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研究生:吳瑋仁
研究生(外文):Wu, Wei-Ren
論文名稱:以石墨烯量子點調制表面電漿子能量於生物感測器之研究
論文名稱(外文):Modulation of Surface Plasmon Resonance Energy Using Graphene Quantum Dots on Biosensors Application
指導教授:邱南福
指導教授(外文):Chiu, Nan-Fu
學位類別:碩士
校院名稱:國立臺灣師範大學
系所名稱:光電科技研究所
學門:工程學門
學類:電資工程學類
論文種類:學術論文
論文出版年:2018
畢業學年度:107
語文別:中文
論文頁數:101
中文關鍵詞:石墨烯量子點金奈米粒子表面電漿子共振胰臟癌腫瘤指標物
外文關鍵詞:Graphene quantum dots (GQDs)Gold nanoparticles (AuNPs)Surface plasmon resonance (SPR)Carbohydrate Antigen 19-9 (CA19-9)
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致謝 i
摘要 ii
Abstract iii
目錄 v
表目錄 viii
圖目錄 ix

第一章 緒論 1
1.1 研究動機 1
1.2 研究目的 2
1.3 論文架構 3

第二章 基本原理與文獻回顧 4
2.1 石墨烯概論 4
2.2 石墨烯量子點 5
2.2.1 石墨烯量子點 5
2.2.2 石墨烯量子點的備製 6
2.2.3 石墨烯子點的光學特性 24
2.2.4 石墨烯量子點的螢光原理 29
2.2.5 石墨烯量子點的生物相容性 31
2.2.6 石墨烯量子點的生物感測應用 32
2.2.7 石墨烯量子點與金奈米粒子的合成特性 40
2.3 表面電漿子共振 41
2.3.1 表面電漿子共振 41
2.3.2 局部表面電漿子共振 42
2.3.3 稜鏡耦合表面電漿子共振 43
2.3.4 表面電漿子共振耦合螢光機制 44
2.4 胰臟癌檢測指標癌症抗原CA19-9 45
2.4.1 胰臟癌檢測 45
2.4.2 癌症抗原CA19-9 45

第三章 實驗方法與材料 47
3.1 石墨烯量子點備製 47
3.1.1 合成石墨烯量子點 47
3.1.2 合成金奈米粒子 49
3.1.3 石墨烯量子點修飾金奈米粒子 50
3.2 SPR生醫晶片備製 51
3.3 SPR生物實驗 52
3.4 實驗耗材 53
3.5 實驗儀器設備 54

第四章 結果與討論 55
4.1 材料分析 55
4.1.1 光學特性分析 55
4.1.2 元素分析 58
4.1.3 形態分析 64
4.2 生物實驗 68
4.2.1 SPR共振角分析 68
4.2.2 電化學分析 70
4.2.3 SPR生物實驗分析 71

第五章 未來展望 73
5.1 未來展望 73
5.1.1 結論 73
5.1.2 未來展望 74

參考文獻 75
附錄 92
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