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研究生:方浩庭
研究生(外文):FANG, HAO-TING
論文名稱:以統合分析及長期追蹤模式探討代謝症候群與非酒精性脂肪肝之相關性
論文名稱(外文):A Study of the Relationship between Metabolic Syndrome and Non-Alcoholic Fatty Liver: A Meta-analysis and Follow-up Study
指導教授:陳富莉陳富莉引用關係
指導教授(外文):CHEN, FU-LI
口試委員:白其卉呂至剛
口試委員(外文):BAI, CHYI-HUEYLEU, JYH-GANG
口試日期:2019-06-06
學位類別:碩士
校院名稱:輔仁大學
系所名稱:公共衛生學系碩士班
學門:醫藥衛生學門
學類:公共衛生學類
論文種類:學術論文
論文出版年:2019
畢業學年度:107
語文別:英文
論文頁數:100
中文關鍵詞:代謝症候群非酒精性脂肪肝隊列研究統合分析
外文關鍵詞:metabolic syndromeNon-alcoholic fatty livercohort studymeta-analysis
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背景:隨著臺灣地區人口老齡化程度加深,各種慢性疾病逐漸成為 公共衛生的新的挑戰。代謝症候群的發生率不斷上升,代謝症候群 是許多慢性疾病的風險因數之一,而代謝症候群和非酒精性脂肪肝 之間的關係尚缺乏長期的研究。 研究方法:本文採用大數據分析和 meta 分析兩種方式進行研究。在 meta 分析中,使用 Embase, Pubmed 和 Cochrane Library 進行文獻搜 集。而在大數據分析中,使用 NHIRD 1996-2013 之間的數據進行分 析。分析方法為 COX 回歸和存活分析。 結果:Meta 分析發現,代謝症候群和高血糖、肥胖均會提高非酒精 性脂肪肝的風險。而在大數據分析中,代謝症候群的成分數量會提 高非酒精性脂肪肝的風險。這在不同性別和年齡中均有顯著差異。 結論:代謝症候群會顯著增加非酒精性脂肪肝的風險,這種風險的 加成效應隨著代謝症候群的成分增多而增強。
Backgroud: As the aging population in Taiwan deepens, various chronic diseases are gradually becoming a new challenge for public health. The incidence of metabolic syndrome is increasing, and metabolic syndrome is one of the risk factors for many chronic diseases, and the relationship between metabolic syndrome and nonalcoholic fatty liver is still lacking in long-term research. Methods: This paper uses big data analysis and meta analysis to conduct research. In the meta-analysis, literature collection was performed using Embase, Pubmed and Cochrane Library. In the big data analysis, the data between NHIRD 1996-2013 was used for analysis. Analytical methods are COX regression and survival analysis. RESULTS: In the meta-analysis, metabolic syndrome, hyperglycemia, and obesity all increased the risk of nonalcoholic fatty liver disease. In big data analysis, the number of components of metabolic syndrome increases the risk of nonalcoholic fatty liver disease. This is reflected in different genders and ages. Conclusion: Metabolic syndrome significantly increases the risk of nonalcoholic fatty liver disease, and the additive effect of this risk increases with the increased composition of metabolic syndrome.
CHAPTER 1................................................................................................................................................ 4 INTRODUCTION........................................................................................................................................4 1.1 Research Origin and Importance...................................................................................................... 4 1.2 Study Objectives.................................................................................................................................. 5 1.3 Glossary............................................................................................................................................... 5 1.3.1 Non-Alcoholic Fatty Liver:......................................................................................................6 1.3.2 Metabolic Syndrome:..............................................................................................................6 1.3.3 Meta-Analysis:.........................................................................................................................6 CHAPTER 2................................................................................................................................................ 7 LITERATURE REVIEW................................................................................................................................ 7 CHAPTER 3.............................................................................................................................................. 13 METHODS................................................................................................................................................13 3.1 Study Design.....................................................................................................................................13 3.2 Systematic review and Meta-analysis.............................................................................................13 Table 1..................................................................................................................................................... 16 3.4.1 Data source.................................................................................................................................... 19 3.4.2 Subjects.......................................................................................................................................... 19 3.4.3 Ethical Considerations...................................................................................................................20 3.4.4 Analysis...........................................................................................................................................20 CHAPTER 4.............................................................................................................................................. 21 RESULTS...................................................................................................................................................21 CHAPTER 5.............................................................................................................................................. 84 DISCUSSION............................................................................................................................................84 5.1 Effect of metabolic risk factors on NAFLD..................................................................................... 84 5.2 Methodological considerations.......................................................................................................87 5.3 Clinical implications..........................................................................................................................88 CHAPTER 6.............................................................................................................................................. 89 CONCLUSION......................................................................................................................................... 89 6.1 Summary and conclusion................................................................................................................ 89 6.2 Research Suggestion........................................................................................................................89 6.3 Study Limitations.............................................................................................................................. 89 Reference.................................................................................................................................................91
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