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研究生:張宇傑
研究生(外文):Chang-Yu-Chieh
論文名稱:以酵素噴覆製程製作之鍍金印刷電路板血糖試片之性能分析
論文名稱(外文):Performance of Gold Plated Printed Circuit Board Blood Glucose Test Strips Using Ink Jet Printing Process
指導教授:張合蔡哲雄蔡哲雄引用關係
指導教授(外文):Chang HoChe-Hsiung Tsai
口試委員:張鴻銘鍾清枝李仁方蔡哲雄張合
口試委員(外文):Jhang,Hong-MingJhong,Cing-JhihLi,Ren-FangChe-Hsiung TsaiChang Ho
口試日期:2016-07-25
學位類別:碩士
校院名稱:國立臺北科技大學
系所名稱:製造科技研究所
學門:工程學門
學類:機械工程學類
論文種類:學術論文
論文出版年:2016
畢業學年度:104
語文別:中文
中文關鍵詞:準確度結晶變異係數標準差噴覆製程血糖試片
外文關鍵詞:CrystalsAccuracyCoefficient of VariationStandard DeviationInk Jet PrintingTest Strips
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本研究是用噴覆的製程來製造出鍍金印刷電路板血糖試片。用噴覆的方法把酵素點在血糖試片上,在與傳統的點膠機來做比較,在這會發現傳統點膠機點上去的酵素結晶粗大而不規則,且分佈相當不均勻。但是使用噴覆製程出來的血糖試片在顯微鏡底下觀察會發現噴覆製程使得在反應區的酵素結晶分佈非常均勻且細小。而且,以糖水來測試新的噴覆製程製作的試片其標準差(STDEV)及變異係數(CV)比傳統點膠機的標準差(STDEV)及變異係數(CV)相較起來低很多,這表示噴覆製程所造出的血糖試片在反應區比較細小且均勻分佈的酵素結晶的確會讓血糖試片的準確度變得好很多。
In this study we focused on the ink jet printing process to produce blood glucose strips made of immersion gold plated printed circuit board, on which was deposited a drop of enzyme solution on the reaction zone of the test strip. Conventional enzyme dispensing processes produced tests trips with coarse enzyme crystals randomly distributed inside the reaction zone of the test strips, while the new ink jet printing process produced tests trips with very fine enzyme crystals evenly distributed inside the reaction zone of the test strips, as demonstrated by the microscopic pictures.
After testing the test strips produced with ink jet printing process, it was found that from the control solution test result, both the standard deviation (STDEV) and the coefficient of variation (CV) of the test strips were significantly lower than test strips produced with conventional enzyme dispensing process. It seems that the presence of very fine enzyme crystals evenly distributed inside the reaction zone of the test strip did contribute significantly to improve the accuracy of the glucose test strips. 
摘 要 i
ABSTRACT ii
致謝 iv
目錄 v
表目錄 vii
圖目錄 viii
第1章 緒論 1
1.1 前言 1
1.2 糖尿病 2
1.3 研究動機與目的 4
1.4 論文架構 5
第2章 理論與文獻 6
2.1 血糖機原理 6
2.1.1 快速血糖機全血測量 6
2.1.2 血糖機歷史發展 7
2.2 電化學偵測葡萄糖之原理 8
2.3 電化學血糖量測 11
2.3.1 葡萄糖去氫酶(GDH) 11
2.3.2 葡萄糖氧化酶(GOD) 11
2.3.3 侵入式量測總結 12
2.4 血糖試片的電極種類 12
2.4.1 二極式電極 13
2.4.2 三極式電極 13
2.4.3 不同製程對反應區之影響 14
2.5 血糖試片的電極材料性質 15
2.5.1 碳膠電極 15
2.5.2 黃金電極 15
2.6 血糖試片酵素 15
2.7 變異係數(CV值) 17
2.8 標準差 (STDEV值) 17
第3章 實驗步驟與器材 18
1. 18
3.1 實驗流程圖 18
3.2噴覆機設計過程 19
3.3 實驗內容 29
3.3.1 微量滴管 29
3.3.2 YSI 2300葡萄糖檢測儀 30
3.3.3 快速血糖機 31
第4章 研究結果與討論 32
4.1 噴覆機成品 32
4.1.1 各單元的詳細介紹 33
4.2 結果與討論 37
4.2.1 不同點膠機製作的血糖試片 37
第5章 結論與未來展望 41
5.1 結論 41
5.2 未來展望 42
參考文獻 43
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23R. F. Lee, Fluid dispensing processes for the Immersion gold plated printed circuit board for blood glucose test strips, Taipei, Taiwan, Neuero Eng. Tech. Rep., 2005.
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25https://zh.wikipedia.org/wiki/%E5%8F%98%E5%BC%82%E7%B3%BB%E6%95%B0
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