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研究生:邱子洛
研究生(外文):Tzu-Lo Chiu
論文名稱:台北和中壢地區不孕症分佈與共病探討
論文名稱(外文):Distribution and comorbidities of infertility in Taipei and Zhongli Districts
指導教授:吳立青
指導教授(外文):Li-Ching Wu
學位類別:碩士
校院名稱:國立中央大學
系所名稱:系統生物與生物資訊研究所
學門:生命科學學門
學類:生物訊息學類
論文種類:學術論文
論文出版年:2018
畢業學年度:106
語文別:英文
論文頁數:63
中文關鍵詞:不孕症共病症
外文關鍵詞:infertilitycomorbidity
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隨者現在社會型態改變,許多人普遍晚婚,加上心理因素或環境污染等因素,都可能會增加不孕的發生,目前不孕症已成為全球關注的議題。在之前的研究就指出,導致不孕症的原因有女性因素、男性因素或原因不明因素,其中有25~28%不孕症是不明原因導致的。在臨床上,有些疾病之間的共病性是有顯著相關性並互相影響。在此研究中,我們利用國泰醫院和壢新醫院的看診資料,並以健保資料庫為輔助,以男性不孕症 (ICD9-CM : 606.9) 和女性不孕症(ICD9-CM : 628.9)為研究對象,探討不同地區不孕症年齡層分佈和不孕症與其他疾病之間的關聯性,並分析藥物使用是否會提高共病的風險。我們的研究結果顯示,兩家醫院在2008-2014年之間女性盛行率以2014年最高,國泰(0.36%)、壢新(0.52%),女性盛行率比男性高。年齡層分佈顯示在兩家醫院有顯著的差異。在女性患者共病方面,兩家醫院都顯示出與卵巢、子宮內膜異位、陰道炎和泌尿道感染這些疾病有顯著關係,而男性則是與泌尿道感染、生殖器官發炎等疾病相關。這些結果與過去研究相符。特別的是,我們在男女患者皆還發現到接觸性皮膚炎及其他濕疹,這疾病或許是不孕症其他誘導原因,還需進一步探討。
With the current social changes, many people are generally married late, and psychological factors or environmental pollution may increase the incidence of infertility. At present, infertility has become a global concern. In previous studies, it was pointed out that the causes of infertility were female factors, male factors or unexplained factors. Among them, 25-28% of infertility was caused by unexplained factors. Clinically, the comorbidities between some diseases are significantly correlated and affect each other. In this study, male infertility (ICD9-CM: 606.9) and female infertility (ICD9-CM: 628.9) are used be as the main subject. We used clinical data from Cathay General Hospital (CGH), Landseed Hospital (LSH) and supplemented with National Health Insurance Research Database (NHIRD) to investigate the relationship between infertility and the other diseases and age distribution of infertility in different regions. Also, we analyzed whether medicine used will increase the risk of comorbidity. Our research shows that the prevalence of females in the two hospitals was highest in 2014 from 2008 to 2014, with CGH (0.36%) and LSH (0.52%), and the prevalence of females was higher than that of males. Age distribution showed that there were significant differences between the two hospitals. In the comorbidity of female patients, both hospitals have been shown to have a significant relationship with ovarian, endometriosis, vaginitis and urinary tract infections, while men are associated with urinary tract infections, genital inflammation and other diseases. These results are consistent with past studies. In particular, we have also found contact dermatitis and other eczema in both male and female patients. It may be other causes of infertility, and needs further investigation.
中文摘要 i
English abstract ii
Tables of content iii
List of figures v
List of tables vi
Supplementary Figures vii
Supplementary Tables viii
Chapter 1 Introduction 1
1-1 Background 1
1-2 Related Work 1
1-3 Motivation 2
1-4 Goal 2
Chapter 2 Material and Methods 3
2-1 Collection of clinical data 3
2-2 Data processing 3
2-3 Procedure of research 6
2-3-1 Finding association between infertility patients and the other diseases 6
2-3-2 Identifying comorbidities differ significantly from the different distribution of age 6
2-3-3 Identifying influence between medicines and comorbidities of infertility 6
2-4 Statistics method 7
Chapter3 Result 9
3-1 Statistics of infertility patients 9
3-2 Select association between patients with infertility and the other diseases 12
3-2-1 Comparing significant comorbidities of infertility in LSH with CGH 16
3-2-2 Mapping results from two hospitals 17
3-2-3 The time difference between infertility and comorbidities 17
3-3 Age 26
3-3-1 Age distribution of infertility patients 26
3-3-2 Identify association between infertility and comorbidities depend on specific age groups 27
3-3 Medicine 31
Chapter4 Discussion and Summary 34
References 40
Supplementary 42
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