臺灣博碩士論文加值系統

本研究主要透過製備材料表面載子型態為P型及N型的光電化學生物感測器，我們將利用此元件來檢測食道鱗狀上皮癌細胞之癌變程度並加以分析。長年來國人罹患癌症的機率節節攀升以致於現今社會對於癌症的預防及治療極為重視，因此找尋能夠最快速檢測癌症的方法，一直以來都是學術界及醫學界間相互交流並共同努力的目標。
本研究利用實驗室所架設的光電流量測系統，透過光生電荷的載子傳輸機制，來討論特徵物質與材料性質間的相關性，並將此結果加以檢測食道鱗狀上皮癌細胞的暫態光電流。本研究著重於表面載子型態為P型之生物感測器，使用不同癌變程度及不同細胞數量來分析癌細胞之光電化學響應間的關係。從研究結果顯示，癌細胞侵襲能力越強使得元件的光電流越小，這是由於光生電荷在載子分離過程中，癌細胞本身少量的穀胱甘肽(L -Glutathione reduced, GSH)不易將電荷分離，使得光電流下降，但這樣的結果仍足以辨識癌化程度，其數值具有一定水準的鑑別度，另外透過調變細胞數量即可以將檢測誤差值降到最低，檢測時間約5分鐘，且元件可重覆使用。
未來將規劃以此生物感測器做原發性腫瘤的追蹤，透過人工智慧技術設計出人性化顯示介面，即能讓大眾更快速且明確的理解檢測結果，爾後將此技術應用於臨床醫學上，在未來將能建立醫師與病患間共同溝通的橋樑，對於癌症知識能夠普及大眾並達到及早發現及早治療的願景將指日可待。

In this study, we fabricated the photoelectrochemical biosensors which surface of materials with P-type and N-type carrier types. We will use this component to detect and analyze the degree of carcinogenesis of esophageal squamous cell carcinoma. Over the years, the probability of people suffering from cancer has gradually increased, so that today's society attaches great importance to the prevention and treatment of cancer. Therefore, looking for the fastest way to detect cancer has always been the goal of mutual exchange and joint efforts between academia and the medical community.
In this study, we used the photocurrent measurement system set up in the laboratory. To discuss the correlation between characteristic substances and material properties through the charge transfer mechanism of photogenerated charges. According to the results, we use to detecting transient photocurrents in esophageal squamous cell carcinoma cells. This study focused on the biosensor with a surface carrier type of P-type, using different degrees of cancer and different cell numbers to analyze the relationship between photoelectrochemical responses of cancer cells. From the research results, the stronger the invasive ability of cancer cells, the smaller the photocurrent of the component. Because of the photogenerated charges are not easy to separate the charge when the carrier is separated so that the photocurrent decreases. However, such a result is still sufficient to identify the degree of canceration, and the value has a certain level of discrimination. In addition, the detection error value can be minimized by modulating the number of cells, the detection time is about 5 minutes, and the components can be reused.
In the future, we will plan to use this biosensor to track the primary tumor and design a humanized display interface through artificial intelligence technology, which will enable the public to understand the test results more quickly and clearly, and then apply this technology to clinical medicine. In the future, we will be able to establish a bridge of communication between physicians and patients. The vision of cancer knowledge to reach the public and achieve early detection and early treatment will be just around the corner.

目錄
光機電整合工程研究所 1
摘要 I
Abstract II
致謝 IV
目錄 V
圖目錄 VIII
表目錄 XII
第一章 緒論 1
1-1 前言 1
1-2癌細胞生物感測器 2
1-2-1 癌症標記物 2
1-2-2 生物感測器的組成 3
1-2-3 生物感測器的種類 4
1-3 光電化學生物感測器 7
1-4 研究動機 9
1-5 論文架構 10
第二章 文獻回顧 11
2-1 二硫化鉬 11
2-1-1 二硫化鉬材料特性 11
2-1-2 二硫化鉬光電特性 11
2-1-3 二硫化鉬合成方法 13
2-2 氧化亞銅 17
2-2-1 氧化亞銅材料特性 17
2-2-2 氧化亞銅光電特性 17
2-2-3 氧化亞銅合成方法 19
2-3 氧化鋅 22
2-3-1 氧化鋅材料特性 22
2-3-2 氧化鋅光電特性 22
2-3-3 氧化鋅合成方式 25
2-4 癌細胞株簡介 27
2-4-1 食道癌細胞 27
2-4-2 穀胱甘肽(L -Glutathione reduced, GSH) 27
2-5 暫態光電流 32
2-5-1 氧化鋅的暫態光電流 33
2-5-2 氧化亞銅的暫態光電流 33
2-5-3 二硫化鉬的暫態光電流 34
第三章 實驗步驟及方法 61
3-1 實驗材料及藥品規格 61
3-2 實驗流程及步驟 62
3-2-1 基板清潔步驟 62
3-2-2 單層二硫化鉬製備步驟 62
3-2-3 氧化亞銅薄膜製備步驟 64
3-2-4 氧化鋅奈米柱製備步驟 65
3-2-5 P型光電化學生物感測器之異質結構製備步驟 67
3-2-6 癌細胞培養步驟 68
3-3 量測儀器介紹 69
3-3-1 光學顯微鏡 (Optical Microscope, OM) 69
3-3-2場發射掃描式電子顯微鏡 (Scanning Electron Microscrope, SEM) 69
3-3-3紫外光-可見光光譜儀 (UV-VIS Spectrometers) 70
3-3-4 X光繞射儀 (X-ray diffractometer) 70
3-3-5光致螢光光譜分析儀(Photoluminescence, PL) 71
3-3-6霍爾效應分析儀(Hall Effect Analyzer) 72
3-3-7 響應分析實驗配置系統 72
第四章 結果與討論 90
4-1 光電化學生物感測器結構特性分析 90
4-1-1 MoS2/p-Cu2O奈米異質結構 90
4-1-2 N-ZnO/P-Cu2O奈米異質接面 92
4-2 光電流響應分析 94
4-2-1 P型及N型結構對於檢測穀胱甘肽之分析 94
4-2-2 P型結構對於辨別癌細胞期數及細胞濃度之分析 96
第五章 結論與未來展望 115
參考文獻 117

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