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研究生:蕭佳偉
研究生(外文):Chia-Wei Hsaio
論文名稱:環保型可水洗雙親性矽水膠之應用與探討
論文名稱(外文):The development of an environmental-friendly and amphiphilic silicone hydrogel
指導教授:楊銘乾
指導教授(外文):Ming-Chien Yang
口試委員:鄭詠馨劉定宇
口試委員(外文):Yung-Hsin ChengTing-Yu Liu
口試日期:2019-06-27
學位類別:碩士
校院名稱:國立臺灣科技大學
系所名稱:材料科學與工程系
學門:工程學門
學類:材料工程學類
論文種類:學術論文
論文出版年:2019
畢業學年度:107
語文別:中文
論文頁數:70
中文關鍵詞:可水洗雙親性矽氧烷大分子矽水膠雙親性透氧性
外文關鍵詞:Amphiphilic siloxane-macromersilicone hydrogelPDMS
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目前矽水膠在水化階段需經過醇類清洗程序以去除未反應的矽單體,因此需要大量的醇類,故而提高了處理的成本,且可能造成環境的污染。為了改善此問題,本研究目的為合成一可水洗雙親性矽氧烷大分子(Amphiphilic siloxane-macromer) 之矽水膠,主要分為雙親性及增加透氧性的合成。雙親性,係將聚二甲基矽氧烷-單羥基封端(Polydimethylsiloxane Hydroxyl-Monoterminal,PDMS-mono-OH)和異佛爾酮二異氰酸酯(IPDI)及聚(乙二醇)甲基丙烯酸酯(PEGMA),形成胺基甲酸酯(Carbamate);透氧性,則利用聚二甲基矽氧烷-雙羥基封端(Polydimethylsiloxane dihydroxyl-terminal,PDMS-diol)和異佛爾酮二異氰酸酯以及(羥乙基)甲基丙烯酸酯(HEMA)形成雙鍵尾端的胺基甲酸酯。最後將兩者依適當比例與交聯劑(EGDMA)和光起始劑(1173)混合,並於紫外光下形成一隱形眼鏡,利用傅立葉紅外線光譜佐證,並探討其接觸角、含水量、透氧率等結果。
Currently, alcohol solution is used to wash out the unreacted monomer after synthesizing silicone hydrogel contact lenses. This process will increase the costs of recycling solution and will contaminate the enviorment. In order to improve these problems, this study is aimed to synthesis an amphiphilic siloxane-macromer washable with DI-water. The synthesis included two parts. The first part was to synthesize an amphiphilic macromer from polydimethylsiloxane hydroxyl-monoterminal (PDMS-mono-OH), isophorone diisocyanate (IPDI), and poly (enthylene glycol) methacrylate (PEGMA). The second part was dedicated to increase the oxygen permeability by synthesizing a macromer from polydimethylsiloxane dihydroxyl-terminal (PDMS-diol), IPDI, and 2-hydroxyethyl methacrylate (HEMA). These two macromers were mixed with crosslinker (EGDMA) and photoinitiator (1173) and cured into silicone hydrogel contact lenses under UV light.
第壹章 緒論 1
1.1 研究背景 1
1.2 研究目的 2
第貳章 文獻回顧 3
2.1 水膠 3
2.2 水膠的合成與分類 3
2.2 功能性水膠 5
2.3 隱形眼鏡種類 9
2.4 隱形眼鏡材料特殊性質 10
2.5 高分子材料表面改質 15
2.6 紫外光硬化交聯處理 17
2.7 Polydimethylsiloxane,PDMS-diol: 19
2.8 Isophorone diisocyanate ,IPDI: 19
2.9 Poly(ethylene glycol) methacrylate,PEGMA: 20
第參章 實驗材料與方法 21
3.1 實驗材料: 21
3.2 實驗設備: 23
3.3 實驗流程: 24
3.4 實驗方法: 25
3.5 傅立葉紅外線光譜分析(Transmittance): 29
3.6 可見光透光率測定(Transmittance): 30
3.7 平衡含水量測定(Equilibrium water content): 30
3.8 透氧係數測定(Oxygen Permeability): 31
3.9 接觸角測試(Contact angle measurement): 31
3.10 拉力測試(Tensile test): 33
3.11 原子力顯微鏡(Atomic force microscope, AFM): 34
3.12 細胞毒性試驗 (In-vitro cytotoxicity): 34
3.13 蛋白質吸附試驗(Protein adsorption): 36
第肆章 結果與討論 38
4.1 傅立葉紅外線光譜分析(Transmittance): 38
4.2 可見光透光率測定(Transmittance): 40
4.3 衡含水量測定(Equilibrium water content): 41
4.4 透氧係數測定(Oxygen Permeability): 43
4.5 接觸角測試(Contact angle measurement): 44
4.6 拉力測試(Tensile test): 46
4.7 原子力顯微鏡測試(Atomic force microscope, AFM): 47
4.8 細胞毒性測試(In-vitro cytotoxicity): 48
4.9 蛋白質吸附試驗(Protein adsorption): 52
第伍章 結論 55
參考文獻 57
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