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研究生:王湘君
研究生(外文):Siang-Jyun Wang
論文名稱:扁桃斑鳩菊萃取物與化療藥物5-FU合併處理對於乳腺癌細胞株MCF-7的毒殺效用分析
論文名稱(外文):The Cytotoxic Effects of Vernonia amygdalina Extract combination with 5-FU against Human Breast Cancer Cell line MCF-7
指導教授:許惠貞許惠貞引用關係
指導教授(外文):Hui-Chen Hsu
口試委員:蔡孟峯劉宛菁陳威戎
口試委員(外文):Meng-Feng TsaiWang-Jing LiuWei-Jung Chen
口試日期:2017-07-31
學位類別:碩士
校院名稱:國立宜蘭大學
系所名稱:生物技術與動物科學系
學門:農業科學學門
學類:畜牧學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:66
中文關鍵詞:MCF-7扁桃斑鳩菊5-氟尿嘧啶細胞凋亡輔助與替代療法
外文關鍵詞:MCF-7Vernonia amygdalina5-Fluorouracil (5-FU)ApoptosisComplementary Alternative Medicine (CAM)
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目錄
中文摘要 I
Abstract II
謝誌 III
目錄 IV
表目錄 V
附圖目錄 VI
附表目錄 VI
第一章 文獻探討 1
一、乳癌介紹 1
二、輔助與替代療法 (Complementary and Alternative Medicine, CAM) 5
三、5-氟尿嘧啶簡介 7
四、扁桃斑鳩菊介紹 10
五、細胞相關調控機制 13
第二章 研究目的 19
第三章 實驗材料與方法 20
一、實驗材料 20
二、實驗方法 24
第四章 結果 30
一、以細胞存活率實驗分析扁桃斑鳩菊甲醇萃取物 (DM) 處理MCF-7細胞之作用濃度 30
二、以細胞存活率實驗分析扁桃斑鳩菊水萃取物 (DWF) 處理MCF-7細胞之作用濃度 30
三、以細胞存活率實驗分析5-FU合併扁桃斑鳩菊甲醇萃取物 (DM) 對於MCF-7細胞之細胞毒殺效果 30
四、5-FU合併扁桃斑鳩菊甲醇萃取物 (DM) 對於MCF-7細胞之細胞週期分析 31
五、5-FU合併扁桃斑鳩菊甲醇萃取物 (DM) 對於MCF-7細胞之細胞凋亡相關蛋白分析 31
六、5-FU合併扁桃斑鳩菊甲醇萃取物 (DM) 對於MCF-7細胞之細胞週期相關蛋白分析 32
七、5-FU合併扁桃斑鳩菊甲醇萃取物 (DM) 對於MCF-7細胞之PI3K/AKT/mTOR相關蛋白之影響 32
八、5-FU合併扁桃斑鳩菊甲醇萃取物 (DM) 對於MCF-7細胞之胸苷酸合成酶 (TS) 之影響 32
第五章 討論 34
第六章 結論 39
第七章 圖表 40
第八章 參考文獻 55


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