(3.238.7.202) 您好!臺灣時間:2021/03/02 00:39
字體大小: 字級放大   字級縮小   預設字形  
回查詢結果

詳目顯示:::

我願授權國圖
: 
twitterline
研究生:何嘉浚
研究生(外文):Chia Chun Hor
論文名稱:中腦環導水管灰質中催產素系統在小鼠緊張導致止痛之角色
論文名稱(外文):The role of the oxytocin system in the periaqueductal gray in stress-induced analgesia in mice
指導教授:邱麗珠邱麗珠引用關係
指導教授(外文):Lih-Chu Chiou
口試日期:2017-07-25
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:英文
論文頁數:82
中文關鍵詞:催產素內生性大麻酯系統中腦環導水管灰質緊張所致的止痛反應
外文關鍵詞:oxytocinendocannabinoid systemperiaqueductal graystress-induced analgesia
相關次數:
  • 被引用被引用:0
  • 點閱點閱:208
  • 評分評分:系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔系統版面圖檔
  • 下載下載:0
  • 收藏至我的研究室書目清單書目收藏:0
催產素(oxytocin)為腦下垂體釋放出的荷爾蒙之一,會在分娩和哺乳期間大量釋放。同時,催產素在中樞系統中也具有神經傳導物質的功能,可以透過活化催產素受器(oxytocin receptor, OTR),一種屬於Gq蛋白偶合受器家族的受器,進行神經元之間的訊息傳遞。Oxytocin具有調節社交行為和非社交行為的作用;其中非社交行為包括食慾、痛覺、壓力所誘導之成癮藥物的復發行為和緊張所致的止痛反應(stress-induced analgesia, SIA)。SIA是當人類或動物緊張時痛覺感受程度降低的一種現象。藥物產生的止痛作用或是緊張所致的止痛反應皆由負責下行性疼痛抑制訊息的中腦環導水管灰質(periaqueductal gray, PAG)腦區所調控,抑制中腦環導水管灰質神經細胞的GABA transmission可以活化下行性疼痛抑制路徑達到止痛效果。有研究指出壓力下或是緊張時,下視丘的oxytocin神經細胞會釋放oxytocin到大腦和脊髓中。目前已知,脊髓中的oxytocin具有止痛作用也貢獻於SIA,而大腦中的oxytocin還未被發現是否有貢獻於SIA中。催產素和血管加壓素,另一種由腦下垂體釋放的神經胜肽/荷爾蒙,會與OTR和血管加壓素受器(vasopressin receptor)結合。過去有電生理的研究顯示,在下視丘的神經細胞發現oxytocin 可活化突觸後的OTR,藉此活化phospholipase C (PLC)的訊息傳遞途徑,繼而促進內生性大麻酯分子(endocannabinoids)的生成。這些內生性大麻酯分子會逆行活化位於突觸前的CB1R,進而抑制GABA釋放。在大鼠的研究也發現將oxytocin直接注入腦室或是不同的腦區會產生止痛作用,可是其作用機制目前還是未知。
因此,我們在這篇論文中使用藥理學和行為的方式驗證(1)緊張時中腦環導水管灰質腹外側區(ventrolateral periaqueductal gray, vlPAG)oxytocin系統是否有參與SIA、(2)活化vlPAG中的OTR是否可以產生止痛作用、(3)活化OTR產生的止痛作用是否經由內生性大麻酯系統所媒介、(4)活化OTR產生的止痛作用是否為鴉片系統依賴性的反應。
我們發現給予小鼠束縛壓力後其縮腳潛伏期(paw withdrawal latency)有明顯增長,確認了緊張時會產生止痛反應。在實驗中的緊張所致止痛作用可以藉由先在腹腔或是vlPAG投與L-368,899(OTR拮抗劑)抑制掉,而其使用劑量並不影響小鼠的活動能力。第二,經束縛壓力處理過的小鼠相較於控制組,其vlPAG均質液中oxytocin胜肽量有明顯增加。由免疫螢光染色結果發現小鼠下視丘oxytocin神經細胞經由束縛壓力處理後有被激活的趨勢。以上的結果顯示緊張時有成功誘導止痛反應,這止痛作用可能來自於緊張時釋放到vlPAG中的oxytocin活化OTR的結果。第三,我們在vlPAG內注射不同劑量的oxytocin(0.01-1 nmol;i.pag.)。在只有0.1 nmol oxytocin劑量下產生具有止痛效果的趨勢,然而在1 nmol劑量則出現pronociception。第四,在vlPAG內注射不同劑量的TGOT(OTR活化劑)皆具有止痛效果,而其縮腳潛伏期呈現鐘形劑量反應曲線。0.03 nmol TGOT劑量下產生最顯著止痛反應而小鼠的活動能力也不受影響,且0.03 nmol TGOT(i.pag.)下產生的止痛可以被經由vlPAG注射L-368,899所抑制。第五,由於vlPAG注射TGOT產生的止痛反應能被AM251(CB1受器拮抗劑;i.pag.)和naloxone(鴉片類受器拮抗劑;i.pag.)所阻斷,指出CB1R和opioid receptors皆參與在TGOT的止痛作用中。
本篇論文的實驗結果可以推測出活化vlPAG中的OTR可以產生顯著的止痛作用,所產生的止痛作用主要由內生性大麻酯與部分鴉片類所媒介。活化OTR產生止痛反應的途徑可能有貢獻於束縛壓力誘導的緊張所致止痛作用。
Oxytocin is a well-known pituitary hormone involved in parturition, lactation and maternal care. It also acts as a neurotransmitter through the oxytocin receptor (OTR), a GqPCR family, playing a pivotal role in both social bonding and non-social behaviours. The latter encompasses feeding, pain perception and several stress-induced responses, such as stress-induced drug reinstatement and stress-induced analgesia (SIA). SIA is a phenomenon whereby the pain sensation of the subject is suppressed upon exposure to stressful stimuli. Either drug-induced analgesic effect or SIA is mediated by the descending pain inhibitory pathway where the midbrain periaqueductal gray (PAG) is the major integrating hub at the supraspinal level, inhibition of the GABA transmission in PAG leads to the activation of descending pain inhibitory pathway. It has been shown that stress can activate the hypothalamic oxytocin neurons and release oxytocin into the brain and the spinal cord. Oxytocin has been reported to be antinociceptive at the spinal level, contributing SIA. However, it remains unclear whether oxytocin can at the supraspinal level to mediate SIA. Oxytocin and vasopressin, another pituitary neuropeptide/hormone, have cross interactions with OTRs and vasopressin receptors. An electrophysiological study has showed that in hypothalamic neurons, activating postsynaptic OTRs can inhibit GABA release via generating endocannabinoid that engages retrogradely at presynaptic cannabinoid 1 (CB1) receptors. In rats, there were some studies showing that oxytocin was antinociceptive when given at the supraspinal level while the underlying mechanism(s) remain confusing.
Collectively, in this study we elucidated (i) the contribution of the oxytocin system in SIA, (ii) the anti-nociceptive effect of OTR activation in the mouse ventrolateral-PAG (vlPAG), (iii) whether the OTR-induced antinociception is an endocannabinoid-dependent effect, and (iv) whether the OTR-induced antinociception interacts with the opioid system, using pharmacological and behavioural approaches.
We found that mice receiving a 30-minute restraint stress showed significantly longer hot-plate latency and higher oxytocin levels in the vlPAG than unrestrained mice. This SIA was prevented by either intraperitoneal (i.p) or intra-periaqueductal gray (i.pag.) microinjection of L-368,899 at doses that did not affect the spontaneous locomotor function. These results suggest that SIA is successfully established and this SIA is possibly due to elevated oxytocin acting at OTRs in the vlPAG. Next, we performed i.pag. microinjection of a broad range (0.001-1nmol) of synthetic oxytocin in mice. Unexpectedly, oxytocin (i.pag.) only at 0.1 nmol produced a marginal antinociception while at 1 nmol displayed pronociceptive effect. We, therefore, further examined effects of TGOT, an OTR-selective agonist, on the mouse hot-plate test. TGOT was antinociceptive at all tested doses, while produced a bell-shape dose-response curve in increasing the hot-plate latency, with the maximal antinociceptive effect at 0.03 nmol (i,pag.). This antinociceptive effect was blocked by i.pag. pretreatment with that antagonist of OTRs (L-368,899), CB1Rs (AM251) and non-selective opioid receptors (naloxone)., suggesting the OTR, CB1R and opioid receptors in the vlPAG are involved in the antinociceptive effect of TGOT.
These results suggest that activating the OTRs in the vlPAG induces a significant antinociceptive effect, which is mainly mediated by endocannabinoids and also partially opioid-dependent. This antinociceptive effect may contribute to SIA induced by restraint stress.
口試委員會審定書。。。i
致謝。。。。。。。。。ii
Abbreviation。。。。。iv
中文摘要。。。。。。。vi
Abstract。。。。。。。viii
Introduction。。。。。1
Aims。。。。。。。。。17
Materials and Methods。18
Results。。。。。。。。25
Discussions。。。。。。35
Conclusions。。。。。。44
Tables。。。。。。。。。45
Figures。。。。。。。。49
References。。。。。。65
Agren G, Uvnas-Moberg K, Lundeberg T (1997) Olfactory cues from an oxytocin-injected male rat can induce anti-nociception in its cagemates. Neuroreport 8:3073-3076.
Aimone LD, Bauer CA, Gebhart GF (1988) Brain-stem relays mediating stimulation-produced antinociception from the lateral hypothalamus in the rat. The Journal of Neuroscience 8:2652-2663.
Bagdas D, Yucel-Ozboluk H, Orhan F, Kanat O, Isbil-Buyukcoskun N, Gurun MS (2013) Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain. Neuroreport 24:941-946.
Basbaum AI, Fields HL (1979) The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. The Journal of Comparative Neurology 187:513-531.
Beecher HK (1946) Pain in Men Wounded in Battle. Annals of Surgery 123:96-105.
Behbehani MM (1995) Functional characteristics of the midbrain periaqueductal gray. Progress in Neurobiology 46:575-605.
Beitz AJ (1985) The midbrain periaqueductal gray in the rat. I. Nuclear volume, cell number, density, orientation, and regional subdivisions. The Journal of Comparative Neurology 237:445-459.
Beitz AJ, Shepard RD (1985) The midbrain periaqueductal gray in the rat. II. A Golgi analysis. The Journal of Comparative Neurology 237:460-475.
Bellgowan PS, Helmstetter FJ (1996) Neural systems for the expression of hypoalgesia during nonassociative fear. Behavioral Neuroscience 110:727-736.
Bodnar RJ, Kelly DD, Spiaggia A, Ehrenberg C, Glusman M (1978) Dose-dependent reductions by naloxone of analgesia induced by cold-water stress. Pharmacology, Biochemistry, and Behavior 8:667-672.
Bodnar RJ, Truesdell LS, Haldar J, Aral IA, Kordower JH, Nilaver G (1986) Elimination of vasopressin analgesia following lesions placed in the rat hypothalamic paraventricular nucleus. Peptides 7:111-117.
Bonaz B, Rivest S (1998) Effect of a chronic stress on CRF neuronal activity and expression of its type 1 receptor in the rat brain. American Journal of Physiology 275:R1438-1449.
Brenowitz SD, Regehr WG (2003) Calcium dependence of retrograde inhibition by endocannabinoids at synapses onto Purkinje cells. The Journal of Neuroscience 23:6373-6384.
Buijs RM (1978) Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord. Cell and Tissue Research 192:423-435.
Busnelli M, Bulgheroni E, Manning M, Kleinau G, Chini B (2013) Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors. Journal of Pharmacology and Experimental Therapeutics 346:318-327.
Butler RK, Finn DP (2009) Stress-induced analgesia. Progress in Neurobiology 88:184-202.
Caldwell JD, Hruby VJ, Hill P, Prange AJ, Jr., Pedersen CA (1986) Is oxytocin-induced grooming mediated by uterine-like receptors? Neuropeptides 8:77-86.
Ceccatelli S, Villar MJ, Goldstein M, Hokfelt T (1989) Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress. Proceedings of the National Academy of Sciences of the United States of America 86:9569-9573.
Cechetto DF, Saper CB (1988) Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. The Journal of Comparative Neurology 272:579-604.
Chesher GB, Chan B (1977) Footshock induced analgesia in mice: its reversal by naloxone and cross tolerance with morphine. Life Sciences 21:1569-1574.
Chieng B, Christie MJ (1994a) Inhibition by opioids acting on mu-receptors of GABAergic and glutamatergic postsynaptic potentials in single rat periaqueductal gray neurones in vitro. British Journal of Pharmacology 113:303-309.
Chieng B, Christie MJ (1994b) Hyperpolarization by opioids acting on mu-receptors of a sub-population of rat periaqueductal gray neurones in vitro. British Journal of Pharmacology 113:121-128.
Chini B, Mouillac B, Balestre MN, Trumpp-Kallmeyer S, Hoflack J, Hibert M, Andriolo M, Pupier S, Jard S, Barberis C (1996) Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin. FEBS Letters 397:201-206.
Chiu YC, Chiou LC (2014) A Novel Mechanism of stress-induced analgesia: Involvement of Orexin, Substance P and mGluR5. Master thesis.
Chiu YT, Chiou LC (2015) A leading role of neuropeptide S in SIA. Master thesis.
Christie MJ, Connor M, Vaughan CW, Ingram SL, Bagley EE (2000) Cellular actions of opioids and other analgesics: implications for synergism in pain relief. Clinical and Experimental Pharmacology & Physiology 27:520-523.
Cohen JL, Ata AE, Jackson NL, Rahn EJ, Ramaker RC, Cooper S, Kerman IA, Clinton SM (2017) Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats. Behavioral Brain Research 319:110-123.
Costa A, Smeraldi A, Tassorelli C, Greco R, Nappi G (2005) Effects of acute and chronic restraint stress on nitroglycerin-induced hyperalgesia in rats. Neuroscience Letters 383:7-11.
Cross SA (1994) Pathophysiology of pain. Mayo Clinic Proceedings 69:375-383.
Cullinan WE, Herman JP, Battaglia DF, Akil H, Watson SJ (1995) Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience 64:477-505.
Dale HH (1906) On some physiological actions of ergot. The Journal of Physiology 34:163-206.
de Kloet ER, Joels M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nature Reviews Neuroscience 6:463-475.
Deblon N, Veyrat-Durebex C, Bourgoin L, Caillon A, Bussier AL, Petrosino S, Piscitelli F, Legros JJ, Geenen V, Foti M, Wahli W, Di Marzo V, Rohner-Jeanrenaud F (2011) Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PloS One 6:e25565.
Delanoy RL, Dunn AJ, Tintner R (1978) Behavioral responses to intracerebroventricularly administered neurohypophyseal peptides in mice. Hormones and Behavior 11:348-362.
Du Vigneaud V, Ressler C, Trippett S (1953) The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. Journal of Biological Chemistry 205:949-957.
Elands J, Barberis C, Jard S (1988) [3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors. American Journal of Physiology 254:E31-38.
Evans JJ, Forrest-Owen W, McArdle CA (1997) Oxytocin receptor-mediated activation of phosphoinositidase C and elevation of cytosolic calcium in the gonadotrope-derived alphaT3-1 cell line. Endocrinology 138:2049-2055.
Fallon JH, Leslie FM (1986) Distribution of dynorphin and enkephalin peptides in the rat brain. The Journal of Comparative Neurology 249:293-336.
Fields HL, Heinricher MM (1985) Anatomy and physiology of a nociceptive modulatory system. Philosophical Transactions of the Royal Society of London B: Biological Sciences 308:361-374.
Finn DP (2010) Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance. Immunobiology 215:629-646.
Franklin K, Paxinos G (1997) The mouse brain in stereotaxic coordinates. San Diego: Academic Press.
Freidinger RM, Pettibone DJ (1997) Small molecule ligands for oxytocin and vasopressin receptors. Medicinal Research Reviews 17:1-16.
Gao L, Yu LC (2004) Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats. Regulatory Peptides 120:53-58.
Gao Q, Li D, Liu W, Xu X, Li H, Fu L, Wang Y (2015) The participation of oxytocin in the abirritation of lateral habenular nucleus on normal adult rats. Brain Research 1602:106-110.
Ge Y, Lundeberg T, Yu LC (2002) Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats. Brain Research 927:204-207.
Gibbs DM (1984) Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress. Life Sciences 35:487-491.
Gimpl G, Fahrenholz F (2001) The oxytocin receptor system: structure, function, and regulation. Physiological Reviews 81:629-683.
Girardot MN, Holloway FA (1985) Effect of age and long-term stress experience on adaptation to stress analgesia in mature rats: role of opioids. Behavioral Neuroscience 99:411-422.
Godinez-Chaparro B, Martinez-Lorenzana G, Rodriguez-Jimenez J, Manzano-Garcia A, Rojas-Piloni G, Condes-Lara M, Gonzalez-Hernandez A (2016) The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. Neuropeptides 60:51-60.
Gravati M, Busnelli M, Bulgheroni E, Reversi A, Spaiardi P, Parenti M, Toselli M, Chini B (2010) Dual modulation of inward rectifier potassium currents in olfactory neuronal cells by promiscuous G protein coupling of the oxytocin receptor. Journal of Neurochemistry 114:1424-1435.
Gu XL, Yu LC (2007) Involvement of opioid receptors in oxytocin-induced antinociception in the nucleus accumbens of rats. The Journal of Pain 8:85-90.
Han Y, Yu LC (2009) Involvement of oxytocin and its receptor in nociceptive modulation in the central nucleus of amygdala of rats. Neuroscience Letters 454:101-104.
Hardy SG (1985) Analgesia elicited by prefrontal stimulation. Brain Research 339:281-284.
Helmstetter FJ, Bellgowan PS (1993) Lesions of the amygdala block conditional hypoalgesia on the tail flick test. Brain Research 612:253-257.
Henke PG (1985) The amygdala and forced immobilization of rats. Behavioral Brain Research 16:19-24.
Hicks C, Jorgensen W, Brown C, Fardell J, Koehbach J, Gruber CW, Kassiou M, Hunt GE, McGregor IS (2012) The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats. Journal of Neuroendocrinology 24:1012-1029.
Ho YC, Lee HJ, Tung LW, Liao YY, Fu SY, Teng SF, Liao HT, Mackie K, Chiou LC (2011) Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. The Journal of Neuroscience 31:14600-14610.
Hohmann AG, Suplita RL, 2nd (2006) Endocannabinoid mechanisms of pain modulation. The AAPS Journal 8:E693-708.
Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435:1108-1112.
Holden JE, Jeong Y, Forrest JM (2005) The endogenous opioid system and clinical pain management. AACN Clinical Issues 16:291-301.
Howlett AC (2005) Cannabinoid receptor signaling. Handbook of Experimental Pharmacology 53-79.
Hugues S, Deschaux O, Garcia R (2004) Postextinction infusion of a mitogen-activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear. Learning and Memory 11:540-543.
Jezova D, Michajlovskij N, Kvetnansky R, Makara GB (1993) Paraventricular and supraoptic nuclei of the hypothalamus are not equally important for oxytocin release during stress. Neuroendocrinology 57:776-781.
Jezova D, Hlavacova N, Makatsori A, Duncko R, Loder I, Hinghofer-Szalkay H (2013) Increased anxiety induced by listening to unpleasant music during stress exposure is associated with reduced blood pressure and ACTH responses in healthy men. Neuroendocrinology 98:144-150.
Jiang CY, Fujita T, Kumamoto E (2014) Synaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices. Journal of Neurophysiology 111:991-1007.
Jin WY, Liu Z, Liu D, Yu LC (2010) Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors. Brain Research 1320:16-21.
Kalivas PW, Gau BA, Nemeroff CB, Prange AJ, Jr. (1982) Antinociception after microinjection of neurotensin into the central amygdaloid nucleus of the rat. Brain Research 243:279-286.
Kavaliers M (1988) Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice. Physiology & Behavior 43:187-193.
Kim CJ, Rhee JS, Akaike N (1997) Modulation of high-voltage activated Ca2+ channels in the rat periaqueductal gray neurons by mu-type opioid agonist. Journal of Neurophysiology 77:1418-1424.
Kimura T (1995) Investigation of the oxytocin receptor at the molecular level. Advances in Experimental Medicine and Biology 395:259-268.
Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (1992) Structure and expression of a human oxytocin receptor. Nature 356:526-529.
Kordower JH, Bodnar RJ (1984) Vasopressin analgesia: specificity of action and non-opioid effects. Peptides 5:747-756.
Kormos V, Gaszner B (2013) Role of neuropeptides in anxiety, stress, and depression: from animals to humans. Neuropeptides 47:401-419.
Kovacs GL, Sarnyai Z, Szabo G (1998) Oxytocin and addiction: a review. Psychoneuroendocrinology 23:945-962.
Kreitzer AC, Regehr WG (2001) Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron 29:717-727.
Lambert RC, Dayanithi G, Moos FC, Richard P (1994) A rise in the intracellular Ca2+ concentration of isolated rat supraoptic cells in response to oxytocin. The Journal of Physiology 478 ( Pt 2):275-287.
Lee HJ, Chang LY, Ho YC, Teng SF, Hwang LL, Mackie K, Chiou LC (2016) Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray. Neuropharmacology 105:577-586.
Lewis JW, Baldrighi G, Akil H (1987) A possible interface between autonomic function and pain control: opioid analgesia and the nucleus tractus solitarius. Brain Research 424:65-70.
Liao HT, Lee HJ, Ho YC, Chiou LC (2011) Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition. British Journal of Pharmacology 163:330-345.
Libet B (1982) Brain stimulation in the study of neuronal functions for conscious sensory experiences. Human Neurobiology 1:235-242.
Lundeberg T, Meister B, Bjorkstrand E, Uvnas-Moberg K (1993) Oxytocin modulates the effects of galanin in carrageenan-induced hyperalgesia in rats. Brain Research 608:181-185.
Lundeberg T, Uvnas-Moberg K, Agren G, Bruzelius G (1994) Anti-nociceptive effects of oxytocin in rats and mice. Neuroscience Letters 170:153-157.
Macdonald K, Feifel D (2012) Oxytocin in schizophrenia: a review of evidence for its therapeutic effects. Acta Neuropsychiatrica 24:130-146.
Manning BH, Mayer DJ (1995) The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test. The Journal of Neuroscience 15:8199-8213.
Manning M, Misicka A, Olma A, Bankowski K, Stoev S, Chini B, Durroux T, Mouillac B, Corbani M, Guillon G (2012) Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics. Journal of Neuroendocrinology 24:609-628.
Mansour A, Fox CA, Akil H, Watson SJ (1995) Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends in Neurosciences 18:22-29.
Martinez-Lorenzana G, Espinosa-Lopez L, Carranza M, Aramburo C, Paz-Tres C, Rojas-Piloni G, Condes-Lara M (2008) PVN electrical stimulation prolongs withdrawal latencies and releases oxytocin in cerebrospinal fluid, plasma, and spinal cord tissue in intact and neuropathic rats. Pain 140:265-273.
Mayer DJ, Wolfle TL, Akil H, Carder B, Liebeskind JC (1971) Analgesia from electrical stimulation in the brainstem of the rat. Science 174:1351-1354.
Mazzuca M, Minlebaev M, Shakirzyanova A, Tyzio R, Taccola G, Janackova S, Gataullina S, Ben-Ari Y, Giniatullin R, Khazipov R (2011) Newborn Analgesia Mediated by Oxytocin during Delivery. Frontiers in Cellular Neuroscience 5:3.
Meagher MW, Grau JW, King RA (1990) Role of supraspinal systems in environmentally induced antinociception: effect of spinalization and decerebration on brief shock-induced and long shock-induced antinociception. Behavioral Neuroscience 104:328-338.
Mens WB, Witter A, van Wimersma Greidanus TB (1983) Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Research 262:143-149.
Millan MJ (2002) Descending control of pain. Progress in Neurobiology 66:355-474.
Miranda-Cardenas Y, Rojas-Piloni G, Martinez-Lorenzana G, Rodriguez-Jimenez J, Lopez-Hidalgo M, Freund-Mercier MJ, Condes-Lara M (2006) Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist. Pain 122:182-189.
Modahl C, Green L, Fein D, Morris M, Waterhouse L, Feinstein C, Levin H (1998) Plasma oxytocin levels in autistic children. Biological Psychiatry 43:270-277.
Mogil JS et al. (2011) Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nature Neuroscience 14:1569-1573.
Ogawa S, Kow LM, Pfaff DW (1992) Effects of lordosis-relevant neuropeptides on midbrain periaqueductal gray neuronal activity in vitro. Peptides 13:965-975.
Ohno-Shosaku T, Maejima T, Kano M (2001) Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 29:729-738.
Oliet SH, Baimoukhametova DV, Piet R, Bains JS (2007) Retrograde regulation of GABA transmission by the tonic release of oxytocin and endocannabinoids governs postsynaptic firing. The Journal of Neuroscience 27:1325-1333.
Ortiz JP, Close LN, Heinricher MM, Selden NR (2008) Alpha(2)-noradrenergic antagonist administration into the central nucleus of the amygdala blocks stress-induced hypoalgesia in awake behaving rats. Neuroscience 157:223-228.
Osborne PB, Vaughan CW, Wilson HI, Christie MJ (1996) Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro. The Journal of Physiology 490 ( Pt 2):383-389.
Ossipov MH, Dussor GO, Porreca F (2010) Central modulation of pain. Journal of Clinical Investigation 120:3779-3787.
Pan Y, Yin Z, Yang J, Zhao Y, Yan X, Qiu P, Wang D (2012) Oxytocin in rat nucleus raphe magnus influences pain modulation. World Journal of Neuroscience Vol.02No.02:4.
Parikh D, Hamid A, Friedman TC, Nguyen K, Tseng A, Marquez P, Lutfy K (2011) Stress-induced analgesia and endogenous opioid peptides: the importance of stress duration. European Journal of Pharmacology 650:563-567.
Patel S, Kingsley PJ, Mackie K, Marnett LJ, Winder DG (2009) Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. Neuropsychopharmacology 34:2699-2709.
Peng F, Qu ZW, Qiu CY, Liao M, Hu WP (2015) Spinal vasopressin alleviates formalin-induced nociception by enhancing GABAA receptor function in mice. Neuroscience Letters 593:61-65.
Petersson M, Eklund M, Uvnas-Moberg K (2005) Oxytocin decreases corticosterone and nociception and increases motor activity in OVX rats. Maturitas 51:426-433.
Pettibone DJ et al. (1993) L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor. Drug Development Research 30:129-142.
Puglisi-Allegra S, Oliverio A (1983) Social isolation: effects on pain threshold and stress-induced analgesia. Pharmacology, Biochemistry, and Behavior 19:679-681.
Rash JA, Aguirre-Camacho A, Campbell TS (2014) Oxytocin and pain: a systematic review and synthesis of findings. Clinical Journal of Pain 30:453-462.
Reeta K, Mediratta PK, Rathi N, Jain H, Chugh C, Sharma KK (2006) Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. Regulatory Peptides 135:85-90.
Reiter MK, Kremarik P, Freund-Mercier MJ, Stoeckel ME, Desaulles E, Feltz P (1994) Localization of Oxytocin Binding Sites in the Thoracic and Upper Lumbar Spinal Cord of the Adult and Postnatal Rat: A Histoautoradiographic Study. European Journal of Neuroscience 6:98-104.
Riebe CJ, Wotjak CT (2011) Endocannabinoids and stress. Stress 14:384-397.
Rivalland ET, Clarke IJ, Turner AI, Pompolo S, Tilbrook AJ (2007) Isolation and restraint stress results in differential activation of corticotrophin-releasing hormone and arginine vasopressin neurons in sheep. Neuroscience 145:1048-1058.
Rivier C, Vale W (1983) Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature 305:325-327.
Robinson DA, Wei F, Wang GD, Li P, Kim SJ, Vogt SK, Muglia LJ, Zhuo M (2002) Oxytocin mediates stress-induced analgesia in adult mice. The Journal of Physiology 540:593-606.
Rood BD, De Vries GJ (2011) Vasopressin innervation of the mouse (Mus musculus) brain and spinal cord. The Journal of Comparative Neurology 519:2434-2474.
Rossi S, De Chiara V, Musella A, Kusayanagi H, Mataluni G, Bernardi G, Usiello A, Centonze D (2008) Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum. The Journal of Neuroscience 28:7284-7292.
Rossoni E, Feng J, Tirozzi B, Brown D, Leng G, Moos F (2008) Emergent synchronous bursting of oxytocin neuronal network. PLoS Computational Biology 4:e1000123.
Russo R, D''Agostino G, Mattace Raso G, Avagliano C, Cristiano C, Meli R, Calignano A (2012) Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems. Peptides 38:81-88.
Schorscher-Petcu A, Sotocinal S, Ciura S, Dupre A, Ritchie J, Sorge RE, Crawley JN, Hu SB, Nishimori K, Young LJ, Tribollet E, Quirion R, Mogil JS (2010) Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. The Journal of Neuroscience 30:8274-8284.
Sofroniew MV (1983) Vasopressin and oxytocin in the mammalian brain and spinal cord. Trends in Neuroscience 6:467-472.
Song Z, Borland JM, Larkin TE, O''Malley M, Albers HE (2016) Activation of oxytocin receptors, but not arginine-vasopressin V1a receptors, in the ventral tegmental area of male Syrian hamsters is essential for the reward-like properties of social interactions. Psychoneuroendocrinology 74:164-172.
Stoop R (2012) Neuromodulation by oxytocin and vasopressin. Neuron 76:142-159.
Suplita RL, 2nd, Gutierrez T, Fegley D, Piomelli D, Hohmann AG (2006) Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacology 50:372-379.
Swanson LW, Hartman BK (1980) Biochemical specificity in central pathways related to peripheral and intracerebral homeostatic functions. Neuroscience letters 16:55-60.
Swanson LW, Sawchenko PE (1983) Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annual Review of Neuroscience 6:269-324.
Teng BL, Nonneman RJ, Agster KL, Nikolova VD, Davis TT, Riddick NV, Baker LK, Pedersen CA, Jarstfer MB, Moy SS (2013) Prosocial effects of oxytocin in two mouse models of autism spectrum disorders. Neuropharmacology 72:187-196.
Thurston CL, Randich A (1992) Effects of vagal afferent stimulation on ON and OFF cells in the rostroventral medulla: relationships to nociception and arterial blood pressure. Journal of Neurophysiology 67:180-196.
Truesdell LS, Bodnar RJ (1987) Reduction in cold-water swim analgesia following hypothalamic paraventricular nucleus lesions. Physiology & behavior 39:727-731.
Tsou K, Brown S, Sanudo-Pena MC, Mackie K, Walker JM (1998) Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83:393-411.
Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC (2016) Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. Nature Communications 7:12199.
Uvnas-Moberg K, Bruzelius G, Alster P, Bileviciute I, Lundeberg T (1992) Oxytocin increases and a specific oxytocin antagonist decreases pain threshold in male rats. Acta Physiologica Scandinavica 144:487-488.
Vaughan CW (2006) Stressed-out endogenous cannabinoids relieve pain. Trends in Pharmacological Sciences 27:69-71.
Vaughan CW, Christie MJ (1997) Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro. The Journal of Physiology 498 ( Pt 2):463-472.
Wang JW, Lundeberg T, Yu LC (2003) Antinociceptive role of oxytocin in the nucleus raphe magnus of rats, an involvement of mu-opioid receptor. Regulatory Peptides 115:153-159.
Wei D, Lee D, Cox CD, Karsten CA, Penagarikano O, Geschwind DH, Gall CM, Piomelli D (2015) Endocannabinoid signaling mediates oxytocin-driven social reward. Proceedings of the National Academy of Sciences of the United States of America 112:14084-14089.
Wideman CH, Murphy HM, McCartney SB (1996) Interactions between vasopressin and food restriction on stress-induced analgesia. Peptides 17:63-66.
Williams PD, Anderson PS, Ball RG, Bock MG, Carroll L, Chiu SH, Clineschmidt BV, Culberson JC, Erb JM, Evans BE, et al. (1994) 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl) sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor. Journal of Medicinal Chemistry 37:565-571.
Wilson-Poe AR, Morgan MM, Aicher SA, Hegarty DM (2012) Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray. Neuroscience 213:191-200.
Wilson RI, Nicoll RA (2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 410:588-592.
Wsol A, Szczepanska-Sadowska E, Kowalewski S, Puchalska L, Cudnoch-Jedrzejewska A (2014) Oxytocin differently regulates pressor responses to stress in WKY and SHR rats: the role of central oxytocin and V1a receptors. Stress 17:117-125.
Xu XJ, Wiesenfeld-Hallin Z (1994a) Is systemically administered oxytocin an analgesic in rats? Pain 57:193-196.
Xu XJ, Wiesenfeld-Hallin Z (1994b) Intrathecal oxytocin facilitates the spinal nociceptive flexor reflex in the rat. Neuroreport 5:750-752.
Yaksh TL, DuChateau JC, Rudy TA (1976) Antagonism by methysergide and cinanserin of the antinociceptive action of morphine administered into the periaqueductal gray. Brain Research 104:367-372.
Yang HP, Wang L, Han L, Wang SC (2013) Nonsocial functions of hypothalamic oxytocin. ISRN Neuroscience 2013:179272.
Yang J, Yang Y, Chen JM, Liu WY, Wang CH, Lin BC (2007) Effect of oxytocin on acupuncture analgesia in the rat. Neuropeptides 41:285-292.
Yang J, Yang Y, Wang CH, Wang G, Xu H, Liu WY, Lin BC (2009) Effect of arginine vasopressin on acupuncture analgesia in the rat. Peptides 30:241-247.
Yang J, Liang JY, Li P, Pan YJ, Qiu PY, Zhang J, Hao F, Wang DX (2011a) Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides. Peptides 32:1255-1261.
Yang J, Pan YJ, Zhao Y, Qiu PY, Lu L, Li P, Chen F, Yan XQ, Wang DX (2011b) Oxytocin in the rat caudate nucleus influences pain modulation. Peptides 32:2104-2107.
Yang J, Liang JY, Zhang XY, Qiu PY, Pan YJ, Li P, Zhang J, Hao F, Wang DX, Yan FL (2011c) Oxytocin, but not arginine vasopressin is involving in the antinociceptive role of hypothalamic supraoptic nucleus. Peptides 32:1042-1046.
Yang J, Li P, Liang JY, Pan YJ, Yan XQ, Yan FL, Hao F, Zhang XY, Zhang J, Qiu PY, Wang DX (2011d) Oxytocin in the periaqueductal grey regulates nociception in the rat. Regulatory Peptides 169:39-42.
Yoshida A, Chen K, Moritani M, Yabuta NH, Nagase Y, Takemura M, Shigenaga Y (1997) Organization of the descending projections from the parabrachial nucleus to the trigeminal sensory nuclear complex and spinal dorsal horn in the rat. The Journal of Comparative Neurology 383:94-111.
Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K (2009) Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. The Journal of Neuroscience 29:2259-2271.
Young WS, 3rd, Gainer H (2003) Transgenesis and the study of expression, cellular targeting and function of oxytocin, vasopressin and their receptors. Neuroendocrinology 78:185-203.
Yu SQ, Lundeberg T, Yu LC (2003) Involvement of oxytocin in spinal antinociception in rats with inflammation. Brain Research 983:13-22.
Yuan Q, Su H, Chau WH, Toa Ng C, Huang JD, Wu W, Lin ZX (2013) Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer''s disease. PloS One 8:e53480.
Zhang R, Tomida M, Katayama Y, Kawakami Y (2004) Response durations encode nociceptive stimulus intensity in the rat medial prefrontal cortex. Neuroscience 125:777-785.
Zhao DQ, Ai HB (2011) Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. PloS One 6:e23362.
Zhou Z, He L, Zhou J (1993) Expression of C-fos protein in CNS following electroacupuncture of the "quanliao" and the electrostimulation of the rat tail. Acupuncture Research 18:14-20.
Zimmerman EA, Nilaver G, Hou-Yu A, Silverman AJ (1984) Vasopressinergic and oxytocinergic pathways in the central nervous system. Federation Proceedings 43:91-96.
QRCODE
 
 
 
 
 
                                                                                                                                                                                                                                                                                                                                                                                                               
第一頁 上一頁 下一頁 最後一頁 top
無相關論文
 
無相關期刊
 
無相關點閱論文
 
系統版面圖檔 系統版面圖檔