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研究生:刑悅銘
研究生(外文):Xing, Yue-Ming
論文名稱:以光固化丙烯酸樹酯材料於 3D 列印製作動靜脈人工血管之研究
論文名稱(外文):Fabrication of Photo-curable Acrylic Polymers for 3D -Printed Arteriovenous Graft Scaffold
指導教授:林欣杰
指導教授(外文):Lin, Hsin-Chieh
口試委員:陳文亮陳冠宇
口試委員(外文):Chen, Wen-LiangChen, Guan-Yu
口試日期:2017-08-25
學位類別:碩士
校院名稱:國立交通大學
系所名稱:材料科學與工程學系奈米科技碩博士班
學門:工程學門
學類:材料工程學類
論文種類:學術論文
論文出版年:2017
畢業學年度:106
語文別:中文
論文頁數:177
中文關鍵詞:丙烯酸樹酯3D列印光固化人工血管
外文關鍵詞:3D printingphoto-curableArteriovenous GraftAVG
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目 錄
中文摘要 i
Abstract ii
謝 誌 iii
圖目錄 viii 表目錄 xviii 第一章 緒論 1
1.1 3D 列印 1
1.1.1 簡介 1
1.1.2 3D 列印製程與傳統產業製程的差別 2
1.1.3 3D 列印製程與客制化製作 3
1.1.4 3D 列印技術及其分類 4
1.2 調控 3D 列印製程參數 8
1.2.1 電腦輔助設計圖型 Computer Aided Design model 8
1.2.2 光固化反應 (Photopolymerization) 11
1.3 動靜脈人工血管 (Arteriovenous Graft, AVG) 12
1.3.1 簡介 12
1.3.2 3D 生物列印技術 (3D Bioprinitng) 17 第二章 21
2.1 實驗器材與藥品 21
2.1.1 3D 列印實驗用試劑 21
2.1.2 生物實驗用試劑 25
2.1.3 各實驗藥品名稱縮寫 25
v
2.1.4 實驗藥品中英對照表 27
2.2 實驗材料與方法 29
2.2.1 實驗用儀器 29
2.2.2 實驗設計 31
2.3 實驗方法 36
2.3.1 Computer Aided Design Model (CAD Model) 繪製 36
2.3.2 上機前光固化時間測試 37
2.3.3 3D 列印墨水配製 38
2.3.4 3D 列印圖形轉檔與裁切 39 2.3.5 3D 列印機操作 42
2.4 合成實驗 44
2.4.1 Poly Ethylene Glycol Diacrylate_2K(PEGDA_2K) 44
2.4.2 Poly Ethylene Glycol Diacrylate_3K(PEGDA_3K) 45
2.4.3 Poly Ethylene Glycol Dimethylacrylate_6K(PEGDMA_6K) 46
2.4.4 Poly Caprolactone Dimethylacrylate_2K(PCLDMA_2K) 47
2.4.5 4-Arm Poly Ethylene Glycol Acrylate_300(4-Arm PEG_300) 48
2.5 分析方法 51
2.6 實驗結果 57
2.6.1 上機前固化測試 57
2.6.2 材料溶解度測試 58
2.6.3 3D 列印製程方式於材料性質的影響 59
2.6.4 光固化 3D 列印之列印速度對樣品解析度的影響 69
2.6.5 光固化 3D 列印材料對於 3D 列印樣品的影響 72
2.6.6 材料前處理對 3D 列印樣品解析度的影響 72
2.6.7 配方材料 73
2.6.8 聚乙二醇二丙烯酸酯系列配方 76
2.6.9 4-丙烯酰酸嗎啉系列配方 80
2.7 光固化 3D 列印後之各配方性質比較與探討 83
2.7.1 配方材料的拉伸性質測試83
2.7.2 不同配方材料對 3D 列印光固化後樣品之透光度影響 85
2.7.3 材料降解性質分析 89
2.7.4 3D 列印樣品耐水流性質分析 93
2.7.5 較俱彈性配方材料之熱重損失分析 94
2.7.6 3D 列印樣品耐壓力性質分析 100
2.7.7 細胞存活度實驗 101
2.8 結論104
2.8.1 較俱彈性的兩種丙烯酸材料比較 104
2.8.2 適用於光固化 3D 列印動靜脈人工血管配方條件 106
2.9 討論 108 第三章 胜肽修飾之非固醇類抗發炎藥物於第一型與第二型環氧合酶選擇性的影響 111
3.1 簡介 111
3.1.2 不同類型的環氧合酶 111
3.1.3 前列腺素 (Prostaglandin) 113
3.1.5 實驗設計 116
3.2 實驗部分 121
3.2.2 實驗用儀器 123
3.2.3 實驗細胞株124
3.2.4 實驗材料選擇 125
3.2.6 末端脫氧核苷酸轉移酶脫氧尿苷三磷酸切口末端標記 132
3.2.7 Mitotracker 粒腺體染色
133 3.2.8 細胞存活度分析 (MTT assay)
133 3.2.9 PGE2 濃度測試134
3.3 實驗結果 136
3.3.1 第一型環氧化酶與第二型環氧化酶藥物選擇性測試 136
3.3.4 修飾後克多炎藥物與內毒素於 CTX_TNA 2 細胞的影響 151
3.4 結論 153
3.4.1 修飾後克多炎藥物對環氧化酶選擇性影響 153
3.4.2 修飾後克多炎藥物對過氧化氫及內毒素誘導對細胞的傷害影響 153
3.5 討論 155
3.6 附錄 157
3.7 參考文獻 160
參考文獻
1. Dimitrov, D.; Schreve, K.; de Beer, N., Advances in three dimensional printing –
state of the art and future perspectives. Rapid Prototyping Journal 2006, 12 (3), 136-
147.
2. Gross, B. C.; Erkal, J. L.; Lockwood, S. Y.; Chen, C.; Spence, D. M., Evaluation
of 3D printing and its potential impact on biotechnology and the chemical sciences.
Anal Chem 2014, 86 (7), 3240-53.
3. contributors, W. 3D printing.
https://en.wikipedia.org/w/index.php?title=3D_printing&oldid=789479245.
4. contributors, W. Computer-aided design.
https://en.wikipedia.org/w/index.php?title=Computeraided_design&oldid=787379246.
5. O'Neill, P. F.; Ben Azouz, A.; Vazquez, M.; Liu, J.; Marczak, S.; Slouka, Z.;
Chang, H. C.; Diamond, D.; Brabazon, D., Advances in three-dimensional rapid
prototyping of microfluidic devices for biological applications. Biomicrofluidics 2014,
8 (5), 052112.
6. Lin, H.; Zhang, D.; Alexander, P. G.; Yang, G.; Tan, J.; Cheng, A. W.; Tuan, R.
S., Application of visible light-based projection stereolithography for live cell-scaffold
fabrication with designed architecture. Biomaterials 2013, 34 (2), 331-9.
7. Wang, J.; Goyanes, A.; Gaisford, S.; Basit, A. W., Stereolithographic (SLA) 3D
printing of oral modified-release dosage forms. Int J Pharm 2016, 503 (1-2), 207-12.
8. Zhang, A. P.; Qu, X.; Soman, P.; Hribar, K. C.; Lee, J. W.; Chen, S.; He, S.,
Rapid fabrication of complex 3D extracellular microenvironments by dynamic optical
projection stereolithography. Adv Mater 2012, 24 (31), 4266-70.
9. Zorlutuna, P.; Annabi, N.; Camci-Unal, G.; Nikkhah, M.; Cha, J. M.; Nichol, J.
161
W.; Manbachi, A.; Bae, H.; Chen, S.; Khademhosseini, A., Microfabricated
biomaterials for engineering 3D tissues. Adv Mater 2012, 24 (14), 1782-804.
10. Garrett, B., 3D Printing: New Economic Paradigms and Strategic Shifts. Global
Policy 2014, 5 (1), 70-75.
11. Petrovic, V.; Vicente Haro Gonzalez, J.; Jordá Ferrando, O.; Delgado Gordillo, J.;
Ramón Blasco Puchades, J.; Portolés Griñan, L., Additive layered manufacturing:
sectors of industrial application shown through case studies. International Journal of
Production Research 2011, 49 (4), 1061-1079.
12. Stansbury, J. W.; Idacavage, M. J., 3D printing with polymers: Challenges among
expanding options and opportunities. Dent Mater 2016, 32 (1), 54-64.
13. Kim, G. D.; Oh, Y. T., A benchmark study on rapid prototyping processes and
machines: Quantitative comparisons of mechanical properties, accuracy, roughness,
speed, and material cost. Proceedings of the Institution of Mechanical Engineers, Part
B: Journal of Engineering Manufacture 2008, 222 (2), 201-215.
14. Guo, S. Z.; Gosselin, F.; Guerin, N.; Lanouette, A. M.; Heuzey, M. C.; Therriault,
D., Solvent-cast three-dimensional printing of multifunctional microsystems. Small
2013, 9 (24), 4118-22.
15. Tumbleston, J. R.; Shirvanyants, D.; Ermoshkin, N.; Janusziewicz, R.; Johnson,
A. R.; Kelly, D.; Chen, K.; Pinschmidt, R.; Rolland, J. P.; Ermoshkin, A.; Samulski, E.
T.; DeSimone, J. M., Additive manufacturing. Continuous liquid interface production
of 3D objects. Science 2015, 347 (6228), 1349-52.
16. Leng, S.; McGee, K.; Morris, J.; Alexander, A.; Kuhlmann, J.; Vrieze, T.;
McCollough, C. H.; Matsumoto, J., Anatomic modeling using 3D printing: quality
assurance and optimization. 3D Printing in Medicine 2017, 3 (1).
17. Kang, H. W.; Park, J. H.; Kang, T. Y.; Seol, Y. J.; Cho, D. W., Unit cell-based
computer-aided manufacturing system for tissue engineering. Biofabrication 2012, 4
162
(1), 015005.
18. Banik, I.; Bhowmick, A. K., Effect of electron beam irradiation on the properties
of crosslinked rubbers. Radiation Physics and Chemistry 2000, 58 (3), 293-298.
19. Gou, M.; Qu, X.; Zhu, W.; Xiang, M.; Yang, J.; Zhang, K.; Wei, Y.; Chen, S.,
Bio-inspired detoxification using 3D-printed hydrogel nanocomposites. Nat Commun
2014, 5, 3774.
20. Larson, K. A.; Luo, J.; Yousuf, A.; Ashton-Miller, J. A.; DeLancey, J. O. L.,
Measurement of the 3D geometry of the fascial arches in women with a unilateral
levator defect and “architectural distortion”. International urogynecology journal
2012, 23 (1), 57-63.
21. Kim, Y. C.; Hong, S.; Sun, H.; Kim, M. G.; Choi, K.; Cho, J.; Choi, H. R.; Koo,
J. C.; Moon, H.; Byun, D.; Kim, K. J.; Suhr, J.; Kim, S. H.; Nam, J.-D., UV-curing
kinetics and performance development of in situ curable 3D printing materials.
European Polymer Journal 2017, 93, 140-147.
22. Lawson, J. H.; Glickman, M. H.; Ilzecki, M.; Jakimowicz, T.; Jaroszynski, A.;
Peden, E. K.; Pilgrim, A. J.; Prichard, H. L.; Guziewicz, M.; Przywara, S.; Szmidt, J.;
Turek, J.; Witkiewicz, W.; Zapotoczny, N.; Zubilewicz, T.; Niklason, L. E.,
Bioengineered human acellular vessels for dialysis access in patients with end-stage
renal disease: two phase 2 single-arm trials. The Lancet 2016, 387 (10032), 2026-
2034.
23. Hoshi, R. A.; Van Lith, R.; Jen, M. C.; Allen, J. B.; Lapidos, K. A.; Ameer, G.,
The blood and vascular cell compatibility of heparin-modified ePTFE vascular grafts.
Biomaterials 2013, 34 (1), 30-41.
24. Prichard, H. L.; Manson, R. J.; DiBernardo, L.; Niklason, L. E.; Lawson, J. H.;
Dahl, S. L., An early study on the mechanisms that allow tissue-engineered vascular
grafts to resist intimal hyperplasia. J Cardiovasc Transl Res 2011, 4 (5), 674-82.
163
25. Kim, H.-H.; Choi, Y. H.; Suh, S.-H.; Lee, J. S.; Jung, Y. H.; So, Y. H.,
Arteriovenous Graft Modeling and Hemodynamic Interpretation. Open Journal of
Fluid Dynamics 2012, 02 (04), 324-330.
26. Donati, G.; Cianciolo, G.; Mauro, R.; Rucci, P.; Scrivo, A.; Marchetti, A.;
Giampalma, E.; Golfieri, R.; Panicali, L.; Iorio, M.; Stella, A.; La Manna, G.; Stefoni,
S., PTFE grafts versus tunneled cuffed catheters for hemodialysis: which is the second
choice when arteriovenous fistula is not feasible? Artif Organs 2015, 39 (2), 134-41.
27. Berardinelli, L., Grafts and graft materials as vascular substitutes for
haemodialysis access construction. Eur J Vasc Endovasc Surg 2006, 32 (2), 203-11.
28. Yin, A.; Zhang, K.; McClure, M. J.; Huang, C.; Wu, J.; Fang, J.; Mo, X.; Bowlin,
G. L.; Al-Deyab, S. S.; El-Newehy, M., Electrospinning collagen/chitosan/poly(Llactic acid-co-epsilon-caprolactone) to form a vascular graft: mechanical and
biological characterization. J Biomed Mater Res A 2013, 101 (5), 1292-301.
29. Hasan, A.; Memic, A.; Annabi, N.; Hossain, M.; Paul, A.; Dokmeci, M. R.;
Dehghani, F.; Khademhosseini, A., Electrospun scaffolds for tissue engineering of
vascular grafts. Acta Biomater 2014, 10 (1), 11 -25.
30. Shin, M.; Matsuda, K.; Ishii, O.; Terai, H.; Kaazempur-Mofrad, M.; Borenstein,
J.; Detmar, M.; Vacanti, J. P., Endothelialized networks with a vascular geometry in
microfabricated poly(dimethyl siloxane). Biomed Microdevices 2004, 6 (4), 269-78.
31. Yao, Y.; Wang, J.; Cui, Y.; Xu, R.; Wang, Z.; Zhang, J.; Wang, K.; Li, Y.; Zhao,
Q.; Kong, D., Effect of sustained heparin release from PCL/chitosan hybrid smalldiameter vascular grafts on anti-thrombogenic property and endothelialization. Acta
Biomater 2014, 10 (6), 2739-49.
32. Kaigler, D.; Silva, E. A.; Mooney, D. J., Guided bone regeneration using
injectable vascular endothelial growth factor delivery gel. J Periodontol 2013, 84 (2),
230-8.
164
33. Kosor, B. Y.; Artunc, C.; Sahan, H., Adhesive retention of experimental fiberreinforced composite, orthodontic acrylic resin, and aliphatic urethane acrylate to
silicone elastomer for maxillofacial prostheses. J Prosthet Dent 2015, 114 (1), 142-8.
34. Sun, K.; Wei, T. S.; Ahn, B. Y.; Seo, J. Y.; Dillon, S. J.; Lewis, J. A., 3D printing
of interdigitated Li-ion microbattery architectures. Adv Mater 2013, 25 (33), 4539-43.
35. Ethier, C. R.; Prakash, S.; Steinman, D. A.; Leask, R. L.; Couch, G. G.; Ojha, M.,
Steady flow separation patterns in a 45 degree junction. Journal of Fluid Mechanics
2000, 411 (32), 1-38.
36. Ha, H.; Hwang, D.; Choi, W. R.; Baek, J.; Lee, S. J., Fluid-dynamic optimal
design of helical vascular graft for stenotic disturbed flow. PLoS One 2014, 9 (10),
e111047.
37. Loth, F.; Fischer, P. F.; Bassiouny, H. S., Blood Flow in End-to-Side
Anastomoses. Annual Review of Fluid Mechanics 2008, 40 (1), 367-393.
38. Seo, J.; Kushner, D. I.; Hickner, M. A., 3D Printing of Micropatterned Anion
Exchange Membranes. ACS Appl Mater Interfaces 2016, 8 (26), 16656-63.
39. Whittaker, J. L.; Dutta, N. K.; Elvin, C. M.; Choudhury, N. R., Fabrication of
highly elastic resilin/silk fibroin based hydrogel by rapid photo-crosslinking reaction.
J. Mater. Chem. B 2015, 3 (32), 6576-6579.
40. Chia, H. N.; Wu, B. M., Recent advances in 3D printing of biomaterials. J Biol
Eng 2015, 9, 4.
41. Mahdavi, A.; Ferreira, L.; Sundback, C.; Nichol, J. W.; Chan, E. P.; Carter, D. J.;
Bettinger, C. J.; Patanavanich, S.; Chignozha, L.; Ben-Joseph, E.; Galakatos, A.;
Pryor, H.; Pomerantseva, I.; Masiakos, P. T.; Faquin, W.; Zumbuehl, A.; Hong, S.;
Borenstein, J.; Vacanti, J.; Langer, R.; Karp, J. M., A biodegradable and biocompatible
gecko-inspired tissue adhesive. Proc Natl Acad Sci U S A 2008, 105 (7), 2307-12.
42. Costa-Almeida, R.; Gasperini, L.; Borges, J.; Babo, P. S.; Rodrigues, M. T.;
165
Mano, J. F.; Reis, R. L.; Gomes, M. E., Microengineered Multicomponent Hydrogel
Fibers: Combining Polyelectrolyte Complexation and Microfluidics. ACS
Biomaterials Science & Engineering 2016, 3 (7), 1322-1331.
43. Feng, Q.; Wei, K.; Lin, S.; Xu, Z.; Sun, Y.; Shi, P.; Li, G.; Bian, L., Mechanically
resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by
weak host-guest interactions assist cell infiltration and in situ tissue regeneration.
Biomaterials 2016, 101, 217-28.
44. Meineke, G.; Hermans, M.; Klos, J.; Lenenbach, A.; Noll, R., A microfluidic
opto-caloric switch for sorting of particles by using 3D-hydrodynamic focusing based
on SLE fabrication capabilities. Lab Chip 2016, 16 (5), 820-8.
45. Tseng, W. C.; Jong, C. M., Improved stability of polycationic vector by dextrangrafted branched polyethylenimine. Biomacromolecules 2003, 4 (5), 1277-84.
46. Xu, G.; Wang, X.; Deng, C.; Teng, X.; Suuronen, E. J.; Shen, Z.; Zhong, Z.,
Injectable biodegradable hybrid hydrogels based on thiolated collagen and
oligo(acryloyl carbonate)-poly(ethylene glycol)-oligo(acryloyl carbonate) copolymer
for functional cardiac regeneration. Acta Biomater 2015, 15, 55-64.
47. He, S.; J. Yaszemski, M.; Yasko, A. W.; Engel, P. S.; Mikos, A. G., Injectable
biodegradable polymer composites based on poly(propylene fumarate) crosslinked
with poly(ethylene glycol)-dimethacrylate. Biomaterials 2000, 21 (23), 2389-2394.
48. He, H.; Adzima, B.; Zhong, M.; Averick, S.; Koepsel, R.; Murata, H.; Russell,
A.; Luebke, D.; Takahara, A.; Nulwala, H.; Matyjaszewski, K., Multifunctional photocrosslinked polymeric ionic hydrogel films. Polymer Chemistry 2014, 5 (8), 2824.
49. Cuchiara, M. P.; Allen, A. C.; Chen, T. M.; Miller, J. S.; West, J. L., Multilayer
microfluidic PEGDA hydrogels. Biomaterials 2010, 31 (21), 5491-7.
50. Wise, S. G.; Byrom, M. J.; Waterhouse, A.; Bannon, P. G.; Weiss, A. S.; Ng, M.
K., A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft
166
with tailored mechanical properties. Acta Biomater 2011, 7 (1), 295-303.
51. Kent, N. J.; Jolivet, L.; O’Neill, P.; Brabazon, D., An evaluation of components
manufactured from a range of materials, fabricated using PolyJet technology.
Advances in Materials and Processing Technologies 2017, 3 (3), 318-329.
52. Gaharwar, A. K.; Arpanaei, A.; Andresen, T. L.; Dolatshahi-Pirouz, A., 3D
Biomaterial Microarrays for Regenerative Medicine: Current State-of-the-Art,
Emerging Directions and Future Trends. Adv Mater 2016, 28 (4), 771-81.
53. Lee, K. Y.; Peters, M. C.; Anderson, K. W.; Mooney, D. J., Controlled growth
factor release from synthetic extracellular matrices. Nature 2000, 408 (6815), 998-
1000.
54. Hoffman-Kim, D.; Mitchel, J. A.; Bellamkonda, R. V., Topography, cell
response, and nerve regeneration. Annu Rev Biomed Eng 2010, 12, 203-31.
55. Kolesky, D. B.; Truby, R. L.; Gladman, A. S.; Busbee, T. A.; Homan, K. A.;
Lewis, J. A., 3D bioprinting of vascularized, heterogeneous cell-laden tissue
constructs. Adv Mater 2014, 26 (19), 3124-30.
56. Derby, B., Printing and prototyping of tissues and scaffolds. Science 2012, 338
(6109), 921-6.
57. Grogan, S. P.; Chung, P. H.; Soman, P.; Chen, P.; Lotz, M. K.; Chen, S.; D'Lima,
D. D., Digital micromirror device projection printing system for meniscus tissue
engineering. Acta Biomater 2013, 9 (7), 7218-26.
58. Soman, P.; Chung, P. H.; Zhang, A. P.; Chen, S., Digital microfabrication of userdefined 3D microstructures in cell-laden hydrogels. Biotechnol Bioeng 2013, 110 (11),
3038-47.
59. Park, J. Y.; Shim, J.-H.; Choi, S.-A.; Jang, J.; Kim, M.; Lee, S. H.; Cho, D.-W.,
3D printing technology to control BMP-2 and VEGF delivery spatially and temporally
to promote large-volume bone regeneration. J. Mater. Chem. B 2015, 3 (27), 5415-
167
5425.
60. Sanders, W. G.; Hogrebe, P. C.; Grainger, D. W.; Cheung, A. K.; Terry, C. M., A
biodegradable perivascular wrap for controlled, local and directed drug delivery. J
Control Release 2012, 161 (1), 81-9.
61. Tu, X.; Wang, L.; Wei, J.; Wang, B.; Tang, Y.; Shi, J.; Zhang, Z.; Chen, Y., 3D
printed PEGDA microstructures for gelatin scaffold integration and neuron
differentiation. Microelectronic Engineering 2016, 158, 30-34.
62. Beamish, J. A.; Zhu, J.; Kottke-Marchant, K.; Marchant, R. E., The effects of
monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol)
diacrylate hydrogels used for tissue engineering. J Biomed Mater Res A 2010, 92 (2),
441-50.
63. Aggarwal, P.; Lawson, J. S.; Tolley, H. D.; Lee, M. L., High efficiency
polyethylene glycol diacrylate monoliths for reversed-phase capillary liquid
chromatography of small molecules. J Chromatogr A 2014, 1364, 96-106.
64. Wong, K. V.; Hernandez, A., A Review of Additive Manufacturing. ISRN
Mechanical Engineering 2012, 2012, 1-10.
65. Kurimoto, M.; Ozaki, H.; Yamashita, Y.; Funabashi, T.; Kato, T.; Suzuoki, Y.,
Dielectric properties and 3d printing of uv-cured acrylic composite with alumina
microfiller. IEEE Transactions on Dielectrics and Electrical Insulation 2016, 23 (5),
2985-2992.
66. Al Mousawi, A.; Poriel, C.; Dumur, F.; Toufaily, J.; Hamieh, T.; Fouassier, J. P.;
Lalevée, J., Zinc Tetraphenylporphyrin as High Performance Visible Light
Photoinitiator of Cationic Photosensitive Resins for LED Projector 3D Printing
Applications. Macromolecules 2017, 50 (3), 746-753.
67. Yeh, Y. C.; Highley, C. B.; Ouyang, L.; Burdick, J. A., 3D printing of
photocurable poly(glycerol sebacate) elastomers. Biofabrication 2016, 8 (4), 045004.
168
68. Lumelsky, Y.; Silverstein, M. S., Biodegradable Porous Polymers through
Emulsion Templating. Macromolecules 2009, 42 (5), 1627-1633.
69. Shapiro, E. M., Biodegradable, polymer encapsulated, metal oxide particles for
MRI-based cell tracking. Magn Reson Med 2015, 73 (1), 376-89.
70. Yoshida, S.; Lamberti, L.; Sciammarella, C., <3D Printing Paper Final
Manuscript.pdf>. 2017.
71. Schuller-Ravoo, S.; Feijen, J.; Grijpma, D. W., Flexible, elastic and tear-resistant
networks prepared by photo-crosslinking poly(trimethylene carbonate) macromers.
Acta Biomater 2012, 8 (10), 3576-85.
72. Xie, H.; Cheng, C.-Y.; Du, L.; Fan, C.-J.; Deng, X.-Y.; Yang, K.-K.; Wang, Y.-Z.,
A Facile Strategy To Construct PDLLA-PTMEG Network with Triple-Shape Effect
via Photo-Cross-Linking of Anthracene Groups. Macromolecules 2016, 49 (10), 3845-
3855.
73. Bae, M.; Divan, R.; Suthar, K. J.; Mancini, D. C.; Gemeinhart, R. A., Fabrication
of Poly(ethylene glycol) Hydrogel Structures for Pharmaceutical Applications using
Electron beam and Optical Lithography. J Vac Sci Technol B Microelectron
Nanometer Struct Process Meas Phenom 2010, 28 (6), C6P24-C6P29.
74. Lu, L.; Guo, P.; Pan, Y., Magnetic-Field-Assisted Projection Stereolithography
for Three-Dimensional Printing of Smart Structures. Journal of Manufacturing
Science and Engineering 2017, 139 (7), 071008.
75. Seo, H.; Heo, S. G.; Lee, H.; Yoon, H., Preparation of PEG materials for
constructing complex structures by stereolithographic 3D printing. RSC Adv. 2017, 7
(46), 28684-28688.
76. Yamada, A.; Niikura, F.; Ikuta, K., A three-dimensional microfabrication system
for biodegradable polymers with high resolution and biocompatibility. Journal of
Micromechanics and Microengineering 2008, 18 (2), 025035.
169
77. Wust, S.; Muller, R.; Hofmann, S., 3D Bioprinting of complex channels-Effects
of material, orientation, geometry, and cell embedding. J Biomed Mater Res A 2015,
103 (8), 2558-70.
78. Song, X.; Pan, Y.; Chen, Y., Development of a Low-Cost Parallel Kinematic
Machine for Multidirectional Additive Manufacturing. Journal of Manufacturing
Science and Engineering 2014, 137 (2), 021005.
79. Sandron, S.; Heery, B.; Gupta, V.; Collins, D. A.; Nesterenko, E. P.; Nesterenko,
P. N.; Talebi, M.; Beirne, S.; Thompson, F.; Wallace, G. G.; Brabazon, D.; Regan, F.;
Paull, B., 3D printed metal columns for capillary liquid chromatography. Analyst
2014, 139 (24), 6343-7.
80. Mohammadi, S.; Maeki, M.; Mohamadi, R. M.; Ishida, A.; Tani, H.; Tokeshi, M.,
An instrument-free, screen-printed paper microfluidic device that enables bio and
chemical sensing. Analyst 2015, 140 (19), 6493-9.
81. Hribar, K. C.; Soman, P.; Warner, J.; Chung, P.; Chen, S., Light-assisted directwrite of 3D functional biomaterials. Lab Chip 2014, 14 (2), 268-75.
82. Hribar, K. C.; Finlay, D.; Ma, X.; Qu, X.; Ondeck, M. G.; Chung, P. H.; Zanella,
F.; Engler, A. J.; Sheikh, F.; Vuori, K.; Chen, S. C., Nonlinear 3D projection printing
of concave hydrogel microstructures for long-term multicellular spheroid and
embryoid body culture. Lab Chip 2015, 15 (11), 2412-8.
83. Ledesma, J.; Bortolato, S. A.; Boschetti, C. E.; Martino, D. M., Optimization of
Environmentally Benign Polymers Based on Thymine and Polyvinyl Sulfonate Using
Plackett-Burman Design and Surface Response. Journal of Chemistry 2013, 2013, 1-
9.
84. Kwisnek, L.; Goetz, J.; Meyers, K. P.; Heinz, S. R.; Wiggins, J. S.; Nazarenko,
S., PEG Containing Thiol–Ene Network Membranes for CO2Separation: Effect of
Cross-Linking on Thermal, Mechanical, and Gas Transport Properties.
170
Macromolecules 2014, 47 (10), 3243-3253.
85. Eshel-Green, T.; Eliyahu, S.; Avidan-Shlomovich, S.; Bianco-Peled, H., PEGDA
hydrogels as a replacement for animal tissues in mucoadhesion testing. Int J Pharm
2016, 506 (1-2), 25-34.
86. Xie, M.; Ge, J.; Xue, Y.; Du, Y.; Lei, B.; Ma, P. X., Photo-crosslinked fabrication
of novel biocompatible and elastomeric star-shaped inositol-based polymer with
highly tunable mechanical behavior and degradation. J Mech Behav Biomed Mater
2015, 51, 163-8.
87. Link, L. A.; Lonnecker, A. T.; Hearon, K.; Maher, C. A.; Raymond, J. E.;
Wooley, K. L., Photo-cross-linked poly(thioether-co-carbonate) networks derived
from the natural product quinic acid. ACS Appl Mater Interfaces 2014, 6 (20), 17370-
5.
88. Mazzoccoli, J. P.; Feke, D. L.; Baskaran, H.; Pintauro, P. N., Mechanical and cell
viability properties of crosslinked low- and high-molecular weight poly(ethylene
glycol) diacrylate blends. J Biomed Mater Res A 2010, 93 (2), 558-66.
89. Morris, V. B.; Nimbalkar, S.; Younesi, M.; McClellan, P.; Akkus, O., Mechanical
Properties, Cytocompatibility and Manufacturability of Chitosan:PEGDA Hybrid-Gel
Scaffolds by Stereolithography. Ann Biomed Eng 2017, 45 (1), 286-296.
90. Al Mousawi, A.; Kermagoret, A.; Versace, D.-L.; Toufaily, J.; Hamieh, T.; Graff,
B.; Dumur, F.; Gigmes, D.; Fouassier, J. P.; Lalevée, J., Copper photoredox catalysts
for polymerization upon near UV or visible light: structure/reactivity/efficiency
relationships and use in LED projector 3D printing resins. Polym. Chem. 2017, 8 (3),
568-580.
91. Johnson, D. W.; Langford, C. R.; Didsbury, M. P.; Lipp, B.; Przyborski, S. A.;
Cameron, N. R., Fully biodegradable and biocompatible emulsion templated polymer
scaffolds by thiol-acrylate polymerization of polycaprolactone macromonomers.
171
Polym. Chem. 2015, 6 (41), 7256-7263.
92. Fairbanks, B. D.; Schwartz, M. P.; Bowman, C. N.; Anseth, K. S., Photoinitiated
polymerization of PEG-diacrylate with lithium phenyl-2,4,6-
trimethylbenzoylphosphinate: polymerization rate and cytocompatibility. Biomaterials
2009, 30 (35), 6702-7.
93. Stach, M.; Lacík, I.; Chorvát, D. a.; Buback, M.; Hesse, P.; Hutchinson, R. A.;
Tang, L., Propagation Rate Coefficient for Radical Polymerization ofN-Vinyl
Pyrrolidone in Aqueous Solution Obtained by PLP−SEC. Macromolecules 2008, 41
(14), 5174-5185.
94. Hong, S.; Sycks, D.; Chan, H. F.; Lin, S.; Lopez, G. P.; Guilak, F.; Leong, K. W.;
Zhao, X., 3D Printing of Highly Stretchable and Tough Hydrogels into Complex,
Cellularized Structures. Adv Mater 2015, 27 (27), 4035-40.
95. Wu, B.; Chassé, W.; Peters, R.; Brooijmans, T.; Dias, A. A.; Heise, A.; Duxbury,
C. J.; Kentgens, A. P. M.; Brougham, D. F.; Litvinov, V. M., Network Structure in
Acrylate Systems: Effect of Junction Topology on Cross-Link Density and
Macroscopic Gel Properties. Macromolecules 2016, 49 (17), 6531-6540.
96. Avadanei, M. I., Photocrosslinking of 1,2-Polybutadiene and Characteristics of
the Crosslinked System. Journal of Macromolecular Science, Part B 2012, 51 (2),
313-327.
97. Javani, M.; Khorasani, S. N.; Abdolmaleki, A.; Nouri Khorasani, A.,
Photocrosslinking of styrene–isoprene–styrene; effect of benzoin and ethylene glycol
dimethacrylate on physical properties. Journal of Adhesion Science and Technology
2014, 28 (10), 975-985.
98. Cai, L.; Wang, S., Poly(ɛ-caprolactone) acrylates synthesized using a facile
method for fabricating networks to achieve controllable physicochemical properties
and tunable cell responses. Polymer 2010, 51 (1), 164-177.
172
99. Jaiswal, M.; Dinda, A. K.; Gupta, A.; Koul, V., Polycaprolactone diacrylate
crosslinked biodegradable semi-interpenetrating networks of polyacrylamide and
gelatin for controlled drug delivery. Biomed Mater 2010, 5 (6), 065014.
100. Amsden, B. G.; Marecak, D., Long-Term Sustained Release from a
Biodegradable Photo-Cross-Linked Network for Intraocular Corticosteroid Delivery.
Mol Pharm 2016, 13 (9), 3004-12.
101. Vijayabaskar, V.; Bhattacharya, S.; Tikku, V. K.; Bhowmick, A. K., Electron
beam initiated modification of acrylic elastomer in presence of polyfunctional
monomers. Radiation Physics and Chemistry 2004, 71 (5), 1045-1058.
102. Yang, C.-M.; Ju, J. B.; Lee, J. K.; Cho, W. I.; Cho, B. W., Electrochemical
performances of electric double layer capacitor with UV-cured gel polymer electrolyte
based on poly[(ethylene glycol)diacrylate]–poly(vinylidene fluoride) blend.
Electrochimica Acta 2005, 50 (9), 1813-1819.
103. Wang, K.; Jia, Y.-G.; Zhu, X. X., Biocompound-Based Multiple Shape Memory
Polymers Reinforced by Photo-Cross-Linking. ACS Biomaterials Science &
Engineering 2015, 1 (9), 855-863.
104. Markiewicz, K. H.; Seiler, L.; Misztalewska, I.; Winkler, K.; Harrisson, S.;
Wilczewska, A. Z.; Destarac, M.; Marty, J. D., Advantages of poly(vinyl phosphonic
acid)-based double hydrophilic block copolymers for the stabilization of iron oxide
nanoparticles. Polym. Chem. 2016, 7 (41), 6391 -6399.
105. Hribar, K. C.; Choi, Y. S.; Ondeck, M.; Engler, A. J.; Chen, S., Digital Plasmonic
Patterning for Localized Tuning of Hydrogel Stiffness. Adv Funct Mater 2014, 24
(31), 4922-4926.
106. Liu, J.; Hwang, H. H.; Wang, P.; Whang, G.; Chen, S., Direct 3D-printing of cellladen constructs in microfluidic architectures. Lab Chip 2016, 16 (8), 1430-8.
107. Jiang, F.; Pu, W.; Li, Y.; Du, D., A double-tailed acrylamide hydrophobically
173
associating polymer: Synthesis, characterization, and solution properties. Journal of
Applied Polymer Science 2015, 132 (38), n/a-n/a.
108. Wu, J.; Soucek, M. D., The effect of multifunctional monomers/oligomers
Additives on electron beam radiation crosslinking of poly (styrene-blockisoprene/butadiene-block-styrene) (SIBS). Radiation Physics and Chemistry 2016,
119, 55-63.
109. Temenoff, J. S.; Athanasiou, K. A.; LeBaron, R. G.; Mikos, A. G., Effect of
poly(ethylene glycol) molecular weight on tensile and swelling properties of
oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J
Biomed Mater Res 2002, 59 (3), 429-37.
110. Butscher, A.; Bohner, M.; Hofmann, S.; Gauckler, L.; Muller, R., Structural and
material approaches to bone tissue engineering in powder-based three-dimensional
printing. Acta Biomater 2011, 7 (3), 907-20.
111. Cha, C.; Soman, P.; Zhu, W.; Nikkhah, M.; Camci-Unal, G.; Chen, S.;
Khademhosseini, A., Structural Reinforcement of Cell-Laden Hydrogels with
Microfabricated Three Dimensional Scaffolds. Biomater Sci 2014, 2 (5), 703-709.
112. Cao, Y.; Lee, B. H.; Peled, H. B.; Venkatraman, S. S., Synthesis of stiffnesstunable and cell-responsive Gelatin-poly(ethylene glycol) hydrogel for threedimensional cell encapsulation. J Biomed Mater Res A 2016, 104 (10), 2401 -11.
113. Kolesky, D. B.; Homan, K. A.; Skylar-Scott, M. A.; Lewis, J. A., Threedimensional bioprinting of thick vascularized tissues. Proc Natl Acad Sci U S A 2016,
113 (12), 3179-84.
114. Hribar, K. C.; Meggs, K.; Liu, J.; Zhu, W.; Qu, X.; Chen, S., Three-dimensional
direct cell patterning in collagen hydrogels with near-infrared femtosecond laser. Sci
Rep 2015, 5, 17203.
115. Ovsianikov, A.; Malinauskas, M.; Schlie, S.; Chichkov, B.; Gittard, S.; Narayan,
174
R.; Lobler, M.; Sternberg, K.; Schmitz, K. P.; Haverich, A., Three-dimensional laser
micro- and nano-structuring of acrylated poly(ethylene glycol) materials and
evaluation of their cytoxicity for tissue engineering applications. Acta Biomater 2011,
7 (3), 967-74.
116. Fozdar, D. Y.; Soman, P.; Lee, J. W.; Han, L. H.; Chen, S., Three-Dimensional
Polymer Constructs Exhibiting a Tunable Negative Poisson's Ratio. Adv Funct Mater
2011, 21 (14), 2712-2720.
117. Soman, P.; Fozdar, D. Y.; Lee, J. W.; Phadke, A.; Varghese, S.; Chen, S., A Threedimensional Polymer Scaffolding Material Exhibiting a Zero Poisson's Ratio. Soft
Matter 2012, 8 (18), 4946-4951.
118. Yu, R.; Yang, X.; Zhang, Y.; Zhao, X.; Wu, X.; Zhao, T.; Zhao, Y.; Huang, W.,
Three-Dimensional Printing of Shape Memory Composites with Epoxy-Acrylate
Hybrid Photopolymer. ACS Appl Mater Interfaces 2017, 9 (2), 1820-1829.
119. Kotz, F.; Arnold, K.; Bauer, W.; Schild, D.; Keller, N.; Sachsenheimer, K.;
Nargang, T. M.; Richter, C.; Helmer, D.; Rapp, B. E., Three-dimensional printing of
transparent fused silica glass. Nature 2017, 544 (7650), 337-339.
120. Soman, P.; Tobe, B. T.; Lee, J. W.; Winquist, A. A.; Singec, I.; Vecchio, K. S.;
Snyder, E. Y.; Chen, S., Three-dimensional scaffolding to investigate neuronal
derivatives of human embryonic stem cells. Biomed Microdevices 2012, 14 (5), 829-
38.
121. Gauvin, R.; Chen, Y. C.; Lee, J. W.; Soman, P.; Zorlutuna, P.; Nichol, J. W.; Bae,
H.; Chen, S.; Khademhosseini, A., Microfabrication of complex porous tissue
engineering scaffolds using 3D projection stereolithography. Biomaterials 2012, 33
(15), 3824-34.
122. Guvendiren, M.; Molde, J.; Soares, R. M.; Kohn, J., Designing Biomaterials for
3D Printing. ACS Biomater Sci Eng 2016, 2 (10), 1679-1693.
175
123. Soman, P.; Lee, J. W.; Phadke, A.; Varghese, S.; Chen, S., Spatial tuning of
negative and positive Poisson's ratio in a multi-layer scaffold. Acta Biomater 2012, 8
(7), 2587-94.
124. G. Perrone, M.; Scilimati, A.; Simone, L.; Vitale, P., Selective COX-1 Inhibition:
A Therapeutic Target to be Reconsidered. Current Medicinal Chemistry 2010, 17 (32),
3769-3805.
125. Injamul Hoque; Arkendu Chatterjee; Somenath Bhattacharya; Raj Biswas; Sonia
Auddy; Mondal, K., A Review on different types of the Non Steroidal AntiInflammatory Drugs (NSAIDs). International Journal of Advanced Multidisciplinary
Research 2016, 3 (9), 41-51.
126. Peskar, B. M., Role of cyclooxygenase isoforms in gastric mucosal defence.
Journal of Physiology-Paris 2001, 95 (1-6), 3-9.
127. Meek, I. L.; Van de Laar, M. A.; H, E. V., Non-Steroidal Anti-Inflammatory
Drugs: An Overview of Cardiovascular Risks. Pharmaceuticals (Basel) 2010, 3 (7),
2146-2162.
128. Loogna, P.; Franzen, L.; Sipponen, P.; Domellof, L., Cyclooxygenase-2 and Bcl-
2 expression in the stomach mucosa of Wistar rats exposed to Helicobacter pylori, N'-
methyl- N'-nitro- N-nitrosoguanidine and bile. Virchows Arch 2002, 441 (1), 77-84.
129. Li, J.; Kuang, Y.; Gao, Y.; Du, X.; Shi, J.; Xu, B., D-amino acids boost the
selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory
drug (NSAID). J Am Chem Soc 2013, 135 (2), 542-5.
130. Zhang, S.; Ye, J.; Dong, G., Neuroprotective effect of baicalein on hydrogen
peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. J
Mol Neurosci 2010, 40 (3), 311-20.
131. Yeh, C. H.; Ma, K. H.; Liu, P. S.; Kuo, J. K.; Chueh, S. H., Baicalein Decreases
Hydrogen Peroxide-Induced Damage to NG108-15 Cells via Upregulation of Nrf2. J
176
Cell Physiol 2015, 230 (8), 1840-51.
132. Qi, Z.; Yin, F.; Lu, L.; Shen, L.; Qi, S.; Lan, L.; Luo, L.; Yin, Z., Baicalein
reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs
activation and ROS production. Inflamm Res 2013, 62 (9), 845-55.
133. Talepoor, A. G.; Kalani, M.; Dahaghani, A. S.; Doroudchi, M., Hydrogen
Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs
10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes.
Int J Toxicol 2017, 36 (2), 133-141.
134. Suk, K.; Lee, H.; Kang, S. S.; Cho, G. J.; Choi, W. S., Flavonoid baicalein
attenuates activation-induced cell death of brain microglia. J Pharmacol Exp Ther
2003, 305 (2), 638-45.
135. Cordero, J. A.; Camacho, M.; Obach, R.; Domenech, J.; Vila, L., In vitro based
index of topical anti-inflammatory activity to compare a series of NSAIDs. European
Journal of Pharmaceutics and Biopharmaceutics 2001, 51 (2), 135-142.
136. Font-Nieves, M.; Sans-Fons, M. G.; Gorina, R.; Bonfill-Teixidor, E.; SalasPerdomo, A.; Marquez-Kisinousky, L.; Santalucia, T.; Planas, A. M., Induction of
COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide
(LPS) control prostaglandin E2 production in astrocytes. J Biol Chem 2012, 287 (9),
6454-68.
137. Yue, G.; Shi, G.; Azaro, M. A.; Yang, Q.; Hu, G.; Luo, M.; Yin, K.; Nagele, R.
G.; Fine, D. H.; Yang, J. M.; Li, H., Lipopolysaccharide (LPS) potentiates hydrogen
peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and
growth factor gene expression. BMC Genomics 2008, 9, 608.
138. Bergsbaken, T.; Fink, S. L.; Cookson, B. T., Pyroptosis: host cell death and
inflammation. Nat Rev Microbiol 2009, 7 (2), 99-109.
139. Martorana, F.; Guidotti, G.; Brambilla, L.; Rossi, D., Withaferin A Inhibits
177
Nuclear Factor-kappaB-Dependent Pro-Inflammatory and Stress Response Pathways
in the Astrocytes. Neural Plast 2015, 2015, 381964.
140. Niranjan, R., The role of inflammatory and oxidative stress mechanisms in the
pathogenesis of Parkinson's disease: focus on astrocytes. Mol Neurobiol 2014, 49 (1),
28-38.
141. Zhang, Y.; Desai, A.; Yang, S. Y.; Bae, K. B.; Antczak, M. I.; Fink, S. P.; Tiwari,
S.; Willis, J. E.; Williams, N. S.; Dawson, D. M.; Wald, D.; Chen, W. D.; Wang, Z.;
Kasturi, L.; Larusch, G. A.; He, L.; Cominelli, F.; Di Martino, L.; Djuric, Z.; Milne,
G. L.; Chance, M.; Sanabria, J.; Dealwis, C.; Mikkola, D.; Naidoo, J.; Wei, S.; Tai, H.
H.; Gerson, S. L.; Ready, J. M.; Posner, B.; Willson, J. K.; Markowitz, S. D., TISSUE
REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH
potentiates tissue regeneration. Science 2015, 348 (6240), aaa2340.
142. Cuzzocrea, S.; Salvemini, D., Molecular mechanisms involved in the reciprocal
regulation of cyclooxygenase and nitric oxide synthase enzymes. Kidney Int 2007, 71
(4), 290-7.
143. Chan, T. A., Nonsteroidal anti-inflammatory drugs, apoptosis, and colon-cancer
chemoprevention. The Lancet Oncology 2002, 3 (3), 166-174.
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