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研究生:尤婉靜
研究生(外文):Wan-Jing You
論文名稱:葉形軟珊瑚Lobophytum sp.的化學成分及抗發炎活性之研究
論文名稱(外文):Chemical constituents and anti-inflammatory activity of the soft coral Lobophytum sp.
指導教授:蘇瑞欣
指導教授(外文):Jui-Hsin Su
學位類別:碩士
校院名稱:國立東華大學
系所名稱:海洋生物研究所
學門:自然科學學門
學類:海洋科學學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
論文頁數:145
中文關鍵詞:葉形軟珊瑚抗發炎
外文關鍵詞:Lobophytum sp.anti-inflammatory
相關次數:
  • 被引用被引用:1
  • 點閱點閱:217
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  • 下載下載:43
  • 收藏至我的研究室書目清單書目收藏:0
在葉形軟珊瑚中煙草烷類化合物為常見的二萜類天然產物。煙草烷類化合物已有文獻發表指出具有幾種生物活性,例如抗癌、抗微生物以及抗發炎活性。本實驗從野外型葉形軟珊瑚中分離純化得到抗發炎化學成分,其包含兩個新的煙草烷類lobophyolide A (1)和B (2)以及五個已知化合物 (3–7),而這些天然產物之結構經由NMR 分析以及質譜儀數據進行鑑定。
在體外抗發炎活性方面,結果顯示化合物1、2、5、6、7 具有降低LPS 刺激樹突細胞產生的IL-12 表現量。此外化合物1、2、5、6、7 也能降低受到LPS 刺激的樹狀細胞釋放一氧化氮 (NO)。因此,化合物1、2、5、6、7 具有發展成為抗發炎劑的優勢。
Diterpenes of the cembrane type are some of the most frequently encountered natural products in soft corals of the genus Lobophytum. Of particular interest, cembranoids have been reported to possess several kinds of biological activities, such as antitumor, antimicrobial and anti-inflammatory activities. During the course of our study on the anti-inflammatory chemical constituents from a wild-type soft coral Lobophytum sp., two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7) have been isolated. The structures of these natural products were identified using NMR analyses, as well as data from mass spectroscopic methods.
The in vitro anti-inflammatory effects of compounds 1, 2, 5, 6, 7 were also tested. The results showed that compounds 1, 2, 5, 6, 7 reduced IL-12 production from LPSstimulated dendritic cell. Moreover, compounds 1, 2, 5, 6, 7 reduced NO release from LPS-activated DCs. Accordingly, our data indicated that compounds1, 2, 5, 6, 7 exhibited as an outstanding lead for the development of anti-inflammatory agent.
中文摘要 IX
英文摘要 X
第一章、緒論 1
第一節、前言 1
第二節、葉形軟珊瑚Lobophytum 屬所含天然物的文獻回顧 3
(一)、Lobophytum caledonense 化合物文獻回顧 3
(二)、Lobophytum compactum 化合物文獻回顧 4
(三)、Lobophytum crassospiculatum 化合物文獻回顧 4
(四)、Lobophytum crassum 化合物文獻回顧 5
(五)、Lobophytum cristagalli 化合物文獻回顧 26
(六)、Lobophytum cristatum 化合物文獻回顧 28
(七)、Lobophytum denticulatum 化合物文獻回顧 29
(八)、Lobophytum depressum 化合物文獻回顧 31
(九)、Lobophytum durum 化合物文獻回顧 32
(十)、Lobophytum hedleyi 化合物文獻回顧 38
(十一)、Lobophytum laevigatum 化合物文獻回顧 39
(十二)、Lobophytum lobophytum 化合物文獻回顧 40
(十三)、Lobophytum michaelae 化合物文獻回顧 40
(十五)、Lobophytum sarcophytoides 化合物文獻回顧 54
(十六)、Lobophytum schoedei 化合物文獻回顧 57
(十七)、Lobophytum sp. 化合物文獻回顧 57
第二章、生物材料與研究方法 71
第一節、生物材料的採集與分類 71
第二節、生物樣品的萃取與分離 73
第三節、實驗器材與材料 75
第三章、結果與討論 77
第一節、Lobophytum sp.所含化合物之結構解析 77
(一)、Lobophyolide A (1) 化合物結構之解析 78
(二)、Lobophyolide B (2) 化合物結構之解析 88
(三)、16-Acetylsinulariol D (3) 化合物結構之解析 98
(四)、(E,E,E)-6,10,14-trimethy-3-methylene-trans-3α,4,7,8,11,12,15,15α-octahydrocyclotetradeca[β]furan-2(3H)-one (4) 化合物結構之解析 106
(五)、Unnamed (5) 化合物結構之解析 110
(六)、Sinarone A (6) 化合物結構之解析 116
(七)、Sinulariol D (7) 化合物結構之解析 122
第二節、新化合物實驗數據整理 128
第四章、生物活性試驗 129
第一節、抗發炎活性試驗 129
(一)、初代骨隨樹突細胞培養 129
(二)、細胞激素釋放偵測 129
(三)、細胞存活率測試 (CCK-8 assay) 129
(四)、一氧化氮檢測 130
第二節、生物活性試驗結果 131
(一)、樹突細胞之細胞激素 (IL-12)釋放偵測結果 131
(二)、樹突細胞之細胞存活率測試結果 132
(三)、樹突細胞之一氧化氮檢測結果 133
第五章、結論 135
第六章、參考文獻 137
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