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研究生:田惠韻
研究生(外文):TIEN, HUI-YUN
論文名稱:利用MATLAB程式分析靜脈注射Tc-99m MIBI體內動力學模式
論文名稱(外文):To Evaluate the Biokinetic Model for Healthy Person Undergone Tc-99m MIBI Examination Via MATLAB Analysis
指導教授:潘榕光
指導教授(外文):PAN, LUNG-KWANG
口試委員:潘榕光陳健懿鄭凱元
口試委員(外文):PAN, LUNG-KWANGCHEN, CHIEN-YICHENG, KAI-YUAN
口試日期:2017-06-26
學位類別:碩士
校院名稱:中臺科技大學
系所名稱:醫學影像暨放射科學系暨研究所
學門:醫藥衛生學門
學類:醫學技術及檢驗學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:67
中文關鍵詞:Tc-99m MIBI體內動力學MATLAB
外文關鍵詞:PET/CTbiokinetic modelMATLAB
相關次數:
  • 被引用被引用:0
  • 點閱點閱:249
  • 評分評分:
  • 下載下載:3
  • 收藏至我的研究室書目清單書目收藏:0
目的:本研究為利用核子醫學技術評估血管注射Tc-99m MIBI於體內心臟攝取時間、甲狀腺吸收代謝時間及肝膽排空時間及腸道代謝時間,還有量化全身之生物半衰期,進而評估體內動力在各器官的分佈比例。
材料與方法:8位受檢者實驗前實驗前皆需禁食6小時,進行靜脈注射Tc-99m MIBI (10~15mCi),利用伽馬攝影機於10分鐘、30分鐘,120分鐘和180分鐘和最後一次240分鐘,正面及背面全身造影(SIMENS E-cam; LEGP; Matrix Size:
256*1024 ),圈取感興趣(ROI)後,各部位隨著時間變化之際數值。將體內動力學模式於人體中分為七個主要的部分,分別為體液、甲狀腺、心臟、肝膽、腸道、其餘器官及排出,每個部分皆有獨特的生物半衰期,並利用Excel及MATLAB程式軟體分析。
結果:利用MATLAB軟體模擬各個器官的生物半衰期和各個路徑的強度百分比,可針對每一個健康受試者各別計算出隨時間變化的最佳體內動力學分析結果,其符合度(AT)針對體液、心臟、甲狀腺、肝臟及腸道系統平均百分比分別為3.26±2.32;13.27±5.04;19.62±8.36; 24.76±17.68; 16.59±6.12。整合8位平均健康者數據,注射10分鐘後,體液、心臟、甲狀腺、肝臟及腸道系統的平均起始值為1;0.03±0.01;0.05±0.0; 0.23±0.08; 0,體液、心臟、甲狀腺、肝臟平均生物半衰期為253±182.69; 315.27±198.05; 203.66±88.29; 85±26.42分鐘。Tc-99m MIBI於體內所造成的全身劑量劑量以平均人 (64Kg; 1.33mCi) 為8.17± 5.02 mSv,亦即3.10 μSv/MBq,低於ICRP提供建議有效劑量9.0 μSv/MBq,反應真實體內循環有進有出,而非封避循環系統,以致算出來有效劑量較低。
結論:藉由MATLAB軟體的輔助計算與分析,可針對Tc-99m MIBI在人體所造成的劑量,以及在各主要器官中分布作精準的定量分析,也將重新修正通用型體內動力學模式,分析的越詳盡,對放射線核種的流程就越能掌握,對於所造成的體內劑量,也就越能夠計算清楚。

Purpose:The biokinetic model of patients undergone Tc-99m MIBI examination were analyzed using a self-developed program in this work.
Materials & Methods:The biokinetic model was defined into six essential compartments (Body Fluid, Heart, Thyroid, Liver, Remainder and GI tract). Each had its unique definition according to the metabolic mechanism of Tc-99m MIBI compound in the routine nuclear medicine examination. We used Gamma camera whole body scan at Taichung Veterans General Hospital to measure the counts of ROIs at for Body Fluid, Heart, Thyroid, Liver, Remainder and GI tract. A total of eleven scanned image was recorded and analyzed for each patient. The time-dependent simultaneous differential equations were defined to derive the counts remained at various timing. The measured time depended counts verse various ROIs were recorded and analyzed by a self-developed MATLAB program.
Results:A quantitative index, AT (Agreement), was introduced to specify the deviation between the actual measurement and analyzed results that were derived from the MATLAB program for each patient. The ATs of all patients was evaluated as 3.26±±2.32;13.27±5.04;19.62±8.36; 24.76±17.68; and 16.59±6.12 for average percentage with Body Fluid, Heart, Thyroid, Liver and GI tract, respectively. The average initial value was 1.00, 0.03±0.01, 0.05±0.0, 0.23±0.08, 0.00. The mean biological half-life was 253±182.69; 315.27±198.05; 203.66±88.29; and 85±26.42 minutes for Body Fluid, Heart, Thyroid, and Liver, respectively. These were derived 10-minutes directly after patients’ administration. Tc-99m MIBI on a permanent internal dose to the body caused to an average person (64Kg; 1.33mCi) whose total dose was 8.17± 5.02 mSv, or 3.10 μSv/MBq. It was low if compared to the ICRP recommended dose 9.0 μSv/MBq.
Conclusion:The derived biokinetic model can provide the essential information in building up the correlated analytical methods in future and verified with the theoretical estimation according to the MATLAB software.

目錄
中文摘要 I
ABSTRACT III
目錄 V
第一章 前言 1
1.1研究動機 1
1.2 研究背景 2
1.3 研究目的 3
第二章 背景回顧與文獻分析 4
2.1應用於一般人體的體內動力學的模型之研究 4
2.2體內動力學之理論分析 7
第三章 材料與方法 11
3.1體內動力學模式 11
3.2 MATLAB程式 15
3.3核醫藥物 16
3.4放射藥物停留的機制 17
3.5 TC-99m MIBI 藥物特性 17
3.6 TC99m核種的物理特性 19
3.7 TC-99m MIBI (全身癌症追蹤檢查) 20
3.8 GAMMA CAMERA(加馬攝影機) 20
3.9 八位接受靜脈注射TC-99M MIBI生理特性 21
第四章 結果 22
4.1符合度(AT-VALUE) 22
4.2 實際測量與理論模擬比較 23
第五章 討論 31
5.1 各個人的器官生物半衰期比較 31
5.2 特殊個案的分析 36
5.3 程式起始值的設定 37
5.4劑量計算 40
5.5相關文獻比較 45
5.5.1 體內動力學模式之半衰期比較 45
第六章 結論 50
未來展望 51
參考文獻 52

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