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研究生(外文):Jhao-Jun Jian
論文名稱(外文):Development of a novel analgesic for neuropathic pain
指導教授(外文):Meei-Ling Tsaur
外文關鍵詞:neuropathic painKv channelspinal cordDRGNS5806
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A. Introduction………1
B. Materials and Methods………3
1. Animals………3
2. Spinal nerve ligation………3
3. Chemicals………3
4. Intrathecal injection………4
5. Pain behavioral tests………4
6. Rotarod test………5
7. Hematological analysis………5
8. Serum analysis………6
9. Tissue processing for immunohistochemistry………6
10. Single antigen immunohistochemistry………6
11. Quantitative measurement in spinal cord………7
12. Quantitative measurement in DRG………7
C. Results………9
1. NS5806 relieves SNL-induced mechanical hypersensitivity………9
2. NS5806 does not impair motor function………9
3. NS5806 does not affect blood cell numbers………10
4. NS5806 does not affect kidney and liver functions………10
5. NS5806 does not affect microglia recruitment and astrocyte proliferation in dorsal horn………11
6. NS5806 does not affect macrophage recruitment and satellite cell proliferation in DRG………12
D. Discussion………13
E. References………16
F. Figures………21
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