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研究生:楊予旻
研究生(外文):Yang, Yu-Min
論文名稱:探討公豬精漿中榖胱甘肽過氧化物酶 5 之氧化修飾
論文名稱(外文):Investigation of The Oxidative Modification of Glutathione Peroxidase 5 in Boar Seminal Plasma
指導教授:陳威戎陳威戎引用關係
指導教授(外文):Chen, Wei-Jung
口試委員:陳銘正游玉祥林景堉
口試委員(外文):Chen, Ming-ChengYu, Yu-HsiangLin, Ching-Yu
口試日期:2017-07-21
學位類別:碩士
校院名稱:國立宜蘭大學
系所名稱:生物技術與動物科學系
學門:農業科學學門
學類:畜牧學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:60
中文關鍵詞:公豬精漿榖胱甘肽過氧化物酶5氧化修飾4-羥基壬烯酸
外文關鍵詞:Boar seminal plasmaGlutathione peroxidase 5Oxidative modification4-hydroxy-2-nonenal
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摘要……….……………………………………………………………………………………I
Abstract……….…………………………………………………………………………….II
致謝…………………………………………………………………………………………III
目錄…………………………………………………………………………………………IV
圖目錄………………………………………………………………………………………VI
表目錄………………………………………………………………………………………VII
名詞縮寫表..………………………………………………………………………………VIII
第一章 前言………………………………………………………………………………..….1
第一節 人工授精……………………………………………………………..…….1
第二節 公豬精液的生成與成分………………………………………………………….2
第三節 現今檢測精液品質之方法….…………………………………………………….3
第四節 氧化傷害……………………………………………..…………………………….5
第五節 蛋白質體學………………………………………………………..…………...9
第二章 實驗目的……………….………………………………….………………………...13
第三章 實驗儀器與藥品試劑…………………..…………………………………………...14
第一節 實驗儀器……………………………………………..…………………………...14
第二節 藥品試劑……………………………………………..…………………………..15
第四章 實驗流程與方法………………………………………..………………………….17
第一節 精液之收集……………………………………..………………………………..18
第二節 精液品質檢測……………………………………..……………………………..18
第三節 精漿樣品前處理與蛋白質萃取……………………………………..…………..19
第四節 蛋白質定量………………………………..………..…………………………….19
第五節 二維凝膠電泳……………………………………..……………………………..19
第六節 二維電泳膠片影像擷取與軟體分析………..…………………………………..21
第七節 膠體內水解……………………………………..………………………………..21
第八節 液相層析電噴灑離子化軌道阱串聯式質譜儀…..……………………………..22
第九節 生物資訊學資料庫搜尋與比對………………..………………………………..23
第十節 統計分析………………………………………..………………………………..25
第十一節 GPX5重組蛋白之HNE修飾培養…………………..………………………25
第十二節 西方墨點轉漬法………..……………………………………………………..26
第十三節 經HNE修飾後GPX5重組蛋白之活性測試…………………………………28
第五章 實驗結果…..……………………………………………………………………….29
第一節 精液樣品之品質檢測…………………………..………………………………..29
第二節 精漿蛋白萃取與二維凝膠電泳分析結果……………………………………….29
第三節 蛋白質身分鑑定………………………………………………………………….30
第四節 蛋白質轉譯後修飾……………………………..………………………………..30
第五節GPX5重組蛋白之HNE修飾培養確認………………………………………….31
第六節 HNE修飾後GPX5重組蛋白之活性測試結果………..………………………31
第七節 HNE修飾後GPX5重組蛋白之轉譯後修飾分析……………………………….31
第六章 討論…..…………………………………………………………………………….33
第一節 蛋白質鑑定…………………………..…………………………………………..33
第二節 氧化修飾…………………………..……………………………………………..35
第三節 重組蛋白GPX5之HNE培養………………………………………….………35
第四節 活性分析測試……………………..…………………………………………….36
第五節 HNE修飾之GPX5蛋白對精子功能之影響……………………………………37
第七章 結論與未來展望…………………………….………………………………………38
第八章 圖表…..…………………………………………………………………………….39
第九章 參考文獻………………………………….…………………………………………52

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