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研究生:簡肇均
研究生(外文):Jhao-Jun Jian
論文名稱:開發一個新型神經痛止痛藥
論文名稱(外文):Development of a novel analgesic for neuropathic pain
指導教授:曹美玲
指導教授(外文):Meei-Ling Tsaur
學位類別:碩士
校院名稱:國立陽明大學
系所名稱:神經科學研究所
學門:醫藥衛生學門
學類:醫學學類
論文種類:學術論文
論文出版年:2017
畢業學年度:106
語文別:英文
論文頁數:29
中文關鍵詞:神經痛電壓門控鉀離子通道脊髓背根神經節
外文關鍵詞:neuropathic painKv channelspinal cordDRGNS5806
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Contents

致謝………i
Contents………ii
中文摘要………iii
Abstract………iv
A. Introduction………1
B. Materials and Methods………3
1. Animals………3
2. Spinal nerve ligation………3
3. Chemicals………3
4. Intrathecal injection………4
5. Pain behavioral tests………4
6. Rotarod test………5
7. Hematological analysis………5
8. Serum analysis………6
9. Tissue processing for immunohistochemistry………6
10. Single antigen immunohistochemistry………6
11. Quantitative measurement in spinal cord………7
12. Quantitative measurement in DRG………7
C. Results………9
1. NS5806 relieves SNL-induced mechanical hypersensitivity………9
2. NS5806 does not impair motor function………9
3. NS5806 does not affect blood cell numbers………10
4. NS5806 does not affect kidney and liver functions………10
5. NS5806 does not affect microglia recruitment and astrocyte proliferation in dorsal horn………11
6. NS5806 does not affect macrophage recruitment and satellite cell proliferation in DRG………12
D. Discussion………13
E. References………16
F. Figures………21
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