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研究生(外文):Hui-Chia Kuo
論文名稱:基於穿戴式裝置之脈搏傳輸時間與生理差 異於血壓估測的關係性分析
論文名稱(外文):The Relational Analysis of Blood Pressure Estimation between Pulse Transit Time and Physiological Differences for Wearable Device
指導教授(外文):Ren-Guay Lee
口試委員(外文):Chen-Mou ChengChwan-lu Tseng
外文關鍵詞:Wearable DevicePPGPTTBlood PressureCuff-less.
  • 被引用被引用:6
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本研究採用「動心醫電公司」的Z1 流速血壓手環,量測共120位受測者,該手環可量測心電圖與光體積變化描計圖的訊號,藉由此兩種訊號的峰值時間差,計算求得脈搏傳輸時間與心率;而脈搏傳輸時間已於多項研究結果中證實與血壓具高相關性,非常適合利用此估算血壓;但人體的血管組成相當複雜,血壓又與血管的關係緊密,故本研究也加入了與血管密切相關的變因:心率、個體間的生理差異(如:身高、體重、年齡、性別)進行估算,並利用多元迴歸分析,建立非侵入式的血壓估算方法。本研究實驗結果顯示於正常血壓區間中,收縮壓誤差可在6.9mmHg ±8.6mmHg,雖未達AAMI標準,但已可確立加入生理參數的估算是有效的。
According to the statistics from Ministry of Health and Welfare, there are three lines in the top ten factors of death in 2014 which were associated with hypertension accounted. Not only the numbers of hypertensive patients had grew but also their ages were getting younger and younger.
The blood pressure measurement is very inconvenience which result in few people have the habit to measure blood pressure. In order to improve peoples habit of measuring blood pressure, we develop a simple method for measuring blood pressure in this study by rising the willing of measuring blood pressure and establishing the habits of blood pressure measurement, also with tracking those statistics they can find out hypertension as soon as possible.
We use the blood velocity band from ZoeTek to measure 120 participant blood pressures. This band can be measured with the simultaneously signals of Photoplethysmogram (PPG) and Electrocardiography (ECG), then computed the interval peak time with these two signals as pulse transit time (PTT). The PTT was confirmed with a high correlation between numbers of research results, this estimation was very suitable for the use in blood pressure. Since the blood vessels composition in human body is very complicated, weve added some parameters such as the heart rate and individual’s physiological differences (e.g., height, weight, age, gender) into account and evaluate them together by using multiple regression analysis. Then we can get testing result from this non-invasive blood pressure measurement method. The study results show the normal blood pressure range, the error in systolic blood pressure 6.9mmHg ± 8.6mmHg. Although not reach the AAMI standard, it has been established that added to a physiological parameter to estimate blood pressure is effective.
摘 要 i
誌 謝 iv
目錄 vi
表目錄 viii
圖目錄 ix
第一章 緒論 1
1.1前言 1
1.2研究動機與目的 3
1.3論文架構 5
第二章 相關背景知識與研究 7
2.1心臟與血壓之生理意義 7
2.1.1心臟收縮與舒張期 8
2.1.2高血壓及低血壓 9
2.2光體積變化描計圖 12
2.3脈搏傳輸時間 13
2.4血壓量測分類與工作原理 14
2.4.1侵入式血壓 14
2.4.2非侵入式血壓量測 15
2.4.3非侵入式連續血壓量測 17
2.5血壓量測方法比較與選用 25
第三章 系統架構與實驗方法 27
3.1系統簡介 27
3.2系統驗證 33
3.3實驗設計方法與流程 39
3.3.1實驗對象 39
3.3.2 實驗位置 39
3.3.3 實驗流程 41
3.4實驗數據分析方法 43
第四章 實驗結果與討論 44
4.1受測群之基本資料 44
4.2血壓分群界定 45
4.3生理參數之於血壓的關係性 50
4.4生理參數應用於估算血壓之比較 55
第五章 結論與未來展望 61
5.1結論 61
5.2未來展望 62
參考文獻 63
附錄A. 受測者自願同意書 69
附錄B. 健康狀況調查表 70
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