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研究生:杜俊緯
研究生(外文):TU, CHUN-WEI
論文名稱:鱘龍魚(Acipernser baerii)軟骨中硫酸軟骨素以及膠原蛋白之特性及其對於傷口癒合能力之研究
論文名稱(外文):Characterization and Wound Healing Activity by the Collagen and Chondroitin Sulfate from Sturgeon Cartilage (Acipernser Baerii)
指導教授:蔡美玲蔡美玲引用關係賴慶紓
指導教授(外文):TSAI, MEI-LINGLAI, CHING-SHU
口試委員:潘敏雄郭星君蔡美玲孫珮珮孫珮珮
口試委員(外文):PAN, MING-HSUINGKUO, HSIN-CHUNTSAI, MEI-LINGSUN, PEI-PEILAI, CHING-SHU
口試日期:2019-07-31
學位類別:碩士
校院名稱:國立高雄科技大學
系所名稱:水產食品科學系
學門:農業科學學門
學類:食品科學類
論文種類:學術論文
論文出版年:2019
畢業學年度:107
語文別:中文
論文頁數:202
中文關鍵詞:鱘龍魚軟骨(Acipenser baerii)硫酸軟骨素膠原蛋白傷口癒合初代人類真皮成纖維細胞 HDFaC57BL6/J
外文關鍵詞:Sturgeon cartilage(Acipenser baerii)Chondroitin sulfateCollagenWound healingHuman dermal fibroblast cell (HDFa)C57BL6/J mice
相關次數:
  • 被引用被引用:0
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目錄 III
附圖目錄 V
附表目錄 V
圖目錄 VI
表目錄 VII
中文摘要 VIII
Abstract X
縮寫全名對照表 XII
壹、文獻整理 1
一、傷口癒合 1
1.1 皮膚 1
1.2 傷口癒合的機制 3
1.3 參與癒合過程的細胞 9
1.4 參與癒合過程的細胞因子及酵素 16
二、傷口癒合對人類的影響 19
2.1 影響傷口癒合的因素 19
三、傷口治療與照護 23
3.1 目前治療傷口的方法 23
3.2 人工敷料 25
四、鱘龍魚簡介 27
4.1 硫酸軟骨素介紹(chondroitin sulfate) 30
4.2 膠原蛋白介紹(collagen) 31
貳、研究目的 35
一、實驗材料 36
二、儀器與廠牌 37
三、藥品 39
四、實驗方法 42
1. 實驗設計 42
2. 一般成分分析 43
3. 鱘龍魚軟骨中硫酸軟骨素之萃取及其萃取率分析 46
4. 膠原蛋白之萃取及其萃取率之分析 47
5. 胺基酸組成分析(amino acid profile) 48
6. SDS不連續聚丙烯醯胺膠體電泳分析(SDS-PAGE) 48
7. 傅立葉轉換紅外光測定(Fourier-transform infrared spectroscopy) 49
8. 示差掃描熱量分析(differential scanning calorimeter) 49
9. 高效液相層析測定(high performance liquid chromatography;HPLC) 50
10. 細胞培養(cell culture and subculture) 53
11. 細胞增生效果(trypan blue assay) 55
12. 細胞侵入性試驗分析(transwell migration assay) 55
13. 細胞劃傷試驗(scratch assay) 56
14. 西方墨點法(Western blotting) 57
15. 即時定量PCR(real time PCR;qRT-PCR) 63
16. 動物實驗(in vivo study) 67
17. 動物組織病理切片 69
18. 統計分析(statistical analysis) 73
肆、結果與討論 74
一、Acipenser baerii軟骨中SCC和CS萃取 74
1.1 Acipenser baerii軟骨之成分分析結果 74
1.2 Acipenser baerii軟骨中膠原蛋白與硫酸軟骨素成份分析 74
二、SCC定性試驗和加速傷口癒合之體內外試驗評估 76
2.1 Acipenser baerii軟骨組織中膠原蛋白(SCC)定性試驗 76
2.2 TSC和SCC加速傷口癒合之體內外試驗評估 81
三、CS定性試驗和加速傷口癒合之體內外試驗評估 101
3.1 Acipenser baerii軟骨組織中硫酸軟骨素(CS)定性試驗 101
3.2 CS加速傷口癒合之體內外試驗評估 105
伍、結論 118
陸、圖表 120
柒、參考文獻 164


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