王伯徹及陳啟楨。1994。夏季鮑魚菇。常見食用菇介紹。食品工業發展研究所。43-45。
水野卓、川合正允。賴慶亮譯。1997。菇類的化學、生化學。國立編譯館。台北,台灣。
李炫璋。2003。牛樟芝菌絲體之體內保肝功能評估及其熱水萃物在體外對基質金屬蛋白水解。國立中興大學食品暨應用生物科技學系碩士論文。台中,台灣。何公瑞。2009。以固態發酵製備高麥角硫因之杏鮑菇穀類及其呈味性質與生理活性。國立中興大學食品暨應用生物科技學系碩士論文。台中,台灣。林孟翰。2013。4-羥基反式2-壬烯 (4-Hydroxy-trans-2-nonenal) 誘導PC12類神經細胞氧化壓力和不完全摺疊蛋白質反應。嘉南藥理科技大學。嘉義,台灣。
吳羽婷。2012。國產杏鮑菇之活性成分、抗氧化性及加工產品之研究。弘光科技大學食品科技所。台中,台灣。
香川芳子 (監修)。2004。五訂食品成分表。女子營養大學出版部。東京,日本。
俞苓、劉民勝及陳有容。2003。杏鮑菇子實體和菌絲體營養成分的比較。食用菌。25(2):7-8。
陳啟楨。1993。幾種具開發潛力的新興食用菇介紹。消費者食品資訊。21: 2-6。
陳建霖。2000。Ergothioneine 對cisplatin誘導小數神經細胞傷害的影響及其作用機制。大葉大學生物產業科技學系碩士論文。彰化縣,台灣。梁鍾鼎、李泔泓、何勝裕、林相汝、吳雅雯、吳長諺、林宗德、余俊強及梁善居。2008。血液生化及血液學參考值。國家實驗動物中心。台北,台灣。
劉仲敏、曹友聲及常琴。1994。人工固態發酵培養冬蟲夏草菌絲體的研究。河南科學。12: 335 338。
Ahmed, M., Davis, J., Aucoin D., Sato, T., Ahuja S., Aimoto S., Elliott, J. I., Nostrand W. V., and Smith, S. (2009) Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils. Nat Struct Mol Biol. 17: 561-567.
Akanmu, D., Cecchini, R., Aruoma, O. I., and Halliwell, B. (1991) The antioxidant action of ergothioneine. Arch Biochem Biophys. 288(1): 10-16.
Aksenov, M. Y., Aksenova, M. V., Butterfield, D. A., Geddes, J. W., and Markesbery, W. R. (2001) Protein oxidation in the brain in Alzheimer's disease. Neuroscience. 103(2): 373-383.
Alam, N., Yoon, K. N., Lee. K. R., Lee, J. S., and Lee. T. S. (2011) Phenolic Compounds Concentration and Appraisal of Antioxidant and Antityrosinase Activities from the Fruiting Bodies of Pleurotus eryngii. Advances Enviro Biol. 5(6): 1104.
Alam, N., Yoon, K. N., Lee, J. S., Cho, H. J., Shim, M. J., and Lee, T. S. (2011) Dietary effect of Pleurotus eryngii on biochemical function and histology in hypercholesterolemic rats. Saudi J Biol Sci. 18(4): 403-409.
Ali, T., and Kim, M. O. (2015) Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus. J Pineal Res. 59(1): 47-59.
Alvarado, J.C., Fuentes-Santamaría, V., Melgar-Rojas, P., Valero, M. L., Gabaldón-Ull, M. C., Miller, J. M., and Juiz, J. M. (2015) Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss. Front Aging Neurosci. 7: 86.
AOAC. (1990) Official methods of analysis. 14.091, 14.103, 14.093, 14.111 and 14.108, 15th Ed. Association of official analytical chemist, Washington, D.C.
Arendt, T., Schindler, C., Brückner, M. K., Eschrich, K., Bigl, V., Zedlick, D., and Marcova, L. (1997) Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele. J Neurosci. 17: 516-529.
Askari, A., and Melville, D. B. (1962) The reaction sequence in ergothioneine biosynthesis: hercynine as an intermediate. J Biol Chem. 237: 1615-1618.
Avila, J., Pérez, M., Lucas J. J., Gómez-Ramos, A., Santa María I., Moreno, F., Smith, M., Perry, G., and Hernández, F. (2004) Assembly in vitro of tau protein and its implications in Alzheimer's disease. Curr Alzheimer Res. 1: 97-101.
Ballatore, C., Lee, V. M.,and Trojanowski, J. Q. (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci. 8: 663-672.
Bao, L., Li, Y., Wang, Q., Han, J., Yang, X., Li, H., Wang, S. Wen, H. Li, S., and Liu, H. (2013) Nutritive and bioactive components in rice fermented with the edible mushroom Pleurotus eryngii. Mycology. 4(2): 96-102.
Barron, J. (2008) Lessons from the Miracle Doctors: A Step-by-step Guide to Optimum Health and Relief from catastrophic illness. Basic health publications, Inc. p. 215.
Baruch-Suchodolsky, R., and Fischer, B. (2009) Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems. Biochemistry. 48: 4354-4370.
Basheer, R., Strecker, R. E., Thakkar, M. M., and McCarley, R. W. (2004) Adenosine and sleep-wake regulation. Prog Neurobiol. 73(6): 379-396.
Bate, C., Tayebi, M., and Williams, Alun. (2010) Phospholipase A2 inhibitors protect against prion and Aβ mediated synapse degeneration. Mol Neurodegener. 5:13.
Benedict, S. R., Newton, E. B., and Behre, J. A. (1925) A new sulfur- containing compound (thiasine) in the blood. J Biol Chem. 67:267–277.
Bennett, B. D., Babu-Khan, S., Loeloff, R., Louis, J. C., Curran, E., Citron, M. and Vassar, R. (2000) J Bioll Chem. 275: 20647-20651.
Bevilaqua, L. R., Medina, J. H., Izquierdo, I., and Cammarota, M. (2005) Memory consolidation induces N-methyl-D-aspartic acid-receptor- and Ca2+/calmodulin-dependent protein kinase II-dependent modifications in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor properties. Neurosci. 136: 397-403.
Biesalski, H. K. (2007) Polyphenols and inflammation: basic interactions. Curr Opin Clin Nutr Metab Care. 10(6): 724-728.
Borghi, R., Patriarca, S., Traverso, N., Piccini, A., Storace, D., Garuti, A., Gabriella, C., Patrizio, O., and Massimo, T. (2007) The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease. Neurobiol Aging. 28(7): 1009-1014.
Bower, G. B., and Miller, N. E. (1958). Rewarding and punishing effects from stimulating the same place in the rat’s brain. J Comp Psychol. 51: 669-674.
Bergin, D.H., Jing, Y., Zhang, H., and Liu, P. (2015) A single intracerebroven -ntricular Aβ25-35 infusion leads to prolonged alterations in arginine metabolism in the rat hippocampus and prefrontal cortex. Neurosci. 298: 367-379.
Bowen, D. M., Smith, C. B., White, P., and Davison, A. N. (1976) Neurotran smitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.Brain. 99: 459-496.
Braak, H., and Del, T. K., (2012) Where, when, and in what form does sporadic Alzheimer disease begin? Curr Opin Neurol. 25: 708-714.
Bravo, L. (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev. 56(11): 317-333.
Briggs, I. (1972) Ergothioneine in the central nervous system. J Neurochem. 19(1): 27-35.
Budson, A. E., and Price, B. H. (2005) Memory dysfunction. N Engl J Med. 352: 692-699.
Carlezon, W. A. Jr., Mague, S. D., Parow, A. M., Stoll, A. L., Cohen, B. M., and Renshaw, P. F. (2005) Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats.Biol Psychiatry. 57(4): 343-350.
Carrillo-Mora, P., Luna, R., and Colín-Barenque, L. (2014) Amyloid beta: multiple mechanism of toxicity and only some protective effect? Oxid Med Cell Longev. 795375: 15.
Cetin, F., and Dincer, S. (2007) The effect of intrahippocampal beta amyloid (1-42) peptide injection on oxidant and antioxidant status in rat brain. Ann N Y Acad Sci. 1100: 510-517.
Chang, S. T. and Hayes, W. A. (1978) The biology and cultivation of edible mushrooms. ISBN: 978-0-12-168050-3.
Cheah, I. K., and Halliwell, B. (2012) Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim Biophys Acta. 1822(5): 784-793.
Chen, J., Mao, D., Yong, Y., Li, J., Wei, H., and Lu, L. (2012) Hepatoprotective and hypolipidemic effects of water-soluble polysaccharidic extract of Pleurotus eryngii. Food Chem. 130(3): 687-394.
Cheng, X., Lee, T., Yao, H., Li, R., and Shen, Y. (2014) High Activities of BACE1 in Brains with Mild Cognitive Impairment. Am J Pathol. 184(1): 141-147.
Cole, S. L. and Vassar, R. (2007) The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer’s Disease. Curr Genomics. 8(8):509-530.
Creemers, J. W. M., Dominguez, D. I., Plets, E., Serneels, L., Taylor, N. A., Multhaup, G., Craessaerts, k., Annaert, W., and Strooper, B. D. (2001) Processing of beta-secretase by furin and other members of the proprotein convertase family.J Biol Chem. 276: 4211-4217.
Crisan, E. V., and Sands, A. (1978) In The Biology and Cultivation of edible mushrooms. Academic Press, New York.pp. 137-165.
Crystal, H. A., Schneider, J. A., Bennett, D. A., Leurgans, S., and Levine, S. R. (2014) Associations of cerebrovascular and Alzheimer's disease pathology with brain atrophy. Curr Alzheimer Res. 11(4): 309-316.
Cui, S. Q., Wang, Q., Zheng, Y., Xiao, B., Sun, H. W., Gu, X. L., Zhang, Y. C., Fu, C. H., Dong, P. X., and Wang, X. M. (2015) Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. Braz J Med Biol Res. 48(6):515-522.
Cunha, R. A. (2001) Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors. Neurochem Int. 38(2): 107-125.
Dawbarn, D., and Allen, S. J. (2008) Molecular and cellular neurobiology series: neurobiology of Alzheimer's disease. 3rd ed. New York. Oxford University Press.
Deacon, R. M., and Rawlins, J. N. (2006) T-maze alternation in the rodent. Nat Protoc. 1(1): 7-12.
Deiana, M., Rosa, A., Casu, V., Piga, R., Assunta Dessì, M., and Aruoma, O. I. (2004) L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids. Clin Nutr. 23(2): 183-193.
Dekker,A. D., Strydom, A., Coppus, A. M., Nizetic, D., Vermeiren, Y., Naudé, P. J., Dam, D. V., Potier, M.C., Fortea, J., and Deyn, P. P. (2015) Behavio- oural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease? Cortex. 73: 36-61.
Deng, Y. Q., Xu, G. G., Duan, P., Zhang, Q., and Wang, J. Z. (2005) Effects of melatonin on wortmannin-induced tau hyperphosphorylation. Acta Pharma -acol Sin. 26(5): 519-526.
Doucet, M. V., O'Toole, E., Connor, T., and Harkin, A. (2015) Small-molecule inhibitors at the PSD-95/nNOS interface protect against glutamate-induced neuronal atrophy in primary cortical neurons. Neurosci. 301: 421-438.
Drechsel, D. N., Hyman, A. A., Cobb, M. H., and Kirschner, M. W. (1992) Modulation of the dynamic instability of tubulin assembly by the microtub ule-associated protein tau. Mol Biol Cell. 3: 1141-1154.
Dubost, N. J., Beelman, R. B., Peterson, D., and Royse, D. J. (2006) Identificati on and Quantification of Ergothioneine in Cultivated Mushrooms by Liqui-d Chromatography-Mass Spectroscopy. Int J Med Mushrooms. 8(3): 215- 222.
Duthey, B. (2013) Alzheimer Disease and other Dementias. A Public Health Approach to Innovation.1-74
Eckert, A., Nisbet, R., Grimm, A., and Götz, J. (2014) March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta. 1842: 1258-1266.
Esler, W. P., and Wolfe, M. S. (2001) A portrait of Alzheimer secretases--new features and familiar faces. Science. 293: 1449-1454.
Estrada, B., Rodriguez, A. and Daniel, R. (2011) Cultural practices to enhance mushroom (Pleurotus eryngii) yield & concentration of the antioxidants selenium & ergothioneine. Mushroom News. Feb 1, 2011.
Evans J.D. (1996) Straightforward Statistics for the Behavioral Sciences.Brooks/Cole Publishing; Pacific Grove, Calif.
Evans, P., Lyras, L., and Halliwell, B. (1999) Measurement of protein carbonyls in human brain tissue. Methods Enzymol. 300: 145-156.
Ey, J., Schömig, E., and Taubert, D. (2007) Dietary Sources and Antioxidant Effects of Ergothioneine. J Agric Food Chem.55(16): 6466-6474.
Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R., Myers, R. H., Pericak-Vance, M. A., Risch, N., and van Duijn C. M. (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 278: 1349-1356.
Finkel, S. (2000) Introduction to behavioural and psychological symptoms of dementia (BPSD).Int J Geriatr Psychiatry.1:S2-4.
Folstein, M. F., Folstein, S. E., and McHugh, P. R. (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 12: 189-198.
Franklin, K. B., and Paxinos, G. (2008) The Mouse Brain in Stereotaxic Coordinates. Elsevier Academic, London.
Franzoni, F., Colognato, R., Galetta, F., Laurenza, I., Barsotti, M., Di Stefano, R., Bocchetti, R., Regoli, F., Carpi, A., Balbarini, A., Migliore, L., and Santoro, G. (2006) An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox. Biomed Pharmacother. 60(8): 456-457.
Furukawa, K., Barger, S. W., Blalock, E. M., Mattson, M. P. (1996) Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid -precursor protein. Nature. 379: 74-78.
Furukawa, K. and Mattson, M. P (1998) Secreted amyloid precursor protein selectively suppressesN-methyl-D-aspartate currents in hippocampal neurons: involvement of cyclic GMP. Neurosci. 83: 429-438.
Gakhar-Koppole, N., Hundeshagen, P., Mandl, C., Weyer, S. W., Allinquant, B., Müller, U., and Ciccolini, F. (2008) Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell derived neurons via activation of the MAPK pathway. Eur J Neurosci. 28: 871-872.
Gao, X., and Yuan, S. (2010) High density lipoproteins-based therapies for cardiovascular disease. J Cardiovasc Dis Res. 1(3): 99-103.
Gasecka, M., Mleczek, M., Siwulski, M., and Niedzielski, P. (2016) Phenolic composition and antioxidant properties of Pleurotus ostreatus and Pleurotus eryngii enriched with selenium and zinc. Eur Food Res Technol. 242:723-732.
Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., and James, L. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349: 704-706.
Goedert, M. (2004) Tau protein and neurodegeneration. Semin Cell Dev Biol.15 (1): 45–49.
Gomes, C. V., Kaster, M. P., Tomé, A. R., Agostinho, P. M., and Cunha, R. A. (2011) Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration. Biochim Biophys Acta. 1808(5): 1380-1399.
Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert M. P., Finch, C. E., Krafft, G. A., Klein, W. L. (2003) Alzheimer’s disease-affected brain: Presence of oligomeric A ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci. 100: 10417-10422.
Gonzaga, M. L. C., Ricardo, N. M. P. S., Heatly, F., and Soares, S. A. (2005) Isolation and characterization of polysaccharides from Agaricusblazei Murill. Carbohydrate Polymers. 60(1): 43–49.
Gowda, S., Desai, P. B., Hull, V. V., Math, A. A., Vernekar, S. N., and Kulkarni, S. S. (2009) A review on laboratory liver function tests. Pan Afr Med J. 3:17.
Gründemann, D., Harlfinger, S., Golz, S., Geerts, A., Lazar, A., Berkels, R., Jung, N., Rubbert, A., and Schömig, E. (2005) Discovery of the ergothioneine transporter. Proc Natl Acad Sci USA. 102(14): 5256-5261.
Gyôrfi, J., and Hajdú, C. S. (2007) Casing-material experiments with Pleurotus eryngii. Int J Horticultural Sci. 13: 33-36.
Haass, C., snd Selkoe, D. J. (2007) Soluble protein oligomers in neurodegeneration : lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol. 8: 101-112.
Halliwell, B. (1992) Reactive oxygen species and the central nervous system. J Neurochem. 59(5): 1609-1623.
Halpern, M. J., Dahlgren A. L., Laakso, I., Sepp¨anen-Laakso, T., Dahlgren, J., and Mcanulty, P.A. (1998) Red-wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res. 26(4): 171-180.
Hamaguchi, T., Ono, K., Murase, A., and Yamada, M. (2009) Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol. 175(6): 2557-2565.
Hanlon, D. P. (1971) Interaction of ergothioneine with metal ions and metalloenzymes. J Med Chem. 14(11): 1084-1087.
Hardy, J., and Selkoe, D. J. (2002) The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics. Science. 297:353-356.
Hardy, J. (2003) The relationship between amyloid and tau. J Mol Neurosci.20:203–206.
Harman, D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol. 11: 298-300.
Huang, M. T., Ho, C. T., and Lee, C. Y. (1992) In phenolic compounds in food and their effects on health II. American Chem Society. 506: 13-14.
Huang, S. J. and Mau, J. L. (2007) Antioxidant properties of methanolic extracts from Antrodia camphorata with various doses of γ-irradiation.Food chem. 105(4): 1702-1710.
Hung, C. W., Chen, Y. C., Hsieh, W. L., Chiou, S. H., and Kao, C. L. (2010) Ageing and neurodegenerative diseases. Ageing Res Rev. 1:36-46.
Ihara, Y., Hayabara, T., Sasaki, K., Kawada, R., Nakashima, Y., and Kuroda, S. (2000) Relationship between oxidative stress and apoE phenotype in Alzheimer's disease. Acta Neurol Scand. 102(6): 346-349.
James, C. S. (1995) Analytical Chemistry of Foods. London: Chapman&Hall 124-125.
Janero, D. R. (1990) Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med. 9(6): 515-540.
Jang, J. H., Aruoma, O. I., Jen, L. S., Chung, H. Y., and Surh, Y. J. (2004) Ergothioneine rescues PC12 cells from beta-amyloid- induced apoptotic death. Free Radic Biol Med. 36(3): 288-299.
Jhoo, J. H., Kim, H. C., Nabeshima, T., Yamada, K., Shin, E. J., Jhoo, W. K., Kim, W., Kang, K. S., Jo, S. A, and Woo, J. I. (2004) Beta-amyloid (1-42) -induced learning and memory deficits in mice: involvement of xidative urdens in the hippocampus and cerebral cortex. Behav Brain es. 155(2): 85-196.
Johnson, R. J., Nakagawa, T., Jalal, D., Sánchez-Lozada, L. G., Kang, D. H., and Ritz, E. (2013) Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant. 28(9): 2221-2228.
Kakio, A., Nishimoto, S., Yanagisawa, K., Kozutsumi, Y., and Matsuzaki, K. (2002) Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochem. 41(23): 7385-7390.
Kamal, A., Stokin, G. B., Yang, Z., Xia, C. H., and Goldstein, L. S. (2000) Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 28(2): 449-459.
Kang, H. I., Seo, K. I., Cho, Y. S., Yee, S. T., Kim, J. Y., Moon, K. D., and Lee, S. D. (2004) Effect of the Crude Polysaccharide of Pleurotus eryngii on the Activation of Immune Cells. J Korean Soci Food Sci Nutrit. 33(7): 1092-1097.
Kemppainen, S., Lindholm, P., Galli, E., Lahtinen, H. M., Koivisto,HHämäläinen, E., Saarma, M., and Tanila, H. (2015) Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice. Behav Brain Res. 291: 1-11.
Kitakaze, M., and Hori, M. (2000) Adenosine therapy: a new approach to chronic heart failure. Expert Opin Investig Drugs. 9(11): 2519-1535.
Klimova, B. and Kuca, K. (2016) Speech and language impairments in dementia. J Applied Biom. 14(2): 97-103.
Kolarova, M., García-Sierra, F., Bartos, A., Ricny, J., and Ripova, D. (2012) Structure and pathology of tau protein in Alzheimer disease. Int J Alzheimers Dis. 2012: 731526.
Koudinov, A., Kezlya, E., Koudinova, N., and Berezov, T. (2009) Amyloid-beta, tau protein, and oxidative changes as a physiological compensatory mechanism to maintain CNS plasticity under Alzheimer's disease and other neurodegenerative conditions. J Alzheimers Dis. 18(2): 381-400.
Kulshreshtha, M., Singh, A., and Vipul, D. A. (2009) Effect of drying conditions on mushroom quality. J Engineering Sci Technol. 4(1): 90-98.
Kumar, A., Singh, M., and Singh, G. (2013) Effect of different pretreatments on the quality of mushrooms during solar drying. J Food Sci and Technol. 50(1): 165-170.
Lambert, J. D., Hong, J., Yang, G. Y., Liao, J., and Yang, C. S. (2005) Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr. 81: 284S-291S.
Ledesma , M. D., Bonay, P., and Avila, J. (1995) Tau protein from Alzheimer's disease patients is glycated at its tubulin-binding domain. J Neurochem. 65: 1658-1664.
Lee, T .T., Tian, Y. R., and Yu, B. (2011) Polysaccharide, Adenosine and Crude Triterpenoid Contents of Pleurotus Eryngii and Its Immunostimulant Capacity in vitro. J Agric Sci and Technol. 1: 1166-1169
Lerner, A. B., Case, J. D., Takahashi, Y., Lee, T. H., and Mori, W. (1958) Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem. 80(10): 2587-2587.
Li, S., and Shah, N. P. (2014) Antioxidant and antibacterial activities of sulphated polysaccharides from Pleurotus eryngii and Streptococcus thermophilus ASCC 1275. Food Chem. 165(15): 262-270.
Lin, C. Y., Huang, C. S., Huang, C. Y., and Yin, M. C. (2009) Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice. J Agric Food Chem. 57(15): 6661-6667.
Lin, J. T., Liu, C. W., Chen, Y. C., Hu, C. C., Juang, L. D., Shiesh, C. C., and Yang, D. J. (2014) Chemical composition, antioxidant and anti- inflammatory properties for ethanolic extracts from Pleurotus eryngii fruiting bodies harvested at different time. LWT - Food Sci and Technol. 55: 374-382.
Lin, W. C., Peng, Y. F., and Hou, C. W. (2015) Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways. Iran J Basic Med Sci. 18(5): 478-484.
Liu, S. J., and Wang, J. Z. (2002) Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin. Acta Pharmacol Sin. 23(2): 183-187.
Loidl-Stahlhofen, A., Hannemann, K., and Spiteller,G. (1994) Generation of α-hydroxyaldehydic compounds in the course of lipid peroxidation. Bio et Biophysica Acta Lipids and Lipid Metabolism. 1213: 140-148.
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., and Markesbery, W. R. (1998) Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci. 158(1): 47-52.
Maccioni, R. B., Muñoz, J. P., and Barbeito, L. (2001) The molecular bases of Alzheimer's disease and other neurodegenerative disorders. Arch Med Res. 32: 367-381.
Mahley, R. W., Weisgraber, K. H., and Huang, Y. (2006) Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease. Proc Natl Acad Sci U S A. 103: 5644-5651.
Mahmoud, M. G., Ibrahim, A. Y., Asker, M. M., and Sayed, O. H. (2014) Therapeutic potential and structural elucidation of a water-soluble polysaccharide of a wild edible mushroom Agaricus bisporus against neurodegenerative disease, Alzheimer. Journal Pharmaceutical Sci. ISSN (Print): 2321-3310.
Markesbery, W. R., and Carney, J. M. (1999) Oxidative alterations in Alzheimer's disease. Brain Pathol. 9: 133-146.
Mattson, M. P. (2004) Pathways towards and away from Alzheimer's disease. Nature. 430(7000): 631-639.
Mazanetz, M. P., and Fischer, P. M. (2007) Untangling tau hyperphosphorrylat -ion in drug design for neurodegenerative diseases. Nature Rev Drug Discovery. 6: 464-479.
Mazzaccara, C., Labruna, G., Cito, G., Scarfò, M., Felice, M. D., Pastore, L., and Sacchetti, L. (2008) Age-Related Reference Intervals of the Main Biochemical and Hematological Parameters in C57BL/6J, 129SV/EV and C3H/HeJ Mouse Strains. PLoS ONE. 3(11): e3772.
Melville, D. B., Otken, C. C., and Kovalenko, V. (1955) on the orgin of animal ergothioneine. J Biol Chem. 216(1): 325-331.
Morris, R. (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods. 11(1): 47-60.
Motohashi, N., Mori, I., and Sugiura, Y. (1976) Complexing of copper ion by ergothioneine. Chem Pharm Bull (Tokyo). 24(10): 2364-2368.
Motohashi, N., and Mori, I. (1986) Thiol-induced hydroxyl radical formation and scavenger effect of thiocarbamides on hydroxyl radicals. J Inorg Biochem. 26(3): 205-212.
Mouton-Liger, F., Paquet, C., Dumurgier, J., Bouras, C., Pradier, L., Gray, F., and Hugon, J. (2012) Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway. Biochim Biophys Acta. 1822(6): 885-896.
Muresann, V., and Muresann, Z. L. (2015) Experimental Cell Research. 334: 45-53.
Musso, C. G., Alvarez Gregori, J., Jauregui, J. R., Macías Núñez J. F. (2012) Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old. World J Nephrol. 1(5): 126-126.
Nagy, Z., Jobst, K. A., Esiri, M. M., Morris, J. H., King, E. M., MacDonald, B., Litchfield, S., Barnetson, L., and Smith, A. D. (1996) Hippocampal pathology reflects memory deficit and brain imaging measurements in Alzheimer's disease: clinicopathologic correlations using three sets of pathologic diagnostic criteria. Dementia. 7: 76-81.
Naidu, A., Xu, Q., Catalano, R., and Cordell, B. (2002) Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain Res. 958: 100-111.
Nakalembe, I., Kabasa, J. D., and Olila, D. (2015) Comparative nutrient composition of selected wild edible mushrooms from two agro-ecological zones, Uganda. Springerplus. 4:433.
Newton, E. B., Benedict, S. R., and Dakin, H. D. (1926) On Thiasine, its structure and identification with ergothioneine. J. Biol. Chem. 72: 367-373.
Okatani, Y., Wakatsuki, A., Reiter, R. J., Miyahara, Y. (2002) Melatonin reduces oxidative damage of neural lipids and proteins in senescence -accelerated mouse. Neurobiol Aging. 23(4): 639-344.
Ono, K., Condron, M. M., Ho, L., Wang, J., Zhao, W., Pasinetti, G. M., and Teplow, D. B. (2008) Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity. J Biol Chem. 283(47): 32176-32187.
Ono, K., Li, L., Takamura, Y., Yoshiike, Y., Zhu, L., Han, F., Mao, X., Ikeda, T., Takasaki, J., Nishijo, H., Takashima, A., Teplow, D. B., Zagorski, M. G., and Yamada, M. (2012) Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specificbinding. J Biol Chem. 287(18): 14631-14643.
Ota, H., Ogawa, S., Ouchi, Y., and Akishita, M. (2015) Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil. Exp Gerontol. 72: 109-16.
Paul, B. D., and Snyder, S. H. (2010) The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ. 17(7): 1134-1140.
Peng, Y., Liu, J., Tang, Y., Liu, J., Han, T., Han, S., Li, H., Hou, C., Liu, J., and Long, J. (2014) High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci. 8: 225-239.
Petkova, A. T., Ishii, Y., Balbach, J. J., Antzutkin, O. N., Leapman, R. D., Delaglio, F., and Tycko, R. (2002) A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR.Proc Natl Acad Sci U S A. 99: 16742-16747.
Picone, P., Nuzzo, D., Caruana, L., Messina, E., Barera, A., Vasto, S., and Di Carlo, M. (2015) Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect. Biochim Biophys Acta. 1853(5): 1046-1059.
Porte, Y., Buhot, M. C., and Mons, N. E. (2008) Spatial memory in the Morris water maze and activation of cyclic AMP response element-binding (CREB) protein within the mouse hippocampus. Learn Mem. 15(12): 885-894.
Prince, M., Prina, Matthew., and Guerchet, Maëlenn.(2013) Analysis of long- -term care for dementia.J caring.1-92.
Querfurth, H. W. and Laferla, F. M. (2010) Alzheimer’s Disease. N Engl J. 362: 329-344.
Raber, J., Huang, J., and Ashford, J. W. (2004) ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging. 25:641-650.
Rahman, I., Gilmour, P. S., Jimenez, L. A., Biswas, S. K., Antonicelli, F., and Aruoma, O. I. (2003) Ergothioneine inhibits oxidative stress- and TNF -alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. Biochem Biophys Res Commun. 302(4): 860-864.
Ramanan, P. N., and Rao, M. N. (1987) Antimicrobial activity of cinnamic acid derivatives. Indian J experimental biol. 25: 42-43.
Ranter, M. (2005) FDA pharmacogenomics guidance sends clear message to industry. Nature Rev Drug Discovery. 4:359.
Reiter, R. J. (1995) Functional pleiotropy of the neurohormone melatonin: antioxidant protection and neuroendocrine regulation. Front Neuroendocrinol. 16(4): 383-415.
Reiter, R. J., Tan, D. X., Terron, M. P., Flores, L. J., and Czarnocki, Z. (2007) Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions. Acta Biochim Pol. 54(1): 1-9.
Reiter, R. J., Tan, D. X., Manchester, L. C., Pilar Terron, M., Flores, L. J., and Koppisepi, S. (2007) Medical implications of melatonin: receptor- mediated and receptor-independent actions. Adv Med Sci. 52: 11-28.
Reynolds, G. (2007) Lobes of Steel. New York Times. 1-4.
Ribeiro, J. A. (1995) Purinergic inhibition of neurotransmitter release in the central nervous system. Pharmacol Toxicol. 77(5): 299-305.
Robaszkiewicz, A., Bartosz, G., Ławrynowicz, M., and Soszynski, M. (2010) The role of polyphenols, β-carotene, and lycopene in the antioxidative action of the extracts of dried, edible mushrooms. J Nutrition and Metabolism. 173274: 173283.
Roses, A. D., and Saunders, A. M. (1994) APOE is a major susceptibility gene for Alzheimer's disease. Curr Opin Biotechnol. 5: 663-667.
Rossi, L., Mazzitelli, S., Arciello, M., Capo, C. R.,and Rotilio, G. (2008) Benefits from dietary polyphenols for brain aging and Alzheimer's disease. Neurochem Res. 33(12): 2390-2400.
Saito, M., Eto, M., Nitta, H., Kanda, Y., Shigeto, M., Nakayama, K., Tawaramoto, K., Kawasaki, F., Kamei, S., Kohara, K., Matsuda, M., Matsuki, M., and Kaku, K. (2004) Effect of apolipoprotein E4 allele on plasma LDL cholesterol response to diet therapy in type 2 diabetic patients. Diabetes Care. 27(6): 1276-1280.
Sato, A., Terata, K., Miura, H., Toyama, K., Loberiza, F. R. Jr., Hatoum, O. A., Saito, T., Sakuma, I., and Gutterman, D. D. (2005) Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol. 288(4): H1633-1640.
Saunders, A. J., Kim, T. W., Tanzi, R. E., Fan, W., Bennett, B. D., Safura, B. K., Luo, Y., Louis, J. C., McCaleb, M., Citron, M., Vassar, R., and Richards, W. G. (1999) BACE maps to chromosome 11 and a BACE homolog, BACE2, reside in the obligate Down syndrome region of chromosome 21. Science. 286:1255.
Scarpini, E., Scheltens, P., and Feldman, H. (2003) Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol. 2: 539-547
Selkoe, D. J. (1997) Alzheimer's disease: genotypes, phenotypes, and treatments. Science. 275: 630-631.
Semar, S., Klotz, M., Letiembre, M., Van Ginneken, C., Braun, A., Jost, V., Bischof, M., Lammers, W. J., Liu, Y., Fassbender, K., Wyss-Coray, T., Kirchhoff, F., and Schäfer K. H. (2013) Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression. J Alzheimers Dis. 36(1): 7-20.
Shires, T. K., Brummel, M. C., Pulido, J. S., and Stegink, L. D. (1997) Ergothioneine distribution in bovine and porcine ocular tissues. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 117(1): 117-120.
Shulman, R. G., Rothman, D. L., Behar, K. L., and Hyder, F. (2004) Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci. 27(8): 489-495.
Siu, A. W., Reiter, R. J., and To, C. H. (1998) The efficacy of vitamin E and melatonin as antioxidants against lipid peroxidation in rat retinal homogenates. J Pineal Res. 24(4): 239-244.
Sjögren, M., and Blennow, K. (2005) The link between cholesterol and Alzheimer's disease. World J Biol Psychiatry. 6(2): 85-97.
Small, D. H., and Barrow, C. J. (2006) Abeta peptide and Alzheimer’s Disease. Celebrating a Century of Research. 1-4.
Smith, M. A., Sayre, L. M., and Perry, G. (1997) Morphological aspects of oxidative damage in Alzheimer’s disease. In Beal, M.F., Bodis-Wollner, I. & Howell, N.(eds), Mitochondria and Free Radicals in Neurodegenerative Diseases. pp. 335–342.
Song, T. Y., Lin, H. C., Chen, C. L., Wu, J. H., Liao, J. W., and Hu, M. L. (2014) Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose. Free Radic Res. 48(9): 1049-1060.
Songin, M., Jeśko, H., Czapski, G., Adamczyk, A., and Strosznajder, R. P. (2007) GSK-3beta and oxidative stress in aged brain. Role of poly (ADP- -ribose) polymerase-1. Folia Neuropathol. 45: 220-229.
Sonn, K., Jaako, K., Jain, K. R., and Zharkovsky, A., (2008) 5XFAD mouse model of Alzheimer's disease: a dissociation between brain pathology
and behavioural phenotype. European Neuropsychopharmacology. 23(1): S33.
Sorrention, G., and Bonavita, V. (2007) Neurodegeneration and Alzheimer’s disease: the lesson from tauopathies. Neurol Sci. 28:63-71.
Squire, L., Berg, D., Bloom. F., Lac, S. D., Ghosh, A., and Spitzer, N. (2013) Fudamental neuroscience. Academic Press is an imprint of Elsevier.
Stadtman, E. R., and Levine, R. L. (2003) Free radical-mediated oxidation of free amino acids and amino acid residues in proteins. Amino Acid. 25: 207-218.
Sultana, R., Perluigi, M., and Butterfield, D. A. (2013) Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain. Free Radic Biol Med. 62: 157-169.
Suzuki, N., Cheung, T. T., Cai, X. D., Odaka, A., Otvos, L. Jr., Eckman, C., Golde, T. E., and Younkin, S. G.(1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science. 264: 1336-1340.
Svedberg, M. M., Hall, H., Hellström-Lindahl, E., Estrada, S., Guan, Z., Nordberg, A., and Långström, B. (2009) [11C]PIB-amyloid binding and levels of Aβ40 and Aβ42 in postmortem brain tissue from Alzheimer patients. Neurochem Int. 54: 347-357.
Tabrizchi, R., and Bedi, S. (2001) Pharmacology of adenosine receptors in the vasculature. Pharmacol Ther. 91(2): 133-147.
Taga, M. S., Miller, E. E., and Pratt, D. E. (1984) Chia seeds as a source of natural lipid antioxidants. J Am Chem Soc. 61(5): 928-931.
Tai, L. M., Mehra, S., Shete, V., Estus, S., Rebeck, G. W., Bu, G., and Ladu, M. J., (2014) Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular Neurodegeneration. 9:2.
Tamagno, E., Guglielmotto, M., Monteleone, D., Vercelli, A., Tabaton, M. (2012) Transcriptional and post-transcriptional regulation of β-secretase. IUBMB Life. 64: 943-950.
Thomann, P. A., Kaiser, E., Schönknecht, P., Pantel, J., Essig, M., and Schröder, J. (2009) Association of total tau and phosphorylated tau 181 protein levels in cerebrospinal fluid with cerebral atrophy in mild cognitive impairment and Alzheimer disease. J Psychiatry Neurosci. 34: 136-142.
Tricoire, H., Locatelli, A., Chemineau, P., and Malpaux, B. (2002) Melatonin enters the cerebrospinal fluid through the pineal recess. Endocrinology. 143(1): 84-90.
Tsai, S. Y., Tsai, H. L., and Mau, J. L. (2007) Antioxidant properties of Agaricus blazei, Agrocybe cylindracea, and Boletus edulis. LWT - Food Science and Technology. 40(8): 1392-1402.
Umemiya, M., Chen, N., Raymond, L. A., and Murphy, T. H (2001) A Calcium-Dependent Feedback Mechanism Participates in Shaping Single NMDA Miniature EPSCs. J Neurosci. 21: 1-9.
Vamanu, E. (2012) Biological Activities of the Polysaccharides Produced in Submerged Culture of Two Edible Pleurotus ostreatusMushrooms. J Biomed Biotechnol. 2012: 565974-565982.
Venkat, P., Chopp, M., and Chen. J. (2015) Models and mechanisms of vascular dementia. Exp Neurol. 272: 97-108.
Vinadé, E. R., Schmidt, A. P., Frizzo, M. E., Izquierdo, I., Elisabetsky, E., and Souza, D. O. (2003) Chronically administered guanosine is anti-convulsant, amnesic and anxiolytic in mice. Brain Res. 977(1): 97-102.
Wallin, A. K., Blennow, K., Andreasen, N., and Minthon, L. (2006) CSF biomarkers for Alzheimer's Disease: levels of beta-amyloid, tau, phosphorylated tau relate to clinical symptoms and survival. Dement Geriatr Cogn Disord. 21: 131-138.
Weber, D., Davies, M. J., and Grune, T. (2015) Determination of protein carbonyls in plasma, cell extracts, tissue homogenates, isolated proteins: Focus on sample preparation and derivatization conditions. Redox Biol. 5: 367-380.
Wei, C. J., Li, W., and Chen, J. F. (2011) Normal and abnormal functions of adenosine receptors in the central nervous system revealed by genetic knockout studies. Biochimica et Biophysica Acta. 1808: 1358-1379.
White, F., Nicoll, J. A., Roses, A.D., and Horsburgh. K. (2001) Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion. Neurobiol Dis. 8: 611-625.
Xiao, J. H., Qi, Y., and Xiong, Q. (2013) Nucleosides, a valuable chemical marker for quality control in traditional Chinese medicine Cordyceps. Recent Pat Biotechnol. 7(2): 153-166.
Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashier, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heinrikson, R. L., and Gurney, M. E. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature. 402: 533-537.
Yang, N. C., Lin, H. C., Wu, J. H., Ou, H. C., Chai, Y. C., Tseng, C. Y., Liao, J. W., and Song, T. Y. (2012) Ergothioneine protects against neuronal injury induced by β-amyloid in mice. Food Chem Toxicol. 50(11): 3902-3911.
Yildirim, N. C., Turkoglu, S., Yildirim, N., and Ince, O. K. (2012) Antioxidant properties of wild edible mushroom Pleurotus eryngii collected from tunceli province of Turkey. Digest J Nanomaterials and Biostructures. 7(4):1647-1654.
Yildiz, S., Yildiz, Ü. C., Gezer, E. D., and Temiz, A. (2002) Some lignocellulosic wastes used as raw material in cultivation of the Pleurotus ostreatus culture mushroom. Pro Biochem. 38: 301-306.
Yoon, I. S., Pietrzik, C. U., Kang, D. E., and Koo, E. H. (2005) Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem. 280(20): 20140-20147
Yu, L., Haley, S., Perret, J., and Harris, M. (2002) Antioxidant properties of hard winter wheat extracts. Food Chem. 78(4): 457-461.
Zervakis, G., and Balis, C. (1996) A pluralistic approach in the study of Pleurotus species with emphasis on compatibility and physiology of the European morphotaxa. Mycological Res. 100: 717-731.
Zhou, F., Gong, K., Song, B., Ma, T., Laar, T. V., Gong, Y., and Zhang, L. (2012) The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth. Biochimica et Biophysica Acta (BBA) - Molecular Cell Res. 8: 1233-1241.
Zhu, B. Z., Mao, L., Fan, R. M., Zhu, J. G., Zhang, Y. N., Wang, J., Kalyanaraman, B., and Frei, B. (2011) Ergothioneine Prevents Copper- Induced Oxidative Damage to DNA and Protein by Forming a Redox- Inactive Ergothioneine−Copper Complex.Chem Res Toxicol. 24(1): 30-34.
Zisu, B., and Shah, N. P. (2003) Effects of pH, Temperature, Supplementation with Whey Protein Concentrate, and Adjunct Cultures on the Production of Exopolysaccharides by Streptococcus thermophilus 1275. J Dairy Sci. 86: 3405–3415.