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研究生:江楠
研究生(外文):JIANG,NAN
論文名稱:海藻酸鈉包覆左手香微膠囊的抗氧化及留色效能之探討
論文名稱(外文):Study of Plectranthus Amboinicus Microcapsule by Sodium Alginate at Antioxidant and Color Retention
指導教授:張乃方
指導教授(外文):CHANG, NAI-FANG
口試委員:張乃方謝堅銘林宏糧
口試委員(外文):CHANG, NAI-FANGHSIEH,CHIEN-MINGLIN,HONG-LIANG
口試日期:2017-07-03
學位類別:碩士
校院名稱:靜宜大學
系所名稱:化粧品科學系
學門:民生學門
學類:美容學類
論文種類:學術論文
論文出版年:2017
畢業學年度:105
語文別:中文
論文頁數:97
中文關鍵詞:海藻酸鈉左手香微膠囊留色抗氧化
外文關鍵詞:Sodium AlginatePlectranthus amboinicusMicrocapsuleColor retentionAntioxidant
相關次數:
  • 被引用被引用:4
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  • 下載下載:198
  • 收藏至我的研究室書目清單書目收藏:1
左手香具有消炎解毒、抗菌和抗氧化活性,常被用於護膚產品和香皂中。在以往的製作中,左手香被粉碎,然後直接加入到產品中,含有植物殘體的產品在色澤和質地較差,並且會降低產品的有效性。本研究將以海藻膠為殼材配合內相凝膠法製備左手香微膠囊,透過微膠囊可以保護他們延長其使用壽命,延緩有效成分的釋放釋並且使其具有天然色素。於過程中研究其微膠囊粒徑大小、包覆率、藥物釋放等性質,之後對左手香海藻酸鈉微膠囊及抗菌和抗氧化活性進行尋找最佳條件的測試。
由實驗結果顯示:左手香海藻酸鈉微膠囊已成功製備。當充當硬化劑的碳酸鈣添加至0.03%時,其包覆率可達82.3%,在顯微形態觀察下,微膠囊呈深色外圍的圓球狀,並且有較窄的粒徑分佈,以及較佳的釋放效能,在弱酸性條件下釋放甚微,在弱鹼性條件下,於8h時其釋放量為23.75%,且之後做到持續緩慢釋放,因此能延長左手香汁液的抗氧化性。但,在抑菌實驗中抑菌效果極其微弱,可能左手香榨取汁液並不如文獻所提到的抗菌效果。經由海藻酸鈉包覆後的左手香可不隨酸鹼度改變顏色,有利於保留左手香的顏色。因此,可藉以此用於化粧保養品及手工皂中,來形成天然色素及提升抗氧化的能力。
Plectranthus amboinicus extracts were used in skin care products and soaps, they focus on the antibacterial and antioxidant activity. In the past, Plectranthus amboinicus was crushed and then added directly to the product. Which products plant residues of the product color and texture is poor, and easy to change color. More importantly, it will reduce the effectiveness of the products. In this study, alginate microcapsule was prepared by sol-gel technology. The microcapsules could prolong the lifetime of Plectranthus amboinicus by protecting them from leaching and releasing them slowly. To find the optimum conditions, the preparation of Plectranthus amboinicus microcapsules and their antibacterial and antioxidant activity were be tested. And keep it in color of the product.
The results showed that the Plectranthus amboinicus microcapsules were prepared successfully. When calcium carbonate was added to 0.03%, the encapsulation efficiency was 82.3%. The particle size distribution was narrow. The addition amount of calcium carbonate was 0.03%, the release rate of microcapsule was 23.75% at 8h (pH=8), after the start of a more stable slow release. And the antioxidant effect of the Plectranthus amboinicus was prolonged. The color of microcapsule is not affected by pH value, which is favorable for color retention. Therefore, the utility model can be used to make up the natural pigment and improve the antioxidant ability.
謝誌 I-II
摘要 III
Abstract IV
目錄 V
表目錄 IX
圖目錄 X

壹、 緒論 1
1-1前言 1
1-2實驗動機 2
1-3天然色素介紹 2
1-4左手香介紹 4
1-5微膠囊介紹 11
1-5-1微膠囊的結構 12
1-5-2微膠囊的特點 14
1-5-3微膠囊的製備 15
1-5-3-1相分離法 16
1-5-3-2界面聚合反應 18
1-5-3-3噴霧乾燥技術 18
1-5-3-4擠壓法 20
1-5-3-5空氣懸浮成膜技術 20
1-5-3-6熔化分散冷凝法 22
1-5-4微膠囊的應用 23
1-6高分子材料 24
1-6-1海藻酸鈉介紹 25
1-6-2幾丁聚醣介紹 30
1-7凝膠作用 33
1-7-1溶膠與凝膠系統 33
1-7-2溶膠與凝膠系統優點 34
1-7-3親水膠的酸鹼應答行為 35
1-8抗氧化能力評估方法 36
1-9抑菌能力評估方法 39
1-10肥皂的介紹 49

貳、 材料與方法 52
2-1試劑與溶劑 52
2-2儀器設備 53
2-3實驗方法 54
2-3-1實驗架構 54
2-3-2左手香汁液製備 55
2-3-3左手香微膠囊製備 55
2-3-3-1微膠囊製備步驟 55
2-3-3-2交聯劑-鈣鹽的選擇 56
2-3-3-3海藻酸鈣及幾丁聚醣複合膜微膠囊的製備 56
2-3-4微膠囊包覆率測定 57
2-3-5微膠囊形態觀察 58
2-3-6微膠囊粒徑測定 58
2-3-7微膠囊不同酸鹼值顏色測定 58
2-3-8微膠囊釋放測定 59
2-3-9抗氧化測定 59
2-3-10抑菌實驗 61
2-3-11手工皂製作 65

參、結果與討論 67
3-1左手香汁液 67
3-2左手香微膠囊的形成 68
3-2-1外觀形態及粒徑分析 68
3-2-2左手香微膠囊的包覆率 71
3-3左手香微膠囊與不同酸鹼值環境之顏色變化 77
3-4左手香微膠囊釋放測定 79
3-5左手香微膠囊抗氧化分析 81
3-6左手香微膠囊抑菌能力評估 83
3-7左手香微膠囊手工皂顏色變化 86
肆、 結論 88
伍、參考文獻 90

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