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研究生:蕭鵬
研究生(外文):Peng Siao
論文名稱:以超音波萃取搭配極致液相層析/串聯式質譜儀分析臺灣食品包裝中全氟烷基化合物
論文名稱(外文):Determination of Perfluoroalkyl Substances in Various Food Packagings in Taiwan Using Ultrasonic Extraction and UPLC-MS/MS
指導教授:陳家揚陳家揚引用關係
口試委員:曾素香陳珮珊陳鑫昌
口試日期:2019-06-28
學位類別:碩士
校院名稱:國立臺灣大學
系所名稱:食品安全與健康研究所
學門:醫藥衛生學門
學類:其他醫藥衛生學類
論文種類:學術論文
論文出版年:2019
畢業學年度:107
語文別:英文
論文頁數:95
中文關鍵詞:抗油食品包裝全氟烷基化合物液相層析/串聯式質譜儀電灑游離超音波萃取
DOI:10.6342/NTU201902362
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全氟烷基化合物(perfluoroalkyl substances, PFASs) 具有抗油防水的特性,廣泛應用於工業製造及消費產品中,然而其持久性及毒性使其成為全球關注之環境汙染物。本研究為開發以超音波萃取搭配極致液相層析/串聯式質譜儀(ultra-performance liquid chromatography/tandem mass spectrometer, UPLC-MS/MS)對於20種PFASs多重殘留一次分析之方法,並實測七大類市售32件抗油食品包裝。本研究最適化UPLC-MS/MS各項參數,超音波萃取之最適合條件,並評估基質效應及萃取效率。最終依據食藥署規範,進行準確度(accuracy)及精密度(precision)之方法確效。100 cm2之樣品經裁剪成碎片後,以甲醇於50°C超音波萃取45分鐘,經離心、過濾、濃縮等步驟至1 mL,上機以UPLC-MS/MS分析。20種PFASs之基質效應因子(Matrix effect factors)為50.2%-80%,除PFHxDA, PFOSA, N-MeFOSA, 8:2 FTOH及8:2 diPAP低於50%;萃取效率(extraction efficiency)為51.5%-98.7%,除PFOSA, N-MeFOSA, 4:2 FTOH, 6:2 FTOH及8:2 FTOH低於6%。偵測極限(limits of detection, LODs)為0.07-11.3 ng/dm2;定量極限(limits of quantification, LOQs)為0.17-18.3 ng/dm2。方法確效(Method validation)參照食藥署公布之食品化學檢驗方法確效規範,20個待測物除4:2 FTOH之外,有19個PFASs通過準確度(accuracy)及精密度(precision)之要求,在三種不同濃度下,回收率(recovery)為70%-117%,精密度(%CV)低於19% (n = 5),線性範圍為5.0-1,000 ng/dm2。實際檢測市售樣品,四件微波爆米花紙袋有三件可檢出短中碳鏈全氟羧酸(PFBA, PFPeA, PFHxA, PFOA, PFDA),檢出範圍8.3-1,960 ng/dm2;兩件檢出氟調聚合醇類(FTOHs),檢出範圍112-7,188 ng/dm2。三件通用防油紙袋有一件檢出全氟羧酸類(PFBA, PFHxA, PFOA, PFDA, PFUnDA, PFDoDA, PFHxDA),檢出範圍5.7-48.6 ng/dm2;兩件檢出氟調聚合醇類(FTOHs),檢出範圍454-2,595 ng/dm2。九件雞塊盒及薯條紙袋有兩件檢出全氟羧酸類(PFBA, PFHxDA),檢出範圍5.0-40.3 ng/dm2;僅有一件檢出氟調聚合醇類(FTOHs),檢出範圍22.4-167 ng/dm2。綜合言之,PFASs於各式抗油之食品包裝檢出濃度低至ppb等級,但仍須留意長期暴露的慢性健康影響。
Perfluoroalkyl substances (PFASs) possess oil-resistant and waterproof properties, and are widely used in industrial manufacturing and consumer products. Because of their persistency and toxicity, PFASs have become an environmental pollutant of global concern. A part of PFASs have been listed in the Stockholm Convention. The purpose of this study was to develop an analytical method for 20 PFASs with an ultra-performance liquid chromatography/triple-quadrupole tandem mass spectrometer (UPLC-MS/MS). This study also measured seven categories of commercial oil-resistant food packaging, in the total of 32 samples in Taiwan. This study optimized UPLC-MS/MS parameters, investigated suitable conditions for ultrasonic extraction, and evaluated the matrix effect and extraction efficiency. The finalized assay was validated according to the TFDA specification, to demonstrate good accuracy and precision. 100-cm2 samples were cut into pieces and were ultra-sonicated in 20-mL methanol at 50℃ for 45 minutes. The supernatant was centrifuged, filtered, and concentrated to 1 mL, then the residue was injected into UPLC-MS/MS. Matrix effect factors of 20 PFASs were 50.2%-80%, except for PFHxDA, PFOSA, N-MeFOSA, 8:2 FTOH and 8:2 diPAP were lower than 50%; extraction efficiencies were 51.5%-98.7%, except for PFOSA, N-MeFOSA, 4:2 FTOH, 6:2 FTOH, 8:2 FTOH were lower than 6%. The linear dynamic ranges of the analytes were 5.0-1,000 ng/dm2 except for 4:2 FTOH didn’t comply with TFDA specifications. Most limits of detection (LODs) were between 0.07 and 11.3 ng/dm2; most limits of quantification (LOQs) were between 0.17 and 18.3 ng/dm2. The recoveries ranged from 70% to 117% on most analytes at three tested levels, and the precisions (%CV) were lower than 19% (n = 5). Three of four microwave popcorn packagings contained four- to nine-carbon perfluoroalkyl acids (PFBA, PFPeA, PFHxA, PFOA, PFDA) at 8.3-1,960 ng/dm2 and two of four contained FTOHs at 121-7,188 ng/dm2. One of three oil-proof paper bags contained perfluoroalkyl acids (PFBA, PFHxA, PFOA, PFDA, PFUnDA, PFDoDA, PFHxDA) at 5.7-48.6 ng/dm2; two of three were found FTOHs at 454-2,595 ng/dm2. PFBA and PFHxDA were observed at two of nine chicken boxes and fry paper bags, ranged from 5.0 to 40.3 ng/dm2; FTOHs were present in one of nine at 22.4-167 ng/dm2. PFASs were detected in some oil-resistant packaging. Although the concentrations of the observed levels on most samples were down to ppb levels, long-term exposure to them chronic adverse health effects from warrants further attention.
口試委員會審定書 #
誌謝 i
中文摘要 ii
ABSTRACT iii
CONTENTS v
LIST OF FIGURES vii
LIST OF TABLES viii
Chapter 1 Introduction 1
1.1 Perfluoroalkyl substances (PFASs) 1
1.2 Determination of oil-resistant food packagings 4
1.3 Objectives 7
Chapter 2 Methods 9
2.1 Reagents and materials 9
2.2 Instruments 10
2.3 Sample collection 11
2.4 Sample preparation 11
2.5 Instrumental analysis 12
2.5.1 Optimization of MS/MS parameters for analytes 12
2.5.2 Optimization of UPLC-MS/MS analytical conditions 13
2.6 Method validation 14
2.6.1 Matrix effect and extraction efficiency 14
2.6.2 Assessment of accuracy and precision 15
2.6.3 Identification, quantification, and data analysis 15
2.6.4 Quality assurance and quality control 16
Chapter 3 Results and Discussions 17
3.1 MS/MS parameter 17
3.2 Chromatography 17
3.2.1 Selection of columns and mobile phases 17
3.2.2 Adjustment of UPLC gradient 19
3.3 Sample preparation 20
3.3.1 Temperature stability test of ultrasonic extraction 20
3.3.2 Optimization of ultrasonic extraction 21
3.3.3 Comparison of static extraction and ultrasonic or volatilization extraction 22
3.3.4 Matrix effect test 23
3.3.5 Adjustment of concentration processes 24
3.4 Method validation 25
3.4.1 IDLs, IQLs, and calibration range 25
3.4.2 LODs and LOQs 26
3.4.3 Matrix effect and extraction efficiency 27
3.4.4 Accuracy and precision 28
3.4.5 Matrix transfer factor 30
3.5 Real sample 32
Chapter 4 Conclusions 37
Reference 39
Figures 45
Tables 60
1.E. Zafeiraki, D. Costopoulou, I. Vassiliadou, E. Bakeas, and L. Leondiadis, Determination of perfluorinated compounds (PFCs) in various foodstuff packaging materials used in the Greek market. Chemosphere, 2014. 94: p. 169-176.
2.I. Zabaleta, E. Bizkarguenaga, D. Bilbao, N. Etxebarria, A. Prieto, and O. Zuloaga, Fast and simple determination of perfluorinated compounds and their potential precursors in different packaging materials. Talanta, 2016. 152: p. 353-63.
3.R. Renner, Evidence of toxic effects and environmental impacts has sent researchers scrambling to obtain more data. Environmental Science & Technology, 2001. 35 (7): p. 154–160.
4.S.D. Richardson, Environmental mass spectrometry: emerging contaminants and current issues. Analytical Chemistry, 2012. 84(2): p. 747-78.
5.C. Lau, K. Anitole, C. Hodes, D. Lai, A. Pfahles-Hutchens, and J. Seed, Perfluoroalkyl acids: a review of monitoring and toxicological findings. Toxicological Sciences, 2007. 99(2): p. 366-94.
6.D. Herzke, E. Olsson, and S. Posner, Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway - a pilot study. Chemosphere, 2012. 88(8): p. 980-7.
7.L. Ahrens and M. Bundschuh, Fate and effects of poly- and perfluoroalkyl substances in the aquatic environment: a review. Environmental Toxicology and Chemistry, 2014. 33(9): p. 1921-9.
8.K. Prevedouros, I.T. Cousins, R.C. Buck, and S.H. Korzeniowski, Sources, Fate and Transport of Perfluorocarboxylates. Environmental Science & Technology, 2006. 40: p. 32–44.
9.D.A. Ellis, J.W. Martin, A.O.D. Silva, S.A. Mabury, Michael D. Hurley, M.P.S. Andersen, and T.J. Wallington, Degradation of Fluorotelomer Alcohols:  A Likely Atmospheric Source of Perfluorinated Carboxylic Acids. Environmental Science & Technology, 2004. 38: p. 3316-3321.
10.M.K. So, S. Taniyasu, P.K. Lam, G.J. Zheng, J.P. Giesy, and N. Yamashita, Alkaline digestion and solid phase extraction method for perfluorinated compounds in mussels and oysters from South China and Japan. Archives of Environmental Contamination and Toxicology, 2006. 50(2): p. 240-8.
11.S. Fang, X. Chen, S. Zhao, Y. Zhang, W. Jiang, L. Yang, and L. Zhu, Trophic magnification and isomer fractionation of perfluoroalkyl substances in the food web of Taihu Lake, China. Environmental Science & Technology, 2014. 48(4): p. 2173-82.
12.J.P. Giesy, S.A. Mabury, J.W. Martin, K. Kannan, P.D. Jones, J.L. Newsted, and K. Coady, Perfluorinated Compounds in the Great Lakes, in Persistent Organic Pollutants in the Great Lakes. 2006. p. 391-438.
13.S. Ullah, T. Alsberg, and U. Berger, Simultaneous determination of perfluoroalkyl phosphonates, carboxylates, and sulfonates in drinking water. Journal of Chromatography A, 2011. 1218(37): p. 6388-95.
14.R.A. Hites, Persistent Organic Pollutants in the Great Lakes: An Overview, in Persistent Organic Pollutants in the Great Lakes. 2006. p. 1-12.
15.R.C. Buck, J. Franklin, U. Berger, J.M. Conder, I.T. Cousins, P. de Voogt, A.A. Jensen, K. Kannan, S.A. Mabury, and S.P. van Leeuwen, Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag, 2011. 7(4): p. 513-41.
16.D. Luebker, K.J. Hansen, N.M. Bass, J.L. Butenhoff, and A.M. Seacat, Interactions of fluorochemicals with rat liver fatty acid-binding protein. Toxicology, 2002. 176: p. 175–185.
17.J. Buekers, A. Colles, C. Cornelis, B. Morrens, E. Govarts, and G. Schoeters, Socio-Economic Status and Health: Evaluation of Human Biomonitored Chemical Exposure to Per- and Polyfluorinated Substances across Status. International Journal of Environmental Research and Public Health, 2018. 15(12).
18.J.W. Martin, S.A. Mabury, K.R. Solomon, and D.C.G. Muir, Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss). Environmental Toxicology and Chemistry, 2003. 22: p. 196–204.
19.G.W. Olsen, J.M. Burris, D.J. Ehresman, J.W. Froehlich, A.M. Seacat, J.L. Butenhoff, and L.R. Zobel, Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environmental Health Perspectives, 2007. 115(9): p. 1298-305.
20.P. Grandjean, E.W. Andersen, E. Budtz-Jørgensen, F. Nielsen, K. Mølbak, P. Weihe, and C. Heilmann, Serum vaccine antibody concentrations in children exposed to perfluorinated compounds. JAMA, 2012. 307: p. 391–397.
21.P. Grandjean and E. Budtz-Jorgensen, Immunotoxicity of perfluorinated alkylates: calculation of benchmark doses based on serum concentrations in children. Environmental Health, 2013. 12(1): p. 35.
22.L.S. Haug, S. Huber, G. Becher, and C. Thomsen, Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure. Environment International, 2011. 37(4): p. 687-93.
23.C. Cornelis, W. D''Hollander, L. Roosens, A. Covaci, R. Smolders, R. Van Den Heuvel, E. Govarts, K. Van Campenhout, H. Reynders, and L. Bervoets, First assessment of population exposure to perfluorinated compounds in Flanders, Belgium. Chemosphere, 2012. 86(3): p. 308-14.
24.J. Fu, Y. Gao, T. Wang, Y. Liang, A. Zhang, Y. Wang, and G. Jiang, Elevated levels of perfluoroalkyl acids in family members of occupationally exposed workers: the importance of dust transfer. Scientific Reports, 2015. 5: p. 9313.
25.H. Fromme, S.A. Tittlemier, W. Volkel, M. Wilhelm, and D. Twardella, Perfluorinated compounds--exposure assessment for the general population in Western countries. International Journal of Hygiene and Environmental Health, 2009. 212(3): p. 239-70.
26.N. Merino, Y. Qu, R.A. Deeb, E.L. Hawley, M.R. Hoffmann, and S. Mahendra, Degradation and Removal Methods for Perfluoroalkyl and Polyfluoroalkyl Substances in Water. Environmental Engineering Science, 2016. 33(9): p. 615-649.
27.G. Ding and W.J.G.M. Peijnenburg, Physicochemical Properties and Aquatic Toxicity of Poly- and Perfluorinated Compounds. Critical Reviews in Environmental Science and Technology, 2013. 43(6): p. 598-678.
28.E. Gorrochategui, E. Perez-Albaladejo, J. Casas, S. Lacorte, and C. Porte, Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells. Toxicology and Applied Pharmacology, 2014. 277(2): p. 124-30.
29.J. M., Conder, R. A., Hoke, Watze de Wolf, M. H., Russell., and R. C.Buck, Are PFCAs Bioaccumulative? A Critical Review and Comparison with Regulatory Criteria and Persistent Lipophilic Compounds. Environmental Science & Technology, 2008. 42: p. 995–1003.
30.C.M. Butt, D.C. Muir, and S.A. Mabury, Biotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: a review. Environmental Toxicology and Chemistry, 2014. 33(2): p. 243-67.
31.C.J. Young and S.A. Mabury, Atmospheric perfluorinated acid precursors: chemistry, occurrence, and impacts. Reviews of Environment Contamination and Toxicology, 2010. 208: p. 1-109.
32.I.E. Jogsten, G. Perello, X. Llebaria, E. Bigas, R. Marti-Cid, A. Karrman, and J.L. Domingo, Exposure to perfluorinated compounds in Catalonia, Spain, through consumption of various raw and cooked foodstuffs, including packaged food. Food and Chemical Toxicology, 2009. 47(7): p. 1577-83.
33.K.H. Harada and A. Koizumi, Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities. Environmental Health and Preventive Medicine, 2009. 14(1): p. 7-19.
34.K.H. Harada, H.R. Yang, C.S. Moon, N.N. Hung, T. Hitomi, K. Inoue, T. Niisoe, T. Watanabe, S. Kamiyama, K. Takenaka, M.Y. Kim, K. Watanabe, T. Takasuga, and A. Koizumi, Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008. Chemosphere, 2010. 79(3): p. 314-9.
35.J.L. Domingo, I. Ericson-Jogsten, G. Perello, M. Nadal, B. Van Bavel, and A. Karrman, Human exposure to perfluorinated compounds in Catalonia, Spain: contribution of drinking water and fish and shellfish. Journal of Agricultural and Food Chemistry, 2012. 60(17): p. 4408-15.
36.3M The Science of Organic Fluorochemistry. 3M Company 1999,AR226-0547.
37.3M Phase-Out Plan for POSF-Based Products. USEPA Docket ID OPPT-2002-0043, 2000.
38.OECD Report of an OECD Workshop on Perfluorocarboxylic Acids (PFCAs) and Precursors. ENV/JM/MONO(2007)11, 2007.
39.OJ Directive 2006/122/ECOF. Off. J. Eur. Union 2006, L 372, 32-34.
40.L.S. Haug, C. Thomsen, and G. Becher, Time trends and the influence of age and gender on serum concentrations of perfluorinated compounds in archived human samples. Environ. Sci. Technol. , 2009. 43: p. 2131–2136.
41.A. Glynn, U. Berger, A. Bignert, S. Ullah, M. Aune, S. Lignell, and P.O. Darnerud, Perfluorinated alkyl acids in blood serum from primiparous women in Sweden: serial sampling during pregnancy and nursing, and temporal trends 1996-2010. Environmental Science & Technology, 2012. 46(16): p. 9071-9.
42.A.L. Brantsaeter, K.W. Whitworth, T.A. Ydersbond, L.S. Haug, M. Haugen, H.K. Knutsen, C. Thomsen, H.M. Meltzer, G. Becher, A. Sabaredzovic, J.A. Hoppin, M. Eggesbo, and M.P. Longnecker, Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women. Environment International, 2013. 54: p. 74-84.
43.G. Schoeters, E. Govarts, L. Bruckers, E. Den Hond, V. Nelen, S. De Henauw, I. Sioen, T.S. Nawrot, M. Plusquin, A. Vriens, A. Covaci, I. Loots, B. Morrens, D. Coertjens, N. Van Larebeke, S. De Craemer, K. Croes, N. Lambrechts, A. Colles, and W. Baeyens, Three cycles of human biomonitoring in Flanders - Time trends observed in the Flemish Environment and Health Study. International Journal of Hygiene and Environmental Health, 2017. 220(2 Pt A): p. 36-45.
44.M. Wilhelm, S. Bergmann, and H.H. Dieter, Occurrence of perfluorinated compounds (PFCs) in drinking water of North Rhine-Westphalia, Germany and new approach to assess drinking water contamination by shorter-chained C4-C7 PFCs. International Journal of Hygiene and Environmental Health, 2010. 213(3): p. 224-32.
45.U.S. Environmental Protection Agency (USEPA). (2016). Fact Sheet: PFOA & PFOS Drinking Water Health Advisories https://www.epa.gov/sites/production/files/2016-06/documents/ drinkingwaterhealthadvisories_pfoa_pfos_updated_5.31.16.pdf (accessed May 28, 2016).
46.Z. Wang, I.T. Cousins, M. Scheringer, R.C. Buck, and K. Hungerbuhler, Global emission inventories for C4-C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, part II: the remaining pieces of the puzzle. Environment International, 2014. 69: p. 166-76.
47.Z. Wang, I.T. Cousins, M. Scheringer, R.C. Buck, and K. Hungerbuhler, Global emission inventories for C4-C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, Part I: production and emissions from quantifiable sources. Environment International, 2014. 70: p. 62-75.
48.EFSA, 2008. Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts. scientific opinion of the panel on contaminants in the food chain. EFSA J. 653, 1–22.
49.M.F. Rahman, S. Peldszus, and W.B. Anderson, Behaviour and fate of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in drinking water treatment: a review. Water Research, 2014. 50: p. 318-40.
50.O.W. Lau and S.K. Wong, Contamination in food from packaging material. Journal of Chromatography A, 2000. A 882: p. 255–270.
51.F. Wikström, H. Williams, K. Verghese, and S. Clune, The influence of packaging attributes on consumer behaviour in food-packaging life cycle assessment studies - a neglected topic. Journal of Cleaner Production, 2014. 73: p. 100-108.
52.H. Gallart-Ayala, O. Núñez, and P. Lucci, Recent advances in LC-MS analysis of food-packaging contaminants. TRAC Trends in Analytical Chemistry, 2013. 42: p. 99-124.
53.Regulation (EC) No 1935/2004 of the European Parliament and of the Council of 27 October 2004 on materials and articles intended to come into contact with food and repealing Directives 80/590/EEC and 89/109/EEC.
54.European Food Safety Authority. (2012). Report of ESCO WG on non-plastic food contact materials. Supporting Publications 139.
55.S. Poothong, S.K. Boontanon, and N. Boontanon, Determination of perfluorooctane sulfonate and perfluorooctanoic acid in food packaging using liquid chromatography coupled with tandem mass spectrometry. Journal of Hazardous Materials, 2012. 205-206: p. 139-43.
56.X. Trier, K. Granby, and J.H. Christensen, Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging. Environmental Science and Pollution Research International, 2011. 18(7): p. 1108-20.
57.A. Vavrouš, L. Vápenka, J. Sosnovcová, K. Kejlová, K. Vrbík, and D. Jírová, Method for analysis of 68 organic contaminants in food contact paper using gas and liquid chromatography coupled with tandem mass spectrometry. Food Control, 2016. 60: p. 221-229.
58.T.H. Begley, K. White, P. Honigfort, M.L. Twaroski, R. Neches, and R.A. Walker, Perfluorochemicals: potential sources of and migration from food packaging. Food Additives & Contaminants, 2005. 22(10): p. 1023-31.
59.M.P. Martinez-Moral and M.T. Tena, Determination of perfluorocompounds in popcorn packaging by pressurised liquid extraction and ultra-performance liquid chromatography-tandem mass spectrometry. Talanta, 2012. 101: p. 104-9.
60.W.A. Gebbink, S. Ullah, O. Sandblom, and U. Berger, Polyfluoroalkyl phosphate esters and perfluoroalkyl carboxylic acids in target food samples and packaging--method development and screening. Environmental Science and Pollution Research International, 2013. 20(11): p. 7949-58.
61.I. Ericson, M. Gomez, M. Nadal, B. van Bavel, G. Lindstrom, and J.L. Domingo, Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: a pilot study. Environment International, 2007. 33(5): p. 616-23.
62.Y. Pan, Y. Shi, J. Wang, Y. Cai, and Y. Wu, Concentrations of perfluorinated compounds in human blood from twelve cities in China. Environmental Toxicology and Chemistry, 2010. 29(12): p. 2695-701.
63.I. Zabaleta, N. Negreira, E. Bizkarguenaga, A. Prieto, A. Covaci, and O. Zuloaga, Screening and identification of per- and polyfluoroalkyl substances in microwave popcorn bags. Food Chemistry, 2017. 230: p. 497-506.
64.Kissa, E. (2001). Fluorinated surfactants and repellents (2nd edn). New York: Marcel Dekker.
65.C. Moreta and M.T. Tena, Fast determination of perfluorocompounds in packaging by focused ultrasound solid-liquid extraction and liquid chromatography coupled to quadrupole-time of flight mass spectrometry. Journal of Chromatography A, 2013. 1302: p. 88-94.
66.M. Surma, W. Wiczkowski, H. Zieliński, and E. Cieślik, Determination of Selected Perfluorinated Acids (PFCAs) and Perfluorinated Sulfonates (PFASs) in Food Contact Materials Using LC-MS/MS. Packaging Technology and Science, 2015. 28(9): p. 789-799.
67.X. Trier, N.J. Nielsen, and J.H. Christensen, Structural isomers of polyfluorinated di- and tri-alkylated phosphate ester surfactants present in industrial blends and in microwave popcorn bags. Environmental Science and Pollution Research International, 2011. 18(8): p. 1422-32.
68.T.H. Begley, W. Hsu, G. Noonan, and G. Diachenko, Migration of fluorochemical paper additives from food-contact paper into foods and food simulants. Food Additives & Contaminants. Part A: Chemistry, Analysis, Control, Exposure & Risk Assessment, 2008. 25(3): p. 384-90.
69.G. Yuan, H. Peng, C. Huang, and J. Hu, Ubiquitous Occurrence of Fluorotelomer Alcohols in Eco-Friendly Paper-Made Food-Contact Materials and Their Implication for Human Exposure. Environmental Science & Technology, 2016. 50(2): p. 942-50.
70.T. Shoeib, Y. Hassan, C. Rauert, and T. Harner, Poly- and perfluoroalkyl substances (PFASs) in indoor dust and food packaging materials in Egypt: Trends in developed and developing countries. Chemosphere, 2016. 144: p. 1573-81.
71.L.A. Schaider, S.A. Balan, A. Blum, D.Q. Andrews, M.J. Strynar, M.E. Dickinson, D.M. Lunderberg, J.R. Lang, and G.F. Peaslee, Fluorinated Compounds in U.S. Fast Food Packaging. Environ Sci Technol Lett, 2017. 4(3): p. 105-111.
72.賴怡潔; 陳家揚, Comparison of Gas Chromatography and Ultra-performance Liquid Chromatography Coupled with Tandem Mass Spectrometry for Determining Perfluorinated Chemicals. 國立臺灣大學環境衛生研究所 2013, 碩士論文.
73.E. Sinclair, S.-K. Kim, H. Akinleye, and K. Kannan, Quantitation of Gas-Phase Perfluoroalkyl Surfactants and Fluorotelomer Alcohols Released from Nonstick Cookware and Microwave Popcorn Bags. Vol. 41. 2007. 1180-5.
74.S. Dolman and M. Pelzing, An optimized method for the determination of perfluorooctanoic acid, perfluorooctane sulfonate and other perfluorochemicals in different matrices using liquid chromatography/ion-trap mass spectrometry. Journal of Chromatography. B: Analytical Technologies in the Biomedical and Life Sciences, 2011. 879(22): p. 2043-50.
75.G. Lv, L. Wang, S. Liu, and S. Li, Determination of perfluorinated compounds inpackaging materials and textiles using pressurized liquid extraction with gaschromatography–mass spectrometry. Analytical Sciences, 2009. 25: p. 425–429.
76.Taiwan Food and Drug Administration, 2013, version 2. Food chemical test method validation guide.
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