臺灣博碩士論文加值系統

本研究由不同比例界面活性劑D，與界面活性劑A形成膠體分散液。並藉由動態光散射儀(dynamic light scattering, DLS)分析界面活性劑D/A奈米聚集體之粒徑及電位，且透過穿透射電子顯微鏡(transmission electron microscope, TEM)、螢光偏極(fluorescence polarization, FL)測量及微分式掃描熱卡計(differential scanning calorimetry, DSC)，分別觀察界面活性劑D/A奈米聚集體其結構、結構中的分子排列情況，及研究奈米聚集體的相變行為。之後，藉由氣/液界面上之Langmuir單層與螢光顯微鏡技術，研究界面活性劑D與界面活性劑A之側向交互作用。實驗結果發現界面活性劑D及界面活性劑A於界面活性劑A莫耳比例為0.1至0.5 (XA=0.1~0.5)時混合界面活性劑D/A分散液可形成穩定之奈米聚集體分散液。此外，活性藥物C是非常不穩定且易於水溶液環境中降解的成分。因此我們欲將界面活性劑D/A奈米聚集體作為其載體，期望能改善活性藥物C的化學穩定性。結果顯示，界面活性劑D/A-C.分散液包覆活性藥物C的包覆效率達到95％以上，且界面活性劑D/A奈米聚集體能提高活性藥物C的穩定性。再藉由人工皮膚體外滲透研究，指出界面活性劑D/A-C.分散液具有藥物累積於人工皮膚內之能力。因此，界面活性劑D/A奈米聚集體有潛力成為藥物載體。

In this study, colloidal properties of mixtures composed of cationic surfactant D and anionic surfactant A are investigated. Particle size and zeta-potential of mixed surfactant D/A nano-aggregates were determined by dynamic light scattering analysis. Transmission electron microscope has been used for structural observation of mixed surfactant D/A dispersions directly. Fluorescence polarization examination was to study the molecular arrangement in the nano-aggreates and differential scanning calorimetry was used to investigate the phase transition behavior of mixed surfactant D/A nano-aggregates. Besides, the lateral interactions between surfactant D and surfactant A in the monolayer domains were investigated by a Langmuir monolayer technique with a fluorescence microscope. The experiment results suggest that surfactant D and surfactant A can form mixed surfactant D/A nano-aggregates as the molar ratio of surfactant A from 0.1 to 0.5. Active drug C is highly instable and very susceptible to degradation in aqueous solution. Therefore, we use surfactant D/A nano-aggregates as carrier to improve chemical stability of active drug C. Results showed that entrapment efficiencies of mixed surfactant D/A nano-aggregates were reached 95%. mixed surfactant D/A vesicles could promote the drug accumulation in artificial skin. Therefore, mixed surfactant D/A vesicles could potentially be a good drug carrier.

摘要 i
Abstract ii
Graphical abstract iii
誌謝 iv
目錄 v
表目錄 ix
圖目錄 x
符號說明 xvi
縮寫說明 xix
第一章 緒論 1
1-1前言 1
1-2研究動機與目的 2
第二章 文獻回顧 3
2-1膠體分散液 3
2-2陰陽離子液胞 3
2-3陰陽離子液胞特性 4
2-3-1雙碳鏈陽離子界面活性劑 5
2-3-2單碳鏈陰離子界面活性劑 5
2-4單分子層與雙層結構之相關性及發展 6
2-5氣/液界面上螢光單分子層顯微鏡觀察 7
2-6活性藥物C結構特徵 8
2-7活性藥物C之應用及發展 8
第三章 實驗設備與方法 13
3-1實驗藥品 13
3-2實驗方法 14
3-2-1膠體分散液製備流程 14
3-2-2動態光散射儀分析 14
3-2-3穿透式電子顯微鏡型態觀察 16
3-2-4螢光偏極化量測 16
3-2-5微分掃描熱卡計分析 17
3-2-6 Langmuir單分子層技術 18
3-2-7包覆活性藥物C分散液製備程序 23
3-2-8藥物包覆效率 23
第四章 結果與討論 31
4-1混合界面活性劑D/A分散液物理特徵 31
4-1-1混合界面活性劑D/A分散液之粒徑、分散度及界面電位 31
4-1-2混合界面活性劑D/A分散液型態觀察 32
4-1-3混合界面活性劑D/A分散液相變行為 32
4-1-4混合界面活性劑D/A分散液螢光偏極值分析 33
4-2混合界面活性劑D/A於氣/液界面上之單分子層行為 33
4-2-1混合界面活性劑D/A單分子層表面壓-每分子佔據面積等溫線分析 33
4-2-2混合界面活性劑D/A單分子層之壓縮模數分析 34
4-2-3混合界面活性劑D/A單分子層之熱力學分析 34
4-2-4混合界面活性劑D/A單分子層型態觀察 35
4-3混合界面活性劑D/A分散液物理特徵 36
4-3-1混合界面活性劑D/A分散液粒之徑、分散度及界面電位 36
4-3-2混合界面活性劑D/A分散液型態觀察 36
4-3-3混合界面活性劑D/A分散液相變行為 37
4-3-4混合界面活性劑D/A分散液螢光偏極值分析 38
4-4混合界面活性劑D/A於氣/液界面上之單分子層行為 38
4-4-1混合界面活性劑D/A單分子層表面壓-每分子佔據面積等溫線分析 38
4-4-2混合界面活性劑D/A單分子層之壓縮模數分析 39
4-4-3混合界面活性劑D/A單分子層之熱力學分析 39
4-4-4混合界面活性劑D/A單分子層型態觀察 40
4-5混合界面活性劑D/A分散液物理特徵 41
4-5-1混合界面活性劑D/A分散液之粒徑、分散度及界面電位 41
4-5-2混合界面活性劑D/A分散液型態觀察 41
4-5-3混合界面活性劑D/A分散液相變行為 42
4-5-4混合界面活性劑D/A分散液螢光偏極值分析 43
4-6混合界面活性劑D/A於氣/液界面上之單分子層行為 43
4-6-1混合界面活性劑D/A單分子層表面壓-每分子佔據面積等溫線分析 43
4-6-2混合界面活性劑D/A單分子層之壓縮模數分析 43
4-6-3混合界面活性劑D/A單分子層之熱力學分析 44
4-6-4混合界面活性劑D/A單分子層型態觀察 45
4-7包覆活性藥物C混合界面活性劑D/A分散液之物性分析 46
4-7-1混合界面活性劑D/A分散液粒徑、電位及包覆效率 46
4-7-2混合界面活性劑D/A系統包覆活性藥物C前後分散液之粒徑、電位的比較 47
4-7-3混合界面活性劑D/A分散液型態觀察 48
4-8包覆活性藥物C混合界面活性劑D/A分散液之化學穩定性 48
4-8-1活性藥物C水溶液儲存於25oC下之化學穩定性 48
4-8-2包覆活性藥物C混合界面活性劑D/A分散液儲存於25oC下之化學穩定性 49
第五章 結論 135
參考文獻 136

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