 蛋白質定量分析 25
10. 西方墨點法 25
11. 組織切片 26
12 免疫螢光染色 26
13. 統計分析 27
伍、結果 28
一、中草藥篩選 28
1. 中草藥對於細胞存活率之影響 28
2. 中草藥抗氧化活性之探討 28
3. 中草藥對促發炎細胞激素釋放之影響 29
4. 中草藥對於巨噬細胞吞噬能力之影響 30
二、利用動物實驗探討中草藥對腫瘤及癌症惡病質之影響 30
1. 當歸補血湯抗氧化能力 30
2. 當歸補血湯對白蛋白及促發炎細胞激素之影響 31
3. 當歸補血湯對腫瘤生長及癌症惡病質之影響 31
4. 當歸補血湯對淋巴細胞之調節作用 31
5. 當歸補血湯對 Th1 及 Th2 之調節作用 32
6. 當歸補血湯對腫瘤相關巨噬細胞分化之影響 32
7. 當歸補血湯對腫瘤血管新生之影響 33
8. 當歸補血湯對腫瘤 NF-κB 和 STAT3 活化之影響 33
陸、討論 34
柒、結論 41
捌、參考文獻 42
玖、圖表 56


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