(54.236.58.220) 您好!臺灣時間:2021/02/27 12:11
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:陳明楷
研究生(外文):Chen, Ming-Kai
論文名稱:Geniposide修復Fluoxetine誘發Neuro2a神經母細胞瘤細胞神經突出生長之抑制
論文名稱(外文):Geniposide Ameriorated Fluoxetine-Suppressed Neurite Outgrowth in Neuro2a Neuroblastoma Cells
指導教授:謝秋蘭謝秋蘭引用關係
指導教授(外文):Hsieh, Chiu-Lan
口試委員:彭耀寰喬長誠謝秋蘭
口試委員(外文):Peng, Yao-HuanChyau, Charng-CherngHsieh, Chiu-Lan
口試日期:2017-07-05
學位類別:碩士
校院名稱:國立彰化師範大學
系所名稱:生物學系
學門:生命科學學門
學類:生物學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:114
中文關鍵詞:神經突出生長Neuro2a細胞氟西汀安柏寧微管相關蛋白2生長相關蛋白43梔子苷京尼平環磷腺苷反應元件結合蛋白
外文關鍵詞:Neurite outgrowthNeuro2a cellsFluoxetineAlprazolamMicrotubule-associated protein-2 (MAP2)Growth-associated protein 43 (GAP43)GeniposideGenipinCREB
相關次數:
  • 被引用被引用:0
  • 點閱點閱:95
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
罹患阿茲海默症、精神分裂症及憂鬱症等神經退化性疾病患者 可能會使喪失生理活力與生活品質。大都數之研究認為這些精神障 礙是由於神經元迴路之功能障礙所引起。神經突出出之生長(Neurite outgrowth)與否乃是據以判斷神經元分化及其功能發展之主要指標。 於神經細胞分化過程中必定有一系列發展階段依存性之變化,諸如 神經突出出延伸(Elongation)、分支(branch)、樹突(dendrites) 與軸突 (axons) 之成熟 (maturation)等。
Alprazolam (APZ; 安柏寧)為美國精神處方用藥第一名之藥物,屬於苯二氮類之抗焦慮精神藥物。而Fluoxetine ( FXT; 百憂解錠)乃屬一種選擇性serotonin 再吸收抑制劑,為臨床上常見之精神藥處方。過量之serotonin會抑制神經突出發育。有關梔子之三主要成分[geniposide (GPS)、genipin (GNP) 及 geniposidic acid (GPSA)],目前FXT、APZ以及梔子化合物對於神經突出發育是否有發育影響實有待釐清。爰此,進行本研究。結果發現精神處方用藥FXT(5 M)會壓抑Neuro2a細胞之神經突出發育,APZ則無顯著效應。佐以GPS (100, 200 M)及GNP (20 M)也可提升有神經突出發育之Neuro2a細胞數,GPSA則無顯著效應。FXT (5M)- GPS(100, 200 M)或FXT (5M)- GNP(10, 20 M)共治療時發現GPS於提升有神經突出發育之Neuro2a細胞數方面較諸GNP有較佳之效果。FXT對神經突出發育標誌基因microtubule-associated protein-2 (MAP2) 及growth-associated protein 43 (GAP43)俱壓抑其表現之效果。反之,GPS則有上調MAP2、 GAP43、TUBB3基因表現,並能修復Neuro2a細胞中為FXT下調之MAP2及 GAP43基因表現。另有趣者,西方墨點法顯示FXT會減少GAP43蛋白量,而MAP2蛋白則無顯著變化。GPS則可提升GAP43及MAP2蛋白量,同時能恢復FXT對Neuro2a細胞中GAP43蛋白之下調量。另有趣者,免疫螢光染色顯示FXT會減少GAP43與MAP2蛋白量,GPS則可提升GAP43及MAP2蛋白量,同時能恢復FXT對Neuro2a細胞中此二蛋白之螢光表現。另則GPS可營救FXT對Neuro2a細胞中p-CREB表現之不良效應。同時本研究亦證知p-CREB之活化乃經由ERK/MAPK 及Akt/mTOR等路徑。
因此, 本研究除闡明FXT對Neuro2a細胞之突出發育有極端不利之不良效應外,並且闡明了其作用細胞之分子機制; 此外,GPS亦經由相同之分子機制達到改善或修復之療效。有鑑於上述研究結果,建議臨床上於開立FXT之同時宜考慮以梔子苷進行輔助治療。
Patients affiliated with neurodegenerative diseases like Alzheimer's disease, Schizophrenia and depression usually may lose physical vitality and life quality. Most of the findings have attributed to the cause inducing such mental disorders to be due to dysfunction of neuronal circuit. Neurite outgrowth is the main marker associated with neuronal differentiation, which acts as the crucial role adhering to the development of neuronal function. During the neuronal differentiation process, serial evolutional stage-dependent changes may take place, including neurite elongation, neurite branching, growth of dendrites and axons.
Alprazolam, available under the trade name Xanax, is a potent, short-acting anxiolytic of the benzodiazepine class —a minor tranquilize. Fluoxetine (FXT, trade name Prozac), a selective serotonin reuptake inhibitor (SSRI), is the most common psychiatric medications clinically prescribed. While over-produced serotonin can suppress neurite development. The role of major iridoid glycosides of Gardenia jasminoides [geniposide (GPS), geniposidic acid (GPSA), and genipin (GNP)] in ameliorating the side effect of FXT (anti-neurite development), is poorly understood. To uncover this, we performed this investigation. FXT (5 µM) decreased the neurite outgrowth in Neuro2a cells. While APZ seemed not to have shown any significant effect.GPS (100 and 200 µM) and GNP (20 µM) ameliorated and increased the percentage of neurite bearing Neuro2a cells. While GPSA seemed not to have shown any significant effect. Cotreatment of FXT (5 µM) with GPS (100 and 200 µM) or GNP (10 and 20 µM) showed that GPS but not GNP was more effective with respect to the stimulation of neurite bearing cell counts. FXT downregulated the gene expression for neurite outgrowth target markers like microtubule-associated protein-2 (MAP2) and growth-associated protein 43 (GAP43). In contrast, GPS upregulated MAP2, GAP43 and TUBB3, otherwise, attenuated the downregulated MAP2 and GAP43 gene expression caused by FXT in Neuro2a cells. Interestingly, results obtained from the immunofluorescence staining showed that FXT decreased the protein expression of GAP43. GPS stimulated the production of MAP2 and GAP43, and at the same time, attenuated the suppressed GAP43 level caused by FXT in Neuro2a cells. Additionally, GPS securded the p-CREB expression in FXT-treated Neuro2a cells, and the activation of CREB is dependent on the ERK/MAPK and AKT/mTOR signaling pathways.
Conclusively, this study has provided a valuable information regarding the possible cellular and molecular mechanisms showing how FXT exerts its detrimental side-effects on the neuronal differentiation, and via the same mechanism how GPS attenuated these side effects. Thus, it is suggested that the distinguished adjuvant role of Geniposide should be considered whenever prescribing Fluoxetine for clinical uses.
目次
中文摘要 i
Abstract iii
目次 v
圖次 ix
表次 xii
前言 xiii
壹、文獻回顧 1
一、神經母細胞瘤(Neuroblastoma, NB) 1
(一)、神經母細胞瘤之危害 1
(二)、神經母細胞瘤之病因 1
(三)、神經母細胞瘤之分期 2
(四)、神經母細胞瘤之治療 3
二、神經突出生長 (Neurite outgrowth) 6
(一)、神經突出之生理意義及模式探討 6
(二)、抑制神經突出生長之機制 9
(三)、促進神經突出生長之機制 11
三、常用於研究神經突出生長之細胞株 (Cell line) 14
四、神經突出生長之標誌蛋白 20
(一)、微管相關蛋白2 (Microtubule-associated protein 2, MAP2 ) 20
(二)、微管相關蛋白Tau (Microtubule-associated protein Tau, MAPT) 21
(三)、生長相關蛋白43 (Growth Associated Protein-43, GAP43) 24
(四)、β-微管蛋白3 (Class III β-tubulin, TUBB3) 26
(五)、環磷酸腺苷反應元件結合蛋白 (cAMP response element-binding protein, CREB) 28
五、氟西汀 ( fluoxetine, FXT) 33
(ㄧ)、氟西汀概述 33
(二)、氟西汀抗憂鬱的藥理機制 33
(三)、氟西汀對神經細胞生長的影響 34
六、安柏寧(Alprazolam, Xanax; APZ) 36
(ㄧ)、安柏寧介紹 36
(二)、安柏寧抗焦慮的藥理機制 36
(三)、安柏寧對神經系統的影響 37
七、梔子 39
(一)、梔子及其功效 39
(二)、梔子之生物活性成分與功效 39
研究架構 43
貳、材料與方法 44
一、實驗材料 44
(一)、細胞株 44
(二)、藥品試劑 44
(三)、實驗儀器 47
二、實驗步驟與方法 48
(一)、細胞培養 48
(二)、細胞繼代與冷凍保存(貼附型細胞) 49
(三)、MTT細胞存活率測定 50
(四)、Neuro2a神經母細胞瘤細胞之Neurite outgrowth分析方法 50
(五)、Neuro2a神經母細胞瘤細胞之基因表現量分析 51
(六)、Neuro2a神經突出生長之訊號蛋白及轉錄因子西方轉漬蛋白分析 55
(七)、Neuro2a神經突出標誌蛋白免疫螢光染色 59
(八)、統計方法 61
參、結果 62
一、Neuro2a 細胞在不同濃度血清下的細胞分化率與生存率之影響 62
二、精神處方用藥對 Neuro2a 細胞分化率及對細胞生存率之影響 63
三、Gardenia jasminoides對Neuro2a細胞分化率及對細胞生存率之影響 64
四、FXT-GPS 共處理對Neuro2a 細胞分化率及對細胞生存率之影響 65
五、梔子苷與氟西汀對 Neuro2a 細胞神經突出生長標誌基因表現量之影響 66
六、梔子苷與氟西汀對 Neuro2a細胞神經突出生長標誌蛋白質表現之影響 67
七、梔子苷與氟西汀對 Neuro2a 細胞調控神經突出生長之轉錄因子CREB 蛋白質表現之影響 68
八、梔子苷與氟西汀對 Neuro2a 細胞調控神經突出生長之 MAPK 路徑蛋白質表現之影響 69
肆、討論 71
結論 77
伍、參考文獻 100
伍、參考文獻
Alessi, D. R., M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen and B. A. Hemmings (1996). "Mechanism of activation of protein kinase B by insulin and IGF-1." The EMBO journal 15(23): 6541-6551.
Anderson, K. E., J. Coadwell, L. R. Stephens and P. T. Hawkins (1998). "Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B." Current Biology 8(12): 684-691.
Atwal, J. K., J. Pinkston-Gosse, J. Syken, S. Stawicki, Y. Wu, C. Shatz and M. Tessier-Lavigne (2008). "PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration." Science 322(5903): 967-970.
Audesirk, T., G. Audesirk, C. Ferguson and D. Shugarts (1991). "Effects of inorganic lead on the differentiation and growth of cultured hippocampal and neuroblastoma cells." Neurotoxicology 12(3): 529-538.
Augusti-Tocco, G. and G. Sato (1969). "ESTABLISHMENT OF FUNCTIONAL CLONAL LINES OF NEURONS FROM MOUSE NEUROBLASTOMA." Proceedings of the National Academy of Sciences 64(1): 311-315.
Avwenagha, O., G. Campbell and M. M. Bird (2003). "Distribution of GAP43, beta-III tubulin and F-actin in developing and regenerating axons and their growth cones in vitro, following neurotrophin treatment." Journal of neurocytology 32(9): 1077-1089.
Banerjee, A., M. C. Roach, P. Trcka and R. F. Ludueña (1990). "Increased microtubule assembly in bovine brain tubulin lacking the type III isotype of beta-tubulin." The Journal of biological chemistry 265(3): 1794-1799.
Bartlett, P. F., H. H. Reid, K. A. Bailey and O. Bernard (1988). "Immortalization of mouse neural precursor cells by the c-myc oncogene." Proceedings of the National Academy of Sciences 85(9): 3255-3259.
Baudry, M., M. M. Chou and X. Bi (2013). "Targeting calpain in synaptic plasticity." Expert Opinion on Therapeutic Targets 17(5): 579-592.
Belmaker, R. H. and G. Agam (2008). "Major Depressive Disorder." The New England Journal of Medicine 358(1): 55-68.
Biedler, J. L., L. Helson and B. A. Spengler (1973). "Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture." Cancer research 33(11): 2643-2652.
Bishop, A. (2009). "Effects of selective serotonin reuptake inhibitors on motor neuron survival." International Journal of General Medicine Volume 2: 109-115.
Blendy, J. A. (2006). "The Role of CREB in Depression and Antidepressant Treatment." Biological Psychiatry 59(12): 1144-1150.
Bolsover, S., J. Fabes and P. N. Anderson (2008). "Axonal guidance molecules and the failure of axonal regeneration in the adult mammalian spinal cord." Restorative neurology and neuroscience 26(2-3): 117-130.
Bolsover, S. R. (2005). "Calcium signalling in growth cone migration." Cell Calcium 37(5): 395-402.
Bourtchuladze, R., B. Frenguelli, J. Blendy, D. Cioffi, G. Schutz and A. J. Silva (1994). "Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein." Cell 79(1): 59-68.
Brazil, D. P. and B. A. Hemmings (2001). "Ten years of protein kinase B signalling: a hard Akt to follow." Trends in Biochemical Sciences 26(11): 657-664.
Brodbeck, D., P. Cron and B. A. Hemmings (1999). "A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain." Journal of Biological Chemistry 274(14): 9133-9136.
Brodeur, G. M. (2003). "Neuroblastoma: biological insights into a clinical enigma." Nature Reviews Cancer 3(3): 203-216.
Brodeur, G. M., J. Pritchard, F. Berthold, N. L. Carlsen, V. Castel, R. P. Castelberry, D. B. Bernardi, A. E. Evans, M. Favrot and F. Hedborg (1993). "Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment." Journal of Clinical Oncology 11(8): 1466-1477.
Caceres, A., M. R. Payne, L. I. Binder and O. Steward (1983). "Immunocytochemical localization of actin and microtubule-associated protein MAP2 in dendritic spines." Proceedings of the National Academy of Sciences 80(6): 1738-1742.
Cai, D., K. Deng, W. Mellado, J. Lee, R. R. Ratan and M. T. Filbin (2002). "Arginase I and Polyamines Act Downstream from Cyclic AMP in Overcoming Inhibition of Axonal Growth MAG and Myelin In Vitro." Neuron 35(4): 711-719.
Cai, D., Y. Shen, M. Bellard, S. Tang and M. T. Filbin (1999). "Prior Exposure to Neurotrophins Blocks Inhibition of Axonal Regeneration by MAG and Myelin via a cAMP-Dependent Mechanism." Neuron 22(1): 89-101.
Chen, Q., W. Zhang, U. Youn, H. Kim, I. Lee, H.-J. Jung, M. Na, B.-S. Min and K. Bae (2009). "Iridoid glycosides from Gardeniae Fructus for treatment of ankle sprain." Phytochemistry 70(6): 779-784.
Cheng, J. Q., A. K. Godwin, A. Bellacosa, T. Taguchi, T. F. Franke, T. C. Hamilton, P. N. Tsichlis and J. R. Testa (1992). "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas." Proceedings of the National Academy of Sciences 89(19): 9267-9271.
Coffey, E. T. (2014). "Nuclear and cytosolic JNK signalling in neurons." Nature Reviews Neuroscience 15(5): 285-299.
Cong, J., D. E. Goll, A. M. Peterson and H. P. Kapprell (1989). "The role of autolysis in activity of the Ca2+-dependent proteinases (mu-calpain and m-calpain)." The Journal of biological chemistry 264(17): 10096-10103.
Console-Bram, L. M., S. G. Fitzpatrick-McElligott and J. G. McElligott (1996). "Distribution of GAP43 mRNA in the immature and adult cerebellum: a role for GAP43 in cerebellar development and neuroplasticity." Developmental Brain Research 95(1): 97-106.
Corbin, J. D. and E. G. Krebs (1969). "A cyclic AMP - stimulated protein kinase in adipose tissue." Biochemical and Biophysical Research Communications 36(2): 328-336.
Cui, Q. (2006). "Actions of Neurotrophic Factors and Their Signaling Pathways in Neuronal Survival and Axonal Regeneration." Molecular Neurobiology 33(2): 155-180.
Cunningham, C. C., N. Leclerc, L. A. Flanagan, M. Lu, P. A. Janmey and K. S. Kosik (1997). "Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280–deficient Melanoma Cell Line." The Journal of Cell Biology 136(4): 845-857.
Das, K. P., T. M. Freudenrich and W. R. Mundy (2004). "Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures." Neurotoxicology and Teratology 26(3): 397-406.
Dehmelt, L., F. M. Smart, R. S. Ozer and S. Halpain (2003). "The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation." The Journal of neuroscience : the official journal of the Society for Neuroscience 23(29): 9479-9490.
Dennis, K., M. Uittenbogaard, A. Chiaramello and S. A. Moody (2002). "Cloning and characterization of the 5′-flanking region of the rat neuron-specific Class III β-tubulin gene." Gene 294(1-2): 269-277.
Dibner, C., U. Schibler and U. Albrecht (2010). "The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks." Annual Review of Physiology 72(1): 517-549.
Dill, J., H. Wang, F. Zhou and S. Li (2008). "Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS." The Journal of Neuroscience 28(36): 8914-8928.
DiTella, M., F. Feiguin, G. Morfini and A. Cáceres (1994). "Microfilament‐associated growth cone component depends upon Tau for its intracellular localization." Cell Motility and the Cytoskeleton 29(2): 117-130.
Du, K. and M. Montminy (1998). "CREB Is a Regulatory Target for the Protein Kinase Akt/PKB." Journal of Biological Chemistry 273(49): 32377-32379.
Edsjö, A., Holmquist, L., and Påhlman, S. (2007). Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation. Seminars in Cancer Biology 17, 248-256.
Ehrich, M. (1995). "USING NEUROBLASTOMA CELL LINES TO ADDRESS DIFFERENTIAL SPECIFICITY TO ORGANOPHOSPHATES." Clinical and Experimental Pharmacology and Physiology 22(4): 291-292.
Fanarraga, M. L., J. Avila and J. C. Zabala (1999). "Expression of unphosphorylated class III β‐tubulin isotype in neuroepithelial cells demonstrates neuroblast commitment and differentiation." European Journal of Neuroscience 11(2): 516-527.
Fish, J. D. and S. A. Grupp (2007). "Stem cell transplantation for neuroblastoma." Bone Marrow Transplantation 41(2): 159-165.
Fricker, A. D., C. Rios, L. A. Devi and I. Gomes (2005). "Serotonin receptor activation leads to neurite outgrowth and neuronal survival." Molecular Brain Research 138(2): 228-235.
Fujita, K., P. Lazarovici and G. Guroff (1989). "Regulation of the differentiation of PC12 pheochromocytoma cells." Environmental Health Perspectives 80: 127-142.
Fulga, T. A., I. Elson-Schwab, V. Khurana, M. L. Steinhilb, T. L. Spires, B. T. Hyman and M. B. Feany (2006). "Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo." Nature Cell Biology 9(2): 139-148.
Gallo, V., A. Bertolotto and G. Levi (1987). "The proteoglycan chondroitin sulfate is present in a subpopulation of cultured astrocytes and in their precursors." Developmental Biology 123(1): 282-285.
Gao, Y., Z.-y. Chen, X. Liang, C. Xie and Y.-f. Chen (2014). "Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms." Pharmaceutical Biology 53(2): 280-285.
Gao, Y., E. Nikulina, W. Mellado and M. T. Filbin (2003). "Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase." The Journal of neuroscience : the official journal of the Society for Neuroscience 23(37): 11770-11777.
Ghosh-Roy, A., Z. Wu, A. Goncharov, Y. Jin and A. D. Chisholm (2010). "Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase." The Journal of Neuroscience 30(9): 3175-3183.
Goldshmit, Y., S. McLenachan and A. Turnley (2006). "Roles of Eph receptors and ephrins in the normal and damaged adult CNS." Brain Research Reviews 52(2): 327-345.
Goll, D. E., V. F. Thompson, L. I. Hongqi, W. E. I. Wei and J. Cong (2003). "The Calpain System." Physiological Reviews 83(3): 731-801.
Gomez, T. M., D. M. Snow and P. C. Letourneau (1995). "Characterization of spontaneous calcium transients in nerve growth cones and their effect on growth cone migration." Neuron 14(6): 1233-1246.
Gomez, T. M. and N. C. Spitzer (1999). "In vivo regulation of axon extension and pathfinding by growth-cone calcium transients." Nature 397(6717): 350-355.
Goold, R. G. and P. R. Gordon-Weeks (2004). "Glycogen synthase kinase 3β and the regulation of axon growth." Biochemical Society Transactions 32(5): 809-811.
Goyal, R. and K. Anil (2007). "Protective effect of alprazolam in acute immobilization stress-induced certain behavioral and biochemical alterations in mice." Pharmacological reports : PR 59(3): 284-290.
Grados‐Munro, E. M. and A. E. Fournier (2003). "Myelin‐associated inhibitors of axon regeneration." Journal of Neuroscience Research 74(4): 479-485.
Greene, L. A. and A. S. Tischler (1976). "Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor." Proceedings of the National Academy of Sciences 73(7): 2424-2428.
Greene, L. A. and A. S. Tischler (1982). "Advances in Cellular Neurobiology." Section 3. Methodologies 3: 373-414.
Grimpe, B. and J. Silver (2002). "The extracellular matrix in axon regeneration." Progress in brain research 137: 333-349.
Gu, X. and N. C. Spitzer (1995). "Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients." Nature 375(6534): 784-787.
Guo, J., C. Walss‐Bass and R. F. Ludueña (2010). "The β isotypes of tubulin in neuronal differentiation." Cytoskeleton 67(7): 431-441.
Haas, A. J., S. Prigent, S. Dutertre, Y. Dréan and Y. Page (2016). "Neurite analyzer: An original Fiji plugin for quantification of neuritogenesis in two-dimensional images." Journal of Neuroscience Methods 271: 86-91.
Haase, G. M., C. Perez and J. B. Atkinson (1999). "Current aspects of biology, risk assessment, and treatment of neuroblastoma." Seminars in Surgical Oncology 16(2): 91-104.
Hajimohammadreza, I., K. J. Raser, R. Nath, R. Nadimpalli, M. Scott and K. K. Wang (1997). "Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis." Journal of Neurochemistry 69(3): 1006-1013.
Hannila, S. S. and M. T. Filbin (2008). "The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury." Experimental Neurology 209(2): 321-332.
He, Q., E. W. Dent and K. F. Meiri (1997). "Modulation of actin filament behavior by GAP43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site." The Journal of neuroscience : the official journal of the Society for Neuroscience 17(10): 3515-3524.
Heimrich, B. and M. Frotscher (1993). "Slice cultures as a model to study entorhinal‐hippocampal interaction." Hippocampus 3(S1): 11-17.
Heine, C. and H. Franke (2014). "Axon Growth and Regeneration." Methods in molecular biology (Clifton, N.J.) 1162: 97-111.
Henley, J. R., K.-h. Huang, D. Wang and M.-m. Poo (2004). "Calcium Mediates Bidirectional Growth Cone Turning Induced by Myelin-Associated Glycoprotein." Neuron 44(6): 909-916.
Heumann, R., G. Valet, D. Maison, J. Kemper, G. Reiser and B. Hamprecht (1977). "Influence of the time in culture on cellular and neuronal properties of neuroblastoma x glioma hybrid cells. With an appendix, mathematical description of the kinetics of the loss in cell volume." Journal of Cell Science 27: 141-155.
Higuchi, M., K. Onishi, N. Masuyama and Y. Gotoh (2003). "The phosphatidylinositol‐3 kinase (PI3K)‐Akt pathway suppresses neurite branch formation in NGF‐treated PC12 cells." Genes to Cells 8(8): 657-669.
Hornburg, D., C. Drepper, F. Butter, F. Meissner, M. Sendtner and M. Mann (2014). "Deep Proteomic Evaluation of Primary and Cell Line Motoneuron Disease Models Delineates Major Differences in Neuronal Characteristics." Molecular & Cellular Proteomics 13(12): 3410-3420.
Hou, S. T., S. X. Jiang and R. A. Smith (2008). "International Review of Cell and Molecular Biology." International review of cell and molecular biology 267: 125-181.
Hrabetova, S. and T. C. Sacktor (1996). "Bidirectional regulation of protein kinase M zeta in the maintenance of long-term potentiation and long-term depression." The Journal of neuroscience : the official journal of the Society for Neuroscience 16(17): 5324-5333.
Hu, Y. G., Ø. Hvalby, S. I. Walaas, K. A. Albert, P. Skjeflo, P. Andersen and P. Greengard (1987). "Protein kinase C injection into hippocampal pyramidal cells elicits features of long term potentiation." Nature 328(6129): 426-429.
Hutson, T., C. Kathe, S. Menezes, M.-C. Rooney, H. Bueler and L. Moon (2014). "Axon Growth and Regeneration." Methods in molecular biology (Clifton, N.J.) 1162: 189-207.
Ishima, T., T. Futamura, Y. Ohgi, N. Yoshimi, T. Kikuchi and K. Hashimoto (2015). "Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin–dopamine activity modulator: A role for serotonin 5-HT1A and 5-HT2A receptors." European Neuropsychopharmacology 25(4): 505-511.
Jacinto, E., V. Facchinetti, D. Liu, N. Soto, S. Wei, S. Jung, Q. Huang, J. Qin and B. Su (2006). "SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity." Cell 127(1): 125-137.
Jaworski, J., S. Spangler, D. P. Seeburg, C. C. Hoogenraad and M. Sheng (2005). "Control of Dendritic Arborization by the Phosphoinositide-3′-Kinase–Akt–Mammalian Target of Rapamycin Pathway." The Journal of Neuroscience 25(49): 11300-11312.
Jessen, U., V. Novitskaya, N. Pedersen, P. Serup, V. Berezin and E. Bock (2001). "The transcription factors CREB and c‐Fos play key roles in NCAM‐mediated neuritogenesis in PC12‐E2 cells." Journal of Neurochemistry 79(6): 1149-1160.
Jiang, Y. Q. and M. M. Oblinger (1992). "Differential regulation of beta III and other tubulin genes during peripheral and central neuron development." Journal of Cell Science 103 ( Pt 3): 643-651.
Jin, N., W. Qian, X. Yin, L. Zhang, K. Iqbal, I. Grundke-Iqbal, C.-X. Gong and F. Liu (2013). "CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer’s disease." Nucleic Acids Research 41(5): 3240-3256.
Johnson‐Green, P. C., K. E. Dow and R. J. Riopelle (1991). "Characterization of glycosaminoglycans produced by primary astrocytes in vitro." Glia 4(3): 314-321.
Jones, P. F., T. Jakubowicz and B. A. Hemmings (1991). "Molecular cloning of a second form of rac protein kinase." Cell Regulation 2(12): 1001-1009.
Kandel, E. R. (2012). "The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB." Molecular Brain 5(1): 1-12.
Karson, C. N., J. E. Newton, R. Livingston, J. B. Jolly, T. B. Cooper, J. Sprigg and R. A. Komoroski (1993). "Human brain fluoxetine concentrations." The Journal of neuropsychiatry and clinical neurosciences 5(3): 322-329.
Kater, S. B., M. P. Mattson, C. Cohan and J. Connor (1988). "Calcium regulation of the neuronal growth cone." Trends in Neurosciences 11(7): 315-321.
Ke, Y. D., A. K. Suchowerska, J. van der Hoven, D. M. Silva, C. W. Wu, J. van Eersel, A. Ittner and L. M. Ittner (2012). "Lessons from Tau-Deficient Mice." International Journal of Alzheimer's Disease 2012: 873270.
Kempf, M., A. Clement, A. Faissner, G. Lee and R. Brandt (1996). "Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner." The Journal of neuroscience : the official journal of the Society for Neuroscience 16(18): 5583-5592.
Keshet, Y. and R. Seger (2010). "MAP Kinase Signaling Protocols." Methods in molecular biology (Clifton, N.J.) 661: 3-38.
Khan, I. A. and R. F. Ludueña (1996). "Phosphorylation of beta III-tubulin." Biochemistry 35(12): 3704-3711.
Kwei, S. L., A. Clement, A. Faissner and R. Brandt (1998). "Differential interactions of MAP2, tau and MAP5 during axogenesis in culture." Neuroreport 9(6): 1035.
Lendahl, U. and R. McKay (1990). "The use of cell lines in neurobiology." Trends in Neurosciences 13(4): 132-137.
Liu, B. P., W. Cafferty, S. O. Budel and S. M. Strittmatter (2006). "Extracellular regulators of axonal growth in the adult central nervous system." Philosophical Transactions of the Royal Society B: Biological Sciences 361(1473): 1593-1610.
Liu, F., I. Grundke-Iqbal, K. Iqbal, Y. Oda, K. Tomizawa and C.-X. Gong (2005). "Truncation and Activation of Calcineurin A by Calpain I in Alzheimer Disease Brain." Journal of Biological Chemistry 280(45): 37755-37762.
Liu, J., X. Zheng, F. Yin, Y. Hu, L. Guo, X. Deng, G. Chen, J. Jiajia and H. Zhang (2006). "Neurotrophic property of geniposide for inducing the neuronal differentiation of PC12 cells." International Journal of Developmental Neuroscience 24(7): 419-424.
Liu, L., E. E. Geisert, A. Frankfurter, A. J. Spano, C. Jiang, J. Yue, I. Dragatsis and D. Goldowitz (2007). "A transgenic mouse Class‐III β tubulin reporter using yellow fluorescent protein." genesis 45(9): 560-569.
Liu, W., G. Li, C. Hölscher and L. Li (2015). "Neuroprotective effects of geniposide on Alzheimer’s disease pathology." Reviews in the Neurosciences 26(4): 371-383.
Lledo, P. M., G. O. Hjelmstad, S. Mukherji, T. R. Soderling, R. C. Malenka and R. A. Nicoll (1995). "Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism." Proceedings of the National Academy of Sciences 92(24): 11175-11179.
Lu, Y., S. Belin and Z. He (2014). "Signaling regulations of neuronal regenerative ability." Current Opinion in Neurobiology 27: 135-142.
Ludueña, R. F. (1998). "Multiple forms of tubulin: different gene products and covalent modifications." International review of cytology 178: 207-275.
Lv, C., X. Liu, H. Liu, T. Chen and W. Zhang (2014). "Geniposide Attenuates Mitochondrial Dysfunction and Memory Deficits in APP/PS1 Transgenic Mice." Current Alzheimer Research 11(6): 580-587.
Lv, C., L. Wang, X. Liu, S. Yan, S. Yan, Y. Wang and W. Zhang (2015). "Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model." Neuropharmacology 89: 175-184.
Malinow, R., H. Schulman and R. W. Tsien (1989). "Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP." Science 245(4920): 862-866.
Mar, F. M., A. Bonni and M. M. Sousa (2014). "Cell intrinsic control of axon regeneration." EMBO reports 15(3): 254-263.
Maris, J. M., M. D. Hogarty, R. Bagatell and S. L. Cohn (2007). "Neuroblastoma." The Lancet 369(9579): 2106-2120.
Matthay, K. K., J. G. Villablanca, R. C. Seeger, D. O. Stram, R. E. Harris, N. K. Ramsay, P. Swift, H. Shimada, C. T. Black, G. M. Brodeur, R. B. Gerbing and C. P. Reynolds (1999). "Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group." The New England Journal of Medicine 341(16): 1165-1173.
Meiri, K. F., M. Willard and M. I. Johnson (1988). "Distribution and phosphorylation of the growth-associated protein GAP43 in regenerating sympathetic neurons in culture." The Journal of neuroscience : the official journal of the Society for Neuroscience 8(7): 2571-2581.
Morales, M. and E. Fifkova (1989). "Distribution of MAP 2 in dendritic spines and its colocalization with actin." Cell and Tissue Research 256(3): 447-456.
Mudher, A. and S. Lovestone (2002). "Alzheimer's disease – do tauists and baptists finally shake hands?" Trends in Neurosciences 25(1): 22-26.
Munoz, L. and A. J. Ammit (2010). "Targeting p38 MAPK pathway for the treatment of Alzheimer's disease." Neuropharmacology 58(3): 561-568.
Muramatsu, R., M. Ueno and T. Yamashita (2009). "Intrinsic regenerative mechanisms of central nervous system neurons." Bioscience trends 3(5): 179-183.
Núñez-Iglesias, M. J., S. Novío, A. Almeida-Dias and M. Freire-Garabal (2010). "Inhibitory effects of alprazolam on the development of acute experimental autoimmune encephalomyelitis in stressed rats." Pharmacology Biochemistry and Behavior 97(2): 350-356.
Obara, Y. and N. Nakahata (2010). "The Signaling Pathway Leading to Extracellular Signal-Regulated Kinase 5 (ERK5) Activation via G-Proteins and ERK5-Dependent Neurotrophic Effects." Molecular Pharmacology 77(1): 10-16.
Onodera, N., A. Kakehata and I. Araki (2013). "Differential Expression of GAP43 Protein in the Rostral Brain Neurons of Early Chick Embryos." The Tohoku Journal of Experimental Medicine 231(4): 293-298.
Otmakhov, N., L. C. Griffith and J. E. Lisman (1997). "Postsynaptic inhibitors of calcium/calmodulin-dependent protein kinase type II block induction but not maintenance of pairing-induced long-term potentiation." The Journal of neuroscience : the official journal of the Society for Neuroscience 17(14): 5357-5365.
Påhlman, S., S. Mamaeva, G. Meyerson, M. E. Mattsson, C. Bjelfman, E. Ortoft and U. Hammerling (1990). "Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function." Acta physiologica Scandinavica. Supplementum 592: 25-37.
Paoletti, L., Elena, C., Domizi, P., and Banchio, C. (2011). Role of Phosphatidylcholine during Neuronal differentiation. IUBMB Life 63, 714-720.
Park, E. H., M. H. Joo, S. H. Kim and C. J. Lim (2003). "Antiangiogenic activity of Gardenia jasminoides fruit." Phytotherapy Research 17(8): 961-962.
Perez-Polo, J. R., K. Werrbach-Perez and E. Tiffany-Castiglioni (1979). "A human clonal cell line model of differentiating neurons." Developmental Biology 71(2): 341-355.
Phan, C.-W., P. David, K.-H. Wong, M. Naidu and V. Sabaratnam (2015). "Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism." PLoS ONE 10(11).
Prabha, S. P., P. N. Ansil, A. Nitha, P. J. Wills and Latha (2012). "Preventive and curative effect of methanolic extract of Gardenia gummifera Linn. f. on thioacetamide induced oxidative stress in rats." Asian Pacific Journal of Tropical Disease 2(2): 90-98.
Pugazhenthi, S., M. Wang, S. Pham, C.-I. Sze and C. B. Eckman (2011). "Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons." Molecular Neurodegeneration 6(1): 1-16.
Qian, Z., M. Micorescu, V. Yakhnitsa and N. H. Barmack (2012). "Climbing fiber activity reduces 14-3-3-θ regulated GABAA receptor phosphorylation in cerebellar Purkinje cells." Neuroscience 201: 34-45.
Qiao, J., J. Wang, H. Wang, Y. Zhang, S. Zhu, A. Adilijiang, H. Guo, R. Zhang, W. Guo, G. Luo, Y. Qiu, H. Xu, J. Kong, Q. Huang and X. M. Li (2016). "Regulation of astrocyte pathology by fluoxetine prevents the deterioration of Alzheimer phenotypes in an APP/PS1 mouse model." Glia 64(2): 240-254.
Rehder, V., J. R. Jensen and S. B. Kater (1992). "The initial stages of neural regeneration are dependent upon intracellular calcium levels." Neuroscience 51(3): 565-574.
Richardson, P. M. and V. M. K. Issa (1984). "Peripheral injury enhances central regeneration of primary sensory neurones." Nature 309(5971): 791-793.
Rodriguez, O. C., A. W. Schaefer, C. A. Mandato, P. Forscher, W. M. Bement and C. M. Waterman-Storer (2003). "Conserved microtubule–actin interactions in cell movement and morphogenesis." Nature Cell Biology 5(7): 599-609.
Sandvig, A., Berry, M., Barrett, L.B., Butt, A., and Logan, A. (2004). Myelin‐, reactive glia‐, and scar‐derived CNS axon growth inhibitors: Expression, receptor signaling, and correlation with axon regeneration. Glia 46, 225-251.
Sotelo, C., et al. (1997). Normal and Abnormal Development of the Cortex. springer, 67-80
Saito, K., J. S. Elce, J. E. Hamos and R. A. Nixon (1993). "Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration." Proceedings of the National Academy of Sciences 90(7): 2628-2632.
Sakamoto, K., K. Karelina and K. Obrietan (2011). "CREB: a multifaceted regulator of neuronal plasticity and protection." Journal of Neurochemistry 116(1): 1-9.
Salto, R., J. D. Vílchez, M. D. Girón, E. Cabrera, N. Campos, M. Manzano, R. Rueda and J. M. López-Pedrosa (2015). "β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells." PLoS ONE 10(8).
Samuels, I. S., S. C. Saitta and G. E. Landreth (2009). "MAP'ing CNS Development and Cognition: An ERKsome Process." Neuron 61(2): 160-167.
Sarbassov, D. D., D. A. Guertin, S. M. Ali and D. M. Sabatini (2005). "Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex." Science 307(5712): 1098-1101.
Schreyer, D. J. and P. J. H. Skene (1993). "Injury‐associated induction of GAP‐43 expression displays axon branch specificity in rat dorsal root ganglion neurons." Journal of Neurobiology 24(7): 959-970.
Schubert, D., S. Humphreys, C. Baroni and M. Cohn (1969). "In vitro DIFFERENTIATION OF A MOUSE NEUROBLASTOMA." Proceedings of the National Academy of Sciences 64(1): 316-323.
Shea, T. B., I. Fischer and V. S. Sapirstein (1985). "Effect of retinoic acid on growth and morphological differentiation of mouse NB2a neuroblastoma cells in culture." Developmental Brain Research 21(2): 307-314.
Shea, T. B., R. K. Sihag and R. A. Nixon (1988). "Neurofilament triplet proteins of NB2a/d1 neuroblastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation." Developmental Brain Research 43(1): 97-109.
Shen, Y. and L.-C. Yu (2008). "Potential Protection of Curcumin against Hypoxia-induced Decreases in Beta-III Tubulin Content in Rat Prefrontal Cortical Neurons." Neurochemical Research 33(10): 2112-2117.
Sheng-xi, M., P. Jing-hua, F. Qin, C. Jian-mei and H. Yi-yang (2013). "The Role of Genipin and Geniposide in Liver Diseases: A Review." Alternative & Integrative Medicine 02(04).
Silva, A. J., J. H. Kogan, P. W. Frankland and S. Kida (1998). "CREB AND MEMORY." Neuroscience 21(1): 127-148.
Škoda, D., K. Kranda, M. Bojar, L. Glosová, J. Bäurle, J. Kenney, D. Romportl, M. Pelichovská and K. Cvachovec (2006). "Antibody formation against β-tubulin class III in response to brain trauma." Brain Research Bulletin 68(4): 213-216.
Smith, P. D., F. Sun, K. Park, B. Cai, C. Wang, K. Kuwako, I. Martinez-Carrasco, L. Connolly and Z. He (2009). "SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo." Neuron 64(5): 617-623.
Snipes, G. J., S. Y. Chan, C. B. McGuire, B. R. Costello, J. J. Norden, J. A. Freeman and A. Routtenberg (1987). "Evidence for the coidentification of GAP43, a growth-associated protein, and F1, a plasticity-associated protein." The Journal of neuroscience : the official journal of the Society for Neuroscience 7(12): 4066-4075.
Song, H.-j., G.-l. Ming, Z. He, M. Lehmann, L. McKerracher, M. Tessier-Lavigne and M.-m. Poo (1998). "Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides." Science 281(5382): 1515-1518.
Soni, K. and M. Parle (2017). "Trachyspermum ammi Seeds Supplementation Helps Reverse Scopolamine, Alprazolam and Electroshock Induced Amnesia." Neurochemical Research 42(5): 1333-1344.
Sorimachi, H., S. Hata and Y. Ono (2011). "Impact of genetic insights into calpain biology." Journal of biochemistry 150(1): 23-37.
Stein, M. D., B. J. Anderson, S. R. Kenney and G. L. Bailey (2017). "Beliefs about the consequences of using benzodiazepines among persons with opioid use disorder." Journal of Substance Abuse Treatment 77: 67-71.
Strittmatter, S. M., C. Fankhauser, P. L. Huang, H. Mashimo and M. C. Fishman (1995). "Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP43." Cell 80(3): 445-452.
Suchy, Y. (2008). "What Have i-pods Gotta Do With It? - Neuroscience (Fourth Edition). PurvesDale, AugustineGeorge J., FitzpatrickDavid, HallWilliam C., LaMantiaAnthony-Samuel, McNamaraJames O., and WhiteLeonard E. (Eds.). 2007. Sunderland, MA: Sinauer Associates, 810 pp., $102.00 (HB)." Journal of the International Neuropsychological Society 14(4): 667-668.
Sweatt, D. J. (2001). "The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory." Journal of Neurochemistry 76(1): 1-10.
Tas, P. W. L., H. G. Kress and K. Koschel (1989). "The sodium channels of the neuroblastoma x glioma 108 CC 15 hybrid cell change their sensitivity for volatile and local anesthetics upon continuous passage." Journal of Neural Transmission 76(2): 99-107.
Teich, A. F., R. E. Nicholls, D. Puzzo, J. Fiorito, R. Purgatorio, M. Fa’ and O. Arancio (2015). "Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach." Neurotherapeutics 12(1): 29-41.
Teng, F. and B. Tang (2006). "Axonal regeneration in adult CNS neurons – signaling molecules and pathways." Journal of Neurochemistry 96(6): 1501-1508.
Wang, L. J., R. Colella, G. Yorke and F. J. Roisen (1996). "The ganglioside GM1 enhances microtubule networks and changes the morphology of Neuro-2a cells in vitro by altering the distribution of MAP2." Experimental Neurology 139(1): 1-11.
Wang, N., M. Zhu, S.-W. Tsao, K. Man, Z. Zhang and Y. Feng (2012). "Up-Regulation of TIMP-1 by Genipin Inhibits MMP-2 Activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma." PLoS ONE 7(9).
Waterman-Storer, C. M. and E. D. Salmon (1997). "Actomyosin-based Retrograde Flow of Microtubules in the Lamella of Migrating Epithelial Cells Influences Microtubule Dynamic Instability and Turnover and Is Associated with Microtubule Breakage and Treadmilling." The Journal of Cell Biology 139(2): 417-434.
Watt, F. and P. L. Molloy (1993). "Specific cleavage of transcription factors by the thiol protease, m-calpain." Nucleic Acids Research 21(22): 5092-5100.
Wei, X. H., X. M. Cheng, J. S. Shen and Z. T. Wang (2008). "Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair." Journal of Ethnopharmacology 117(2): 339-344.
Wirth, A., K. Holst and E. Ponimaskin (2017). "How serotonin receptors regulate morphogenic signalling in neurons." Progress in Neurobiology 151: 35-56.
Wu, H.-Y., K. Tomizawa, Y. Oda, F.-Y. Wei, Y.-F. Lu, M. Matsushita, S.-T. Li, A. Moriwaki and H. Matsui (2004). "Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration." Journal of Biological Chemistry 279(6): 4929-4940.
Wu, P.-Y., Y.-C. Lin, C.-L. Chang, H.-T. Lu, C.-H. Chin, T.-T. Hsu, D. Chu and S. H. Sun (2009). "Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells." Cellular Signalling 21(6): 881-891.
Yamazaki, M., K. Chiba, T. Mohri and H. Hatanaka (2004). "Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells." European Journal of Pharmacology 488(1-3): 35-43.
Yin, F., T. Jiang and E. Cadenas (2013). "Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling." Biochemical Society Transactions 41(1): 101-105.
Yoshimura, T., Y. Kawano, N. Arimura, S. Kawabata, A. Kikuchi and K. Kaibuchi (2005). "GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity." Cell 120(1): 137-149.
Yu, A. L., A. L. Gilman, F. M. Ozkaynak, W. B. London, S. G. Kreissman, H. X. Chen, M. Smith, B. Anderson, J. G. Villablanca, K. K. Matthay, H. Shimada, S. A. Grupp, R. Seeger, P. C. Reynolds, A. Buxton, R. A. Reisfeld, S. D. Gillies, S. L. Cohn, J. M. Maris, P. M. Sondel and C. s. Group (2010). "Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma." The New England Journal of Medicine 363(14): 1324-1334.
Zheng, J. Q. and M.-m. Poo (2007). "Calcium Signaling in Neuronal Motility." Annual review of cell and developmental biology 23(1): 375-404.
Zhou, F.-Q. and W. D. Snider (2006). "Intracellular control of developmental and regenerative axon growth." Philosophical Transactions of the Royal Society B: Biological Sciences 361(1473): 1575-1592.
Zhou, F.-Q., M. Walzer, Y.-H. Wu, J. Zhou, S. Dedhar and W. D. Snider (2006). "Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism." Journal of Cell Science 119(13): 2787-2796.
Zhou, F.-Q., C. M. Waterman-Storer and C. S. Cohan (2002). "Focal loss of actin bundles causes microtubule redistribution and growth cone turning." The Journal of Cell Biology 157(5): 839-849.
Zhou, Y., M. Liang, W. Li, K. Li, P. Li, Y. Hu and Z. Yang (2009). "Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity." Environmental Toxicology and Pharmacology 28(3): 342-349.
Zmuda, J. F. and R. J. Rivas (2000). "Actin disruption alters the localization of tau in the growth cones of cerebellar granule neurons." Journal of Cell Science 113 ( Pt 15): 2797-2809.
蘇心柔。(2015)。維生素 C 與穀胱甘肽預防精神用藥誘發出生雛雞畸形之分子機制。國立彰化師範大學生物技術研究所碩士論文。
沈姿玲。(2015)。以 CoQ10 與肉鹼預防精神藥物誘發雞胚胎之粒線體功能障礙。國立彰化師範大學生物技術研究所碩士論文。
連結至畢業學校之論文網頁點我開啟連結
註: 此連結為研究生畢業學校所提供,不一定有電子全文可供下載,若連結有誤,請點選上方之〝勘誤回報〞功能,我們會盡快修正,謝謝!
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
系統版面圖檔 系統版面圖檔