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研究生:葉大銘
研究生(外文):YEH, DA-MING
論文名稱:利用田口分析法對數位乳房假體影像品質的最佳化與臨床驗証
論文名稱(外文):Optimizing the Imaging Quality of Digital Mammographic Phantom using Taguchi Analysis with Clinical Verification
指導教授:潘榕光
指導教授(外文):PAN, LUNG-KWANG
口試委員:趙敏劉榮東曾顯群陳健懿
口試委員(外文):CHAO, MINLIU, JUNG-TUNGTSENG, HSIEN-CHUNCHEN, CHIEN-YI
口試日期:2017-01-10
學位類別:博士
校院名稱:中臺科技大學
系所名稱:醫學影像暨放射科學系暨研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:129
中文關鍵詞:田口方法乳房假體
外文關鍵詞:Taguchidigital mammographic phantomdominate factor
相關次數:
  • 被引用被引用:2
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數位乳房假體影像品質的最佳化與臨床驗証,主要是利用田口式方法,將得到的實驗結果,再驗證於臨床的影像。
本論文的主題是以乳房診斷影像品質之最佳化,研究設計是以ACR 標準的乳房假體為理論基礎,由假體的研究中選出影響影像品質的參數條件,有靶核(target/filter)、電壓值(kVp)、管電流(mAs)及視窗(FOV)四項,此四項因子依改良式田口的實驗設計- L18(2x3)方式進行實驗,所得到的結果,透過因子之間的反應圖分析及變異數分析,發現電壓值在25 至28 kVp 時的影響力最為明顯,因此電壓值為主要的控制因子。其他三項因子對影像品質的影響項較不顯著。另外,針對乳房的不同厚度,對影像品質所產生的影響,本論文也利用不同乳房假體厚度,包括2.4 cm、3.4 cm、4.4 cm 及5.4 cm 四種不同厚度,透過田口式方法,找尋厚度與參數條件之間的影響,並經由兩位放射科醫生評分後,發現厚度5.4 cm 的假體,在提高kVp 值仍無法達到MQSA 70 分的標準值,因此,建議乳房攝影經壓迫後,厚度大於5 cm 之患者,應改採其他檢查方式或搭配其他檢查方法,以降低誤診率。
另外,本論文也針對ACR 假體內腫瘤、纖維化、鈣化與參數條件之間的關係,透過田口式方法,分別找出腫瘤、纖維化與鈣化的最佳化,發現不同的組織特性,可以藉由改變不同的操作因子,而獲得解析度的改善。例如,對假體內腫瘤而言,主要控制因子為管電流(mAs),改變管電流可以改善影像的清晰度,而變動靶核,可以使鈣化更清楚,對假體內纖維化的組織,增加電壓值,可以讓是纖維化的組織或者是病變組織,區分更清楚。此一現象,是未來必須收集更多的臨床影像加以驗證。
Optimizing the Imaging Quality of Digital Mammographic Phantom using Taguchi Analysis with Clinical Verification was accomplished in this thesis dissertation.
This thesis talks about how to optimize the imaging quality of digital mammographic phantom. The research was used ACR breast phantom as theoretical basis, then optimized the parameters that influence the quality of the images, including target/ filter, kVp, mAs, and FOV. According to a revised Taguchi method- L18 (2x3), When the kVp was set between
25 kVp to 28 kVp, it had most significant effect. Therefore, kVp was the dominant control factor while others were minor. Furthermore, this thesis applied 4 different thickness of breast phantom, including 2.4 cm, 3.4 cm, 4.4 cm and 5.4 cm, to study the influence to the quality of image with different thickness of breast. We used Taguchi method to locate the effect between thickness and parameters. And after two radiologists’ evaluation, we discovered that 5.4cm breast phantom couldn’t reach MQSA 70 points even when raising kVp. Therefore, we suggested that for breast thickness above 5 cm after compress, should use or add other examine method to decrease misdiagnosis rate.
We used Taguchi method and ACR RMI-156 breast phantom to test whether optimized parameter could improve image quality or not. Under the IRB agreement, we collected 1558 breast images in total, while 1400 of them were adopted in our experiment. Of all thr 1400 cases were put into 4 categories based on ACR breast composition standard. Among these four types, 37 mm to 42 mm was selected in our research as it fitted Taiwanese female average size. Nevertheless, each type had two shooting parameters, 25 kVp and 28 kVp, 30 sets in total. We had three radiologists with 5-8 years of working experience to evaluate image quality based on three dimensions, exposure, contrast and sharpness. It showed that 28 kVp group scored better that 25 kVp in all three dimensions.
This thesis used Taguchi method to identify the effect between tumor, fibrosis and calcification in ACR phantom images, and the derived optimal parameters were changed with specific objects inside the mammographic phantom. For example, the dominant factor for tumor was mAs, therefore changing mAs could improve the clearness of image, and changing target nucleus could easily inspect calcification or diseased tissue better. This result needed to collect more clinical images to verify in the future.
目錄
一、 前言......................................................................................1
1.1 研究動機和目的..............................................................1
1.2 背景回顧(田口方法) .......................................................3
1.3 文獻分析..........................................................................5
二、 研究理論 L18、L9.............................................................7
三、 材料與方法........................................................................ 11
3.1 調整參數選定................................................................ 11
3.2 選定田口直交表............................................................12
3.3 蒐集原始資料................................................................14
3.4 參數調整........................................................................15
3.5 、影像評分標準............................................................17
3.6 、評分過程....................................................................20
四、 實驗數據分析....................................................................21
4.1 影像品質........................................................................21
4.2 劑量................................................................................30
五、 討論....................................................................................36
5.1 乳房攝影........................................................................36
5.2 假體厚度之關係............................................................47
5.3 假體內腫瘤病變、纖維化及鈣化點的關係................74
5.4 乳房攝影最佳化的臨床驗證........................................91
六、 未來展望..........................................................................108
七、 結論..................................................................................109
八、 參考文獻.......................................................................... 111

參考文獻
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