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研究生:李 文
研究生(外文):Lee Wen
論文名稱:牛蒡萃取物及牛蒡發酵液對高脂飲食誘發肥胖大鼠雄性生殖功能之影響
論文名稱(外文):The Effect of Burdock Extract and Fermented Liquid on Male Reproductive Function in High Fat Diet-Induced Obese Rats
指導教授:龔瑞林龔瑞林引用關係
指導教授(外文):Kong, Zwe-Ling, Ph. D.
口試委員:潘子明劉興華林培正簡怡雯潘崇良
口試日期:2016-06-24
學位類別:碩士
校院名稱:國立臺灣海洋大學
系所名稱:食品科學系
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:中文
論文頁數:86
中文關鍵詞:牛蒡綠原酸菊糖生殖功能
外文關鍵詞:Arcticum lappa LHyperglycemiaReproductive Function
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牛蒡 (Arcticum lappa L.)被研究出有抗菌、抗發炎、抗氧化、防癌、保肝功 效及能明顯減少老鼠的體重。本研究探討牛蒡萃取物及牛蒡發酵液對肥胖大鼠之 影響,動物實驗餵食高脂飲食誘導肥胖,藉以評估牛蒡萃取物及牛蒡發酵液對肥 胖大鼠血液參數(血糖及血脂),連續餵食牛蒡萃取物之低脂飲食,證實對於控制 老鼠體重及降血糖、血脂有良好的效果,實驗證明,牛蒡提取物及牛蒡發酵液能 改善大鼠的合成代謝活性,加強睪丸激素的分泌,增加精子的數量,HFD 組精 子異常率為 12.23% ± 0.91%,連續餵食 5 週則降至 4.24% ± 0.23%,男性生殖功 能方面,BFL、BDE 也可以恢復生精小管及精子形態,改有利於睪固酮生合成, 對於精子參數方面,其總數、泳動性、睪丸組織型態對於肥胖所帶來的損傷皆有 明顯回復的效果。
綜合以上結果,推測 BFL、BDE 可藉由降低肥胖所引起之高血糖及胰島素 阻抗,並且提高抗氧化酵素活性,有效減緩體內之氧化壓力;另一方面,BFL、 BDE 可提高胰島素作用,降低體內游離脂肪酸濃度,減少發炎反應的發生,增 加睪固酮生成量達到改善男性生殖功能之效果。
關鍵字:牛蒡、綠原酸、菊糖、肥胖、生殖功能

Burdock (Arcticum lappa L.), has been shown to exhibit antibacterial, anti-inflammatory, antioxidant, anticarciogenic, and hepatoprotective effects and can induce substantial weight loss in rats; it has commonly been applied in deswelling, detoxification, and chronic dermatitis treatments. This paper discusses the effect of burdock dried extract (BDE) and fermented liquid (BFL) on obese rats. A high-fat diet (HFD) was employed to induce obesity in the rats, and the effect of BDE and BFL on their blood parameters (glucose and lipids) was examined. Continuous feeding of a low-fat BDE and BFL diet to the obese rats effectively controlled their weights and reduced their blood glucose and lipids. The experiment results confirmed that BDE and BFL improves the anabolic activities of human bodies, promotes the generation of testicular hormones, and facilitates sperm production. The sperm abnormality rate of rats in the HFD group was 12.23% ± 0.91%; however, the rate dropped to 4.24% ± 0.23% after they were fed BDE for 5 successive weeks. Regarding male reproductive functions, BFL and BDE recovered the morphology of seminiferous tubules and sperm and facilitated the synthesis of testosterone. Regarding sperm parameters, BFL and BDE substantially repaired obesity-induced damage on the total number and motility of sperm and the morphology of testicular tissues.
BFL and BDE can reduce obesity-induced hyperglycemia and insulin resistance, increase antioxidant enzyme activities, and effectively lower in-vivo oxidative stress. Additionally, BFL and BDE promote insulin activities, reduce in-vivo free fatty acid concentration, prevent inflammatory reactions, and increase the production of testosterone, thereby improving male reproductive functions.
Keywords: Arcticum lappa L., Obesity, Hyperglycemia, Reproductive Function
謝誌 III
摘要 IV
Abstract V
目錄 VI
圖目錄 X
表目錄 XII
縮寫表 XIII
緒論 1
壹、文獻回顧 2
一、肥胖(Obesity)與男性不孕症(Reproductive Function)關係 2
(一) 肥胖定義 2
1. 肥胖的定義與指標 2
2. 肥胖的健康風險 3
(二) 男性不孕症 3
二、牛蒡簡介與藥理活性 6
(一) 牛蒡簡介 6
(二) 牛蒡藥理活性 7
1. 抗氧化活性 7
2. 抗突變活性 7
3. 抗衰老作用 8
4. 降血糖作用 8
5. 降血膽固醇活性 8
6. 保肝活性 9
7. 消炎活性 9
8. 抑菌活性 9
9. 胃黏膜保護活性 10
10. 抗肥胖作用 10
貳、實驗流程 12
參、實驗材料 13
一、樣品來源 13
二、實驗動物 13
三、動物飼料 13
四、藥品 14
(一) DPPH自由基清除能力之測定 14
(二) 葡萄糖 (glucose) 含量測定 14
(三) 總三酸甘油酯 (total triglyceride) 濃度測定 14
(四) 總膽固醇 (total cholesterol) 濃度測定 14
(五) 胰島素 (insulin) 含量測定 14
(六) 抗氧化酵素分析 15
(七) 抗發炎能力分析 15
(八) 菊糖含量 15
(九) 總多酚含量 15
(十) 綠原酸 (Chlorogenic acid) 與咖啡酸 (Caffeic acid) 含量 16
五、儀器設備 16
肆、實驗方法 18
一、牛蒡抗氧化分析 18
(一) DPPH自由基清除能力 18
(二) 菊糖含量 18
(三) 總多酚含量 18
(四) 綠原酸 (Chlorogenic acid) 與咖啡酸 (Caffeic acid) 含量 18
二、動物實驗 19
(一) 肥胖大鼠之誘導與分組 19
(二) 實驗動物飼養 20
(三) 血液樣品分析 20
1. 血漿分析 20
2. 葡萄糖 (Glucose) 含量測定 20
3. 胰島素 (Insulin) 含量測定 21
4. 瘦素 (Leptin) 含量測定 21
5. HOMA-IR 值計算 21
6. 總三酸甘油酯 (Total triglyceride) 濃度測定 21
7. 總膽固醇 (Total cholesterol) 濃度測定 21
8. 低密度脂蛋白膽固醇 ( LDL-C) 22
9. 高密度脂蛋白膽固醇 ( HDL-C) 22
10. 血漿之脂質過氧化影響 22
11. 抗氧化酵素測定 23
12. 抗發炎能力分析 23
13. 雄性生殖功能分析 26
14. 抗氧化能力分析 28
三、統計分析 30
伍、實驗結果與討論 31
一、牛蒡抗氧化分析 31
二、動物實驗分析 31
(一) BFL及BDE對於肥胖大鼠體重之變化 31
(二) BFL及BDE對於肥胖大鼠血漿生化指標之影響 32
(三) BFL及BDE對於血漿天門冬胺酸轉胺酶、丙胺酸轉胺酶、尿素及肌酸酐含量 33
(四) BFL及BDE對於肥胖大鼠生殖功能之影響 33
陸、結論 37
柒、參考文獻 38
捌、附錄實驗動物照護及使用委員會審查同意書........…………………………...72

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