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When it comes to adulteration of cooking oil, impact of heavy metals on the organism, or the daily plastic products containing additives with endocrine disrupting chemicals, non-target detection of harmful substances also catch our attention. In addition to being widely used to analyze the surface of inorganic materials, the time-of-flight secondary mass spectrometry has a wide range of applications in biochemistry because of simultaneous detection of organic molecules. Therefore, the first part of this study will focus on adulteration of 77 animal oils. With hierarchical cluster analysis, K-means algorithm, and principal component analysis for oil species identification, we successfully distinguish eight of five types of oils such as lard, butter and fish oil. Different from the previous measurement on the total metal concentration when the organism is contaminated by heavy metals, our study combines bio-slice and mass spectrometry technology to successfully observe the distribution of copper in zebrafish and may validate certain toxicological mechanisms. In the last part, we conducted non-target analysis on 28 plastic products. Compared with traditional instrument analysis, we have little concern for the type of solvent used and extraction efficiency since our pretreatment is solvent-free and suitable for non-target analysis. It also comes to our concern that, four of twenty-eight plastic products contains DINP, one contain DEHP, which are endocrine disrupting chemicals and ten of twenty-eight products contains DOTP. It may enter human body under long-term use.
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