臺灣博碩士論文加值系統

膽管腫瘤所引起的嚴重問題之一為膽道阻塞。目前膽道阻塞的主要治療方式之一為膽道支架的置入。然而膽道支架在置入後六至八個月則可能再發生阻塞現象。有鑑於此，本研究探討利用可降解多層覆膜改善此問題的可能性。
本研究為了改善膽管支架置入後可能發生的再阻塞現象，探討可用於膽管支架的可降解多層覆膜及其自潔機制。本研究分為兩部分進行，第一部分以交叉沉浸法製作不同可降解材料的高分子薄膜。此製程對於薄膜厚度及均勻度能有良好控制。再使用各薄膜層降解速度不同之特性，使其降解時，底層薄膜快速降解，導致上層之慢速降解層失去支撐進而剝離，達到薄膜自潔之目的。其中在多層膜降解實驗的部分，本研究使用水膠層上覆蓋PLGA層的多層薄膜，以便在短時間內驗證多層膜之自潔特性。
第二部分為探討兩種轉印之方法，在環形結構上製作其結構。首先利用矽微米線狀結構搭配電鍍製程製作可撓性模具，配合鎳鈦合金彈簧進行環形熱壓，並成功在厚度30um的PLGA薄膜上製做出環形結構。由實驗結果得到在壓印時間20分鐘、轉印溫度85°C及轉印壓力0.04MPa的製程條件下具有90.01%的轉寫率。第二為探討使用PDMS軟膜對水膠進行環形轉印的可行性，結果證實此方法可轉印出水膠環形結構，轉寫率達97.7%。此部分初步驗證可降解環形結構之製作方法。此二方法未來將應用在支架上具自潔功能的多層薄膜製作。

Currently in the study of bile duct carcinoma, biliary stenosis is the biggest problem by tumor in the bile duct, and biliary stent as one way of treatment, then it may happen restenosis phenomenon when you place the biliary stent. In this view point, we present the study to explore using multi-layered biodegradable film to improve this problem.
In this research, in order to improve when placing biliary stent may occur restenosis phenomenon, we explore the self-cleaning properties of multilayer film and the method of fabricating the multilayer film. Therefore, this study divided into two parts to research this purpose. The first part is using a shuttle dipping method to fabricate each layer of polymer film, and this process is good for film thickness and uniformity control, and then using different characteristics in degradation rate of each layer, so that bottom film rapidly degraded, resulting a slow degradation of the upper layer loss the support then peel off to achieve the purpose of self-cleaning film. Among the part of multilayer film degradation experiment, we dip the PLGA on the hydrocolloids to verity the self-cleaning by multilayer in the short time.
The second part is to explore the microstructure fabrication by circular imprint methods. First, we use silicon linear microstructure master and electroforming method to fabricate flexible molds, then use a nitinol spring to carry on a circular thermal imprint. It successfully makes circular structures on a 30um thickness PLGA film, and the experimental results indicate the special circular imprint process with duration 20 minutes, temperature 85C and pressure 0.04Mpa can achieve the transfer rate by 90.01%. The second is to explore the feasibility of using PDMS soft mold of endless transfer by hydrocolloids. The results confirmed that the circular PDMS structure can be transferred to circular hydrocolloids structure, even the rate reach 97.7%. This part achieves the fabrication of degradable circular structure. The two methods could be applied to fabricate microstructure circular membranes for biomedical stents in the future.

摘要
Abstract
目錄
圖目錄
表目錄
第一章 、緒論
1-1 研究背景
1-2 研究動機與目的
1-3 論文架構
第二章、文獻回顧
2-1 聚氨酯（Polyurethane,PU）簡介
2-1-1 PU 基本結構
2-1-2 PU合成方法
2-2聚乳酸-甘醇酸高分子(PLGA)簡介
2-3聚乳酸(PLA)高分子簡介
2-3-1 光學活性
2-3-2 分子量
2-3-3 生物可降解性質
2-4 微/奈米轉印技術
2-5薄膜製程
2-6高分子降解
2-7 鎳鈦合金材料介紹
2-8 鎳鈦合金熱處理
第三章、實驗背景與設備
3-1實驗背景
3-2實驗設備
3-2-1 微/奈米轉印機台
3-2.-2 真空熱壓機
3-2-3 光纖雷射系統
3-2-4 擴張設備
3-2-5 壓縮設備
3-2-6 熱風循環烘箱 (Cyclic Oven)
3-3量測儀器
3-3-1 光學顯微鏡 (Optical Microscope, OM)
3-3-2 Z軸量測平台
3-3-3 掃描式電子顯微鏡
3-3-4 綠光表面干涉儀(CCI)
3-3-4 精密量測天平(Analytical Balances)
第四章、實驗規劃
4-1 PU材料製備跟改質測試
4-1-1 材料性質
4-1-2 以交叉dipping法製作PU薄膜
4-1-3 PU/PEG共混薄膜製作
4-1-4 PU-HDMI接枝PEG
4-1-5 PU薄膜表面親水性量測
4-2 PLGA材料及實驗製備
4-2-1 材料性質
4-2-2 以交叉Dipping法製作PLGA membrane
4-2-3 PU/PLGA 薄膜均勻度和厚度量測
4-3 多層膜結構降解實驗
4-3-1 水膠-PLGA薄膜降解
4-3-2 PLGA薄膜降解
4-3-3 PU-PLGA-PLA降解
4-4微米模具熱壓製程
4-4-1矽母模製作
4-4-2電鑄鎳金屬微米模具製備
4-4-3 PU-PLGA壓印
4-4-4 轉寫率評估方式
4-5 環形熱壓轉印實驗
4-5-1 轉印環形模具
4-5-2鎳鈦合金擴張製程和擴張力量測測
4-5-3 環形熱壓轉印製程
4-6 環形轉印實驗
4-6-1 PDMS材料與製備介紹
4--2 環形轉印實驗流程
第五章、實驗結果分析
5-1 PU薄膜改質水接觸角量測
5-2 PU-PLGA薄膜均勻度和厚度量測
5-2-1 PU/PLGA薄膜均勻度測試結果
5-2-2 交叉沉浸厚度之推算
5-3 多層膜降解分析與討論
5-3-1 水膠-PLGA降解實驗結果
5-3-1 PU-PLGA薄膜降解實驗結果
5-3-2 PU-PLGA-PLA薄膜降解實驗結果
5-4 熱壓結果與討論
5-4-1鎳膜製作結果
5-4-2 PLGA薄膜壓印結果與討論
5-5 環形熱壓印結果討論與分析
5-5-1鎳鈦擴張力測試
5-5-2 環形熱壓轉印結果討論
5-6 PDMS環形轉印結果討論
5-6-1 PDMS環形轉印轉印實驗分析
第六章、結論與未來展望
6-1 結論
6-2 未來展望
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