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研究生:涂孟萱
研究生(外文):Tu, Meng-Shiuan
論文名稱:硫辛酸抑制NLRP3發炎體活化而減緩高脂飲食及STZ誘發第二型糖尿病大鼠內臟脂肪組織發炎反應之研究
論文名稱(外文):Alpha-lipoic acid alleviates inflammation in visceral adipose tissues of high-fat-diet and streptozotocin-induced Type 2 diabetic rats via suppressing NLRP3 inflammasome activation
指導教授:沈賜川吳瑞碧丁俞文
指導教授(外文):Shen, Szu-ChuanWu, Swi-BeaTing, Yu-Wen
學位類別:碩士
校院名稱:國立臺灣師範大學
系所名稱:人類發展與家庭學系
學門:教育學門
學類:普通科目教育學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:62
中文關鍵詞:第二型糖尿病內臟脂肪組織發炎反應NLRP3發炎體
外文關鍵詞:type 2 diabetesNLRP3 inflammasomevisceral adipose tissueinflammation
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中文摘要 ii
英文摘要 iii
圖次 vi
表次 viii

第一章 前言 1

第二章 文獻回顧 2
第一節 糖尿病 2
一、糖尿病簡介 2
二、胰島素簡介 2
三、糖尿病分類 3
四、糖尿病診斷方法 5
第二節 肥胖 7
一、肥胖的定義與形成原因 7
二、肥胖流行病學 7
三、脂肪組織 8
四、肥胖與代謝性疾病 10
五、代謝性發炎反應(metaflammation) 11
第三節 NLRP3發炎體 12
一、NOD-like receptor (NLRs) 12
二、NLRP3發炎體結構及活化機制 13
三、NLRP3發炎體與肥胖 16
第四節 硫辛酸 17
一、硫辛酸特性 17
二、硫辛酸與第二型糖尿病 18
三、硫辛酸的治療潛力 19

第三章 研究動機與實驗架構 20
第一節 研究動機 20
第二節 實驗架構 21

第四章 實驗之材料與方法 22
第一節 實驗材料 22
第二節 實驗設備 24
第三節 實驗方法 25

第五章 結果與討論 32
第一節 硫辛酸對第二型糖尿病大鼠生理之影響 32
第二節 硫辛酸對第二型糖尿病大鼠血糖調節功能之影響 38
第三節 硫辛酸對第二型糖尿病大鼠血清脂質之影響 43
第四節 硫辛酸對胰島素訊息傳遞相關蛋白表現量之影響 45
第五節 硫辛酸對NLRP3發炎體訊息傳遞相關蛋白表現量之影響 48

第六章 結語 58

第七章 參考文獻 59
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