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研究生(外文):CHUNG, CHUN
論文名稱:近紅外光骨組織特性量測研究
論文名稱(外文):Bone tissue characterization based on near-infrared detection techniques
指導教授:孫家偉孫家偉引用關係
指導教授(外文):SUN, CHIA-WEI
口試委員:陳韋達郭浩中鍾仁傑呂隆昇呂才學
口試委員(外文):CHEN,WEI-TAGUO,HAO-ZHONGZHONG,REN-JIELU,LONG-SHENGLU,CAI-XUE
口試日期:2017-08-21
學位類別:碩士
校院名稱:國立交通大學
系所名稱:光電工程研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2017
畢業學年度:106
語文別:中文
論文頁數:31
中文關鍵詞:骨質疏鬆雙能量X光能量吸收儀超音波骨質密度儀近紅外光影像系統
外文關鍵詞:osteoporosisDual energy X-ray absorptiometryUltrasonic bone densitometerNear infrared image system
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骨質疏鬆症是普遍且影響壽命與生活品質的流行病,世界衛生組織列為僅次於心血管疾病的第二大疾病。骨質疏鬆症是一個隱形殺手,因骨質疏鬆症造成之骨折,常因需要強制長時間臥床而併發其他疾患如心臟病、肺炎而死亡,骨折後第一年死亡約為12-20%。對於骨質疏鬆症著重於及早診斷及早防治,而要得到正確的診斷必須有精確檢測骨質密度的儀器設備。目前醫院普遍使用之雙能量X光能量吸收儀(DXA),雖然精確度高且再現度佳,但機器需要大空間放置、並且有游離輻射及費用昂貴的缺點,普及不易,更簡易且精確之診斷儀器有其發展之必要性。
本研究利用實驗室自行研發之光學骨質密度量測儀,以近紅外光擴散造影系統(diffuse optical imaging system; DOIS),設計出一簡易近紅外光學骨質密度測量儀。從健康受試者中,我們檢測雙側遠端橈骨骨質密度,並對照雙能量X光能量吸收儀量測、Micro-CT結果,探討光學骨質密度測定儀之精確度及再現度,期許能作為未來除雙能量X光能量吸收儀外,更普及與方便之骨質密度量測工具雛形。除骨質密度部分的研究,為量化皮膚中的膠原蛋白,我們也開發了一套偏振分析儀進行了膠原蛋白的量測,希望未來能結合實驗室的PS-OCT系統,更進一步地確認偏振分析系統的可行性。
Osteoporosis is a popular disease that greatly influence our life, According to World Health Organization, osteoporosis is the second majority ailment. This disease kills lot of people by fracture and other concurrent disease like heart attack and pneumonia. For instance, hip fractures, the most fatal type of fracture; it has been estimated that approximately twenty percent of all patients die within a year. Moreover, the declines in functional status and psychological health and the increased phases of disability that are usually associated with bone disease and fractures can have a profound impact on patients’ quality of life. Individuals suffering osteoporotic-related fractures consistently report significant reductions in quality-adjusted life years. In this case, diagnosis of the bone mineral density to prevent and to remedy such disease becomes important.
Therefore in this work our aim is to build a system with uncomplicated architecture and a low cost but still have a favorable bone test result. We hired beer lambert’s law to observe optical attenuation and validate the result by comparing the result with DXA, finally we get a good result and provide a possibility to acquire bone density with a simple system.
中文摘要 i
Abstract ii
誌謝 iv
目錄 v
圖目錄 vii
表目錄 vii
第一章 緒論 1
1.1 研究背景 1
1.1.1 骨質疏鬆的定義與診斷 2
1.1.2 骨質疏鬆的併發症 4
1.2 文獻回顧 4
1.3.1 骨質密度量測研究動機及目的 6
1.3.2 膠原蛋白量測研究動機及目的 7
第二章 實驗原理與方法 8
2.1.1 擴散光學 8
2.1.2 光偏振分析法 9
2.2實驗流程 10
2.2.1 離體量測 10
2.2.2活體量測 11
2.2.3膠原蛋白系統量測 12
2.3 活體實驗受測者條件篩選 14
2.4 骨質密度量測儀結果分析 14
2.5 偏振量測儀結果分析 15
第三章 實驗儀器與系統 16
3.1 系統簡介 16
3.1.1 骨質密度量測系統 16
3.1.2 膠原蛋白偏振分析系統 17
3.2 光學系統元件 19
3.2.1 雷射二極體 19
3.2.2 光偵測器 20
3.2.3 光纖耦合器 21
3.2.5 定電流電路 21
第四章 實驗結果 22
4.1 骨質密度實驗結果 22
4.1.1 離體實驗結果 22
4.1.2 活體實驗結果 23
4.2 偏振分析實驗結果 25
第五章 結果討論 26
5.1 近紅外光骨質密度儀 26
5.2 膠原蛋白偏振分析系統 27
第六章 結論與未來展望 29
Reference 30
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