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研究生:林桂篁
研究生(外文):LIN, GUEI-HUANG
論文名稱:紫珠之成分研究
論文名稱(外文):The Constituents of the Callicarpa bodinieri
指導教授:詹于誼
指導教授(外文):CHAN, YU-YI
口試委員:呂彥禮郭賓崇
口試委員(外文):LEU, YANN-LIIKUO, PING-CHUNG
口試日期:2018-01-16
學位類別:碩士
校院名稱:南臺科技大學
系所名稱:生物科技系
學門:生命科學學門
學類:生物科技學類
論文種類:學術論文
論文出版年:2018
畢業學年度:106
語文別:中文
論文頁數:108
中文關鍵詞:紫珠結構分析
外文關鍵詞:Callicarpa bodinieri
相關次數:
  • 被引用被引用:0
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將乾燥後的紫珠地上部共得到42個化合物,經由光譜分析及文獻比對,證實其結構分別為:
kumatakenin、luteolin、apigenin、chrysoeril、5-hydroxy-7,3’,4’-trimethoxyflavone、2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one、betulinic acid、lupeol、ursolic acid、ursolic acid及oleanolic acid之混合物、squalene、(3β)-lup-20(29)-en-3-yl alkanate、2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid、3β-hydroxy-urs-11-en-28,13β-olide、3α,23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12-en-28-oic acid、3α,23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12,20(30)-dien-28-oic acid、stigmasterol及β-sitosterol之混合物、β-sitosteryl glucoside、α-tocopherylquinone、α-tocopherol、5 -hydroxymethyl-γ-tocopherol、1,2 -bis- (5-γ-tocopherol) ethane、syringaresinol、medioresinol、curcasinlignan A、vanillin、4-hydroxybenzaldehyde、protocatechualdehyde、pheophytin-a、132-hydroxy(132-S)pheophytin-a、132-hydroxy(132-S)pheophytin-a及132-hydroxy(132-R)pheophytin-a之混合物、173-ethoxypheophorbide-a、173-ethoxypheophorbide-b、132-hydroxypheophorbide-b ethyl ester、methyl-21-hydroxy-(21S)-pheophorbide-a、methyl-21-hydroxy-(21S)-pheophorbide-b、132-hydroxy(132-S)pheophorbide-a及132-hydroxy(132-R)pheophorbide-a之混合物、4-hydroxyphenethyl tetradecanoate、phthalide及4-megastigmen-3,9-dione。其中3α,23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12,20(30)-dien-28-oic acid為新化合物。

Forty-two compounds were isolated from the aerial parts of Callicarpa bodinieri and characterized by comprensive analyses of their 1D and 2D NMR and mass spectral data. They are
kumatakenin, luteolin, apigenin, chrysoeril, 5-hydroxy-7,3’,4’-trimethoxyflavone, 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one, betulinic acid, lupeol, ursolic acid, ursolic acid and oleanolic acid mixtures, squalene, (3β)-lup-20(29)-en-3-yl alkanate, 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid, 3β-hydroxy-urs-11-en-28,13β-olide, 3α,23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12-en-28-oic acid, 3α,23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12,20(30)-dien-28-oic acid, stigmasterol and β-sitosterol mixtures, β-sitosteryl glucoside, α-tocopherylquinone, α-tocopherol, 5 -hydroxymethyl-γ-tocopherol, 1,2 -bis- (5-γ-tocopherol) ethane, syringaresinol, medioresinol, curcasinlignan A, vanillin, 4-hydroxybenzaldehyde, protocatechualdehyde, pheophytin-a, 132-hydroxy(132-S)pheophytin-a, 132-hydroxy(132-S)pheophytin-a and 132-hydroxy(132-R)pheophytin-a mixtures, 173-ethoxypheophorbide-a, 173-ethoxypheophorbide-b, 132-hydroxypheophorbide-b ethyl ester, methyl-21-hydroxy-(21S)-pheophorbide-a, methyl-21-hydroxy-(21S)-pheophorbide-b, 132-hydroxy(132-S)pheophorbide-a and 132-hydroxy(132-R)pheophorbide-a mixtures, 4-hydroxyphenethyl tetradecanoate, phthalide and 4-megastigmen-3,9-dione. Among these compounds, 3α,23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12,20(30)-dien-28-oic acid is a new compound.

目錄
Abstract ---------------------------------------------------------------------------------III
中文摘要 ----------------------------------------------------------------------------------IV
致謝 --------------------------------------------------------------------------------------V
目錄 --------------------------------------------------------------------------------------VI
第一章 緒論---------------------------------------------------------------------------------1
第一節 緒言-------------------------------------------------------------------------1
第二節 紫珠之型態--------------------------------------------------------------------2
第二章 紫珠屬植物之成分研究概況 --------------------------------------------------------------4
第一節 紫珠屬植物之化學成分回顧 ------------------------------------------------------4
第二節 紫珠屬植物藥理活性之研究概況 --------------------------------------------------30
第三章 抽取與分離 --------------------------------------------------------------------------33
第四章 構造研究-----------------------------------------------------------------------------45
第一節luteolin (153) ------------------------------------------------------------------45
第二節syringaresinol (203) ------------------------------------------------------------47
第三節curcasinlignan A (204) ----------------------------------------------------------49
第四節ursolic acid (23) ---------------------------------------------------------------55
第五節2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid (193) ----------------------------57
第六節3β-hydroxy-urs-11-en-28,13β-olide (194) -----------------------------------------63
第七節3α-23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12-en-28-oic acid (195) ------------68
第八節3α-23-O-isopropylidenyl-2α,19α-dihydroxy-urs-12,20(30)-dien-28-oic acid (196) ---74
第五章 結論---------------------------------------------------------------------------------81
第六章 實驗部分-----------------------------------------------------------------------------82
第一節 本實驗所用之儀器與藥品------------------------------------------------------------82
第二節 植物之採集與鑑定------------------------------------------------------------------83
第三節 紫珠成分之萃取與分離 -------------------------------------------------------------83
第四節 光譜數據整理 ---------------------------------------------------------------------85
參考文獻 ----------------------------------------------------------------------------------100

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