|
Chapter I.
Alcoforado Diniz, J., and Coulthurst, S.J. (2015). Intraspecies competition in Serratia marcescens is mediated by yype VI-secreted Rhs effectors and a conserved effector-associated accessory protein. J Bacteriol 197, 2350-2360.
Anderson, M.C., Vonaesch, P., Saffarian, A., Marteyn, B.S., and Sansonetti, P.J. (2017). Shigella sonnei encodes a functional T6SS esed for interbacterial competition and niche occupancy. Cell Host Microbe 21, 769-776.
Aschtgen, M.S., Bernard, C.S., De Bentzmann, S., Lloubes, R., and Cascales, E. (2008). SciN is an outer membrane lipoprotein required for type VI secretion in enteroaggregative Escherichia coli. J Bacteriol 190, 7523-7531.
Aschtgen, M.S., Gavioli, M., Dessen, A., Lloubes, R., and Cascales, E. (2010a). The SciZ protein anchors the enteroaggregative Escherichia coli type VI secretion system to the cell wall. Mol Microbiol 75, 886-899.
Aschtgen, M.S., Thomas, M.S., and Cascales, E. (2010b). Anchoring the type VI secretion system to the peptidoglycan: TssL, TagL, TagP... what else? Virulence 1, 535-540.
Aschtgen, M.S., Zoued, A., Lloubes, R., Journet, L., and Cascales, E. (2012). The C-tail anchored TssL subunit, an essential protein of the enteroaggregative Escherichia coli Sci-1 Type VI secretion system, is inserted by YidC. Microbiologyopen 1, 71-82.
Bartonickova, L., Sterzenbach, T., Nell, S., Kops, F., Schulze, J., Venzke, A., Brenneke, B., Bader, S., Gruber, A.D., Suerbaum, S., et al. (2013). Hcp and VgrG1 are secreted components of the Helicobacter hepaticus type VI secretion system and VgrG1 increases the bacterial colitogenic potential. Cell Microbiol 15, 992-1011.
Basler, M., Ho, B.T., and Mekalanos, J.J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell 152, 884-894.
Basler, M., and Mekalanos, J.J. (2012). Type 6 secretion dynamics within and between bacterial cells. Science 337, 815.
Bernard, C.S., Brunet, Y.R., Gavioli, M., Lloubes, R., and Cascales, E. (2011). Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol 193, 2158-2167.
Bingle, L.E., Bailey, C.M., and Pallen, M.J. (2008). Type VI secretion: a beginner''s guide. Curr Opin Microbiol 11, 3-8.
Bondage, D.D., Lin, J.S., Ma, L.S., Kuo, C.H., and Lai, E.M. (2016). VgrG C terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor-effector complex. Proc Natl Acad Sci U S A 113, E3931-E3940.
Bonemann, G., Pietrosiuk, A., Diemand, A., Zentgraf, H., and Mogk, A. (2009). Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J 28, 315-325.
Bonemann, G., Pietrosiuk, A., and Mogk, A. (2010). Tubules and donuts: a type VI secretion story. Mol Microbiol 76, 815-821.
Brencic, A., and Lory, S. (2009). Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA. Mol Microbiol 72, 612-632.
Brencic, A., McFarland, K.A., McManus, H.R., Castang, S., Mogno, I., Dove, S.L., and Lory, S. (2009). The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Mol Microbiol 73, 434-445.
Brunet, Y.R., Bernard, C.S., Gavioli, M., Lloubes, R., and Cascales, E. (2011). An epigenetic switch involving overlapping fur and DNA methylation optimizes expression of a type VI secretion gene cluster. PLoS Genet 7, e1002205.
Brunet, Y.R., Khodr, A., Logger, L., Aussel, L., Mignot, T., Rimsky, S., and Cascales, E. (2015). H-NS silencing of the Salmonella pathogenicity island 6-encoded type VI secretion system limits Salmonella enterica serovar Typhimurium interbacterial killing. Infect Immun 83, 2738-2750.
Buell, C.R., Joardar, V., Lindeberg, M., Selengut, J., Paulsen, I.T., Gwinn, M.L., Dodson, R.J., Deboy, R.T., Durkin, A.S., Kolonay, J.F., et al. (2003). The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000. Proc Natl Acad Sci U S A 100, 10181-10186.
Carruthers, M.D., Nicholson, P.A., Tracy, E.N., and Munson, R.S., Jr. (2013). Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition. PLoS One 8, e59388.
Casabona, M.G., Silverman, J.M., Sall, K.M., Boyer, F., Coute, Y., Poirel, J., Grunwald, D., Mougous, J.D., Elsen, S., and Attree, I. (2013). An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in Pseudomonas aeruginosa. Environ Microbiol 15, 471-486.
Castang, S., McManus, H.R., Turner, K.H., and Dove, S.L. (2008). H-NS family members function coordinately in an opportunistic pathogen. Proc Natl Acad Sci U S A 105, 18947-18952.
Chou, S., Bui, N.K., Russell, A.B., Lexa, K.W., Gardiner, T.E., LeRoux, M., Vollmer, W., and Mougous, J.D. (2012). Structure of a peptidoglycan amidase effector targeted to Gram-negative bacteria by the type VI secretion system. Cell Rep 1, 656-664.
Chow, J., and Mazmanian, S.K. (2010). A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe 7, 265-276.
Cianfanelli, F.R., Alcoforado Diniz, J., Guo, M., De Cesare, V., Trost, M., and Coulthurst, S.J. (2016). VgrG and PAAR proteins define distinct versions of a functional type VI secretion system. PLoS Pathog 12, e1005735.
Cui, S., Xiao, J., Wang, Q., and Zhang, Y. (2016). H-NS binding to evpB and evpC and repressing T6SS expression in fish pathogen Edwardsiella piscicida. Arch Microbiol 198, 653-661.
Das, S., and Chaudhuri, K. (2003). Identification of a unique IAHP (IcmF associated homologous proteins) cluster in Vibrio cholerae and other proteobacteria through in silico analysis. In Silico Biol 3, 287-300.
Dong, T.G., Ho, B.T., Yoder-Himes, D.R., and Mekalanos, J.J. (2013). Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae. Proc Natl Acad Sci U S A 110, 2623-2628.
Dudley, E.G., Thomson, N.R., Parkhill, J., Morin, N.P., and Nataro, J.P. (2006). Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol 61, 1267-1282.
Durand, E., Nguyen, V.S., Zoued, A., Logger, L., Pehau-Arnaudet, G., Aschtgen, M.S., Spinelli, S., Desmyter, A., Bardiaux, B., Dujeancourt, A., et al. (2015). Biogenesis and structure of a type VI secretion membrane core complex. Nature 523, 555-560.
Durand, E., Zoued, A., Spinelli, S., Watson, P.J., Aschtgen, M.S., Journet, L., Cambillau, C., and Cascales, E. (2012). Structural characterization and oligomerization of the TssL protein, a component shared by bacterial type VI and type IVb secretion systems. J Biol Chem 287, 14157-14168.
Evans, M.L., and Chapman, M.R. (2014). Curli biogenesis: order out of disorder. Biochim Biophys Acta 1843, 1551-1558.
Felisberto-Rodrigues, C., Durand, E., Aschtgen, M.S., Blangy, S., Ortiz-Lombardia, M., Douzi, B., Cambillau, C., and Cascales, E. (2011). Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar. PLoS Pathog 7, e1002386.
Folkesson, A., Lofdahl, S., and Normark, S. (2002). The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells. Res Microbiol 153, 537-545.
Geibel, S., and Waksman, G. (2014). The molecular dissection of the chaperone-usher pathway. Biochim Biophys Acta 1843, 1559-1567.
Goodman, A.L., Kulasekara, B., Rietsch, A., Boyd, D., Smith, R.S., and Lory, S. (2004). A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev Cell 7, 745-754.
Goodman, A.L., Merighi, M., Hyodo, M., Ventre, I., Filloux, A., and Lory, S. (2009). Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen. Genes Dev 23, 249-259.
Goosens, V.J., Monteferrante, C.G., and van Dijl, J.M. (2014). The Tat system of Gram-positive bacteria. Biochim Biophys Acta 1843, 1698-1706.
Green, E.R., and Mecsas, J. (2016). Bacterial secretion systems: an overview. Microbiol Spectr 4.
Haapalainen, M., Mosorin, H., Dorati, F., Wu, R.F., Roine, E., Taira, S., Nissinen, R., Mattinen, L., Jackson, R., Pirhonen, M., et al. (2012). Hcp2, a secreted protein of the phytopathogen Pseudomonas syringae pv. tomato DC3000, is required for fitness for competition against bacteria and yeasts. J Bacteriol 194, 4810-4822.
Hachani, A., Allsopp, L.P., Oduko, Y., and Filloux, A. (2014). The VgrG proteins are "à la carte" delivery systems for bacterial type VI effectors. J Biol Chem 289, 17872-17884.
Ho, B.T., Dong, T.G., and Mekalanos, J.J. (2014). A view to a kill: the bacterial type VI secretion system. Cell Host Microbe 15, 9-21.
Hood, R.D., Singh, P., Hsu, F., Guvener, T., Carl, M.A., Trinidad, R.R., Silverman, J.M., Ohlson, B.B., Hicks, K.G., Plemel, R.L., et al. (2010). A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe 7, 25-37.
Hunt, T.A., Kooi, C., Sokol, P.A., and Valvano, M.A. (2004). Identification of Burkholderia cenocepacia genes required for bacterial survival in vivo. Infect Immun 72, 4010-4022.
Ishikawa, T., Rompikuntal, P.K., Lindmark, B., Milton, D.L., and Wai, S.N. (2009). Quorum sensing regulation of the two hcp alleles in Vibrio cholerae O1 strains. PLoS One 4, e6734.
Jiang, F., Waterfield, N.R., Yang, J., Yang, G., and Jin, Q. (2014). A Pseudomonas aeruginosa type VI secretion phospholipase D effector targets both prokaryotic and eukaryotic cells. Cell Host Microbe 15, 600-610.
Kitaoka, M., Miyata, S.T., Brooks, T.M., Unterweger, D., and Pukatzki, S. (2011). VasH is a transcriptional regulator of the type VI secretion system functional in endemic and pandemic Vibrio cholerae. J Bacteriol 193, 6471-6482.
Koskiniemi, S., Lamoureux, J.G., Nikolakakis, K.C., t''Kint de Roodenbeke, C., Kaplan, M.D., Low, D.A., and Hayes, C.S. (2013). Rhs proteins from diverse bacteria mediate intercellular competition. Proc Natl Acad Sci U S A 110, 7032-7037.
Leiman, P.G., Basler, M., Ramagopal, U.A., Bonanno, J.B., Sauder, J.M., Pukatzki, S., Burley, S.K., Almo, S.C., and Mekalanos, J.J. (2009). Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin. Proc Natl Acad Sci U S A 106, 4154-4159.
Lertpiriyapong, K., Gamazon, E.R., Feng, Y., Park, D.S., Pang, J., Botka, G., Graffam, M.E., Ge, Z., and Fox, J.G. (2012). Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization. PLoS One 7, e42842.
Li, L., Zhang, W., Liu, Q., Gao, Y., Gao, Y., Wang, Y., Wang, D.Z., Li, Z., and Wang, T. (2013). Structural Insights on the bacteriolytic and self-protection mechanism of muramidase effector Tse3 in Pseudomonas aeruginosa. J Biol Chem 288, 30607-30613.
Lin, J.S., Wu, H.H., Hsu, P.H., Ma, L.S., Pang, Y.Y., Tsai, M.D., and Lai, E.M. (2014). Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens. PLoS Pathog 10, e1003991.
Logger, L., Aschtgen, M.S., Guerin, M., Cascales, E., and Durand, E. (2016). Molecular dissection of the interface between the type VI Secretion TssM cytoplasmic domain and the TssG baseplate component. J Mol Biol 428, 4424-4437.
Lucchini, S., Rowley, G., Goldberg, M.D., Hurd, D., Harrison, M., and Hinton, J.C. (2006). H-NS mediates the silencing of laterally acquired genes in bacteria. PLoS Pathog 2, e81.
Lv, Y., Xiao, J., Liu, Q., Wu, H., Zhang, Y., and Wang, Q. (2012). Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Vet Microbiol 157, 190-199.
Ma, A.T., McAuley, S., Pukatzki, S., and Mekalanos, J.J. (2009). Translocation of a Vibrio cholerae type VI secretion effector requires bacterial endocytosis by host cells. Cell Host Microbe 5, 234-243.
Ma, A.T., and Mekalanos, J.J. (2010). In vivo actin cross-linking induced by Vibrio cholerae type VI secretion system is associated with intestinal inflammation. Proc Natl Acad Sci U S A 107, 4365-4370.
Ma, L.S., Hachani, A., Lin, J.S., Filloux, A., and Lai, E.M. (2014). Agrobacterium tumefaciens deploys a superfamily of type VI secretion DNase effectors as weapons for interbacterial competition in planta. Cell Host Microbe 16, 94-104.
MacIntyre, D.L., Miyata, S.T., Kitaoka, M., and Pukatzki, S. (2010). The Vibrio cholerae type VI secretion system displays antimicrobial properties. Proc Natl Acad Sci U S A 107, 19520-19524.
Miyata, S.T., Bachmann, V., and Pukatzki, S. (2013). Type VI secretion system regulation as a consequence of evolutionary pressure. J Med Microbiol 62, 663-676.
Miyata, S.T., Kitaoka, M., Wieteska, L., Frech, C., Chen, N., and Pukatzki, S. (2010). The Vibrio cholerae type VI secretion system: evaluating its role in the human disease cholera. Front Microbiol 1, 117.
Mougous, J.D., Cuff, M.E., Raunser, S., Shen, A., Zhou, M., Gifford, C.A., Goodman, A.L., Joachimiak, G., Ordonez, C.L., Lory, S., et al. (2006). A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312, 1526-1530.
Mougous, J.D., Gifford, C.A., Ramsdell, T.L., and Mekalanos, J.J. (2007). Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nat Cell Biol 9, 797-803.
Murdoch, S.L., Trunk, K., English, G., Fritsch, M.J., Pourkarimi, E., and Coulthurst, S.J. (2011). The opportunistic pathogen Serratia marcescens utilizes type VI secretion to target bacterial competitors. J Bacteriol 193, 6057-6069.
Natale, P., Bruser, T., and Driessen, A.J. (2008). Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane--distinct translocases and mechanisms. Biochim Biophys Acta 1778, 1735-1756.
Navarre, W.W., McClelland, M., Libby, S.J., and Fang, F.C. (2007). Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA. Genes Dev 21, 1456-1471.
Nguyen, V.S., Logger, L., Spinelli, S., Legrand, P., Huyen Pham, T.T., Nhung Trinh, T.T., Cherrak, Y., Zoued, A., Desmyter, A., Durand, E., et al. (2017). Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex. Nat Microbiol 2, 17103.
Osipiuk, J., Xu, X., Cui, H., Savchenko, A., Edwards, A., and Joachimiak, A. (2011). Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa. J Struct Funct Genomics 12, 21-26.
Pallen, M., Chaudhuri, R., and Khan, A. (2002). Bacterial FHA domains: neglected players in the phospho-threonine signalling game? Trends Microbiol 10, 556-563.
Parsons, D.A., and Heffron, F. (2005). sciS, an icmF homolog in Salmonella enterica serovar Typhimurium, limits intracellular replication and decreases virulence. Infect Immun 73, 4338-4345.
Planamente, S., Salih, O., Manoli, E., Albesa-Jove, D., Freemont, P.S., and Filloux, A. (2016). TssA forms a gp6-like ring attached to the type VI secretion sheath. EMBO J 35, 1613-1627.
Pukatzki, S., Ma, A.T., Revel, A.T., Sturtevant, D., and Mekalanos, J.J. (2007). Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. Proc Natl Acad Sci U S A 104, 15508-15513.
Pukatzki, S., Ma, A.T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W.C., Heidelberg, J.F., and Mekalanos, J.J. (2006). Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 103, 1528-1533.
Purcell, M., and Shuman, H.A. (1998). The Legionella pneumophila icmGCDJBF genes are required for killing of human macrophages. Infect Immun 66, 2245-2255.
Records, A.R., and Gross, D.C. (2010). Sensor kinases RetS and LadS regulate Pseudomonas syringae type VI secretion and virulence factors. J Bacteriol 192, 3584-3596.
Renzi, F., Rescalli, E., Galli, E., and Bertoni, G. (2010). Identification of genes regulated by the MvaT-like paralogues TurA and TurB of Pseudomonas putida KT2440. Environ Microbiol 12, 254-263.
Roest, H.P., Mulders, I.H., Spaink, H.P., Wijffelman, C.A., and Lugtenberg, B.J. (1997). A Rhizobium leguminosarum biovar trifolii locus not localized on the sym plasmid hinders effective nodulation on plants of the pea cross-inoculation group. Mol Plant Microbe Interact 10, 938-941.
Russell, A.B., Hood, R.D., Bui, N.K., LeRoux, M., Vollmer, W., and Mougous, J.D. (2011). Type VI secretion delivers bacteriolytic effectors to target cells. Nature 475, 343-347.
Russell, A.B., LeRoux, M., Hathazi, K., Agnello, D.M., Ishikawa, T., Wiggins, P.A., Wai, S.N., and Mougous, J.D. (2013). Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors. Nature 496, 508-512.
Russell, A.B., Peterson, S.B., and Mougous, J.D. (2014). Type VI secretion system effectors: poisons with a purpose. Nat Rev Microbiol 12, 137-148.
Russell, A.B., Singh, P., Brittnacher, M., Bui, N.K., Hood, R.D., Carl, M.A., Agnello, D.M., Schwarz, S., Goodlett, D.R., Vollmer, W., et al. (2012). A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe 11, 538-549.
Salomon, D., Gonzalez, H., Updegraff, B.L., and Orth, K. (2013). Vibrio parahaemolyticus type VI secretion system 1 is activated in marine conditions to target bacteria, and is differentially regulated from system 2. PLoS One 8, e61086.
Sana, T.G., Hachani, A., Bucior, I., Soscia, C., Garvis, S., Termine, E., Engel, J., Filloux, A., and Bleves, S. (2012). The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells. J Biol Chem 287, 27095-27105.
Sana, T.G., Soscia, C., Tonglet, C.M., Garvis, S., and Bleves, S. (2013). Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. PLoS One 8, e76030.
Santic, M., Molmeret, M., Barker, J.R., Klose, K.E., Dekanic, A., Doric, M., and Abu Kwaik, Y. (2007). A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol. Cell Microbiol 9, 2391-2403.
Sarris, P.F., Skandalis, N., Kokkinidis, M., and Panopoulos, N.J. (2010). In silico analysis reveals multiple putative type VI secretion systems and effector proteins in Pseudomonas syringae pathovars. Mol Plant Pathol 11, 795-804.
Schell, M.A., Ulrich, R.L., Ribot, W.J., Brueggemann, E.E., Hines, H.B., Chen, D., Lipscomb, L., Kim, H.S., Mrazek, J., Nierman, W.C., et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol 64, 1466-1485.
Schlieker, C., Zentgraf, H., Dersch, P., and Mogk, A. (2005). ClpV, a unique Hsp100/Clp member of pathogenic proteobacteria. Biol Chem 386, 1115-1127.
Schroder, O., and Wagner, R. (2000). The bacterial DNA-binding protein H-NS represses ribosomal RNA transcription by trapping RNA polymerase in the initiation complex. J Mol Biol 298, 737-748.
Schwarz, S., West, T.E., Boyer, F., Chiang, W.C., Carl, M.A., Hood, R.D., Rohmer, L., Tolker-Nielsen, T., Skerrett, S.J., and Mougous, J.D. (2010). Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions. PLoS Pathog 6, e1001068.
Shneider, M.M., Buth, S.A., Ho, B.T., Basler, M., Mekalanos, J.J., and Leiman, P.G. (2013). PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature 500, 350-353.
Shrivastava, S., and Mande, S.S. (2008). Identification and functional characterization of gene components of type VI secretion system in bacterial genomes. PLoS One 3, e2955.
Silby, M.W., Winstanley, C., Godfrey, S.A., Levy, S.B., and Jackson, R.W. (2011). Pseudomonas genomes: diverse and adaptable. FEMS Microbiol Rev 35, 652-680.
Silverman, J.M., Agnello, D.M., Zheng, H., Andrews, B.T., Li, M., Catalano, C.E., Gonen, T., and Mougous, J.D. (2013). Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates. Mol Cell 51, 584-593.
Silverman, J.M., Austin, L.S., Hsu, F., Hicks, K.G., Hood, R.D., and Mougous, J.D. (2011). Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation. Mol Microbiol 82, 1277-1290.
Stathopoulos, C., Hendrixson, D.R., Thanassi, D.G., Hultgren, S.J., St Geme, J.W., 3rd, and Curtiss, R., 3rd (2000). Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes Infect 2, 1061-1072.
Suarez, G., Sierra, J.C., Sha, J., Wang, S., Erova, T.E., Fadl, A.A., Foltz, S.M., Horneman, A.J., and Chopra, A.K. (2008). Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila. Microb Pathog 44, 344-361.
Tseng, T.T., Tyler, B.M., and Setubal, J.C. (2009). Protein secretion systems in bacterial-host associations, and their description in the gene ontology. BMC Microbiol 9 Suppl 1, S2.
Veesler, D., and Cambillau, C. (2011). A common evolutionary origin for tailed-bacteriophage functional modules and bacterial machineries. Microbiol Mol Biol Rev 75, 423-433.
Wang, J., Li, C., Yang, H., Mushegian, A., and Jin, S. (1998a). A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice. J Bacteriol 180, 6764-6768.
Wang, X., Wang, Q., Xiao, J., Liu, Q., Wu, H., Xu, L., and Zhang, Y. (2009). Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish Shellfish Immunol 27, 469-477.
Wang, Y.D., Zhao, S., and Hill, C.W. (1998b). Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli. J Bacteriol 180, 4102-4110.
Whalen, M.C., Innes, R.W., Bent, A.F., and Staskawicz, B.J. (1991). Identification of Pseudomonas syringae pathogens of Arabidopsis and a bacterial locus determining avirulence on both Arabidopsis and soybean. Plant Cell 3, 49-59.
Whitney, J.C., Chou, S., Russell, A.B., Biboy, J., Gardiner, T.E., Ferrin, M.A., Brittnacher, M., Vollmer, W., and Mougous, J.D. (2013). Identification, structure, and function of a novel type VI secretion peptidoglycan glycoside hydrolase effector-immunity pair. J Biol Chem 288, 26616-26624.
Williams, S.G., Varcoe, L.T., Attridge, S.R., and Manning, P.A. (1996). Vibrio cholerae Hcp, a secreted protein coregulated with HlyA. Infect Immun 64, 283-289.
Wu, C.F., Lin, J.S., Shaw, G.C., and Lai, E.M. (2012). Acid-induced type VI secretion system is regulated by ExoR-ChvG/ChvI signaling cascade in Agrobacterium tumefaciens. PLoS Pathog 8, e1002938.
Wu, H.Y., Chung, P.C., Shih, H.W., Wen, S.R., and Lai, E.M. (2008). Secretome analysis uncovers an Hcp-family protein secreted via a type VI secretion system in Agrobacterium tumefaciens. J Bacteriol 190, 2841-2850.
Xin, X.F., and He, S.Y. (2013). Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants. Annu Rev Phytopathol 51, 473-498.
Young, J.M., Takikawa, Y., Gardan, L., and Stead, D. E. (1992). Changing concepts in the taxonomy of plant pathogenic bacteria. Annual Review of Phytopathology 30, 67-105.
Zheng, J., and Leung, K.Y. (2007). Dissection of a type VI secretion system in Edwardsiella tarda. Mol Microbiol 66, 1192-1206.
Zoued, A., Durand, E., Bebeacua, C., Brunet, Y.R., Douzi, B., Cambillau, C., Cascales, E., and Journet, L. (2013). TssK is a trimeric cytoplasmic protein interacting with components of both phage-like and membrane anchoring complexes of the type VI secretion system. J Biol Chem 288, 27031-27041.
Chapter II.
Alcoforado Diniz, J., Liu, Y.C., and Coulthurst, S.J. (2015). Molecular weaponry: diverse effectors delivered by the type VI secretion system. Cell Microbiol 17, 1742-1751.
Basler, M., Ho, B.T., and Mekalanos, J.J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell 152, 884-894.
Basler, M., Pilhofer, M., Henderson, G.P., Jensen, G.J., and Mekalanos, J.J. (2012). Type VI secretion requires a dynamic contractile phage tail-like structure. Nature 483, 182-186.
Bentley, S.D., Chater, K.F., Cerdeno-Tarraga, A.M., Challis, G.L., Thomson, N.R., James, K.D., Harris, D.E., Quail, M.A., Kieser, H., Harper, D., et al. (2002). Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141-147.
Bingle, L.E., Bailey, C.M., and Pallen, M.J. (2008). Type VI secretion: a beginner''s guide. Curr Opin Microbiol 11, 3-8.
Bladergroen, M.R., Badelt, K., and Spaink, H.P. (2003). Infection-blocking genes of a symbiotic Rhizobium leguminosarum strain that are involved in temperature-dependent protein secretion. Mol Plant Microbe Interact 16, 53-64.
Bleves, S., Sana, T.G., and Voulhoux, R. (2014). The target cell genus does not matter. Trends Microbiol 22, 304-306.
Bleves, S., Viarre, V., Salacha, R., Michel, G.P., Filloux, A., and Voulhoux, R. (2010). Protein secretion systems in Pseudomonas aeruginosa: a wealth of pathogenic weapons. Int J Med Microbiol 300, 534-543.
Blokesch, M. (2015). Competence-induced type VI secretion might foster intestinal colonization by Vibrio cholerae: Intestinal interbacterial killing by competence-induced V. cholerae. Bioessays 37, 1163-1168.
Bonemann, G., Pietrosiuk, A., Diemand, A., Zentgraf, H., and Mogk, A. (2009). Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J 28, 315-325.
Borgeaud, S., Metzger, L.C., Scrignari, T., and Blokesch, M. (2015). The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer. Science 347, 63-67.
Boyer, F., Fichant, G., Berthod, J., Vandenbrouck, Y., and Attree, I. (2009). Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources? BMC Genomics 10, 104.
Brunet, Y.R., Khodr, A., Logger, L., Aussel, L., Mignot, T., Rimsky, S., and Cascales, E. (2015). H-NS silencing of the Salmonella pathogenicity island 6-encoded type VI secretion system limits Salmonella enterica serovar Typhimurium interbacterial killing. Infect Immun 83, 2738-2750.
Chow, J., and Mazmanian, S.K. (2010). A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe 7, 265-276.
Costa, T.R., Felisberto-Rodrigues, C., Meir, A., Prevost, M.S., Redzej, A., Trokter, M., and Waksman, G. (2015). Secretion systems in Gram-negative bacteria: structural and mechanistic insights. Nat Rev Microbiol 13, 343-359.
Cui, S., Xiao, J., Wang, Q., and Zhang, Y. (2016). H-NS binding to evpB and evpC and repressing T6SS expression in fish pathogen Edwardsiella piscicida. Arch Microbiol.
Domínguez, D.C., Guragain, M., and Patrauchan, M. (2015). Calcium binding proteins and calcium signaling in prokaryotes. Cell Calcium 57, 151-165.
Durand, E., Cambillau, C., Cascales, E., and Journet, L. (2014). VgrG, Tae, Tle, and beyond: the versatile arsenal of type VI secretion effectors. Trends Microbiol 22, 498-507.
Eijkelkamp, B.A., Stroeher, U.H., Hassan, K.A., Elbourne, L.D., Paulsen, I.T., and Brown, M.H. (2013). H-NS plays a role in expression of Acinetobacter baumannii virulence features. Infect Immun 81, 2574-2583.
Forster, A., Planamente, S., Manoli, E., Lossi, N.S., Freemont, P.S., and Filloux, A. (2014). Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes. J Biol Chem 289, 33032-33043.
Green, E.R., and Mecsas, J. (2016). Bacterial secretion systems: an overview. Microbiol Spectr 4.
Gu, J., Feng, Y., Feng, X., Sun, C., Lei, L., Ding, W., Niu, F., Jiao, L., Yang, M., Li, Y., et al. (2014). Structural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysin. PLoS Pathog 10, e1004109.
Haapalainen, M., Mosorin, H., Dorati, F., Wu, R.F., Roine, E., Taira, S., Nissinen, R., Mattinen, L., Jackson, R., Pirhonen, M., et al. (2012). Hcp2, a secreted protein of the phytopathogen Pseudomonas syringae pv. tomato DC3000, is required for fitness for competition against bacteria and yeasts. J Bacteriol 194, 4810-4822.
Hachani, A., Allsopp, L.P., Oduko, Y., and Filloux, A. (2014). The VgrG proteins are "à la carte" delivery systems for bacterial type VI effectors. J Biol Chem 289, 17872-17884.
Hachani, A., Wood, T.E., and Filloux, A. (2016). Type VI secretion and anti-host effectors. Curr Opin Microbiol 29, 81-93.
Hood, R.D., Singh, P., Hsu, F., Guvener, T., Carl, M.A., Trinidad, R.R., Silverman, J.M., Ohlson, B.B., Hicks, K.G., Plemel, R.L., et al. (2010). A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria. Cell Host Microbe 7, 25-37.
Huynh, T.V., Dahlbeck, D., and Staskawicz, B.J. (1989). Bacterial blight of soybean: regulation of a pathogen gene determining host cultivar specificity. Science 245, 1374-1377.
Jiang, F., Waterfield, N.R., Yang, J., Yang, G., and Jin, Q. (2014). A Pseudomonas aeruginosa type VI secretion phospholipase D effector targets both prokaryotic and eukaryotic cells. Cell Host Microbe 15, 600-610.
Jobichen, C., Chakraborty, S., Li, M., Zheng, J., Joseph, L., Mok, Y.K., Leung, K.Y., and Sivaraman, J. (2010). Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda. PLoS One 5, e12910.
Kapitein, N., Bonemann, G., Pietrosiuk, A., Seyffer, F., Hausser, I., Locker, J.K., and Mogk, A. (2013). ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion. Mol Microbiol 87, 1013-1028.
Kieser, T., Bibb, M. J., Buttner, M. J., Chater, K. F., and Hopwood, D. A. (2000). Practical Streptomyces Genetics (Norwich, England: The John Innes Foundation).
King, E.O., Ward, M.K., and Raney, D.E. (1954). Two simple media for the demonstration of pyocyanin and fluorescin. J Lab Clin Med 44, 301-307.
Lin, J.S., Ma, L.S., and Lai, E.M. (2013). Systematic dissection of the Agrobacterium type VI secretion system reveals machinery and secreted components for subcomplex formation. PLoS One 8, e67647.
Lin, J.S., Wu, H.H., Hsu, P.H., Ma, L.S., Pang, Y.Y., Tsai, M.D., and Lai, E.M. (2014). Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens. PLoS Pathog 10, e1003991.
Lopilato, J.E., Garwin, J.L., Emr, S.D., Silhavy, T.J., and Beckwith, J.R. (1984). D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. J Bacteriol 158, 665-673.
McCarter, S.M., Jones, J. B., Gitaitis, R. D. and Smitley, D. R. (1983). Survival of Pseudomonas syringae pv. tomato in association with tomato seed, soil, host tissue, and epiphytic weed hosts in Georgia. Phytopathology 73, 6.
Michiels, J., Xi, C., Verhaert, J., and Vanderleyden, J. (2002). The functions of Ca(2+) in bacteria: a role for EF-hand proteins? Trends Microbiol 10, 87-93.
Mougous, J.D., Cuff, M.E., Raunser, S., Shen, A., Zhou, M., Gifford, C.A., Goodman, A.L., Joachimiak, G., Ordonez, C.L., Lory, S., et al. (2006). A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. Science 312, 1526-1530.
Mougous, J.D., Gifford, C.A., Ramsdell, T.L., and Mekalanos, J.J. (2007). Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nat Cell Biol 9, 797-803.
Navarre, W.W., McClelland, M., Libby, S.J., and Fang, F.C. (2007). Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA. Genes Dev 21, 1456-1471.
Nelson, M.S., and Sadowsky, M.J. (2015). Secretion systems and signal exchange between nitrogen-fixing rhizobia and legumes. Front Plant Sci 6, 491.
Planamente, S., Salih, O., Manoli, E., Albesa-Jove, D., Freemont, P.S., and Filloux, A. (2016). TssA forms a gp6-like ring attached to the type VI secretion sheath. EMBO J 35, 1613-1627.
Pukatzki, S., Ma, A.T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W.C., Heidelberg, J.F., and Mekalanos, J.J. (2006). Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 103, 1528-1533.
Rico, A., and Preston, G.M. (2008). Pseudomonas syringae pv. tomato DC3000 uses constitutive and apoplast-induced nutrient assimilation pathways to catabolize nutrients that are abundant in the tomato apoplast. Mol Plant Microbe Interact 21, 269-282.
Russell, A.B., Hood, R.D., Bui, N.K., LeRoux, M., Vollmer, W., and Mougous, J.D. (2011). Type VI secretion delivers bacteriolytic effectors to target cells. Nature 475, 343-347.
Russell, A.B., LeRoux, M., Hathazi, K., Agnello, D.M., Ishikawa, T., Wiggins, P.A., Wai, S.N., and Mougous, J.D. (2013). Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors. Nature 496, 508-512.
Russell, A.B., Peterson, S.B., and Mougous, J.D. (2014). Type VI secretion system effectors: poisons with a purpose. Nat Rev Microbiol 12, 137-148.
Russell, A.B., Singh, P., Brittnacher, M., Bui, N.K., Hood, R.D., Carl, M.A., Agnello, D.M., Schwarz, S., Goodlett, D.R., Vollmer, W., et al. (2012). A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host Microbe 11, 538-549.
Ryu, C.M. (2015). Against friend and foe: type 6 effectors in plant-associated bacteria. J Microbiol 53, 201-208.
Sabala, I., Jagielska, E., Bardelang, P.T., Czapinska, H., Dahms, S.O., Sharpe, J.A., James, R., Than, M.E., Thomas, N.R., and Bochtler, M. (2014). Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans. FEBS J 281, 4112-4122.
Salomon, D., Klimko, J.A., and Orth, K. (2014). H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1. Microbiology 160, 1867-1873.
Salomon, D., Klimko, J.A., Trudgian, D.C., Kinch, L.N., Grishin, N.V., Mirzaei, H., and Orth, K. (2015). Type VI secretion system toxins horizontally shared between marine bacteria. PLoS Pathog 11, e1005128.
Sana, T.G., Hachani, A., Bucior, I., Soscia, C., Garvis, S., Termine, E., Engel, J., Filloux, A., and Bleves, S. (2012). The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells. J Biol Chem 287, 27095-27105.
Sarris, P.F., Skandalis, N., Kokkinidis, M., and Panopoulos, N.J. (2010). In silico analysis reveals multiple putative type VI secretion systems and effector proteins in Pseudomonas syringae pathovars. Mol Plant Pathol 11, 795-804.
Schafer, A., Tauch, A., Jager, W., Kalinowski, J., Thierbach, G., and Puhler, A. (1994). Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145, 69-73.
Shneider, M.M., Buth, S.A., Ho, B.T., Basler, M., Mekalanos, J.J., and Leiman, P.G. (2013). PAAR-repeat proteins sharpen and diversify the type VI secretion system spike. Nature 500, 350-353.
Silverman, J.M., Agnello, D.M., Zheng, H., Andrews, B.T., Li, M., Catalano, C.E., Gonen, T., and Mougous, J.D. (2013). Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates. Mol Cell 51, 584-593.
Stauber, J.L., Loginicheva, E., and Schechter, L.M. (2012). Carbon source and cell density-dependent regulation of type III secretion system gene expression in Pseudomonas syringae pathovar tomato DC3000. Res Microbiol 163, 531-539.
Unterweger, D., Kitaoka, M., Miyata, S.T., Bachmann, V., Brooks, T.M., Moloney, J., Sosa, O., Silva, D., Duran-Gonzalez, J., Provenzano, D., et al. (2012). Constitutive type VI secretion system expression gives Vibrio cholerae intra- and interspecific competitive advantages. PLoS One 7, e48320.
Whitney, J.C., Beck, C.M., Goo, Y.A., Russell, A.B., Harding, B.N., De Leon, J.A., Cunningham, D.A., Tran, B.Q., Low, D.A., Goodlett, D.R., et al. (2014). Genetically distinct pathways guide effector export through the type VI secretion system. Mol Microbiol 92, 529-542.
Whitney, J.C., Quentin, D., Sawai, S., LeRoux, M., Harding, B.N., Ledvina, H.E., Tran, B.Q., Robinson, H., Goo, Y.A., Goodlett, D.R., et al. (2015). An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells. Cell 163, 607-619.
Xin, X.F., and He, S.Y. (2013). Pseudomonas syringae pv. tomato DC3000: a model pathogen for probing disease susceptibility and hormone signaling in plants. Annu Rev Phytopathol 51, 473-498.
Yanez, M., Gil-Longo, J., and Campos-Toimil, M. (2012). Calcium binding proteins. Adv Exp Med Biol 740, 461-482.
Zheng, J., Ho, B., and Mekalanos, J.J. (2011). Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in Vibrio cholerae. PLoS One 6, e23876.
Zheng, J., and Leung, K.Y. (2007). Dissection of a type VI secretion system in Edwardsiella tarda. Mol Microbiol 66, 1192-1206.
Zoued, A., Brunet, Y.R., Durand, E., Aschtgen, M.S., Logger, L., Douzi, B., Journet, L., Cambillau, C., and Cascales, E. (2014). Architecture and assembly of the Type VI secretion system. Biochim Biophys Acta 1843, 1664-1673.
Chapter III.
Anderson, M.C., Vonaesch, P., Saffarian, A., Marteyn, B.S., and Sansonetti, P.J. (2017). Shigella sonnei encodes a functional T6SS esed for interbacterial competition and niche occupancy. Cell Host Microbe 21, 769-776.
Balleza, E., Lopez-Bojorquez, L.N., Martinez-Antonio, A., Resendis-Antonio, O., Lozada-Chavez, I., Balderas-Martinez, Y.I., Encarnacion, S., and Collado-Vides, J. (2009). Regulation by transcription factors in bacteria: beyond description. FEMS Microbiol Rev 33, 133-151.
Basler, M., Ho, B.T., and Mekalanos, J.J. (2013). Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell 152, 884-894.
Bernard, C.S., Brunet, Y.R., Gavioli, M., Lloubes, R., and Cascales, E. (2011). Regulation of type VI secretion gene clusters by sigma54 and cognate enhancer binding proteins. J Bacteriol 193, 2158-2167.
Blokesch, M. (2015). Competence-induced type VI secretion might foster intestinal colonization by Vibrio cholerae: Intestinal interbacterial killing by competence-induced V. cholerae. Bioessays 37, 1163-1168.
Bordi, C., Lamy, M.C., Ventre, I., Termine, E., Hachani, A., Fillet, S., Roche, B., Bleves, S., Mejean, V., Lazdunski, A., et al. (2010). Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis. Mol Microbiol 76, 1427-1443.
Brencic, A., and Lory, S. (2009). Determination of the regulon and identification of novel mRNA targets of Pseudomonas aeruginosa RsmA. Mol Microbiol 72, 612-632.
Brencic, A., McFarland, K.A., McManus, H.R., Castang, S., Mogno, I., Dove, S.L., and Lory, S. (2009). The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Mol Microbiol 73, 434-445.
Brunet, Y.R., Bernard, C.S., Gavioli, M., Lloubes, R., and Cascales, E. (2011). An epigenetic switch involving overlapping fur and DNA methylation optimizes expression of a type VI secretion gene cluster. PLoS Genet 7, e1002205.
Brunet, Y.R., Khodr, A., Logger, L., Aussel, L., Mignot, T., Rimsky, S., and Cascales, E. (2015). H-NS silencing of the Salmonella pathogenicity island 6-encoded type VI secretion system limits Salmonella enterica serovar Typhimurium interbacterial killing. Infect Immun 83, 2738-2750.
Carrica Mdel, C., Fernandez, I., Sieira, R., Paris, G., and Goldbaum, F.A. (2013). The two-component systems PrrBA and NtrYX co-ordinately regulate the adaptation of Brucella abortus to an oxygen-limited environment. Mol Microbiol 88, 222-233.
Casabona, M.G., Silverman, J.M., Sall, K.M., Boyer, F., Coute, Y., Poirel, J., Grunwald, D., Mougous, J.D., Elsen, S., and Attree, I. (2013). An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in Pseudomonas aeruginosa. Environ Microbiol 15, 471-486.
Cases, I., and de Lorenzo, V. (2005). Promoters in the environment: transcriptional regulation in its natural context. Nat Rev Microbiol 3, 105-118.
Cases, I., de Lorenzo, V., and Ouzounis, C.A. (2003). Transcription regulation and environmental adaptation in bacteria. Trends Microbiol 11, 248-253.
Castang, S., McManus, H.R., Turner, K.H., and Dove, S.L. (2008). H-NS family members function coordinately in an opportunistic pathogen. Proc Natl Acad Sci U S A 105, 18947-18952.
Cathelyn, J.S., Crosby, S.D., Lathem, W.W., Goldman, W.E., and Miller, V.L. (2006). RovA, a global regulator of Yersinia pestis, specifically required for bubonic plague. Proc Natl Acad Sci U S A 103, 13514-13519.
Chatterjee, A., Cui, Y., Hasegawa, H., and Chatterjee, A.K. (2007). PsrA, the Pseudomonas sigma regulator, controls regulators of epiphytic fitness, quorum-sensing signals, and plant interactions in Pseudomonas syringae pv. tomato strain DC3000. Appl Environ Microbiol 73, 3684-3694.
Chatterjee, A., Cui, Y., Yang, H., Collmer, A., Alfano, J.R., and Chatterjee, A.K. (2003). GacA, the response regulator of a two-component system, acts as a master regulator in Pseudomonas syringae pv. tomato DC3000 by controlling regulatory RNA, transcriptional activators, and alternate sigma factors. Mol Plant Microbe Interact 16, 1106-1117.
Chen, L., Zou, Y., She, P., and Wu, Y. (2015). Composition, function, and regulation of T6SS in Pseudomonas aeruginosa. Microbiol Res 172, 19-25.
Chow, J., and Mazmanian, S.K. (2010). A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe 7, 265-276.
Cui, S., Xiao, J., Wang, Q., and Zhang, Y. (2016). H-NS binding to evpB and evpC and repressing T6SS expression in fish pathogen Edwardsiella piscicida. Arch Microbiol 198, 653-661.
D''Argenio, D.A., and Miller, S.I. (2004). Cyclic di-GMP as a bacterial second messenger. Microbiology 150, 2497-2502.
Dong, T.G., and Mekalanos, J.J. (2012). Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52. Nucleic Acids Res 40, 7766-7775.
Dudley, E.G., Thomson, N.R., Parkhill, J., Morin, N.P., and Nataro, J.P. (2006). Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli. Mol Microbiol 61, 1267-1282.
Goodman, A.L., Kulasekara, B., Rietsch, A., Boyd, D., Smith, R.S., and Lory, S. (2004). A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev Cell 7, 745-754.
Goodman, A.L., Merighi, M., Hyodo, M., Ventre, I., Filloux, A., and Lory, S. (2009). Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen. Genes Dev 23, 249-259.
Green, E.R., and Mecsas, J. (2016). Bacterial secretion systems: an overview. Microbiol Spectr 4.
Haapalainen, M., Mosorin, H., Dorati, F., Wu, R.F., Roine, E., Taira, S., Nissinen, R., Mattinen, L., Jackson, R., Pirhonen, M., et al. (2012). Hcp2, a secreted protein of the phytopathogen Pseudomonas syringae pv. tomato DC3000, is required for fitness for competition against bacteria and yeasts. J Bacteriol 194, 4810-4822.
Hudaiberdiev, S., Choudhary, K.S., Vera Alvarez, R., Gelencser, Z., Ligeti, B., Lamba, D., and Pongor, S. (2015). Census of solo LuxR genes in prokaryotic genomes. Front Cell Infect Microbiol 5, 20.
Ishikawa, T., Rompikuntal, P.K., Lindmark, B., Milton, D.L., and Wai, S.N. (2009). Quorum sensing regulation of the two hcp alleles in Vibrio cholerae O1 strains. PLoS One 4, e6734.
Joshi, A., Kostiuk, B., Rogers, A., Teschler, J., Pukatzki, S., and Yildiz, F.H. (2017). Rules of engagement: the type VI secretion system in Vibrio cholerae. Trends Microbiol 25, 267-279.
Kapitein, N., and Mogk, A. (2014). Type VI secretion system helps find a niche. Cell Host Microbe 16, 5-6.
Kim, J., Lee, J.Y., Lee, H., Choi, J.Y., Kim, D.H., Wi, Y.M., Peck, K.R., and Ko, K.S. (2017). Microbiological features and clinical impact of the type VI secretion system (T6SS) in Acinetobacter baumannii isolates causing bacteremia. Virulence, 1-12.
Kitaoka, M., Miyata, S.T., Brooks, T.M., Unterweger, D., and Pukatzki, S. (2011). VasH is a transcriptional regulator of the type VI secretion system functional in endemic and pandemic Vibrio cholerae. J Bacteriol 193, 6471-6482.
Leonard, S., Hommais, F., Nasser, W., and Reverchon, S. (2017). Plant-phytopathogen interactions: bacterial responses to environmental and plant stimuli. Environ Microbiol 19, 1689-1716.
Lesic, B., Starkey, M., He, J., Hazan, R., and Rahme, L.G. (2009). Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis. Microbiology 155, 2845-2855.
Lin, J.S., Wu, H.H., Hsu, P.H., Ma, L.S., Pang, Y.Y., Tsai, M.D., and Lai, E.M. (2014). Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens. PLoS Pathog 10, e1003991.
Lucchini, S., Rowley, G., Goldberg, M.D., Hurd, D., Harrison, M., and Hinton, J.C. (2006). H-NS mediates the silencing of laterally acquired genes in bacteria. PLoS Pathog 2, e81.
Lv, Y., Xiao, J., Liu, Q., Wu, H., Zhang, Y., and Wang, Q. (2012). Systematic mutation analysis of two-component signal transduction systems reveals EsrA-EsrB and PhoP-PhoQ as the major virulence regulators in Edwardsiella tarda. Vet Microbiol 157, 190-199.
Mesbah, N.M., and Wiegel, J. (2012). Life under multiple extreme conditions: diversity and physiology of the halophilic alkalithermophiles. Appl Environ Microbiol 78, 4074-4082.
Moscoso, J.A., Mikkelsen, H., Heeb, S., Williams, P., and Filloux, A. (2011). The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling. Environ Microbiol 13, 3128-3138.
Mougous, J.D., Gifford, C.A., Ramsdell, T.L., and Mekalanos, J.J. (2007). Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Nat Cell Biol 9, 797-803.
Navarre, W.W., McClelland, M., Libby, S.J., and Fang, F.C. (2007). Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA. Genes Dev 21, 1456-1471.
Papenfort, K., and Bassler, B.L. (2016). Quorum sensing signal-response systems in Gram-negative bacteria. Nat Rev Microbiol 14, 576-588.
Pukatzki, S., Ma, A.T., Sturtevant, D., Krastins, B., Sarracino, D., Nelson, W.C., Heidelberg, J.F., and Mekalanos, J.J. (2006). Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Proc Natl Acad Sci U S A 103, 1528-1533.
Records, A.R., and Gross, D.C. (2010). Sensor kinases RetS and LadS regulate Pseudomonas syringae type VI secretion and virulence factors. J Bacteriol 192, 3584-3596.
Renzi, F., Rescalli, E., Galli, E., and Bertoni, G. (2010). Identification of genes regulated by the MvaT-like paralogues TurA and TurB of Pseudomonas putida KT2440. Environ Microbiol 12, 254-263.
Sana, T.G., Flaugnatti, N., Lugo, K.A., Lam, L.H., Jacobson, A., Baylot, V., Durand, E., Journet, L., Cascales, E., and Monack, D.M. (2016). Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut. Proc Natl Acad Sci U S A 113, E5044-E5051.
Sana, T.G., Hachani, A., Bucior, I., Soscia, C., Garvis, S., Termine, E., Engel, J., Filloux, A., and Bleves, S. (2012). The second type VI secretion system of Pseudomonas aeruginosa strain PAO1 is regulated by quorum sensing and Fur and modulates internalization in epithelial cells. J Biol Chem 287, 27095-27105.
Sana, T.G., Soscia, C., Tonglet, C.M., Garvis, S., and Bleves, S. (2013). Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa. PLoS One 8, e76030.
Schafer, A., Tauch, A., Jager, W., Kalinowski, J., Thierbach, G., and Puhler, A. (1994). Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145, 69-73.
Schell, M.A., Ulrich, R.L., Ribot, W.J., Brueggemann, E.E., Hines, H.B., Chen, D., Lipscomb, L., Kim, H.S., Mrazek, J., Nierman, W.C., et al. (2007). Type VI secretion is a major virulence determinant in Burkholderia mallei. Mol Microbiol 64, 1466-1485.
Schroder, O., and Wagner, R. (2000). The bacterial DNA-binding protein H-NS represses ribosomal RNA transcription by trapping RNA polymerase in the initiation complex. J Mol Biol 298, 737-748.
Silverman, J.M., Austin, L.S., Hsu, F., Hicks, K.G., Hood, R.D., and Mougous, J.D. (2011). Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation. Mol Microbiol 82, 1277-1290.
Stauber, J.L., Loginicheva, E., and Schechter, L.M. (2012). Carbon source and cell density-dependent regulation of type III secretion system gene expression in Pseudomonas syringae pathovar tomato DC3000. Res Microbiol 163, 531-539.
Studholme, D.J., and Dixon, R. (2003). Domain architectures of sigma54-dependent transcriptional activators. J Bacteriol 185, 1757-1767.
Sun, F., Zhang, Y., Qiu, Y., Yang, H., Yang, W., Yin, Z., Wang, J., Yang, R., Xia, P., and Zhou, D. (2014). H-NS is a repressor of major virulence gene loci in Vibrio parahaemolyticus. Front Microbiol 5, 675.
Tischler, A.D., and Camilli, A. (2004). Cyclic diguanylate (c-di-GMP) regulates Vibrio cholerae biofilm formation. Mol Microbiol 53, 857-869.
Totten, P.A., Lara, J.C., and Lory, S. (1990). The rpoN gene product of Pseudomonas aeruginosa is required for expression of diverse genes, including the flagellin gene. J Bacteriol 172, 389-396.
Wang, X., Wang, Q., Xiao, J., Liu, Q., Wu, H., Xu, L., and Zhang, Y. (2009). Edwardsiella tarda T6SS component evpP is regulated by esrB and iron, and plays essential roles in the invasion of fish. Fish Shellfish Immunol 27, 469-477.
Weber, B.S., Hennon, S.W., Wright, M.S., Scott, N.E., de Berardinis, V., Foster, L.J., Ayala, J.A., Adams, M.D., and Feldman, M.F. (2016). Genetic Dissection of the Type VI Secretion System in Acinetobacter and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis. MBio 7, e01253-01216.
Wu, C.F., Lin, J.S., Shaw, G.C., and Lai, E.M. (2012). Acid-induced type VI secretion system is regulated by ExoR-ChvG/ChvI signaling cascade in Agrobacterium tumefaciens. PLoS Pathog 8, e1002938.
Zheng, J., Tung, S.L., and Leung, K.Y. (2005). Regulation of a type III and a putative secretion system in Edwardsiella tarda by EsrC is under the control of a two-component system, EsrA-EsrB. Infect Immun 73, 4127-4137.
Zoued, A., Brunet, Y.R., Durand, E., Aschtgen, M.S., Logger, L., Douzi, B., Journet, L., Cambillau, C., and Cascales, E. (2014). Architecture and assembly of the Type VI secretion system. Biochim Biophys Acta 1843, 1664-1673.
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