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研究生:李昱瑋
研究生(外文):Li, Yu-Wei
論文名稱:多針射頻消融裝置設計用於治療良性攝護腺腫大
論文名稱(外文):DESIGN OF MULTI-NEEDLE RADIOFREQUENCY ABLATION DEVICE FOR BENIGN PROSTATIC HYPERPLASIA TREATMENT
指導教授:林啓萬施文彬
指導教授(外文):Lin, Chii-WannShih, Wen-Pin
口試委員:劉建豪
口試委員(外文):Chien-Hao Liu
口試日期:2018-07-14
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:醫學工程學研究所
學門:工程學門
學類:綜合工程學類
論文種類:學術論文
論文出版年:2018
畢業學年度:106
語文別:英文
論文頁數:75
中文關鍵詞:radiofrequency ablation (RFA)tumor ablationbenign prostatic hyperplasia (BPH)bipolar needle ablationtransurethral needle ablation (TUNA)thermal lesion formation
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過去研究已經進行了許多嘗試來開發治療良性攝護腺腫大(BPH)的方法。射頻消融術(RFA)是臨床實踐中廣泛應用的技術,用於局部治療成型腫瘤,然而,射頻消融在良性攝護腺腫大治療的應用仍處於發展階段。經尿道針刺高溫消融切除術(TUNA)已被證明可有效改善良性攝護腺腫大病患的排尿症狀,但TUNA的術後成果具有高復發率。
本文討論了射頻消融的最新技術,採用有限元素法(FEM)來構建具有雙極電極的射頻溫控系統。數值模擬揭示了在射頻消融術的過程中消融體積對于目標溫度設定有強烈依賴性。本研究使用統計方法,比較細胞組織損傷以及因各種限制因素而產生的不同大小熱損傷,進而透過模擬和體外實驗結果相比,可以得知電極針消融裝置的結構設計的安全性與有效性。

關鍵字 - 射頻消融術(RFA),腫瘤消融切除術,良性攝護腺腫大(BPH),雙極針消融術,經尿道針刺高溫消融切除術(TUNA),熱損傷形成
Many attempts have been made to develop a method for treatment of benign prostatic hyperplasia (BPH). Radiofrequency ablation (RFA) is a widely applied technique in clinical practice for the local treatment of solid tumors. However, the application of RFA in the treatment of BPH is still in its developing stage. Transurethral Needle Ablation (TUNA) procedures have been shown to be efficacious for improving voiding symptoms in men with BPH. However, TUNA has also been noted to have a high retreatment rate.
This paper discusses the state-of-the-art of RFA, employing Finite Element Method (FEM) in order to build a temperature-controlled RF system with bipolar electrodes. The numerical simulation reveals a strong dependence of ablation volume on the set target temperature during RFA. Results were drawn from simulation and ex-vivo experiments, to retrospectively evaluate the safety and efficacy of the structural design of the needle ablation device, by determining cell tissue damage and the size of thermal lesions with various limiting factors using statistical methods.
Verification letter from the Oral Examination Committee I
ACKNOWLEDGEMENTS II
摘要 IV
ABSTRACT V
Contents VI
List of Figures VIII
List of Tables XIII
Chapter I Introduction 1
1.1 Background 1
1.1.1 Relevant Anatomy 1
1.2 Research Purpose 6
1.3 Contribution to Knowledge 6
1.4 Organization of the Dissertation 7
Chapter II Literature Review 8
2.1 Current Treatment of BPH and Its Downsides 8
2.1.1 Transurethral Resection of the Prostate 8
2.1.2 Transurethral Needle Ablation of the Prostate (TUNA) 9
2.1.3 TUNA vs. TURP 11
2.2 Radiofrequency Ablation (RFA) 12
2.2.1 RFA Settings 13
2.3 Calculation of the Ablation Zone Boundary 14
Chapter III Research Methodology 18
3.1 Mathematical modeling 18
3.2 Numerical Simulations 20
3.2.1 Material dimensions and properties of FE model 20
3.2.2 Initial and boundary conditions 25
3.2.3 Monopolar Electrode 26
3.3 Methods to Control Applied Power 27
3.3.1 Roll-Off Controller 27
3.3.2 On-Off Controller 28
3.3.3 Proportional Controller 30
3.4 Experimental Settings 32
3.4.1 Experimental Setup 32
3.4.2 Experimental Operating Steps 34
Chapter IV Data Analysis 38
4.1 Simulation Result 38
4.1.1 On-Off Controller vs. Proportional Controller 51
4.2 Experimental Results 52
4.3 Monopolar Electrode vs. Bipolar Electrodes 58
Chapter V Discussion and Further Work 62
Chapter VII Conclusions 69
References 70
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