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研究生:陳家威
研究生(外文):Chia-WeiChen
論文名稱:經顱直流電刺激術對海洛因依賴者神經認知功能之療效研究
論文名稱(外文):Therapeutic Effects of Transcranial Direct Current Stimulation on Neurocognitive Function in Patients with Heroin Dependence
指導教授:楊延光楊延光引用關係郭乃文郭乃文引用關係
指導教授(外文):Yen Kuang YangNai-Wen Guo
學位類別:碩士
校院名稱:國立成功大學
系所名稱:行為醫學研究所
學門:社會及行為科學學門
學類:心理學類
論文種類:學術論文
論文出版年:2019
畢業學年度:107
語文別:英文
論文頁數:48
中文關鍵詞:經顱直流電刺激術海洛因依賴前額葉認知功能
外文關鍵詞:tDCSheroin dependenceprefrontal cortexneurocognitive function
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本研究旨在探討經顱直流電刺激術對腦部認知功能的療效,並經不同的刺激位置,比較兩前額葉腦區對經顱直流電刺激術的反應是否相同。研究設計為一隨機分派、對抗平衡的雙因子實驗,受試者間變項為兩前額葉腦區-背外側前額葉與眶額葉皮質;受試者內變項為實驗操弄-假處理與真處理。研究參與者有海洛因依賴之診斷,合併中重度菸草使用。研究發現經顱直流電刺激術對於認知表現無顯著的效果,兩腦區與實驗處理的交互作用亦不顯著。未來方向將擴大研究樣本、增加治療強度或且結合神經心理復健,在認知訓練過程同時施以經顱直流電刺激術以增益認知學習的效果。
This study aims at probing the effect of transcranial direct current stimulation on neurocognitive function in patients with heroin dependence. Through different stimulation sites of prefrontal cortex targeted, effects from two stimulation sites would be compared and further tested if they benefit frontal function to the same extent. This experiment is a randomized, counterbalanced, sham-controlled factorial design, which includes two prefrontal areas to be targeted, dorsolateral prefrontal cortex and orbitofrontal cortex, as one between variable; while two experimental treatments, sham and active treatments, as one within variable. All research participants have been diagnosed as heroin dependence and shared a characteristic of heavy tobacco use to a moderate or severe extent. Results showed that no significant effects were obtained on their neurocognitive performance; moreover, no final conclusion has yet to be reached about the interaction effect of stimulation sites and experimental treatments. This study would like to suggest scaling a larger sample, treatment intensity or dosage, and/or combining neuropsychological rehabilitation to shape a more specific cognitive learning that may be facilitated by tDCS.
中文摘要 ....II
ABSTRACT ....IV
致謝 ....VI
TABLE OF CONTENTS ....VIII
LIST OF TABLES ....IX
LIST OF FIGURES ....X
LIST OF ABBREVIATION ....XI
1. INTRODUCTION
 1.1 BACKGROUND OF RESEARCH ....01
 1.2 COGNITIVE PROFILES IN HEROIN AND NICOTINE DEPENDENCE ....04
 1.3 NEUROSTIMULATION IN COGNITION ....07
 1.4 AIMS OF RESEARCH ....13
2. METHODS
 2.1 RESEARCH DESIGN ....14
 2.2 PARTICIPANTS ....14
 2.3 MATERIALS ....16
 2.4 PROCEDURE ....19
 2.5 STATISTICAL METHOD ....21
3. RESULTS
 3.1 TREATMENT OUTCOMES ....22
 3.2 CHANGE INDUCED BY ACTIVE TREATMENT ....31
4. DISCUSSION ....35
5. CONCLUSION ....41
REFERENCE ....42
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