本整合性研究之目的為探討電燒器械沾黏特性與熱傷害在經過奈米表面處理後之影響，於臨床電燒之手術來說，熱傷害降低是現今電燒器械最需克服之重點項目之一，類鑽碳表面處理之電燒器械經由掃描式電子顯微鏡與原子力顯微鏡觀測表面型態，同時並建立三維腦部之醫學模型來模擬臨床手術時之情況，最後再配合動物鼠實驗來證明此新式表面處理技術之功能性與有效性，大鼠也將術後0、2、7以及28天犧牲並做組織切片觀察之。
結果可以發現於電燒刀之手術時，組織溫度降低於較厚表面處理之電燒器械，由熱影像溫度偵測儀發現表面處理之電燒器械臨床溫度比未經過處理之電燒器械低，另外經過表面處理之電燒器械也可以產生較小之傷口以及由電燒器械所發出之熱影響範圍。
因此，本研究結果指出類鑽碳電燒器械可防止對組織過高之熱傷害以及使得熱量於組織間傳遞時較為平均，以防止溫度過高造成傷害。

The objective of the present research was to investigate the thermal injury in the brain after minimally invasive electrosurgery using instruments with copper-doped diamond-like carbon (DLC-Cu) surface coating. The surface morphologies of DLC-Cu thin films were characterized using scanning electron microscopy and atomic force microscopy. Three-dimensional brain models were reconstructed using magnetic resonance imaging to simulate the electrosurgical operation. In adult rats, a monopolar electrosurgical instrument coated with the DLC-Cu thin film was used to generate lesions in the brain. Animals were sacrificed for evaluations on postoperative days 0, 2, 7, and 28. Data indicated that the temperature decreased significantly when minimally invasive electrosurgical instruments with nanostructure DLC-Cu thin films were used, and continued to decrease with increasing film thickness. On the other hand, the DLC-Cu-treated device created a relatively small thermal injury area and lateral thermal effect in the brain tissues. These results indicated that the DLC-Cu thin film minimized excessive thermal injury, and uniformly distributed the temperature in the brain. Taken together, our study results suggest that the DLC-Cu film on copper electrode substrates is an effective means for improving the performance of electrosurgical instruments.

中文摘要.....................................................................................................................Ⅰ
Abstract......................................................................................................................Ⅱ
Contents..................................................................................................................... Ⅲ
Ⅳ
Figure captions............................................................................................................ V
Chapter 1 Introduction 6
Chapter 2 Literature Review 8
Chapter 3 Materials and Methods 10
Chapter 4 Results and Discussion 12
Chapter 5 Conclusion 16
References 17

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