(3.210.184.142) 您好!臺灣時間:2021/05/09 08:40
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:邱泳崴
研究生(外文):Yong-Wei Chiu
論文名稱:可調式高能射頻脈衝電刺激器
論文名稱(外文):Adjustable High Energy Pulsed Radiofrequency Stimulator
指導教授:邱弘緯邱弘緯引用關係
口試委員:呂隆昇陳筱青林木鍊
學位類別:碩士
校院名稱:國立臺北科技大學
系所名稱:電子工程系研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
畢業學年度:104
語文別:中文
中文關鍵詞:射頻脈衝、經皮神經電刺激、電刺激器、高能、生醫電子
外文關鍵詞:PRF、TENS、Stimulator、High energy、Bimedical engineering
相關次數:
  • 被引用被引用:1
  • 點閱點閱:127
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
本論文研究目的為結合經皮神經刺激(TENS)與射頻(RF)波形的止痛效果,透過TENS「門閥理論」止痛原理及RF電場作用,改善TENS電刺激因皮膚阻抗太高而無法直接刺激到深層組織的問題,達到克服皮膚阻抗同時具有低週波電刺激止痛效果。
此外我們也研究探討了PRF參數使用不同的Duty及高能高電壓是否產生不同的效應,且利用動物實驗來驗證出結果。因此綜合以上幾項理念故設計出可調式高能脈衝電射刺激器,此PRF神經電刺激器分為五個部分,一、電源電路,二、脈衝高壓弦波電路,三、電壓與電流量測,四、MCU控制與計算數據,五、資料儲存系統。
The purpose of this study is to combine both advantages of transcutaneous electrical nerve stimulation (TENS) and radiofrequency (RF) for treatment of pain. Accroding to analgesic effects of TENS based on the gate control theory, we combine it with RF electric field to improve the limited by epidermal impedance is too high to directly stimulate the pain points.
In addition, we also study different PRF parameters. Whether the use of different Duty and high energy and high voltage produces different effects, and the use of animal experiments to verify the results. Therefore, based on the above idea is designed as an adjustable high energy pulsed radiofrequency stimulator. This PRF peripheral nerve stimulation is mainly divided into five parts; 1) Power source. 2) Pulsed high voltage sine wave circuit 3) Voltage and current measurement. 4) MCU control and calculates data. 5) Data storage system.
摘要 i
ABSTRACT ii
誌謝 iii
目錄 v
表目錄 vii
圖目錄 viii
第一章 緒論 1
1.1 前言 1
1.2 研究背景 1
1.3 研究動機 3
1.4研究目的 4
1.5論文架構 5
第二章 電刺激止痛機轉與學說 6
2.1疼痛的基礎認知 6
2.1.1疼痛機轉與學說 7
2.1.2疼痛的分類 7
2.2神經傳導 8
2.2.1神經元 8
2.2.2神經纖維的種類 9
2.3經皮神經電刺激 10
2.3.1經皮神經電刺激止痛機轉 10
2.4射頻電刺激 11
2.4.1射頻熱凝療法 11
2.4.2脈衝式射頻電刺激 13
2.5電穿孔效應 14
第三章 PRF電刺激器系統 16
3.1電刺激器系統 16
3.2 PRF電刺激器系統架構 17
3.2.1 Power Source 18
3.2.2 MCU 25
3.2.3 Interface 27
3.2.4 Waveform Modulator 31
3.2.5 PRF Driver 42
3.2.6 Amplitude Dectection and Current Sensor 49
3.2.7 Data Storage System 58
3.3電刺激器成品實照 65
第四章 動物試驗 67
4.1實驗方法: 67
4.2動物準備 67
4.3疼痛模型建立 68
4.4 Von Frey測試大白鼠疼痛敏感指數 68
4.5 實驗步驟 70
4.6 實驗結果 72
第五章 結論與未來展望 74
5.1 結論 74
5.2未來展望 74
參考文獻 75
[1] Medical Data International, Market and Technology Report, U.S. market for painmanagement products, Report RP821922, June 1999.
[2] D. Bouhassira, et al., "Prevalence of chronic pain with neuropathic characteristics in the general population," Pain, vol. 136, pp. 380-387, 2008.
[3] Pomeranz, B. and D. Chiu, Naloxone blockade of acupuncture analgesia: Endorphin implicated. Life Sciences, 1976. 19(11): p. 1757-1762
[4] R. Chang, B. Pomeranz, Electroacupuncture analgesia could be mediated by at least two pain-relieving mechanisms: endorphin and non-endorphin systems, Life Sci. 25 (1979) 1957–1962.
[5] C. Chavkin, L.F. James, A. Goldstein, Dynorphin is a specific endogenous legend of the k-opioid receptor, Science 215 (1982) 413–415.
[6] X.H. Chen, J.S. Han, All three types of opioid receptors in the spinal cord are important for 2/15 Hz electroacupuncture analgesia, Eur. J. Pharmacol. 211 (1992) 203–210.
[7] Y. Wang, Y. Zhang, W. Wang, Y. Cao, J.S. Han, New evidence for synergistic analgesia produced by endomorphin and dynorphin, Chin. J. Pain Med. 8 (2002) 118–119.
[8] Z. Han, Y.H. Jiang, Y. Wan, Y. Wang, J.K. Chang, J.S. Han, Endomorphin-1 mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat, Neurosci. Lett. 274 (1999) 75–78.
[9] M. Sluijter and G. Racz, "Technical Aspects of Radiofrequency," Pain Practice, vol. 2, pp. 195-200, 2002.
[10] Munglani R. The longer term effect of pulsed radiofrequency for neuropathic pain. Pain 1999;80(1-2):437-439.
[11] M. E. Sluijter and M. v. Kleef, "Characteristics and mode of action of radiofrequency lesions " Current Pain and Headache Reports, vol. 2, pp. 143-150, 1998.
[12] W. M. Geurts, et al., "Radiofrequency Treatments in Low Back Pain," Pain Practice, vol. 2, pp. 226-234, 2002.
[13] G. A. M. Barendse, et al., "Randomized Controlled Trial of Percutaneous Intradiscal Radiofrequency Thermocoagulation for Chronic Discogenic Back Pain: Lack of Effect From a 90-Second 70 C Lesion," Spine, vol. 26, pp. 287-292, 2001.
[14] Kanpolat, et al., "Percutaneous Controlled Radiofrequency Trigeminal Rhizotomy for the Treatment of Idiopathic Trigeminal Neuralgia: 25-year Experience with 1600 Patients," Neurosurgery, vol. 48, pp. 524-534, 2001.
[15] Li, C. L., and A. Bak. "Excitability characteristics of the A-and C-fibers in a peripheral nerve." Experimental neurology 50.1 (1976): 67-79.
[16] Condés-Lara, Miguel, et al. "Hypothalamospinal oxytocinergic antinociception is mediated by GABAergic and opiate neurons that reduce A-delta and C fiber primary afferent excitation of spinal cord cells." Brain research 1247 (2009): 38-49.
[17] Wall, Patrick D. "The Gate Control Theory of Pain Mechanisms a Re- Examination and Re-Statement." Brain 101.1 (1978): 1-18.
[18] G. F. Michael Gofeld, "Radiofrequency Denervation of the Lumbar Zygapophysial Joints—Targeting the Best Practice," Pain Medicine, vol. 9, pp. 204-211, 2008.
[19] M. Alex Cahana, DAAPM,* Jan Van Zundert, MD, PhD, FIPP, Lucian Macrea, MD,* Maarten van Kleef, MD, PhD, FIPP, and Menno Sluijter, MD, PhD, FIPP "Review Article : Pulsed radiofrequency: current clinical and biological literature available," Pain Medicine, vol. Volume 7 Issue 5, Pages 411 - 423, 2006.
[20] Bogduk, Nikolai. "Pulsed radiofrequency." Pain Medicine 7.5 (2006): 396-407.
[21] M. E. Sluijter and M. v. Kleef, "Characteristics and mode of action of radiofrequency lesions " Current Pain and Headache Reports, vol. 2, pp. 143-150, 1998.
[22] M. Sluijter and G. Racz, "Technical Aspects of Radiofrequency," Pain Practice, vol. 2, pp. 195-200, 2002.
[23] Munglani R. The longer term effect of pulsed radiofrequency for neuropathic pain. Pain 1999;80(1-2):437-439.
[24] Zimmermann, U., P. Scheurich, G. Pilwat and R. Benz, "Cells with manipulated functions: new perspectives for cell biology", Medicine and Technology, Angew. Chem. Ed. Eng., Vol. 20, pp. 325-345, 1981.
[25] Lee, S.W., H. Yowanto and Y.C. Tai, "A micro cell lysis device", Sens. Actuators A, Phys., Vol. 73, pp. 74-79, 1999.
[26] Kotnik, T., G. Pucihar, M. Rebersek, D. Miklavcic and L.M. Mir, "Role of pulse shape in cell membrane electropermeabilization", Biochim. Biophys. Acta, Vol. 1614, pp. 193-200, 2003.
[27] Lin, Y. C., M. Li, C. S. Fan and L. W. Wu, "A microchip for electroporation of primary endothelial cells", Sens. Actuators A, Phys., Vol. 108, pp. 12-19, 2003.
[28] Puc, M., S. Corovic, K. Flisar, M. Petkovsek, J. Nastran, and D. Miklavcic, "Techniques of signal generation required for electropermeabilization - Survey of electropermeabilization devices", Bioelectrochemistry, Vol. 64, pp. 113-124, 2004
[29] Dixon W, "The up-and-down method for small samples", Journal of the American Statistical Association,Vol. 60, pp. 967-978,1965
[30] S.R. Chaplan, F.W.Bach, J.W. Porgel, J.M. Chung, T.L. Yaksh, "Quantitative assessment of tactile allodynia in the rat paw", Journal of Neuroscience Methods,Vol. 53,pp. 55-63,1994
電子全文 電子全文(網際網路公開日期:20210809)
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關論文
 
無相關期刊
 
無相關點閱論文
 
系統版面圖檔 系統版面圖檔