臺灣博碩士論文加值系統

生醫材料之產品特別重視安全性、可靠性及有效性，為改善在與生物體接觸使用的生醫材料所衍生的缺點，如導管形成血栓、細胞沾黏、植入物產生感染等；本研究選擇常用的醫療級矽膠材料為實驗對象，將六甲基二矽烷（Hexamethyldisilazane）透過噴射式大氣電漿以及溶膠凝膠法兩種製程，在醫療級矽膠材料表面製備一層氧化矽疏水性薄膜，以增進矽膠材料於生醫材料之人體友善適用性。實驗結果顯示：噴射式大氣電漿在不同間距下所產生之氧化矽薄膜表面性質不同，在薄膜與矽膠基材間添加SBMA單體，可增加氧化矽薄膜之貼合性，而仍可保持氧化矽薄膜之疏水性；因此，以噴射式大氣電漿鍍膜所獲得之最佳實驗參數，以添加SBMA單體、間距20mm為最佳；另一方面，以溶膠凝膠法製備氧化矽薄膜塗佈於試片上，發現前述兩種方式，均可使試片具疏水性效果，其最大接觸角分別達到146.3°及148.9°。觀察其表面形貌之變化，發現兩種製程之氧化矽粒徑大小雖然皆在70～100 nm；但由分析材料結構得知大氣電漿之氧化矽結晶度優於溶膠凝膠法，且薄膜在高溫度環境下的狀態也比溶膠凝膠法薄膜更穩定。

The products of biomedical materials pay attention to safety, reliability and effectiveness. In order to improve the defect of biomedical materials in organisms, such as catheter thrombosis, cell adhesion, infection of implants, etc., In this study, A hydrophobic film was prepared by using （Hexamethyldisilazane, HMDSN） as precursor by Atmospheric Pressure Plasma Jet and a sol-gel method, and the drophobic film was applied to silicone rubber. The suitability of materials as medical materials.
The experimental results indicate that the surface properties of the Atmospheric Pressure Plasma Jet coating at different intervals are different. Adding SBMA monomer between the film and the substrate increases the adhesion of the film, which not only improves the contact angle, but also increases the durability of the film. The best experimental parameters of the slurry membrane system are SBMA monomer with a spacing of 20mm. The SiOx film prepared by another traditional process Sol-Gel method is coated on the test piece and found to have hydrophobic effect and maximum contact angle. up to 146.3° and 148.9°.Observing the change of surface morphology, it is found that the particle size of SiOx in the two processes is 70-100 nm. However, it is known from the analysis of the material structure that the SiOx crystallinity of atmospheric plasma is superior to that of Sol-Gel method, and the film is excellent. The state in a high temperature environment is also more stable than the Sol-Gel film.

摘要i
ABSTRACTii
誌謝iii
目錄iv
表目錄vi
圖目錄vii
第一章 緒論1
1.1前言1
1.2研究動機與目的2
第二章 文獻回顧3
2.1生醫材料3
2.2醫用薄膜3
2.3表面改質技術3
2.4有機矽化合物4
2.4.1有機矽材料歷史發展4
2.4.2 六甲基二矽烷5
2.5磺基甜菜鹼SBMA6
2.6疏水性薄膜製備方法7
2.6.1電漿法7
2.6.2無機-有機混成法8
2.6.3化學氣相沉積法8
2.6.4溶膠凝膠法9
第三章 實驗步驟及研究方法12
3.1實驗藥品12
3.2實驗流程及參數12
3.2.1實驗流程圖12
3.2.2實驗參數13
3.3實驗設備介紹14
3.3.1噴射式大氣電漿（APPJ）14
3.3.2大腔體陶瓷燒結爐15
3.3.3場發射掃描式電子顯微鏡（SEM）16
3.3.4熱重量分析儀（TGA）17
3.3.5水滴接觸角儀18
3.3.6傅立葉紅外線光譜儀（FTIR）19
3.3.7　X-射線繞射分析儀20
第四章 實驗結果與討論21
4.1接觸角分析21
4.2表面形貌觀察26
4.3 FTIR光譜分析33
4.4 XRD分析37
4.5 TGA熱重分析38
第五章 結論39
參考文獻40

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