臺灣博碩士論文加值系統

有機與無機中空粒子是目前應用廣泛的特殊材料。可以用於光學元件與作為藥物載體。一般製備微、奈米中空粒子之方法以「模板法」最常見。首先以有機、無機材料包覆模板顆粒，再以鍛燒或溶劑去除模板而得到中空粒子。模板可為球體、圓柱或是平板。而細菌的形態可以是球形（球菌）、棒狀（桿菌）、弧形（弧菌）或是螺旋形（螺旋菌）。在本研究中，我們以比菲德氏菌（Bifidobacterium）做為生物模板，製作微米級二氧化矽中空棒。二氧化矽外殼之形成乃藉由進行溶膠凝膠反應。結果顯示，二氧化矽溶膠顆粒可以順利形成厚膜，包覆於比菲德氏菌表面。鍛燒後，細菌模板順利移除而微米中空棒也如預期製備完成，再經由粒徑分析儀與Bio-TEM等儀器分析尺寸、中空與形貌。


關鍵詞：中空棒、溶膠凝膠法、比菲德氏菌、生物模板

Organic and inorganic hollow particles are widely used special materials. They can be used in optical devices and as a drug vehicle. The most common method to prepare micro/nano hollow particles is the “template” method. First, the template particles are coated with an organic or inorganic material. Then the template moieties are removed by calcination or by solvent dissolution to obtain hollow particles. The template may be spheres, cylinders, or plates. And the morphology of the bacteria can be spherical (Coccus), rodlike (Bacillus), curved (Vibrio), or spiral (Spirillum). In this study, we used Bifidobacterium as a bio-template to produce micro-sized silica hollow rods. Silica shells were formed by the sol-gel reaction. The results showed that silica sol particles could form a thick film over the surface of Bifidobacterium. After calcination, the bacterial templates were removed and the micro hollow rods were obtained as expected. The samples were analyzed by the Submicron Particle Size Analyzer, Bio-TEM, and other instruments for particle size, hollowness, and morphology.


Keywords: Hollow Rods, Sol-Gel Method, Bifidobacterium, Bio-Template

摘　　要
Abstract
目　　錄
圖目錄
表目錄
第一章 緒論
1.1前言
1.2研究動機
1.3奈米材料簡介
1.3.1表面效應（Surface effects）
1.3.2小尺寸效應（Small scale effects）
1.3.3量子尺寸效應（Quantum effects）
1.3.4巨觀量子隧道效應（Macroscopic quantum tunnelling effects）
第二章 文獻回顧
2.1中空球簡介
2.2中空球製備方法
2.3溶膠-凝膠法(Sol-gel method)
2.4 乳酸菌
第三章 實驗
3.1實驗藥品
3.2實驗儀器
3.3實驗方法與步驟
3.3.1實驗架構
3.3.2 溶膠凝膠法之製備系統
3.3.3 以乳酸菌為模板製備二氧化矽中空棒
3.4分析方法
3.4.1粒徑分析儀（Submicron Particle Size Analyzer）
3.4.2 掃描式電子顯微鏡（Scanning Electron Microscopy，SEM）
3.4.3穿透式電子顯微鏡（Transmission Electron Microscopy，TEM）
第四章 結果與討論
4.1製備溶膠凝膠
4.1.1水解時間對溶膠粒子之粒徑分析
4.2模板之取得方式與分析
4.2.1取得乳酸菌之實驗流程
4.2.2穿透式顯微鏡分析
4.3以乳酸菌為模板製備二氧化矽中空棒
4.3.1穿透式式顯微鏡分析
4.3.2掃描式電子顯微鏡分析
第五章 結論

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