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研究生:鍾玫棽
研究生(外文):Mei-Ling Chung
論文名稱:分化型甲狀腺癌患者接受高劑量原子碘治療體內劑量評估及輻射防護病房汙染管控
論文名稱(外文):Internal dosimetry dose assessment and I-131 ward radiation contamination survey in DTC patients with high dose radioiodine therapy
指導教授:賴永昌賴永昌引用關係
指導教授(外文):Yung-Chang Lai
口試委員:鍾相彬劉祺章
口試委員(外文):Shiang-Bin JongChi-Chang Liu
學位類別:碩士
校院名稱:高雄醫學大學
系所名稱:公共衛生學系職業安全衛生碩士班
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:76
中文關鍵詞:分化型甲狀腺癌高劑量原子碘治療遠距輻射測量系統醫療體內輻射劑量環境輻射汙染
外文關鍵詞:Differentiated Thyroid CancerRadio Ablation IodineRemote-Measurement systemMedical Internal Radiation DoseEnvironmental Radiation Contamination
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本研究分作兩個部分,分別為體內劑量研究及環境輻射汙染研究。
體內劑量研究以服用高劑量分化型甲狀腺病患作為高劑量輻射暴露
族群,體內劑量以服用 100mCi 為 0.92±0.29 Sv,而服用 200mCi 的體內劑量則為 1.97±0.76 Sv,將 100mCi 及 200mCi 病患之體內劑量進行T-test,得到 p-value > 0.05 無顯著,證實投予劑量和服藥後輻射藥物劑量滯留呈正比相關性;環境輻射暴露研究以輻射防護病房進行環境輻射暴露研究,做為模擬輻射暴露居家環境的情形,發現病患以肢端接觸的地方如冰箱門把、電視遙控器及廁所門把等肢端接觸等處將有
較高的輻射汙染量。另外,靠近空調的衣櫃之頂板上的灰塵因空氣流
動使得上面附著較高的輻射量。
This research is divided into "Internal dosimetry" and "Environment dose". For the first part, Differentiated Thyroid Cancer (DTC) patients who took radioiodine 100mCi would get the internal dose 0.92±0.29 Sv Sv, those who took 200mCi would get the internal dose 1.97±0.76 Sv. It’s statistically non-significant for the internal dosimetry, same as clinical result and it proofs the dose gave from doctor and radiation dose after drug retention are positive correlations; Second part, Environmental Radiation Contamination in the radiation protectoral therapy, in all tests, "Fridge doorknob", "Remote control" and "Bathroom doorknob" those touch by hands are top 3 dirty spots, the highest is "Fridge doorknob", it
can be 1187.8 Bq. The other hypothesis is dust could catch the organic iodine by patient expiration May or the other types of Iodine-131 after human metabolism.
圖目錄 v
表目錄 vii
摘要 viii
Abstract ix
一、 緒論 1
1-1 研究背景 1
1-2 研究動機 7
二、 文獻回顧 10
2-1 放射性碘(I-131) 10
2-1-1 放射性碘與分化型甲狀腺癌 10
2-2 體內劑量MIRD (medical internal radiation dose) 15
2-2-1 輻射生物效應(Biological effects of radiation) 18
2-2-2 輻射暴露途徑與防護 23
2-2-3 生物方法之人體劑量估算 26
2-3 環境劑量(Environmental Radiation) 28
2-3-1 放射性環境汙染與劑量監測 29
2-3-2輻射偵檢器 31
2-3-2-1 Radiation monitoring and room image system G-M detector 33
2-3-2-2 CAPTUS ® 3000 THYROID UPTAKE SYSTEM 34
三、 研究方法 36
3-1 體內劑量評估 36
3-1-1 研究對象 36
3-1-2 研究地點 37
3-1-3 研究程序 38
3-2輻射防護病房汙染管控 40
3-2-1 採樣地點 40
3-2-2 採樣方法與範圍 42
3-2-3 統計分析 51
四、 研究結果 52
4-1 體內劑量評估 52
4-1-1 分化型甲狀腺癌病患特徵與體內劑量結果 52
4-1-2 rhTSH使用與體內劑量殘留之關係 56
4-2輻射防護病房汙染管控 59
五、 研究結論 62
六、 參考文獻 64
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