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研究生:王品淨
研究生(外文):Pin-Ching Wang
論文名稱:耐力運動後碳水化合物回補對於胰島素敏感度的影響
論文名稱(外文):The Effect of Post-Exercise Carbohydrate Replacement on Insulin Sensitivity
指導教授:巫錦霖巫錦霖引用關係
口試委員:張振崗程一雄
口試日期:2017-06-26
學位類別:碩士
校院名稱:國立中興大學
系所名稱:運動與健康管理研究所
學門:民生學門
學類:運動休閒及休閒管理學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:43
中文關鍵詞:碳水化合物回補胰島素敏感度耐力運動
外文關鍵詞:Carbohydrate replacementInsulin SensitivityEndurance Exercise
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研究指出運動可增加肌肉對葡萄糖的吸收,進而改善胰島素阻抗的現象,然而很少有研究在於運動後將碳水化合物回補來填充消耗的肝醣,對於胰島素敏感度是否有影響,因此本研究旨在探討耐力運動後碳水化合物回補及無回補對於翌日胰島素敏感度的影響。
本研究採交叉試驗,8名健康成年男性於下午進行90分鐘且70 %VO2max之跑步運動,運動後給予碳水化合物 (CHO)或安慰劑 (PLA)回補,並且攝取低碳水化合物的晚餐,經隔夜禁食,於翌日早晨進行葡萄糖耐受試驗,採集空腹血液及30、60、90、120分鐘之血液樣本,以分析葡萄糖、胰島素、C-胜鍊胰島素 (C-peptide)、dehydroepiandrosterone-sulfate (DHEAS)、malonaldehyde (MDA)、superoxidase dismutase (SOD),並採集五分鐘休息氣體樣本分析脂肪及碳水化合物氧化情形。兩次實驗間隔一週沖刷期。
在休息狀態下,兩組的碳水化合物氧化率與脂肪氧化率皆無顯著差異 (p>0.05)。兩組之血清葡萄糖、C-peptide、MDA、SOD濃度也皆無顯著差異,血清胰島素的濃度CHO組具有高於PLA組之趨勢,並於30分鐘採血點顯著高於PLA組 (p=0.039)。
結果顯示耐力運動後碳水化合物回補,會使胰島素濃度有上升的趨勢,未來建議將受測者個體受訓練的程度納入考量進行更深入的探討。
It has been suggested that exercise increases muscle uptake of glucose and improve insulin sensitivity. However, limited studies have focused on carbohydrate (CHO) replacement after exercise to replenish the glycogen on the effect of insulin sensitivity. Hence, the purpose of this study was to investigate the effects of CHO replacement after endurance exercise on insulin sensitivity in the following day.
Subjects completed 2 experimental trials in randomize cross-over design. Two experimental trials were separated by a week wash out period. Eight healthy adult males ran at 70 % VO2max for 90mins in the afternoon. Subjects were given carbohydrate (CHO) or placebo (PLA) drinks with a low CHO dinner after exercise. Following overnight fasting, subjects undertook the oral glucose tolerance test (OGTT). The blood samples were collected at 0, 30, 60, 90 and 120mins in order to analyze serum glucose, insulin, C-peptide, dehydroepiandrosterone-sulfate (DHEAS), malonaldehyde (MDA) and superoxidase dismutase (SOD) concentrations. Expired gas samples were collected to analyze the rate of fat and CHO oxidation. After a week of washout period, the second experiment was conducted.
There was no significant difference (p> 0.05) in CHO and fat oxidation rate between the two groups at rest state, so as the concentrations of serum glucose, C-peptide, MDA and SOD. The concentration of serum insulin in CHO group was significantly higher than that in PLA group (p = 0.039) at 30min during OGTT.
This study suggested that CHO replacement after endurance exercise lead to a rising tendency of insulin concentration. The individuals' training level may take into consideration in the future studies.
目錄
第一章 緒論 1
第一節 研究背景 1
第二節 研究目的 1
第二章 文獻回顧 2
第一節 耐力運動與肌肉肝醣的合成 2
一、耐力運動及其效應 2
二、肌肉肝醣合成途徑 3
第二節 運動與胰島素敏感度 4
一、胰島素的作用 4
二、胰島素阻抗(insulin resistance) 5
三、運動對胰島素敏感度的影響 5
第三章 研究方法 8
第一節 研究對象 8
第二節 研究設計 8
第三節 實驗流程 8
一、初步試驗 8
二、主要試驗 9
三、回補液及安慰劑 9
四、晚餐內容 10
五、葡萄糖耐受試驗 10
第四節 分析方法 10
一、血液樣本分析 10
二、氣體樣本分析 12
三、血漿體積校正方法 13
四、資料統計分析 13
第四章 結果 14
第一節 受測者基本資料 14
第二節 休息氣體樣本分析 14
第三節 血液生化分析 14
一、血清葡萄糖濃度變化 14
二、血清胰島素濃度變化 15
三、血清C-peptide濃度變化 15
四、血漿SOD活性變化 15
五、血漿MDA濃度變化 15
六、血清DHEAS濃度變化 15
第五章 討論 16
第一節 血清葡萄糖與胰島素之變化 16
一、碳水化合物回補造成胰島素濃度上升之理論基礎 16
二、能量缺乏與賀爾蒙變化 16
三、促進胰島素敏感度與能量缺乏之必要性 18
第二節 運動與氧化壓力之探討 19
第三節 DHEAS對胰島素敏感度之影響 19
第六章 結論與建議 21
參考文獻 22
中文文獻 22
英文文獻 23
附件 38
附件一、受測者資訊 38
附件二、研究自願同意書 41
附件三、醫學問卷 42
中文文獻
行政院衛福部(1998)。台灣地區食品營養成分資料庫(初版)。台北:行政院衛福部,152-75。
林正常(2008)。咖啡因與碳水化合物增補對阻力運動後能量代謝與合成性荷爾蒙之影響。行政院國家科學委員會專題研究計畫成果報告 (NSC 96-2413-H-034 -002 -)。
林正常、郭堉圻、黃國晉(2001)。阻抗運動對肌酸激酶及丙二醛的影響。體育學報,31,35-46。
林學宜、林培元、徐廣明、徐台閣(2000)。不同強度運動對抗氧化酵素及丙二醛的影響。體育學報,29,137-148。
陳怡舟(2000)。耐力運動對脂肪代謝之影響。中華體育季刊,14(2),102-109。
陳金柱、李思遠、郭宗正(2006)。胰島素阻抗之病理生理學。台灣醫界,49(9),p28-34。
陳慕聰、何建德(2007)。Dehydroepiandrosterone(DHEA)在運動與健康中所扮演的角色。大專體育,88,199-204。
劉錫崑、曾文培(2007)。自由車選手經歷全國公路錦標賽後抗氧化能力之改變。體育學報,40(2),13-25。
簡盟月、吳英黛(2006)。胰島素阻抗與運動訓練的效果-細胞與分子層面之探討。物理治療,31(2),p130-141。


英文文獻
Alessio, H. M. (1993). Exercise-induced oxidative stress. Medicine & Science in Sports & Exercise, 25(2), 218-224.
Baar, K. (2014). Nutrition and the adaptation to endurance training. Sports Medicine, 44 Suppl 1, S5-12. doi:10.1007/s40279-014-0146-1
Bjornholm, M., Kawano, Y., Lehtihet, M., & Zierath, J. R. (1997). Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes, 46(3), 524-527.
Bogardus, C., Thuillez, P., Ravussin, E., Vasquez, B., Narimiga, M., & Azhar, S. (1983). Effect of muscle glycogen depletion on in vivo insulin action in man. Journal of Clinical Investigation, 72(5), 1605-1610. doi:10.1172/JCI111119
Booth, F. W., & Thomason, D. B. (1991). Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models. Physiological Reviews, 71(2), 541-585.
Bruce, C. R., Brolin, C., Turner, N., Cleasby, M. E., van der Leij, F. R., Cooney, G. J., & Kraegen, E. W. (2007). Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification. American Journal of Physiology - Endocrinology and Metabolism, 292(4), E1231-1237. doi:10.1152/ajpendo.00561.2006
Cermak, N. M., & van Loon, L. J. (2013). The use of carbohydrates during exercise as an ergogenic aid. Sports Medicine, 43(11), 1139-1155. doi:10.1007/s40279-013-0079-0
Chibalin, A. V., Yu, M., Ryder, J. W., Song, X. M., Galuska, D., Krook, A., . . . Zierath, J. R. (2000). Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. Proceedings of the National Academy of Sciences of the United States of America, 97(1), 38-43.
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., 3rd, . . . Birnbaum, M. J. (2001). Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science, 292(5522), 1728-1731. doi:10.1126/science.292.5522.1728
Coggan, A. R., Kohrt, W. M., Spina, R. J., Bier, D. M., & Holloszy, J. O. (1990). Endurance training decreases plasma glucose turnover and oxidation during moderate-intensity exercise in men. Journal of Applied Physiology (1985), 68(3), 990-996.
Dela, F., Handberg, A., Mikines, K. J., Vinten, J., & Galbo, H. (1993). GLUT 4 and insulin receptor binding and kinase activity in trained human muscle. The Journal of Physiology, 469, 615-624.
Dill, D. B., & Costill, D. L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology, 37(2), 247-248.
Eriksson, S. S. (2003). Digestionsorganen. In P. Nilsson-Ehle (Ed.), Laurells Klinisk Kemi i praktisk medicin (8 ed ed.). Lund: Studentlittteratur.
Etgen, G. J., Jr., Brozinick, J. T., Jr., Kang, H. Y., & Ivy, J. L. (1993). Effects of exercise training on skeletal muscle glucose uptake and transport. American Journal of Physiology, 264(3 Pt 1), C727-733.
Fleshner, M., Pugh, C. R., Tremblay, D., & Rudy, J. W. (1997). DHEA-S selectively impairs contextual-fear conditioning: support for the antiglucocorticoid hypothesis. Behavioral Neuroscience, 111(3), 512-517.
Frosig, C., Jorgensen, S. B., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. (2004). 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism, 286(3), E411-417. doi:10.1152/ajpendo.00317.2003
Frosig, C., Rose, A. J., Treebak, J. T., Kiens, B., Richter, E. A., & Wojtaszewski, J. F. (2007). Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. Diabetes, 56(8), 2093-2102. doi:10.2337/db06-1698
Gazdag, A. C., Wetter, T. J., Davidson, R. T.,Robinson, K. A., Buse, M. G., Yee, A. J., …Cartee, G.D. (2000). Lower calorie intake enhances muscle insulin action and reduces hexosamine levels. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 278, R504-512.
Gibala, M. J., Little, J. P., van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., . . . Tarnopolsky, M. A. (2006). Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. The Journal of Physiology, 575(Pt 3), 901-911. doi:10.1113/jphysiol.2006.112094
Goodyear, L. J., Giorgino, F., Sherman, L. A., Carey, J., Smith, R. J., & Dohm, G. L. (1995). Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. Journal of Clinical Investigation, 95(5), 2195-2204. doi:10.1172/JCI117909
Hansen, P. A., Gulve, E. A., Marshall, B. A., Gao, J., Pessin, J. E., Holloszy, J. O., & Mueckler, M. (1995). Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter. The Journal of Biological Chemistry, 270(4), 1679-1684.
Hardie, D. G. (2004). The AMP-activated protein kinase pathway--new players upstream and downstream. Journal of Cell Science, 117(Pt 23), 5479-5487. doi:10.1242/jcs.01540
Hargreaves, M. (1999). Metabolic responses to carbohydrate ingestion: Effects on exercise performance. In D. R. M. Lamb, R. (Ed.), Perspectives in Exercise Science and Sports Medicine (pp. 93-124). Carmel, IN: Cooper.
Harrison, M., O'Gorman, D. J., McCaffrey, N., Hamilton, M. T., Zderic, T. W., Carson, B. P., & Moyna, N. M. (2009). Influence of acute exercise with and without carbohydrate replacement on postprandial lipid metabolism. Journal of Applied Physiology (1985), 106(3), 943-949. doi:10.1152/japplphysiol.91367.2008
Hawley, J. A., & Houmard, J. A. (2004). Introduction-preventing insulin resistance through exercise: a cellular approach. Medicine & Science in Sports & Exercise, 36(7), 1187-1190.
Hawley, J. A., & Lessard, S. J. (2008). Exercise training-induced improvements in insulin action. Acta Physiologica, 192(1), 127-135. doi:10.1111/j.1748-1716.2007.01783.x.
Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., … Hardie, D. G. (2005). Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism, 2(1), 9-19. doi:10.1016/j.cmet.2005.05.009
Holloszy, J. O. (2005). Exercise-induced increase in muscle insulin sensitivity. Journal of Applied Physiology (1985), 99(1), 338-343. doi:10.1152/japplphysiol.00123.2005
Houmard, J. A., Shaw, C. D., Hickey, M. S., & Tanner, C. J. (1999). Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle. American Journal of Physiology, 277(6 Pt 1), E1055-1060.
Howlett, K. F., Sakamoto, K., Garnham, A., Cameron-Smith, D., & Hargreaves, M. (2007). Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle. Diabetes, 56(6), 1608-1614. doi:10.2337/db06-1398
Howlett, K. F., Sakamoto, K., Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F., & Goodyear, L. J. (2002). Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes, 51(2), 479-483.
Howlett, K. F., Sakamoto, K., Yu, H., Goodyear, L. J., & Hargreaves, M. (2006). Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise. Metabolism, 55(8), 1046-1052. doi:10.1016/j.metabol.2006.03.016
Huang, Y.J., Chen, M. T., Fang, C. L., Lee, W. C., Yang, S. C., & Kuo, C. H.(2006). A possible link between exercise-training adaptation and dehydroepiandrosterone sulfate- an oldest-old female study. International Journal of Medical Sciences, 3(4), 141-147.
Ivy, J. L., Young, J. C., McLane, J. A., Fell, R. D., & Holloszy, J. O. (1983). Exercise training and glucose uptake by skeletal muscle in rats. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology, 55(5), 1393-1396.
Jessen, N., & Goodyear, L. J. (2005). Contraction signaling to glucose transport in skeletal muscle. Journal of Applied Physiology (1985), 99(1), 330-337. doi:10.1152/japplphysiol.00175.2005
Ji, L. L. (1995). Exercise and oxidative stress: role of the cellular antioxidant systems. Exercise and Sport Sciences Reviews, 23, 135-166.
Kanter, M. M., Nolte, L. A., & Holloszy, J. O. (1993). Effects of an antioxidant vitamin mixture on lipid peroxidation at rest and postexercise. Journal of Applied Physiology (1985), 74(2), 965-969.
Kim, Y. B., Inoue, T., Nakajima, R., Shirai-Morishita, Y., Tokuyama, K., & Suzuki, M. (1999). Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Biochemical and Biophysical Research Communications, 254(3), 720-727. doi:10.1006/bbrc.1998.9940
Kirwan, J. P., del Aguila, L. F., Hernandez, J. M., Williamson, D. L., O'Gorman, D. J., Lewis, R., & Krishnan, R. K. (2000). Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle. Journal of Applied Physiology (1985), 88(2), 797-803.
Kjaer, M., Kiens, B., Hargreaves, M., & Richter, E. A. (1991). Influence of active muscle mass on glucose homeostasis during exercise in humans. Journal of Applied Physiology (1985), 71(2), 552-557.
Knudsen, S. H., Karstoft, K., Pedersen, B. K., van Hall, G., & Solomon, T. P. (2014). The immediate effects of a single bout of aerobic exercise on oral glucose tolerance across the glucose tolerance continuum. Physiological Reports, 2(8). doi:10.14814/phy2.12114
Kraniou, G. N., Cameron-Smith, D., & Hargreaves, M. (2006). Acute exercise and GLUT4 expression in human skeletal muscle: influence of exercise intensity. Journal of Applied Physiology (1985), 101(3), 934-937. doi:10.1152/japplphysiol.01489.2005
Krook, A., Wallberg-Henriksson, H., & Zierath, J. R. (2004). Sending the signal: molecular mechanisms regulating glucose uptake. Medicine & Science in Sports & Exercise, 36(7), 1212-1217.
Lessard, S. J., Rivas, D. A., Chen, Z. P., Bonen, A., Febbraio, M. A., Reeder, D. W., . . . Hawley, J. A. (2007). Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes, 56(7), 1856-1864. doi:10.2337/db06-1065
Martin, W. H., 3rd. (1996). Effects of acute and chronic exercise on fat metabolism. Exercise and Sport Sciences Reviews, 24, 203-231.
Mikulski, T., Ziemba, A., & Nazar, K. (2008). Influence of body carbohydrate store modification on catecholamine and lactate responses to graded exercise in sedentary and physically active subjects. Journal of Physiology and Pharmacology, 59(3), 603-616.
Mikulski, T., Ziemba, A., & Nazar, K. (2010). Metabolic and hormonal responses to body carbohydrate store depletion followed by high or low carbohydrate meal in sedentary and physically active subjects. Journal of Physiology and Pharmacology, 61(2), 193-200.
Peronnet, F., & Massicotte, D. (1991). Table of nonprotein respiratory quotient: an update. Canadian Journal of Sport Sciences, 16(1), 23-29.
Pessin, J. E., & Saltiel, A. R. (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. Journal of Clinical Investigation, 106(2), 165-169. doi:10.1172/JCI10582
Reaven, G. M. (1988). Banting lecture 1988. Role of insulin resistance in human disease. Diabetes, 37(12), 1595-1607.
Ren, J. M., Semenkovich, C. F., Gulve, E. A., Gao, J., & Holloszy, J. O. (1994). Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle. The Journal of Biological Chemistry, 269(20), 14396-14401.
Rivera-Brown, A. M., & Frontera, W. R. (2012). Principles of exercise physiology: responses to acute exercise and long-term adaptations to training. PM&R, 4(11), 797-804. doi:10.1016/j.pmrj.2012.10.007
Ross, R., Dagnone, D., Jones, P. J., Smith, H., Paddags, A., Hudson, R., & Janssen, I. (2000). Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Annals of Internal Medicine, 133(2), 92-103.
Ross, R., Janssen, I., Dawson, J., Kungl, A. M., Kuk, J. L., Wong, S. L., . . . Hudson, R. (2004). Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obesity Research, 12(5), 789-798. doi:10.1038/oby.2004.95
Rubenstein, A. C. C., J. L.; Melani, F.; Steiner, D. F. (1969). Secretion of proinsulin C-peptide by pancreatic β cells and its circulation in blood. Nature, 224, 697-699. doi:10.1038/224697a0
Rutter, G. A., Da Silva Xavier, G., & Leclerc, I. (2003). Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochemical Journal, 375(Pt 1), 1-16. doi:10.1042/BJ20030048
Saltiel, A. R. (2000). Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. Journal of Clinical Investigation, 106(2), 163-164. doi:10.1172/JCI10533
Segal, K. R., Edano, A., Abalos, A., Albu, J., Blando, L., Tomas, M. B., & Pi-Sunyer, F. X. (1991). Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. Journal of Applied Physiology (1985), 71(6), 2402-2411.
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003). Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes, 52(8), 1888-1896.
Singh, V. B., Kalimi, M., Phan, T. H., & Boadle-Biber, M. C. (1994). Intracranial dehydroepiandrosterone blocks the activation of tryptophan hydroxylase in response to acute sound stress. Molecular and Cellular Neuroscience, 5(2), 176-181. doi:10.1006/mcne.1994.1019
Sriwijitkamol, A., Ivy, J. L., Christ-Roberts, C., DeFronzo, R. A., Mandarino, L. J., & Musi, N. (2006). LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training. American Journal of Physiology - Endocrinology and Metabolism, 290(5), E925-932. doi:10.1152/ajpendo.00429.2005
Steiner, D. F., Park, S. Y., Stoy, J., Philipson, L. H., & Bell, G. I. (2009). A brief perspective on insulin production. Diabetes, Obesity and Metabolism, 11 Suppl 4, 189-196. doi:10.1111/j.1463-1326.2009.01106.x
Treadway, J. L., James, D. E., Burcel, E., & Ruderman, N. B. (1989). Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. American Journal of Physiology, 256(1 Pt 1), E138-144.
Wojtaszewski, J. F., Hansen, B. F., Gade, Kiens, B., Markuns, J. F., Goodyear, L. J., & Richter, E. A. (2000). Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes, 49(3), 325-331.
Wojtaszewski, J. F., Nielsen, J. N., & Richter, E. A. (2002). Invited review: effect of acute exercise on insulin signaling and action in humans. Journal of Applied Physiology (1985), 93(1), 384-392. doi:10.1152/japplphysiol.00043.2002
Woods, A., Johnstone, S. R., Dickerson, K., Leiper, F. C., Fryer, L. G., Neumann, D., . . . Carling, D. (2003). LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Current Biology, 13(22), 2004-2008.
Zierath, J. R. (2002). Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle. Journal of Applied Physiology (1985), 93(2), 773-781. doi:10.1152/japplphysiol.00126.2002
Zierath, J. R., He, L., Guma, A., Odegoard Wahlstrom, E., Klip, A., & Wallberg-Henriksson, H. (1996). Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia, 39(10), 1180-1189.
Zierath, J. R., Krook, A., & Wallberg-Henriksson, H. (2000). Insulin action and insulin resistance in human skeletal muscle. Diabetologia, 43(7), 821-835. doi:10.1007/s001250051457
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