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研究生:姚姿卉
研究生(外文):Tzu-HuiYao
論文名稱:果蠅中飢餓後學習表現提升之探討
論文名稱(外文):Investigation of Fasting-dependent Learning in Drosophila melanogaster
指導教授:姜學誠
指導教授(外文):Hsueh-Cheng Chiang
學位類別:碩士
校院名稱:國立成功大學
系所名稱:藥理學研究所
學門:醫藥衛生學門
學類:藥學學類
論文種類:學術論文
論文出版年:2018
畢業學年度:106
語文別:英文
論文頁數:54
中文關鍵詞:食物限制認知AKT蕈狀體原腦前內側多巴胺神經叢
外文關鍵詞:Food restrictionCognitiveAKTMushroom bodyDopaminergic protocerebral anterior medial neurons
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肥胖是導致慢性疾病的主要危險因子之一,進食限制在許多物種中被認為是一種有效降低疾病發生及促進健康的方法。然而,我們對於進食限制在認知與神經功能上的瞭解尚處於早期階段。我們在此利用懲罰式嗅覺訓練及共軛焦成像技術來研究進食限制在果蠅上的影響,我們發現在訓練前短暫的禁食可以提升年輕果蠅的學習表現,此現象是與蛋白質合成有關的,且須透過同時剝奪甜味與能量來誘發。降低protocerebral anterior medial (PAM)的多巴胺神經叢中PI3K/AKT訊號傳遞路徑可促成飢餓後學習的形成。阻斷PAM的多巴胺神經叢、ellipsoid body (EB)、mushroom body (MB) 神經元的胞吞作用會破壞飢餓後學習的形成。我們的研究揭示飢餓後學習的部分神經迴路以及PAM多巴胺神經叢的新作用。
Obesity is one of the major risk factors for chronic diseases. Food restriction is considered as a good way of reducing the onset of diseases and in promoting health among different species. However, our knowledge of food restriction in cognition and neuronal functions still in its infancy and remains to be established. Here, we used aversive olfactory conditioning and confocal imaging techniques to evaluate food restriction effects on the fruit fly Drosophila melanogaster. We showed that mild fasting before conditioning enhance learning performance in young flies and such enhancement is protein synthesis-dependent and required both sweet and energy deprivation. Reduced phosphoinositide-3-kinase (PI3K)/AKT signaling pathway in dopaminergic protocerebral anterior medial (PAM) cluster is accountable for this fasting-dependent learning. Blocking synaptic endocytosis in dopaminergic PAM neurons, ellipsoid body (EB), and mushroom body (MB)  neurons impedes the fasting-dependent learning formation. Our results reveal part of the circuitry of fasting-dependent learning and the new role of dopaminergic PAM neurons.
中文摘要 I
Abstract III
Acknowledgement V
Abbreviation VII
Content IX
List of figures XI
Introduction 1
Material & Method 6
Result 10
Fasting enhances learning performance within a critical period 11
Starvation doesn’t affect odor and pain sensitivity 11
Short and Long-term deprivation of Sweet and energy can enhance learning 12
Fasting-dependent learning relies on protein synthesis 12
Fasting-dependent learning forms through PI3K signaling pathway in dopaminergic PAM neurons 13
Overexpression of the PI3K signaling pathway disrupt learning enhancement in starved flies 14
Fasting-dependent learning forms in the distinct subsets of PAM neurons 14
Loss of neuronal function impaired fasting-dependent learning 15
Dopaminergic PAM neurons and MB are in close proximity 16
Both VT45650 and R58E02 participate in fasting-dependent learning information transmission 16
Sensory information about fasting-dependent learning is also transmitted through the EB 17
The MB  lobe is essential for fasting-dependent learning formation 17
The MB112C and MB210B output neurons do not play a role in the modulation of fasting-dependent learning 18
Discussion 20
Conclusion 26
Reference 28
Figure 38
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