臺灣博碩士論文加值系統

本篇研究合成Diels-Alder reaction所需的diene及dienophile兩片段，藉由Diels-Alder reaction來合成(-)-Oseltamivir之六環骨架。我們利用便宜起始物ethyl acrylate、1,3-dichloro-2-propanol、crotonic acid、allyl bromide與3-pentanone分別合成diene與dienophile。

In this study, the diene and dienophile fragments of Diels-Alder reaction were synthesized and the six-member ring of (-)-Oseltamivir was synthesized by Diels-Alder reaction. We synthesized diene and dienophile by using the cheap starting materials such as 1,3-dichloro-2-propanol, crotonic acid, allyl bromide and 3-pentanone.

摘要 i
Abstract ii
縮寫表 iii
目次 vi
Figure目錄 viii
Scheme 目錄 ix
第一章 緒論 1
1-1 (-)-Oseltamivir之起源 1
1-2 (-)-Oseltamivir文獻回顧 4
1-3 (-)-Oseltamivir合成策略 18
第二章　(-)-Oseltamivir之全合成研究 22
2-1以1,3-dichloro-2-propanol為起始物合成片段98 23
2-2以allyl bromide為起始物合成片段98 25
2-3以crotonic acid為起始物合成片段98 27
2-4以allyl bromide為起始物合成片段98 30
2-5以3-pentanone為起始物合成片段 97 31
2-6以片段 97、片段98合成diene 81 32
第三章 結論 37
參考文獻 40
儀器與試劑 43
實驗步驟與光譜數據 45
附錄 59

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