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研究生:陳若梅
研究生(外文):CHEN, JO-MEI
論文名稱:探討致癌蛋白Aurora-A以及其下游受質HURP對於細胞增生以及高基氏體組成之探討
論文名稱(外文):The Mechanisms by Which Aurora-A and Its Downstream Substrate HURP Regulate Cell Proliferation and Golgi Complex Assembly
指導教授:余長澤
指導教授(外文):YU, CHANG-TZE
口試委員:黃阿梅蔡玉真張純純陳昶翰邱紹智余長澤
口試委員(外文):HUANG, A-MEITSAI, YU-CHENJANG, CHUEN-CHUENCHEN, CHANG-HANCHIU, SHAO-CHIHYU, CHANG-TZE
口試日期:2017-07-06
學位類別:博士
校院名稱:國立暨南國際大學
系所名稱:應用化學系
學門:自然科學學門
學類:化學學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:188
中文關鍵詞:磷酸化細胞週期細胞增生高基氏體微管穩定性微管
外文關鍵詞:Aurora-AHURPAstrinCCP1αTAT1Golgistable MT
相關次數:
  • 被引用被引用:1
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Aurora-A與HURP 為兩個具細胞轉型(cell transformation)活性的因
子,高量表現在多種癌症組織中;此兩蛋白功能多元,參與在包括細胞
週期調控等多種細胞生理的調節過程。本博士論文主旨在揭露Aurora-
A 與HURP 新的細胞功能。論文架構分為兩大面向,一是Aurora-A 透
過磷酸化下游受質Astrin 與HURP 調控細胞週期的進行,另一是HURP
經由調控穩定性微管(stable microtubule,stable MT)促進高基氏體的組
裝。Aurora-A 於mitosis 磷酸化Astrin,藉此促進Astrin 與相關M 期調
控蛋白的交互作用,進而保證mitosis 的順利進行。此外,Aurora-A 亦
透過磷酸化HURP 來活化p38 與NF-кB,接著刺激Cyclin-E1 的表現與
加速G1/S 的行進。另一方面,HURP 也同時經由NF-кB 轉錄調控了
CCP1 與αTAT1 此兩個stable MT 生成酵素的表現,以製造stable MT,
繼而維持高基氏體的彩帶型(Golgi ribbon)的結構。
Aurora-A and HURP play roles in cell transformation. The two versatile proteins
govern numerous cellular physiological functions, such as cell cycle progression. The
new cellular functions of Aurora-A and HURP are revealed in this doctoral dissertation.
The conceptual framework of this study is divided into two major parts. First, Aurora-
A phosphorylates Astrin and HURP to regulate cell cycle progression. Second, HURP
direct Golgi assembly by regulating stable microtubules (stable MTs). Aurora-A
phosphorylates Astrin in mitosis and facilitates the interaction between Astrin and
various mitosis regulating proteins to ensure the mitosis progression. Besides, Aurora-
A phosphorylates HURP and the phospho-HURP activates p38 and NF-кB. HURP/NF-
кB elevates the expression level of cyclin E1 to accelerate G1/S transition. Furthermore,
HURP transcriptionally regulates the expression of Golgi assembly factors, such as
GRASP65, GRASP55 and Golgin160, and CCP1 and αTAT1, which are the two stable
microtubules generating enzymes, thereby maintaining the Golgi ribbon structure.
中文摘要………………………………………………………………………………i
Abstract……………………...……………………………………………………….ii
目錄……………………………………………..…………………………………....iii
前言……………………………………………………………………………………1
研究背景與動機………………………………………………………………………3
第一節 蛋白質後轉譯修飾………………………………………………………..3
第二節 蛋白質磷酸化的細胞重要性……………………………………………..4
第三節 細胞週期(cell cycle)……………………………………………………....5
第一小節 細胞週期檢查點(cell cycle checkpoint)…………………….. 5
第二小節 週期素、週期素依賴激酶與週期素依賴激酶抑制因子(cyclin、
Cdk and CDKI)……………………………………………….6
第三小節 細胞週期調控蛋白與癌症…………………………………...8
第四節 高基氏體(Golgi)…………………………………………..………………9
第一小節 高基氏體結構組成……………………………………………9
第二小節 高基氏體結構變化…………………………………………..10
第三小節 高基氏體組裝因子…………………………………………..11
第五節 高基氏體與細胞骨架(cytoskeleton)………………………………….....15
第一小節 微管(microtubule)與其修飾…………………………………15
第二小節 穩定性微管(stable MT)與高基氏體的關係………………...17
第六節 標的分子…………………………………………………………………19
第一小節 Aurora-A……………………………………………………..19
第二小節 Astrin…………………………………………………………24
第三小節 HURP………………………………………………………...26
第四小節 NF-κB………………………………………………………...28
iv
關鍵詞縮寫與中文翻譯……………………………………………………………..31
參考文獻……………………………………………………………………………..36
研究結果……………………………………………………………………………..52
一. HURP 透過NF-кB 提高stable MT 與高基氏體組裝因子促進高基氏體之組
成………………………………………………………………………………53
二. HURP 透過NF-κB 進核以提高Cyclin E1 的表現量並加速G1/S 的行
進………………………………………………………………………………92
三. Aurora-A 透過磷酸化Astrin 調控其與M 期蛋白交互作用並促成M 期的進
行……………………………………………………………………………..106
參與實驗室其他研究………………………………………………………………122
Andrés-Delgado L, Antón OM, Bartolini F, Ruiz-Sáenz A, Correas I, Gundersen
GG, Alonso MA. INF2 promotes the formation of detyrosinated microtubules
necessary for centrosome reorientation in T cells. J Cell Biol. 2012 Sep
17;198(6):1025-37.
Alberts B, Bray D, Hopkin K, Johnson AD, Lewis J, Raff M, Lewis J, Roberts K,
Walter P. (2009). Essential cell biology (3rd ed.). Garland Science.
Alberts B, Johnson AD, Lewis J, Raff M, Roberts K, Walter P. (2007). Molecular
Biology of the Cell (5th ed). Garland Science.
Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter
T, Dixon J, Mustelin T. Protein tyrosine phosphatases in the human genome. Cell.
2004 Jun 11;117(6):699-711.
Alvarez C, Garcia-Mata R, Hauri HP, Sztul E. The p115-interactive proteins GM130
and giantin participate in endoplasmic reticulum-Golgi traffic. J Biol Chem. 2001 Jan
26;276(4):2693-700.
Andrews PD, Knatko E, Moore WJ, Swedlow JR. Mitotic mechanics: the auroras
come into view. Curr Opin Cell Biol. 2003 Dec;15(6):672-83.
Audagnotto M, Dal Peraro M. Protein post-translational modifications: In silico
prediction tools and molecular modeling. Comput Struct Biotechnol J. 2017 Mar
31;15:307-319.
Baeza-Raja B, Muñoz-Cánoves P. p38 MAPK-induced nuclear factor-kappaB activity
is required for skeletal muscle differentiation: role of interleukin-6. Mol Biol Cell.
2004 Apr;15(4):2013-26.
Barr FA, Puype M, Vandekerckhove J, Warren G. GRASP65, a protein involved in
the stacking of Golgi cisternae. Cell. 1997 Oct 17;91(2):253-62.
Bartek J, Lukas J. Mammalian G1- and S-phase checkpoints in response to DNA
damage. Curr Opin Cell Biol. 2001 Dec;13(6):738-47.
Bavetsias V, Linardopoulos S. Aurora Kinase Inhibitors: Current Status and Outlook.
Front Oncol. 2015 Dec 21;5:278.
3366
3366
32
Berdnik D, Knoblich JA. Drosophila Aurora-A is required for centrosome maturation
and actin-dependent asymmetric protein localization during mitosis. Curr Biol. 2002
Apr 16;12(8):640-7.
Bharadwaj R, Yu H. The spindle checkpoint, aneuploidy, and cancer. Oncogene. 2004
Mar 15;23(11):2016-27.
Bird AW, Hyman AA. Building a spindle of the correct length in
human in human cells requires the interaction between TPX2 and Aurora A. J Cell
Biol. 2008 Jul 28;182(2):289-300.
Bischoff JR, Plowman GD. The Aurora/IPl1p kinase family: regulators of
chromosome segregation and cytokinesis. Trends Cell Biol. 1999 Nov;9(11):454-9.
Brantley DM, Chen CL, Muraoka RS, Bushdid PB, Bradberry JL, Kittrell F, Medina
D, Matrisian LM, Kerr LD, Yull FE. Nuclear factor-kappaB (NF-kappaB) regulates
proliferation and branching in mouse mammary epithelium. Mol Biol Cell. 2001
May;12(5):1445-55.
Buschhorn HM, Klein RR, Chambers SM, Hardy MC, Green S, Bearss D, Nagle RB.
Aurora-A over-expression in high-grade PIN lesions and prostate cancer.
Prostate. 2005 Sep 1;64(4):341-6.
Buvelot S, Tatsutani SY, Vermaak D, Biggins S. The budding yeast
Ipl1/Aurora protein kinase regulates mitoticspindle disassembly. J Cell Biol. 2003 Feb
3;160(3):329-39.
Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala
HM, Dent P, Grant S. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol
disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression
while enhancing apoptosis in human myeloid leukemia cells. Cancer Res. 2001 Mar
15;61(6):2583-91.
Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW. Hepatoma
up-regulated protein is required for chromatin-induced microtubule assembly
independently of TPX2. Mol Biol Cell. 2008 Nov;19(11):4900-8.
Cervigni RI, Bonavita R, Barretta ML, Spano D, Ayala I, Nakamura N, Corda D,
Colanzi A. JNK2 controls fragmentation of the Golgi complex and the G2/M
3377
3377
33
transition through phosphorylation of GRASP65. J Cell Sci. 2015 Jun
15;128(12):2249-60.
Chakravarty A, Shinde V, Tabernero J, Cervantes A, Cohen RB, Dees EC, Burris
H, Infante JR, Macarulla T, Elez E, Andreu J, Rodriguez-Braun E, Rosello S, von
Mehren M, Meropol NJ, Langer CJ, ONeil B, Bowman D, Zhang M, Danaee
H, Faron-Yowe L, Gray G, Liu H, Pappas J, Silverman L, Simpson C, Stringer
B, Tirrell S, Veiby OP, Venkatakrishnan K, Galvin K, Manfredi M, Ecsedy JA. Phase
I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054,
a small-molecule inhibitor of Aurora A kinase. Cancer Res. 2011 Feb 1;71(3):675-85.
Chang ML, Lin SM, Yeh CT. HURP expression-assisted risk scores identify
prognosis distinguishable sub groups in early stage liver cancer. PLoS One.
2001;6(10):e26323.
Chapter4 Gene Transcription. Figure 4-H-3; Figure 4-H-4. Molecular Biology Web
Book. http://www.web-books.com /MoBio/Free/Ch4H3.htm.
Chen J, Liu QJ, Wang D, Zhou XY, Xiong D, Li HJ, Li CL. Hepatoma upregulated
protein expression is involved in the pathogenesis of human breast carcinogenesis.
Oncol Lett. 2014 Dec;8(6):2543-2548.
Cheng HC, Qi RZ, Paudel H, Zhu HJ. Regulation and function of protein kinases and
phosphatases. Enzyme Res. 2011;2011:794089.
Cheng TS, Hsiao YL, Lin CC, Yu CT, Hsu CM, Chang MS, Lee CI, Huang
CY, Howng SL, Hong YR. Glycogen synthase kinase 3beta interacts with and
phosphorylates the spindle-associated protein astrin. J Biol Chem. 2008 Jan
25;283(4):2454-64.
Cheng TS, Hsiao YL, Lin CC, Hsu CM, Chang MS, Lee CI, Yu RC, Huang
CY, Howng SL, Hong YR. hNinein is required for targeting spindle-associated
protein Astrin to the centrosome during the S and G2 phases. Exp Cell Res. 2007 May
1;313(8):1710-21.
Chiu AW, Huang YL, Huan SK, Wang YC, Ju JP, Chen MF, Chou CK. Potential
molecular marker for detecting transitional cell carcinoma. Urology. 2002
Jul;60(1):181-5.
3388
3388
34
Chung HJ, Park JE, Lee NS, Kim H, Jang CY. Phosphorylation of Astrin regulates its
kinetochore funciton. J Biol Chem. 2016 Aug 19;291(34):17579-92.
Cohen P. The regulation of protein function by multisite phosphorylation--a 25 year
update. Trends Biochem Sci. 2000 Dec;25(12):596-601.
Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C,
Séraphin B, Jacquemier J, Birnbaum D. TACC1-chTOG-Aurora A protein complex in
breast cancer. Oncogene. 2003 Nov 6;22(50):8102-16.
Corda D, Barretta ML, Cervigni RI, Colanzi A. Golgi complex fragmentation in
G2/M transition: An organelle-based cell-cycle checkpoint. IUBMB Life. 2012
Aug;64(8):661-70.
Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis
CD, Sassone-Corsi P.
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aur
ora kinases. Mol Cell Biol. 2002 Feb;22(3):874-85.
Deakin NO, Turner CE. Paxillin inhibits HDAC6 to regulate microtubule acetylation,
Golgi structure, and polarized migration. J Cell Biol. 2014 Aug 4;206(3):395-413.
Dunsch AK, Linnane E, Barr FA, Gruneberg U. The astrin-kinastrin/SKAP complex
localizes to microtubule plus ends and facilitates chromosome alignment. J Cell Biol.
2011 Mar 21;192(6):959-68.
Dutertre S, Descamps S, Prigent C. On the role of aurora-A in centrosome function.
Oncogene. 2002 Sep 9;21(40):6175-83.
Du J, Jablonski S, Yen TJ, Hannon GJ. Astrin regulates Aurora-A localization.
Biochem Biophys Res Commun. 2008 May 30;370(2):213-9.
Eissa S, Shawky SM, Matboli M, Mohamed S, Azzazy HM. Direct detection of
unamplified hepatoma upregulated protein RNA in urine using gold nanoparticles for
bladder cancer diagnosis. Clin Biochem. 2014 Jan;47(1-2):104-10.
Feinstein TN, Linstedt AD. Mitogen-activated protein kinase kinase 1-dependent
Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition. Mol
Biol Cell. 2007 Feb;18(2):594-604.
3399
3399
35
Francisco L, Wang W, Chan CS. Type 1 protein phosphatase acts in opposition to
IpL1 protein kinase in regulating yeast chromosome segregation. Mol Cell Biol. 1994
Jul;14(7):4731-40.
Freed-Pastor WA, Prives C. Mutant p53: one name, many proteins. Genes Dev. 2012
Jun 15;26(12):1268-86.
Garnham CP, Roll-Mecak A. The chemical complexity of cellular microtubules:
tubulin post-translational modification enzymes and their roles in tuning microtubule
functions. Cytoskeleton (Hoboken). 2012 Jul;69(7):442-63.
Giacinti C, Giordano A. RB and cell cycle progression. Oncogene. 2006 Aug
28;25(38):5220-7.
Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic
serine-threonine kinases. J Cell Sci. 1999 Nov;112(Pt 21):3591-601.
Giustiniani J, Couloubaly S, Baillet A, Pourci ML, Cantaloube I, Fourniat C, Paul
JL, Poüs C. Basal endothelial nitric oxide synthase (eNOS) phosphorylation on
Ser(1177) occurs in a stable microtubule- and tubulin acetylation-dependent manner.
Exp Cell Res. 2009 Dec 10;315(20):3509-20.
Glover DM, Leibowitz MH, McLean DA, Parry H. Mutations in Aurora prevent
centrosome separation leading to the formation of monopolar spindles. Cell. 1995 Apr
7;81(1):95-105.
Gomez CR, Kosari F, Munz JM, Schreiber CA, Knutson GJ, Ida CM, El Khattouti A,
Karnes RJ, Cheville JC, Vasmatzis G, Vuk-Pavlović S. Prognostic value of discs large
homolog 7 transcript levels in prostate cancer. PLoS One. 2013 Dec 9;8(12):e82833.
Gonatas NK, Stieber A, Gonatas JO. Fragmentation of the Golgi apparatus in
neurodegenerative diseases and cell death. J Neurol Sci. 2006 Jul 15;246(1-2):21-30.
Gruber J, Harborth J, Schnabel J, Weber K, Hatzfeld M. The
mitotic-spindle-associated protein astrin is essential for progression through mitosis. J
Cell Sci. 2002 Nov 1;115(Pt 21):4053-9.
Gu J, Gong Y, Huang M, Lu C, Spitz MR, Wu X. Polymorphisms of STK15
(Aurora-A) gene and lung cancer risk in Caucasians. Carcinogenesis. 2007
Feb;28(2):350-5.
4400
4400
36
Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr.
NF-kappaB controls cell growth and differentiation through transcriptional regulation
of cyclin D1. Mol Cell Biol. 1999 Aug;19(8):5785-99.
Hanania R, Sun HS, Xu K, Pustylnik S, Jeganathan S, Harrison RE. Classically
activated macrophages use stable microtubules for matrix metalloproteinase-9
(MMP-9) secretion. J Biol Chem. 2012 Mar 9;287(11):8468-83.
Hannak E, Kirkham M, Hyman AA, Oegema K. Aurora-A kinase is required for
centrosome maturation in Caenorhabditis elegans. J Cell Biol. 2001 Dec
24;155(7):1109-16.
Hardwick LJ, Philpott A. Nervous decision-making: to divide or differentiate. Trends
Genet. 2014 Jun;30(6):254-61.
Hayden MS, West AP, Ghosh S. NF-kappaB and the immune response.
Oncogene. 2006 Oct 30;25(51):6758-80.
Hill AA, Anderson-Baucum EK, Kennedy AJ, Webb CD, Yull FE, Hasty AH.
Activation of NF-κB drives the enhanced survival of adiposetissue macrophages in
an obesogenic environment. Mol Metab. 2015 Jul 28;4(10):665-77.
Hsu JM, Lee YC, Yu CT, Huang CY. Fbx7 functions in the SCF complex regulating
Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by
a proline-rich region. J Biol Chem. 2004 Jul 30;279(31):32592-602.
WHO statistics website: http://www.who.int/cancer/en/
Huang YL, Chiu AW, Huan SK, Wang YC, Ju JP, Lu CL.
Prognostic significance of hepatoma-up-regulated protein expression in patients with
urinary bladder transitional cell carcinoma. Anticancer Res. 2003
May-Jun;23(3B):2729-33.
Iyer DR, Rhind N. The Intra-S Checkpoint Responses to DNA Damage. Genes
(Basel). 2017 Feb 17;8(2). pii: E74.
Janke C, Bulinski JC. Post-translational regulation of the microtubule cytoskeleton:
mechanisms and functions. Nat Rev Mol Cell Biol. 2011 Nov 16;12(12):773-86.
4411
4411
37
Jiang Y, Zhang Y, Lees E, Seghezzi W. AuroraA overexpression overrides the mitotic
spindle checkpoint triggered by nocodazole, a microtubule destabilizer.
Oncogene. 2003 Nov 13;22(51):8293-301.
Laforge M, Rodrigues V, Silvestre R, Gautier C, Weil R, Corti O, Estaquier J.
NF-κB pathway controls mitochondrial dynamics. Cell Death Differ. 2016
Jan;23(1):89-98.
Li D, Zhu J, Firozi PF, Abbruzzese JL, Evans DB, Cleary K, Friess H, Sen S.
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic ca
ncer. Clin Cancer Res. 2003 Mar;9(3):991-7.
Liu Q, Kaneko S, Yang L, Feldman RI, Nicosia SV, Chen J, Cheng JQ.
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphoryla
tion of serine 215. J Biol Chem. 2004 Dec 10;279(50):52175-82.
Liu Q, Ruderman JV. Aurora A, mitotic entry, and spindle bipolarity. Proc Natl Acad
Sci U S A. 2006 Apr 11;103(15):5811-6.
Liu S, Majeed W, Kudlyk T, Lupashin V, Storrie B .
Identification of Rab41/6d effectors provides an explanation for the differential
effects of Rab41/6d and Rab6a/a’ on Golgi organization. Front Cell Dev Biol. 2016
Mar 1;4:13.
Kaltschmidt B, Kaltschmidt C, Hehner SP, Dröge W, Schmitz ML.
Repression of NF-kappaB impairs HeLa cell proliferation by functional interference
with with cell cycle checkpoint regulators. Oncogene. 1999 May 27;18(21):3213-25.
Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus
RB, Czerniak BA, Sen S. Phosphorylaiton by aurora kinase A induces
Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004
Jan;36(1):55-62.
Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim
Biophys Acta. 2010 Oct-Dec;1799(10-12):829-39.
Katayama H, Zhou H, Li Q, Tatsuka M, Sen S. Interaction and feedback regulation
between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic
cell division cycle. J Biol Chem. 2001 Dec 7;276(49):46219-24.
4422
4422
38
Kilchmann F, Marcaida MJ, Kotak S, Schick T, Boss SD, Awale M, Gönczy
P2, Reymond JL. Discovery of a selective Aurora A kinase inhibitor by virtual
screening. J Med Chem. 2016 Aug 11;59(15):7188-211.
Kim Y, Holland AJ, Lan W, Cleveland DW. Aurora kinases and protein phosphatase
1 mediate chromosome congression through regulation of CENP-E. Cell. 2010 Aug
6;142(3):444-55.
Kinoshita K, Noetzel TL, Pelletier L, Mechtler K, Drechsel DN, Schwager A, Lee
M, Raff JW, Hyman AA. Aurora-A phosphorylation of TACC3/maskin is required for
centrosome-dependent microtubule assembly in mitosis. J Cell Biol. 2005 Sep
26;170(7):1047-55.
Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW. HURP is part
of a Ran-dependent complex involved in spindle formation. Curr Biol. 2006 Apr
18;16(8):743-54.
Koreishi M, Gniadek TJ, Yu S, Masuda J, Honjo Y, Satoh A. The golgin tether
giantin regulates the secretory pathway by controllin stack organization within Golgi
apparatus. PLoS One. 2013;8(3):e59821.
Kreis TE. Microtubules containing detyrosinated tubulin are less dynamic. EMBO
J. 1987 Sep;6(9):2597-606.
Kumar V, Behera R, Lohite K, Karnik S, Kundu GC. p38 kinase is crucial for
osteopontin-induced furin expressin that supports cervical cancer progression. Cancer
Res. 2010 Dec 15;70(24):10381-91.
Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O,
Hatakeyama K, Ushio Y, Saya H, Hirota T. CENP-A phosphorylation by Aurora-A in
prophase is required for enrichment of Aurora-B at inner centromeres and for
kinetochore function. Dev Cell. 2003 Dec;5(6):853-64.
Kuo TC, Chang PY, Huang SF, Chou CK, Chao CC. Knockdown of HURP inhibits
the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and
accumulation of p53. Biochem Pharmacol. 2012 Mar 15;83(6):758-68.
Kuriyan J, Thanos D. Structure of the NF-kappa B transcription factor:
a holisticinteraction with DNA. Structure. 1995 Feb 15;3(2):135-41.
4433
4433
39
Lapenna S, Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nat Rev
Drug Discov. 2009 Jul;8(7):547-66.
Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring
Harb Perspect Biol. 2009 Dec;1(6):a001651.
Ma N, Matsunaga S, Morimoto A, Sakashita G, Urano T, Uchiyama S, Fukui K.
The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachme
nt and contributes to the targeting of Aurora-A to mitotic spindles. J Cell Sci. 2011
Feb 1;124(Pt 3):394-404.
Magiera MM, Janke C. Post-translational modifications of tubulin. Curr
Biol. 2014 May 5;24(9):R351-4.
Maki CG, Huibregtse JM, Howley PM. In vivo ubiquitination and
proteasome-mediated degradation of p53(1). Cancer Res. 1996 Jun 1;56(11):2649-54.
Manfredi MG, Ecsedy JA, Chakravarty A, Silverman L, Zhang M, Hoar KM, Stroud
SG, Chen W, Shinde V, Huck JJ, Wysong DR, Janowick DA, Hyer ML, Leroy PJ,
Gershman RE, Silva MD, Germanos MS, Bolen JB, Claiborne CF, Sells TB.
Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor
of aurora A kinase using novel in vivo pharmacodynamic assays. Clin Cancer Res.
2011 Dec 15;17(24):7614-24.
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase
complement of the human genome. Science. 2002 Dec 6;298(5600):1912-34.
Marumoto T, Zhang D, Saya H. Aurora-A - a guardian of poles. Nat Rev Cancer.
2005 Jan;5(1):42-50.
Medeiros MC, Frasnelli SC, Bastos Ade S, Orrico SR, Rossa C Jr. Modulation of cell
proliferation, survival and gene expression by RAGE and TLR signaling in cells of
the innate and adaptive immune response: role of p38 MAPK and NF-KB. J Appl
Oral Sci. 2014 Jun;22(3):185-93.
Mehrhof FB, Schmidt-Ullrich R, Dietz R, Scheidereit C. Regulation of vascular
smooth muscle cell proliferation: role of NF-kappaB revisited. Circ Res. 2005 May
13;96(9):958-64.
4444
4444
40
Meraldi P, Honda R, Nigg EA. Aurora-A overexpression reveals tetraploidization as
a major route to centrosome amplification in p53-/- cells. EMBO J. 2002 Feb
15;21(4):483-92.
Michaelis M, Selt F, Rothweiler F, Löschmann N, Nüsse B, Dirks WG, Zehner R,
Cinatl J Jr. Aurora kinases as targets in drug-resistant neuroblastoma cells. PLoS One.
2014 Sep 30;9(9):e108758.
Mizuno M, Singer SJ. A possible role for stable microtubules in intracellular transport
from the endoplasmic reticulum to the Golgi apparatus. J Cell Sci. 1994 May;107 ( Pt
5):1321-31.
Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya
H, Toyoshima YY, Kinoshita K, Wynshaw-Boris A, Hirotsune S. NDEL1
phosphorylation by Aurora-A kinase is essential for centrosomal maturation,
separation, and TACC3 recruitment. Mol Cell Biol. 2007 Jan;27(1):352-67.
Munro S. The golgin coiled-coil proteins of the Golgi apparatus. Cold Spring Harb
Perspect Biol. 2011 Jun 1;3(6).
Naghavi MH. Stable microtubule subsets facilitate early HIV-1 infection. AIDS Res
Hum Retroviruses. 2014 Mar;30(3):211-2.
Naghavi MH, Gundersen GG, Walsh D. Plus-end tracking proteins, CLASPs, and a
viral Akt mimic regulate herpesvirus-induced stable microtubule formation and virus
spread. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18268-73.
Natalia S. Pellegata, Ronald J. Antoniono, J. Leslie Redpath, Eric J. Stanbridge. DNA
damage and p53-mediated cell cycle arrest: A reevaluation. Proc Natl Acad Sci U S
A. 1996 Dec 24; 93(26): 15209–15214.
Nikonova AS, Astsaturov I, Serebriiskii IG, Dunbrack RL Jr, Golemis EA. Aurora A
kinase (AURKA) in normal and pathological cell division. Cell Mol Life Sci. 2013
Feb;70(4):661-87.
Nojima H. G1 and S-phase checkpoints, chromosome instability, and cancer. Methods
Mol Biol. 2004;280:3-49.
Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and
its regulation. Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034.
4455
4455
41
Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B.
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53.
Nature. 1993 Apr 29;362(6423):857-60.
Olson CM, Hedrick MN, Izadi H, Bates TC, Olivera ER, Anguita J.
p38 mitogen-activated protein kinase controls NF-kappaBtranscriptional activation an
d tumor necrosis factor alphaproduction through RelA phosphorylation mediated by
mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi
antigens. Infect Immun. 2007 Jan;75(1):270-7.
Oueslati A, Fournier M, Lashuel HA. Role of post-translational modifications in
modulating the structure, function and toxicity of alpha-synuclein: implications for
Parkinson's disease pathogenesis and therapies. Prog Brain Res. 2010;183:115-45.
Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors.
Oncogene. 1999 Nov 22;18(49):6853-66.
Patton SM, Piñero DJ, Surguladze N, Beard J, Connor JR. Subcellular localization of
iron regulatory proteins to Golgi and ER membranes. J Cell Sci. 2005 Oct 1;118(Pt
19):4365-73.
Petersen J, Paris J, Willer M, Philippe M, Hagan IM. The S. pombe aurora-related
kinase Ark1 associates with mitotic sturctures in a stage dependent manner and is
required for chromosome segregation. J Cell Sci. 2001 Dec;114(Pt 24):4371-84.
Piperno G, LeDizet M, Chang XJ. Microtubules containing acetylated alpha-tubulin
in mammalian cells in culture. J Cell Biol. 1987 Feb;104(2):289-302.
Piva R, Belardo G, Santoro MG. NF-kappaB: a stress-regulated switch
for cell survival. Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):478-86.
Popelka H, Klionsky DJ. Post-translationally-modified structures in the autophagy
machinery: an integrative perspective. FEBS J. 2015 Sep;282(18):3474-88.
Qin ZH, Tao LY, Chen X. Dual roles of NF-kappaB in cell survival and implications
of NF-kappaB inhibitors in neuroprotective therapy. Acta Pharmacol Sin. 2007
Dec;28(12):1859-72.
Reichardt W, Jung V, Brunner C, Klein A, Wemmert S, Romeike BF, Zang
KD, Urbschat S The putative serine/threonine kinase gene STK15 on chromosome
20q13.2 is amplified in human gliomas. Oncol Rep. 2003 Sep-Oct; 10(5):1275-9.
4466
4466
42
Ryan SD, Ferrier A, Kothary R. A novel role for the cytoskeletal linker protein
dystonin in the maintenance of microtubule stability and the regulation of ER-Golgi
transport. Bioarchitecture. 2012 Jan 1;2(1):2-5.
Sabo Y, Walsh D, Barry DS, Tinaztepe S, de Los Santos K, Goff SP, Gundersen
GG, Naghavi MH. HIV-1 induces the formation of stable microtubules to enhance
early infection. Cell Host Microbe. 2013 Nov 13;14(5):535-46.
Santarella RA, Koffa MD, Tittmann P, Gross H, Hoenger A. HURP wraps
microtubule ends with an additional tubulin sheet that has a novel conformation of
tubulin. J Mol Biol. 2007 Feb 2;365(5):1587-95.
Satinover DL, Leach CA, Stukenberg PT, Brautigan DL. Activation of Aurora-A
kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein. Proc Natl
Acad Sci U S A. 2004 Jun 8;101(23):8625-30.
Schmidt JC, Kiyomitsu T, Hori T, Backer CB, Fukagawa T, Cheeseman IM.
Aurora B kinase controls the targeting of the Astrin-SKAP complex to biorented
kinetochores. J Cell Biol. 2010 Oct 18;191(2):269-80.
Scrittori L, Hans F, Angelov D, Charra M, Prigent C, Dimitrov S.
pEg2 aurora-A kinase, histone H3 phosphorylation,
and chromosomeassembly in Xenopus egg extract. J Biol Chem. 2001 Aug
10;276(32):30002-10.
Sells TB, Chau R, Ecsedy JA, Gershman RE, Hoar K, Huck J, Janowick DA,
Kadambi VJ, LeRoy PJ, Stirling M, Stroud SG, Vos TJ, Weatherhead GS, Wysong
DR, Zhang M, Balani SK, Bolen JB, Manfredi MG, Claiborne CF. MLN8054 and
Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors. ACS Med
Chem Lett. 2015 Apr 22;6(6):630-4.
Segal NH, Blachere NE, Shiu HY, Leejee S, Antonescu CR, Lewis JJ, Wolchok
JD, Houghton AN. Antigens recognized by autologous antibodies of patients with soft
tissue sarcoma. Cancer Immun. 2005 Mar 4;5:4.
Silljé HH, Nagel S, Körner R, Nigg EA. HURP is a Ran-importin beta-regulated
protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr
Biol. 2006 Apr 18;16(8):731-42.
4477
4477
43
Skoufias DA, Burgess TL, Wilson L. Spatial and temporal colocalization of the Golgi
apparatus and microtubules rich in detyrosinated tubulin. J Cell Biol. 1990 Nov;111(5
Pt 1):1929-37.
Sun C, Chan F, Briassouli P, Linardopoulos S. Aurora kinase inhibition
down-regulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents.
Biochem Biophys Res Commun. 2007 Jan 5;352(1):220-5.
Tang CJ, Lin CY, Tang TK. Dynamic localization and functional implications of
Aurora-C kinase during male mouse meiosis. Dev Biol. 2006 Feb 15;290(2):398-410.
Tang, Wang. Cell cycle regulation of Golgi membrane dynamics Trends Cell Biol.
2013 Jun;23(6):296-304.
Taylor WR, Stark GR. Regulation of the G2/M transition by p53. Oncogene. 2001
Apr 5;20(15):1803-15.
Tedeschi A, Ciciarello M, Mangiacasale R, Roscioli E, Rensen WM, Lavia P.
RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and
regulates chromosome segregation in human cells. J Cell Sci. 2007 Nov 1;120(Pt
21):3748-61.
Thein KH, Kleylein-Sohn J, Nigg EA, Gruneberg U. Astrin is required for
the maintenance of sister chromatid cohesion and centrosome integrity. J Cell
Biol. 2007 Jul 30;178(3):345-54.
Thyberg J, Moskalewski S. Microtubules and the organization of the Golgi complex.
Exp Cell Res. 1985 Jul;159(1):1-16.
Thyberg J, Moskalewski S. Relationship between the Golgi complex and
microtubules enriched in detyrosinated or acetylated alpha-tubulin: studies on cells
recovering from nocodazole and cells in the terminal phase of cytokinesis. Cell Tissue
Res. 1993 Sep;273(3):457-66.
Toji S, Yabuta N, Hosomi T, Nishihara S, Kobayashi T, Suzuki S, Tamai K, Nojima
H. The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
Genes Cells. 2004 May;9(5):383-97.
Tran AD, Marmo TP, Salam AA, Che S, Finkelstein E, Kabarriti R, Xenias
HS, Mazitschek R, Hubbert C, Kawaguchi Y, Sheetz MP, Yao TP, Bulinski JC.
4488
4488
44
HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions. J Cell
Sci. 2007 Apr 15;120(Pt 8):1469-79.
Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y.
A Ran signalling pathway mediated by the mitotic kinase Aurora-A in spindle
assembly. Nat Cell Biol. 2003 Mar;5(3):242-8.
Tsou AP, Yang CW, Huang CY, Yu RC, Lee YC, Chang CW, Chen BR, Chung
YF, Fann MJ, Chi CW, Chiu JH, Chou CK. Identification of a novel cell cycle
regulated gene, HURP, overexpressed in human hepatocellular carcinoma.
Oncogene. 2003 Jan 16;22(2):298-307.
Uehara R, Goshima G. Functional central spindle assembly requires de novo
microtubule generation in the interchromosomal region during anaphase. J Cell
Biol. 2010 Oct 18;191(2):259-67.
Urban MB, Schreck R, Baeuerle PA. NF-kappa B contacts DNA by a heterodimer of
the p50 and p65 subunit. EMBO J. 1991 Jul;10(7):1817-25.
Valente C, Colanzi A. Mechanisms and Regulation of the Mitotic Inheritance of the
Golgi Complex. Front Cell Dev Biol. 2015 Dec 16;3:79.
Wong J, Lerrigo R, Jang CY, Fang G. Aurora A regulates the activity of HURP by
controlling the accessibility of its microtubule-binding domain. Mol Biol Cell. 2008
May;19(95):2083-91.
Wang YC, Lee YH, Huang GC, Lin YH, Fan-Chiang MH, Chiu AW, Huang YL.
Enhanced transformation and chemosensitivity of NIH3T3 cells transduced with
hepatoma up-regulated protein. Biochem Biophys Res Commun. 2006 Feb
3;340(1):244-9.
Wang Y, Seemann J. Golgi biogenesis. Cold Spring Harb Perspect Biol. 2011 Oct
1;3(10):a005330.
Webster DR, Borisy GG. Microtubules are acetylated in domains that turn over
slowly. J Cell Sci. 1989 Jan;92 ( Pt 1):57-65.
Webster DR, Patrick DL. Beating rate of isolated neonatal cardiomyocytes is
regulated by the stable microtubule subset. Am J Physiol Heart Circ
Physiol. 2000 May;278(5):H1653-61.
4499
4499
45
Wong J, Fang G. HURP controls spindle dynamics to promote proper
interkinetochore tension and efficient kinetochore capture. J Cell Biol. 2006 Jun
19;173(6):879-91.
Wong J, Lerrigo R, Jang CY, Fang G. Aurora A regulates the activity of HURP by
controlling the accessibility of its microtubule-binding domain. Mol Biol Cell. 2008
May;19(5):2083-91.
Wu JM, Chen CT, Coumar MS, Lin WH, Chen ZJ, Hsu JT, Peng YH, Shiao HY, Lin
WH, Chu CY, Wu JS, Lin CT, Chen CP, Hsueh CC, Chang KY, Kao LP, Huang
CY, Chao YS, Wu SY, Hsieh HP, Chi YH.
Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal an
d kinetochore microtubules. Proc Natl Acad Sci U S A. 2013 May
7;110(19):E1779-87.
Xiang Y, Seemann J, Bisel B, Punthambaker S, Wang Y. Active ADP-ribosylation
factor-1 (ARF1) is required for mitotic Golgi fragmentation. J Biol Chem. 2007 Jul
27;282(30):21829-37.
Yadav S, Puthenveedu MA, Linstedt AD. Golgin160 recruits the dynein motor to
position the Golgi apparatus. Dev Cell. 2012 Jul 17;23(1):153-65.
Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM. Reduction of
detyrosinated microtubules and Golgi fragmentation are linked to tau-induced
degeneration in astrocytes. J Neurosci. 2003 Nov 19;23(33):10662-71.
Yuan J, Li M, Wei L, Yin S, Xiong B, Li S, Lin SL, Schatten H, Sun QY. Astrin
regulates meiotic spindle organization, spindle pole tethering and cell cycle
progression in mouse oocytes. Cell Cycle. 2009 Oct 15;8(20):3384-95.
Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY. Phosphorylation and
stabilization of HURP by Aurora-A: implication of HURP as a transforming target
of Aurora-A. Mol Cell Biol. 2005 Jul;25(14):5789-800.
Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S.
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploid
y and transformation. Nat Genet. 1998 Oct;20(2):189-93.
5500
5500
46
Zhao L, Qin LX, Ye QH, Zhu XQ, Zhang H, Wu X, Chen J, Liu YK, Tang ZY.
KIAA0008 gene is associated with invasive phenotype of human hepatocellular
carcinoma--a functional analysis. J Cancer Res Clin Oncol. 2004 Dec;130(12):719-27.
Zhou Z, Sun X, Zou Z, Sun L, Zhang T, Guo S, Wen Y, Liu L, Wang Y, Qin J, Li
L, Gong W, Bao S. PRMT5 regulates Golgi apparatus structure through methylation
of the golgin GM130. Cell Res. 2010 Sep;20(9):1023-33.
Zhu X, Kaverina I. Golgi as an MTOC: making microtubules for its own good.
Histochem Cell Biol. 2013 Sep;140(3):361-7.
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