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研究生:王思蘋
研究生(外文):Wang, Sih-Ping
論文名稱:鞋墊形無線多電極生醫電阻抗系統之研究
論文名稱(外文):The study of wireless multi-electrode bioimpedance system insoles
指導教授:鄭國順鄭國順引用關係
指導教授(外文):Cheng, Kuo-Sheng
口試委員:孫永年王士豪王明習林灶生黃基哲
口試委員(外文):Yung-Nien SunShyh-Hau WangMing-Shi WangJzau-Sheng LinJi-jer Huang
口試日期:2017-07-20
學位類別:碩士
校院名稱:國立成功大學
系所名稱:生物醫學工程學系
學門:生命科學學門
學類:生物化學學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:英文
論文頁數:49
中文關鍵詞:生醫電阻抗無線傳輸多電極鞋墊
外文關鍵詞:bioimpedancewireless transmissionmulti-electrodeinsoles
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隨著糖尿病人口的急遽增加,而糖尿病足是最常見的慢性併發症,它包括神經性病變、血管病變和血管合併神經性病變三大類型,其最後的結果皆會因血流灌注不足進而造成足部組織壞死甚至截肢,再加上病人常因足部產生潰瘍,傷口不易癒合才就診,此時足部通常已經產生不同程度的血循病變。若能早期偵測血流灌注的變化,就能提早治療,進一步預防潰瘍的發生;另外,有別於其他量測的血流方法,生物電阻抗技術在量測血流方面應用廣泛,可以提供有用資訊,以便作為疾病預防及診斷之參考,也提供了更加簡單、快速和便利的量測方式,不再受限於場合。本研究目的在於 1、研製一套具有無線傳輸的電阻抗量測系統和2、設計鞋墊形的多電極。本研究中,此系統硬體設計包括四個部分為阻抗量測、電極設計、通道切換裝置與無線傳輸。系統軟體功能主要分為三個部分,有無線傳輸,數據擷取和阻抗值校正。本系統阻抗測量訊號的總諧波失真為0.403%,最大誤差為於3.51%,同時具有模組化電路設計以方便整合與擴充和容易操作之電腦圖形控制介面的特點。再者電極的設計,使用海綿加上食鹽水測試,其標準差小於0.921。結果顯示系統具有可行性和很好的再現性。
Diabetic foot caused by neuropathy, vascular lesions or neurovascular lesions is the most common chronic complication. With the rapid increase in the population of diabetes, Diabetic foot is a serious problem. All lesions will eventually cause tissue necrosis or amputation due to poor perfusion. Because of feeling missing, the occurrence of ulcers usually accompanies different degrees of lesions. So, if patients can early detect the variation of perfusion, they will prevent the occurrence of ulcers. In contrast to traditional methods, bioimpedance provides a simple, fast and convenient way to measure and doesn’t limit by place. It also provides valuable information for disease prevention and diagnosis. In this study, the hardware design includes impedance measurement, wireless transmission, electrode design, and channel selection circuitry. The software design contains wireless transmission, data acquisition and impedance calibration. The total harmonic distortion of bioimpedance measuring circuit of the proposed system is 0.403% and the maximal error is 3.51%. In addition, the proposed system also has the module circuitry design for convenience of integration and graphical user interface for ease of use. In electrode design, we add normal saline into foam rubber to measure. The standard deviation is below 0.921. From the experimental results, the developed system has feasibility and good reproducibility.
中文摘要 I
ABSTRACT II
致謝 III
List of Tables VII
List of Figures VIII

Chapter 1 Introduction 1
1.1 Diabetes Foot 1
1.1.1 Epidemiology of Diabetes Foot 1
1.1.2 Causes of Diabetes Foot 2
1.2 Methods Used to Measure Blood Flow 3
1.2.1 Bioimpedance 3
1.2.2 Doppler Ultrasound 4
1.2.3 Laser Doppler 5
1.2.4 Photoplethysmography (PPG) 6
1.3 Bioimpedance 7
1.3.1 Electrical Properties of Biological Tissue 8
1.3.2 Electrical Impedance 9
1.3.3 Blood Flow Impedance Characterization 10
1.3.4 Literature Review 13
1.4 Motivation and Purpose 14

Chapter 2 Materials and Methods 16
2.1 Research Overview 16
2.2 Hardware Design 16
2.2.1 MCU 17
2.2.2 Impedance Measurement Circuit 19
2.2.3 Electrode Design and Position 25
2.2.4 Multiplexer (MUX) 25
2.2.5 Wireless Transmission 27
2.2.6 Power Supply 28
2.3 Software Design 29
2.3.1 Graphic User Interface (GUI) 29
2.3.2 System Control Program 31
2.4 Calibration 32

Chapter 3 Results 34
3.1 Wireless multi-electrode bioimpedance system 34
3.2 The evaluation of Developed System 36
3.2.1 Total Harmonic Distortion 36
3.2.2 Output Impedance 38
3.2.3 Current Stability 39
3.2.4 The Measurement Error Test 39
3.2.5 The Reproducibility of Measurement 40
3.2.6 The measurement of saline 41

Chapter 4 Discussions 43
4.1 The evaluation of Developed System 43
4.1.1 Total Harmonic Distortion (THD) 43
4.1.2 Current Stability 43
4.1.3 The Measurement Error 44
4.1.4 The Reproducibility of Measurement 45
4.1.5 The measurement of saline 45

Chapter 5 Conclusions and Prospects 46

References 47
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