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研究生:謝旻融
研究生(外文):Hsieh, Min-Jung
論文名稱:補充咖啡因對高強度間歇訓練後年輕肥胖女性運動能力、血糖控制能力及身體組成之影響
論文名稱(外文):Effects of Caffeine Supplementation on Performance, Glucose Tolerance, and Body Composition after High-Intensity Interval Training in Obese Young Women
指導教授:侯建文侯建文引用關係
指導教授(外文):Hou, Chien-Wen
口試日期:2019-06-20
學位類別:碩士
校院名稱:臺北市立大學
系所名稱:運動科學研究所
學門:民生學門
學類:運動科技學類
論文種類:學術論文
論文出版年:2019
畢業學年度:107
語文別:英文
論文頁數:52
中文關鍵詞:口服葡萄糖耐量試驗胰島素敏感度睪固酮內毒素
外文關鍵詞:OGTTinsulin sensitivitytestosteroneendotoxin
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背景:在全球肥胖率持續提升的情況下,亞洲女性的肥胖風險也不斷攀升。高強度間歇訓練近期被視為是個有效且省時的減肥策略,而咖啡因被認為是個具有產熱、減重、控制食慾及運動增能的膳食成分。本研究欲調查高強度間歇訓練的介入並同時搭配咖啡因增補是否能有效改善肥胖年輕女性之身體組成、血糖控制、荷爾蒙、心肺適能和無氧能力。方法:招募24名年齡介於18-30歲的肥胖台灣女性,隨機分配至安慰劑(HIIT-PLA)或咖啡因(HIIT-CAF)組,分別在高強度間歇訓練前一小時給予安慰劑和咖啡因補充劑,劑量均為每公斤體重3毫克。所有受試者每週皆進行三次高強度間歇訓練(10組60秒的飛輪訓練,強度設定為90%的最大心率,組間休息60秒),共持續8週,並在訓練介入前後分別測量身體組成、血糖控制能力、荷爾蒙、心肺適能和無氧能力。結果:HIIT-PLA及HIIT-CAF兩組皆降低體脂肪百分率及睪固酮濃度,並提升心肺適能及無氧能力,不過兩組在胰島素敏感度、血糖控制及內毒素方面卻有分歧的結果,HIIT-PLA組在訓練後顯著提升血糖和胰島素,內毒素有上升的趨勢,而HIIT-CAF組則抑制了此效果。在身體質量指數及血脂肪檢驗(高密度脂蛋白膽固醇及三酸甘油酯)方面並沒有任何改變。結論:高強度間歇訓練可以提升心肺適能、無氧能力,並且降低體脂肪百分率及睪固酮。然而,對年輕肥胖女性而言,搭配咖啡因增補可以改善因高強度間歇訓練所誘導之內毒素提升及胰島素敏感度下降等負面結果。
Background: Global obesity rates continue to rise, especially in Asia, and females are known to be at an increased risk. High-intensity interval training (HIIT) has been recently proposed as a time efficient strategy for fat loss outcomes, while caffeine is a dietary ingredients recommended for its thermogenic and weight loss, appetite control and ergogenic effects. The present study investigates whether an HIIT intervention combined with caffeine is effective in improving body composition, glycemic control, hormonal, cardiorespiratory, and anaerobic capacity outcomes in obese young female participants. Methods: Twenty-four obese Taiwanese females aged 18-30 years were recruited and randomly assigned to placebo (HIIT-PLA) or caffeine (HIIT-CAF) group, and the dose are both 3 mg.kg-1.BW-1, given one hour prior to HIIT. All subjects performed HIIT three times per week for 8 weeks (10 × 60-s cycling efforts at 90% maximal heart rate, 60-s recovery). Anthropometric, body composition, glycemic control, hormones, cardiorespiratory, and anaerobic capacity were measured at baseline before commencing the training and after the training completion. Results: Both HIIT-CAF and HIIT-PLA groups showed significant reduction in body fat percentage (BF%) and testosterone, and significant improvement in cardiorespiratory fitness and anaerobic capacity. Differential improvement was found for insulin sensitivity, glucose control, and endotoxin, in which HIIT elevated both glucose and insulin responses significantly, and a trend toward increase in endotoxin post the intervention in the HIIT-PLA, whereas suppressed them in the HIIT-CAF group. No significant change was found in BMI or lipid profile (HDL-C and TG) in either condition. Conclusion: HIIT improves cardiorespiratory, anaerobic fitness, and reduces BF% and testosterone. However, adverse HIIT-induced endotoxic and insulin sensitivity responses, which may be related to hormonal responses, can may be ameliorated by caffeine intake in young females with obesity.
ORIGINAL STATEMENT………………………...…………..…………ii
VERIFICATION LETTER…………..………………………………….iii
ENGLISH ABSTRACT……………………...…………………………..iv
CHINESE ABSTRACT……………………….…………………………vi
ACKNOWLEDGEMENTS…………………….………………………viii
CONTENTS………………………………………...…………………….ix
LIST OF TABLES………………………………….…………………….xi
LIST OF FIGURES………………………………….…………………..xii
LIST OF ABBREVIATIONS………………………..………………….xiii
CHAPTER 1 BACKGROUND………………………………………...1
CHAPTER 2 LITERATURE REVIEW
2.1 Obesity problem……………………………………….………..3
2.2 Gut microbiota and health……………………………………….4
2.3 Caffeine…………………………………………………………5
2.3.1 Caffeine source and intake……………………….………5
2.3.2 Caffeine metabolism……………………………………..6
2.3.3 Caffeine and body composition………………………….7
2.3.4 Caffeine as an ergogenic aid…………………………….9
2.4 HIIT……………………………………………………………11
CHAPTER 3 MATERIALS AND METHODS
3.1 Study design and participants……………………..……………14
3.2 Experiment procedures………………………………………...14
3.2.1 Baseline assessment…………………………………….15
3.2.2 Oral glucose tolerance test (OGTT)…………………….15
3.2.3 Hormones, endotoxins, and lipid profiles tests...………..15
3.2.4 Cardiorespiratory capacity assessment…………………16
3.2.5 Anaerobic capacity test……………………………..…..16
3.2.6 Supplementation protocol……………………………....16
3.2.7 HIIT protocol……………….…………………………..17
3.2.8 Post intervention measurements………………………..17
3.3 Data analysis and statistics……………………………………..17
CHAPTER 4 RESULTS
4.1 Body composition and lipid profile outcomes……………..…...18
4.2 Metabolic outcomes of glucose and insulin……………………19
4.3 Hormones: endotoxins, testosterone and cortisol outcomes……22
4.4 Obesity secondary outcomes of cardiorespiratory and anaerobic capacity……………………………………………………………………25
CHAPTER 5 DISCUSSION AND CONCLUSION
5.1 Main finding……………………………………..…………….27
5.2 Body composition and lipid profile outcomes……...…………..27
5.3 Metabolic outcomes of glucose and insulin……………………29
5.4 Hormones: endotoxins, testosterone and cortisol outcomes……30
5.5 Obesity secondary outcomes of cardiorespiratory and anaerobic capacity……………………………………………………………………33
5.6 Conclusion……………………………………………………..34
REFERENCES…………………………………………………………..36
Acheson, K. J., Gremaud, G., Meirim, I., Montigon, F., Krebs, Y., Fay, L. B. et al. (2004). Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? The American journal of clinical nutrition, 79(1), 40-46.
Adhihetty, P. J., Irrcher, I., Joseph, A.-M., Ljubicic, V., & Hood, D. A. (2003). Plasticity of skeletal muscle mitochondria in response to contractile activity. Experimental physiology, 88(1), 99-107.
Agustí, A., García-Pardo, M. P., López-Almela, I., Campillo, I., Maes, M., Romaní-Pérez, M., & Sanz, Y. (2018). Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function. Frontiers in neuroscience, 12, 155.
Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R. et al. (2017). Functional foods and lifestyle approaches for diabetes prevention and management. Nutrients, 9(12), 1310.
Almenning, I., Rieber-Mohn, A., Lundgren, K. M., Løvvik, T. S., Garnæs, K. K., & Moholdt, T. (2015). Effects of high intensity interval training and strength training on metabolic, cardiovascular and hormonal outcomes in women with polycystic ovary syndrome: a pilot study. PLoS One, 10(9), e0138793.
Andersson, B., Märin, P., Lissner, L., Vermeulen, A., & Björntorp, P. (1994). Testosterone concentrations in women and men with NIDDM. Diabetes care, 17(5), 405-411.
Antunes, B. M., Campos, E. Z., dos Santos, R. V. T., Rosa‐Neto, J. C., Franchini, E., Bishop, N. C., & Lira, F. S. (2019). Anti‐inflammatory response to acute exercise is related with intensity and physical fitness. Journal of cellular biochemistry, 120(4), 5333-5342.
Armstrong, L. E., & Vanheest, J. L. (2002). The unknown mechanism of the overtraining syndrome. Sports medicine, 32(3), 185-209.
Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., & Madsen, J. (1990). Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. The American journal of clinical nutrition, 51(5), 759-767.
Astrup, A., Toubro, S., Cannon, S., Hein, P., & Madsen, J. (1991). Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study. Metabolism, 40(3), 323-329.
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W. et al. (2006). Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. The Journal of Clinical Endocrinology & Metabolism, 91(11), 4237-4245.
Babraj, J. A., Vollaard, N. B., Keast, C., Guppy, F. M., Cottrell, G., & Timmons, J. A. (2009). Extremely short duration high intensity interval training substantially improves insulin action in young healthy males. BMC endocrine disorders, 9(1), 3.
Bakuradze, T., Parra, G. A. M., Riedel, A., Somoza, V., Lang, R., Dieminger, N. et al. (2014). Four-week coffee consumption affects energy intake, satiety regulation, body fat, and protects DNA integrity. Food research international, 63, 420-427.
Ballard, T. L., Halaweish, F. T., Stevermer, C. L., Agrawal, P., & Vukovich, M. D. (2006). Naringin does not alter caffeine pharmacokinetics, energy expenditure, or cardiovascular haemodynamics in humans following caffeine consumption. Clinical and experimental pharmacology and physiology, 33(4), 310-314.
Bastard, J.-P., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H. et al. (2006). Recent advances in the relationship between obesity, inflammation, and insulin resistance. European cytokine network, 17(1), 4-12.
Beaumont, R., Cordery, P., Funnell, M., Mears, S., James, L., & Watson, P. (2017). Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. Journal of sports sciences, 35(19), 1920-1927.
Bekaert, M., Van Nieuwenhove, Y., Calders, P., Cuvelier, C. A., Batens, A.-H., Kaufman, J.-M. et al. (2015). Determinants of testosterone levels in human male obesity. Endocrine, 50(1), 202-211.
Belza, A., Toubro, S., & Astrup, A. (2009). The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. European journal of clinical nutrition, 63(1), 57.
Bhurosy, T., & Jeewon, R. (2014). Overweight and obesity epidemic in developing countries: a problem with diet, physical activity, or socioeconomic status? The Scientific World Journal, 2014.
Bi, S., Scott, K. A., Hyun, J., Ladenheim, E. E., & Moran, T. H. (2005). Running wheel activity prevents hyperphagia and obesity in Otsuka long-evans Tokushima Fatty rats: role of hypothalamic signaling. Endocrinology, 146(4), 1676-1685.
Biddle, S. J., & Batterham, A. M. (2015). High-intensity interval exercise training for public health: a big HIT or shall we HIT it on the head? International Journal of Behavioral Nutrition and Physical Activity, 12(1), 95.
Bilski, J., Teległów, A., Zahradnik-Bilska, J., Dembiński, A., & Warzecha, Z. (2009). Effects of exercise on appetite and food intake regulation. Medicina Sportiva, 13(2), 82-94.
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005). Host-bacterial mutualism in the human intestine. science, 307(5717), 1915-1920.
Bonati, M., Latini, R., Galletti, F., Young, J. F., Tognoni, G., & Garattini, S. (1982). Caffeine disposition after oral doses. Clinical Pharmacology & Therapeutics, 32(1), 98-106.
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012). Lack of exercise is a major cause of chronic diseases. Comprehensive Physiology, 2(2), 1143.
Boudou, P., Sobngwi, E., Mauvais-Jarvis, F., Vexiau, P., & Gautier, J. (2003). Absence of exercise-induced variations in adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. European Journal of Endocrinology, 149(5), 421-424.
Boulé, N. G., Weisnagel, S. J., Lakka, T. A., Tremblay, A., Bergman, R. N., Rankinen, T. et al. (2005). Effects of exercise training on glucose homeostasis: the HERITAGE Family Study. Diabetes care, 28(1), 108-114.
Boutcher, S. H. (2010). High-intensity intermittent exercise and fat loss. Journal of obesity, 2011.
Bracken, R. M., Linnane, D. M., & Brooks, S. (2009). Plasma catecholamine and nephrine responses to brief intermittent maximal intensity exercise. Amino Acids, 36(2), 209-217.
Brix-Christensen, V., Andersen, S. K., Andersen, R., Mengel, A., Dyhr, T., Andersen, N. T. et al. (2004). Acute Hyperinsulinemia Restrains Endotoxin-induced Systemic Inflammatory ResponseAn Experimental Study in a Porcine Model. Anesthesiology: The Journal of the American Society of Anesthesiologists, 100(4), 861-870.
Burgomaster, K. A., Howarth, K. R., Phillips, S. M., Rakobowchuk, M., MacDonald, M. J., McGee, S. L., & Gibala, M. J. (2008). Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. The Journal of physiology, 586(1), 151-160.
Burgomaster, K. A., Hughes, S. C., Heigenhauser, G. J., Bradwell, S. N., & Gibala, M. J. (2005). Six sessions of sprint interval training increases muscle oxidative potential and cycle endurance capacity in humans. Journal of applied physiology, 98(6), 1985-1990.
Burton-Freeman, B., Gietzen, D. W., & Schneeman, B. O. (1999). Cholecystokinin and serotonin receptors in the regulation of fat-induced satiety in rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 276(2), R429-R434.
Caldwell, A. R., Tucker, M. A., Butts, C. L., McDermott, B. P., Vingren, J. L., Kunces, L. J. et al. (2017). Effect of caffeine on perceived soreness and functionality following an endurance cycling event. Journal of strength and conditioning research, 31(3), 638-643.
Campbell, I. W., & Haslam, D. W. (2005). Obesity: your questions answered: Churchill Livingstone.
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D. et al. (2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56(7), 1761-1772.
Carter, B. E., & Drewnowski, A. (2012). Beverages containing soluble fiber, caffeine, and green tea catechins suppress hunger and lead to less energy consumption at the next meal. Appetite, 59(3), 755-761.
Cheng, C.-F., Hsu, W.-C., Kuo, Y.-H., Shih, M.-T., & Lee, C.-L. (2016). Caffeine ingestion improves power output decrement during 3-min all-out exercise. European journal of applied physiology, 116(9), 1693-1702.
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo Jr, J. L. et al. (2003). The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. Jama, 289(19), 2560-2571.
Chu, N. F. (2005). Prevalence of obesity in Taiwan. Obesity Reviews, 6(4), 271-274.
Ciolac, E. G., Bocchi, E. A., Bortolotto, L. A., Carvalho, V. O., Greve, J. M., & Guimaraes, G. V. (2010). Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertension Research, 33(8), 836.
Clausen, J. P. (1977). Effect of physical training on cardiovascular adjustments to exercise in man. Physiological reviews, 57(4), 779-815.
Collaboration, P. S. (2009). Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. The Lancet, 373(9669), 1083-1096.
Colquitt, J. L., Pickett, K., Loveman, E., & Frampton, G. K. (2014). Surgery for weight loss in adults. The Cochrane Library.
Conde, S. V., da Silva, T. N., Gonzalez, C., Carmo, M. M., Monteiro, E. C., & Guarino, M. P. (2012). Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats. British Journal of Nutrition, 107(1), 86-95.
Connell, C. J., Thompson, B., Kuhn, G., & Gant, N. (2016). Exercise-induced fatigue and caffeine supplementation affect psychomotor performance but not covert visuo-spatial attention. PLoS One, 11(10), e0165318.
Cornelissen, V. A., & Smart, N. A. (2013). Exercise training for blood pressure: a systematic review and meta‐analysis. Journal of the American Heart Association, 2(1), e004473.
Costill, D., Dalsky, G. P., & Fink, W. (1978). Effects of caffeine ingestion on metabolism and exercise performance. Medicine and science in sports, 10(3), 155-158.
da Silva, L. A., Wouk, J., Weber, V., Eltchechem, C., de Almeida, P., & Martins, J. C. L. (2017). Mechanisms and biological effects of caffeine on substrate metabolism homeostasis: A systematic review. J Appl Pharm Sci, 7, 215.
Dallas, C., Gerbi, A., Tenca, G., Juchaux, F., & Bernard, F.-X. (2008). Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE). Phytomedicine, 15(10), 783-792.
De Matteis, R., Arch, J., Petroni, M., Ferrari, D., Cinti, S., & Stock, M. (2002). Immunohistochemical identification of the β 3-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine. International journal of obesity, 26(11), 1442.
Ding, J. L., & Ho, B. (2010). Endotoxin detection–from limulus amebocyte lysate to recombinant factor C Endotoxins: Structure, Function and Recognition (pp. 187-208): Springer.
Dunn, S. L. (2009). Effects of exercise and dietary intervention on metabolic syndrome markers of inactive premenopausal women. Sydney: University of New South Wales.
Egawa, T., Hamada, T., Kameda, N., Karaike, K., Ma, X., Masuda, S. et al. (2009). Caffeine acutely activates 5′ adenosine monophosphate–activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metabolism, 58(11), 1609-1617.
Esbjornsson-Liljedahl, M., Bodin, K., & Jansson, E. (2002). Smaller muscle ATP reduction in women than in men by repeated bouts of sprint exercise. Journal of applied physiology, 93(3), 1075-1083.
Famose, J., Guérin, F., & Sarrazin, P. (2005). Les croyances sur soi: clarification conceptuelle, formation et relations à la performance sportive, pour une revue des théories sur le soi. Croyances et performance sportive. Processus sociocognitifs associés aux comportements sportifs, 19-52.
Fei, N., & Zhao, L. (2013). An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice. The ISME journal, 7(4), 880.
Ferré, S. (2008). An update on the mechanisms of the psychostimulant effects of caffeine. Journal of neurochemistry, 105(4), 1067-1079.
Fex, A., Leduc-Gaudet, J.-P., Filion, M.-E., Karelis, A. D., & Aubertin-Leheudre, M. (2015). Effect of elliptical high intensity interval training on metabolic risk factor in pre-and type 2 diabetes patients: A pilot study. Journal of Physical Activity and Health, 12(7), 942-946.
Fisone, G., Borgkvist, A., & Usiello, A. (2004). Caffeine as a psychomotor stimulant: mechanism of action. Cellular and Molecular Life Sciences CMLS, 61(7-8), 857-872.
Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999). Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological reviews, 51(1), 83-133.
Frey, M. A. B., Siervogel, R. M., Selm, E. A., & Kezdi, P. (1980). Cardiovascular response to cooling of limbs determined by noninvasive methods. European journal of applied physiology and occupational physiology, 44(1), 67-75.
Gavrieli, A., Karfopoulou, E., Kardatou, E., Spyreli, E., Fragopoulou, E., Mantzoros, C., & Yannakoulia, M. (2013). Effect of different amounts of coffee on dietary intake and appetite of normal‐weight and overweight/obese individuals. Obesity, 21(6), 1127-1132.
Gibala, M. J., Little, J. P., MacDonald, M. J., & Hawley, J. A. (2012). Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of physiology, 590(5), 1077-1084.
Gibala, M. J., Little, J. P., Van Essen, M., Wilkin, G. P., Burgomaster, K. A., Safdar, A., . . . Tarnopolsky, M. A. (2006). Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. The Journal of physiology, 575(3), 901-911.
Gibala, M. J., & McGee, S. L. (2008). Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? Exercise and sport sciences reviews, 36(2), 58-63.
Gibala, M. J., McGee, S. L., Garnham, A. P., Howlett, K. F., Snow, R. J., & Hargreaves, M. (2009). Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle. Journal of applied physiology, 106(3), 929-934.
Gillen, J. B., & Gibala, M. J. (2013). Is high-intensity interval training a time-efficient exercise strategy to improve health and fitness? Applied Physiology, Nutrition, and Metabolism, 39(3), 409-412.
Gillen, J. B., Percival, M. E., Ludzki, A., Tarnopolsky, M. A., & Gibala, M. J. (2013). Interval training in the fed or fasted state improves body composition and muscle oxidative capacity in overweight women. Obesity, 21(11), 2249-2255.
Glaister, M. (2005). Multiple sprint work. Sports medicine, 35(9), 757-777.
Glaister, M., Williams, B. H., Muniz-Pumares, D., Balsalobre-Fernández, C., & Foley, P. (2016). The effects of caffeine supplementation on physiological responses to submaximal exercise in endurance-trained men. PLoS One, 11(8), e0161375.
Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C. et al. (2010). International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition, 7(1), 5.
Graham, T., & Spriet, L. (1991). Performance and metabolic responses to a high caffeine dose during prolonged exercise. Journal of applied physiology, 71(6), 2292-2298.
Graham, T., & Spriet, L. (1995). Metabolic, catecholamine, and exercise performance responses to various doses of caffeine. Journal of applied physiology, 78(3), 867-874.
Graham, T. E. (2001). Caffeine and exercise. Sports medicine, 31(11), 785-807.
Greenberg, J. A., Boozer, C. N., & Geliebter, A. (2006). Coffee, diabetes, and weight control. The American journal of clinical nutrition, 84(4), 682-693.
Greenberg, J. A., & Geliebter, A. (2012). Coffee, hunger, and peptide YY. Journal of the American College of Nutrition, 31(3), 160-166.
Gremeaux, V., Drigny, J., Nigam, A., Juneau, M., Guilbeault, V., Latour, E., & Gayda, M. (2012). Long-term lifestyle intervention with optimized high-intensity interval training improves body composition, cardiometabolic risk, and exercise parameters in patients with abdominal obesity. American Journal of Physical Medicine & Rehabilitation, 91(11), 941-950.
Grossman, A., & Sutton, J. R. (1985). Endorphins: what are they? How are they measured? What is their role in exercise? Medicine and science in sports and exercise, 17(1), 74-81.
Gutch, M., Kumar, S., Razi, S. M., Gupta, K. K., & Gupta, A. (2015). Assessment of insulin sensitivity/resistance. Indian journal of endocrinology and metabolism, 19(1), 160.
Hadjicharalambous, M., Georgiades, E., Kilduff, L. P., Turner, A., Tsofliou, F., & Pitsiladis, Y. (2006). Influence of caffeine on perception of effort, metabolism and exercise performance following a high-fat meal. Journal of sports sciences, 24(8), 875-887.
Hallsworth, K., Thoma, C., Hollingsworth, K. G., Cassidy, S., Anstee, Q. M., Day, C. P., & Trenell, M. I. (2015). Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clinical science, 129(12), 1097-1105.
Handelsman, D. J., Hirschberg, A. L., & Bermon, S. (2018). Circulating testosterone as the hormonal basis of sex differences in athletic performance. Endocrine reviews, 39(5), 803-829.
Harland, B. F. (2000). Caffeine and nutrition. Nutrition, 16(7), 522-526.
Harpaz, E., Tamir, S., Weinstein, A., & Weinstein, Y. (2017). The effect of caffeine on energy balance. Journal of basic and clinical physiology and pharmacology, 28(1), 1-10.
Heckman, M. A., Weil, J., & De Mejia, E. G. (2010). Caffeine (1, 3, 7‐trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. Journal of food science, 75(3), R77-R87.
Jessen, A., Buemann, B., Toubro, S., Skovgaard, I., & Astrup, A. (2005). The appetite‐suppressant effect of nicotine is enhanced by caffeine. Diabetes, Obesity and Metabolism, 7(4), 327-333.
Kaess, B. M., Jóźwiak, J., Nelson, C. P., Lukas, W., Mastej, M., Windak, A. et al. (2014). The relation of rapid changes in obesity measures to lipid profile-insights from a nationwide metabolic health survey in 444 Polish cities. PLoS One, 9(1), e86837.
Karabudak, E., Türközü, D., & Köksal, E. (2015). Association between coffee consumption and serum lipid profile. Experimental and therapeutic medicine, 9(5), 1841-1846.
Kawaguchi, M., Scott, K. A., Moran, T. H., & Bi, S. (2005). Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 288(6), R1800-R1805.
Keating, S., Johnson, N., Mielke, G., & Coombes, J. (2017). A systematic review and meta‐analysis of interval training versus moderate‐intensity continuous training on body adiposity. Obesity Reviews, 18(8), 943-964.
Kelly, D., & Jones, T. (2015). Testosterone and obesity. Obesity Reviews, 16(7), 581-606.
Kim, J., Jeon, Y., Hwang, H., Suh, H., & Lim, K. (2012). Effects of oral caffeine and capsaicin administration on energy expenditure and energy substrates utilization in resting rats: Federation of American Societies for Experimental Biology.
Kim, S. H., & Reaven, G. (2010). Obesity and insulin resistance: an ongoing saga. Diabetes, 59(9), 2105-2106.
Kogure, A., Sakane, N., Takakura, Y., Umekawa, T., Yoshioka, K., Nishino, H. et al. (2002). Effects of caffeine on the uncoupling protein family in obese yellow KK mice. Clinical and experimental pharmacology and physiology, 29(5‐6), 391-394.
Komine, S., Akiyama, K., Warabi, E., Oh, S., Kuga, K., Ishige, K. et al. (2017). Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis. Scientific reports, 7(1), 11977.
Kong, Z., Fan, X., Sun, S., Song, L., Shi, Q., & Nie, J. (2016). Comparison of high-intensity interval training and moderate-to-vigorous continuous training for cardiometabolic health and exercise enjoyment in obese young women: a randomized controlled trial. PLoS One, 11(7), e0158589.
Laurent, D., Schneider, K. E., Prusaczyk, W. K., Franklin, C., Vogel, S. M., Krssak, M. et al. (2000). Effects of caffeine on muscle glycogen utilization and the neuroendocrine axis during exercise. The Journal of Clinical Endocrinology & Metabolism, 85(6), 2170-2175.
Laursen, P. B. (2010). Training for intense exercise performance: high‐intensity or high‐volume training? Scandinavian journal of medicine & science in sports, 20, 1-10.
Liou, K., Ho, S., Fildes, J., & Ooi, S.-Y. (2016). High intensity interval versus moderate intensity continuous training in patients with coronary artery disease: a meta-analysis of physiological and clinical parameters. Heart, Lung and Circulation, 25(2), 166-174.
Lopez, D. S., Advani, S., Qiu, X., Tsilidis, K. K., Khera, M., Kim, J., & Canfield, S. (2019). Caffeine intake is not associated with serum testosterone levels in adult men: cross-sectional findings from the NHANES 1999–2004 and 2011–2012. The Aging Male, 22(1), 45-54.
Luo, Z., Saha, A. K., Xiang, X., & Ruderman, N. B. (2005). AMPK, the metabolic syndrome and cancer. Trends in pharmacological sciences, 26(2), 69-76.
Mach, N., & Fuster-Botella, D. (2017). Endurance exercise and gut microbiota: A review. Journal of Sport and Health Science, 6(2), 179-197.
Maillard, F., Pereira, B., & Boisseau, N. (2018). Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports medicine, 48(2), 269-288.
Maillard, F., Rousset, S., Pereira, B., Traore, A., Del Amaze, P. d. P., Boirie, Y. et al. (2016). High-intensity interval training reduces abdominal fat mass in postmenopausal women with type 2 diabetes. Diabetes & metabolism, 42(6), 433-441.
Marangon, A. F. C., Helou, T., & Gonzalez, D. V. (2012). Effect of caffeine on lipid profile in ciclism practitioners. Journal of the International Society of Sports Nutrition, 9(S1), P20.
McCormick, J. K., Yarwood, J. M., & Schlievert, P. M. (2001). Toxic shock syndrome and bacterial superantigens: an update. Annual Reviews in Microbiology, 55(1), 77-104.
McCusker, R. R., Goldberger, B. A., & Cone, E. J. (2003). Caffeine content of specialty coffees. Journal of analytical toxicology, 27(7), 520-522.
Metcalfe, R. S., Babraj, J. A., Fawkner, S. G., & Vollaard, N. B. (2012). Towards the minimal amount of exercise for improving metabolic health: beneficial effects of reduced-exertion high-intensity interval training. European journal of applied physiology, 112(7), 2767-2775.
Milanović, Z., Sporiš, G., & Weston, M. (2015). Effectiveness of high-intensity interval training (HIT) and continuous endurance training for VO 2max improvements: a systematic review and meta-analysis of controlled trials. Sports medicine, 45(10), 1469-1481.
Mitchell, D. C., Knight, C. A., Hockenberry, J., Teplansky, R., & Hartman, T. J. (2014). Beverage caffeine intakes in the US. Food and Chemical Toxicology, 63, 136-142.
Moholdt, T. T., Amundsen, B. H., Rustad, L. A., Wahba, A., Løvø, K. T., Gullikstad, L. R. et al. (2009). Aerobic interval training versus continuous moderate exercise after coronary artery bypass surgery: a randomized study of cardiovascular effects and quality of life. American heart journal, 158(6), 1031-1037.
Morse, J. J., Pallaska, G., Pierce, P. R., Fields, T. M., Galen, S. S., & Malek, M. H. (2016). Acute low-dose caffeine supplementation increases electromyographic fatigue threshold in healthy men. Journal of strength and conditioning research, 30(11), 3236-3241.
Mourier, A., Gautier, J.-F., De Kerviler, E., Bigard, A. X., Villette, J.-M., Garnier, J.-P. et al. (1997). Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM: effects of branched-chain amino acid supplements. Diabetes care, 20(3), 385-391.
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants, 20(1), 1-30.
Nevill, M., Holmyard, D., Hall, G., Allsop, P., Van Oosterhout, A., Burrin, J., & Nevill, A. (1996). Growth hormone responses to treadmill sprinting in sprint-and endurance-trained athletes. European journal of applied physiology and occupational physiology, 72(5-6), 460-467.
Opal, S. M., Scannon, P. J., Vincent, J.-L., White, M., Carroll, S. F., Palardy, J. E. et al. (1999). Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. The Journal of infectious diseases, 180(5), 1584-1589.
Organization, W. H. (2009). WHO guidelines approved by the guidelines review committee. Geneva: WHO.
Organization, W. H. (2014). Global Status Report on Noncommunicable Diseases, Geneva, Switzerland. World Health Organization.
Ouerghi, N., Fradj, M. K. B., Bezrati, I., Khammassi, M., Feki, M., Kaabachi, N., & Bouassida, A. (2017). Effects of high-intensity interval training on body composition, aerobic and anaerobic performance and plasma lipids in overweight/obese and normal-weight young men. Biology of sport, 34(4), 385.
Pasquali, R. (2006). Obesity and androgens: facts and perspectives. Fertility and sterility, 85(5), 1319-1340.
Peirce, V., Carobbio, S., & Vidal-Puig, A. (2014). The different shades of fat. Nature, 510(7503), 76.
Pettenuzzo, L. F., Noschang, C., von Pozzer Toigo, E., Fachin, A., Vendite, D., & Dalmaz, C. (2008). Effects of chronic administration of caffeine and stress on feeding behavior of rats. Physiology & behavior, 95(3), 295-301.
Pietiläinen, K. H., Kaprio, J., Borg, P., Plasqui, G., Yki‐Järvinen, H., Kujala, U. M. et al. (2008). Physical inactivity and obesity: a vicious circle. Obesity, 16(2), 409-414.
Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C. et al. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464(7285), 59.
Racotta, I. S., LeBlanc, J., & Richard, D. (1994). The effect of caffeine on food intake in rats: involvement of corticotropin-releasing factor and the sympatho-adrenal system. Pharmacology Biochemistry and Behavior, 48(4), 887-892.
Raetz, C. R., & Whitfield, C. (2002). Lipopolysaccharide endotoxins. Annual review of biochemistry, 71(1), 635-700.
Rakobowchuk, M., Tanguay, S., Burgomaster, K. A., Howarth, K. R., Gibala, M. J., & MacDonald, M. J. (2008). Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 295(1), R236-R242.
Ramachandran, A., & Snehalatha, C. (2010). Rising burden of obesity in Asia. Journal of obesity, 2010.
Ramos, J. S., Dalleck, L. C., Tjonna, A. E., Beetham, K. S., & Coombes, J. S. (2015). The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports medicine, 45(5), 679-692.
Richards, J. C., Johnson, T. K., Kuzma, J. N., Lonac, M. C., Schweder, M. M., Voyles, W. F., & Bell, C. (2010). Short‐term sprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to β‐adrenergic stimulation. The Journal of physiology, 588(15), 2961-2972.
Rokholm, B., Baker, J. L., & Sørensen, T. I. A. (2010). The levelling off of the obesity epidemic since the year 1999–a review of evidence and perspectives. Obesity Reviews, 11(12), 835-846.
Rosa, J. C., Lira, F. S., Eguchi, R., Pimentel, G. D., Venâncio, D. P., Cunha, C. A. et al. (2011). Exhaustive exercise increases inflammatory response via toll like receptor‐4 and NF‐κBp65 pathway in rat adipose tissue. Journal of cellular physiology, 226(6), 1604-1607.
Rose, A. J., & Hargreaves, M. (2003). Exercise increases Ca2+–calmodulin‐dependent protein kinase II activity in human skeletal muscle. The Journal of physiology, 553(1), 303-309.
Rowell, L. B., Blackmon, J. R., & Bruce, R. A. (1964). Indocyanine green clearance and estimated hepatic blood flow during mild to maximal exercise in upright man. The Journal of clinical investigation, 43(8), 1677-1690.
Rudelle, S., Ferruzzi, M. G., Cristiani, I., Moulin, J., Macé, K., Acheson, K. J., & Tappy, L. (2007). Effect of a thermogenic beverage on 24‐hour energy metabolism in humans. Obesity, 15(2), 349-355.
Sökmen, B., Armstrong, L. E., Kraemer, W. J., Casa, D. J., Dias, J. C., Judelson, D. A., & Maresh, C. M. (2008). Caffeine use in sports: considerations for the athlete. The Journal of Strength & Conditioning Research, 22(3), 978-986.
Sakamoto, W., Nishihira, J., Fujie, K., MIZUNO, S., OZAKI, M., & YUKAWA, S. (2000). Coffee and fitness-coffee suppresses lipopolysaccharide-induced liver injury in rats. Journal of nutritional science and vitaminology, 46(6), 316-320.
Santos, R. M. M., & Lima, D. R. A. (2016). Coffee consumption, obesity and type 2 diabetes: A mini-review. European journal of nutrition, 55(4), 1345-1358.
Sarwer, D. B., & Polonsky, H. M. (2016). The Psychosocial Burden of Obesity. Endocrinology and Metabolism Clinics, 45(3), 677-688.
Sato, K., & Iemitsu, M. (2015). Exercise and sex steroid hormones in skeletal muscle. The Journal of steroid biochemistry and molecular biology, 145, 200-205.
Sawyer, B. J., Tucker, W. J., Bhammar, D. M., Ryder, J. R., Sweazea, K. L., & Gaesser, G. A. (2016). Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults. Journal of applied physiology, 121(1), 279-288.
Schneiker, K. T., Bishop, D., Dawson, B., & Hackett, L. P. (2006). Effects of caffeine on prolonged intermittent-sprint ability in team-sport athletes. Medicine and science in sports and exercise, 38(3), 578-585.
Sherwood, N. E., & Jeffery, R. W. (2000). The behavioral determinants of exercise: implications for physical activity interventions. Annual review of nutrition, 20(1), 21-44.
Skelly, L. E., Andrews, P. C., Gillen, J. B., Martin, B. J., Percival, M. E., & Gibala, M. J. (2014). High-intensity interval exercise induces 24-h energy expenditure similar to traditional endurance exercise despite reduced time commitment. Applied Physiology, Nutrition, and Metabolism, 39(7), 845-848.
Smirmaul, B. P., de Moraes, A. C., Angius, L., & Marcora, S. M. (2017). Effects of caffeine on neuromuscular fatigue and performance during high-intensity cycling exercise in moderate hypoxia. European journal of applied physiology, 117(1), 27-38.
Smith, L. L. (2000). Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? Medicine & Science in Sports & Exercise, 32(2), 317.
Specio, S. E., Wee, S., O’Dell, L. E., Boutrel, B., Zorrilla, E. P., & Koob, G. F. (2008). CRF 1 receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology, 196(3), 473-482.
Srinivasan, S. R., Myers, L., & Berenson, G. S. (2002). Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes, 51(1), 204-209.
Stensvold, D., Tjønna, A. E., Skaug, E.-A., Aspenes, S., Stølen, T., Wisløff, U., & Slørdahl, S. A. (2010). Strength training versus aerobic interval training to modify risk factors of metabolic syndrome. Journal of applied physiology, 108(4), 804-810.
Stone, N. J., Robinson, J. G., Lichtenstein, A. H., Merz, C. N. B., Blum, C. B., Eckel, R. H. et al. (2014). 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 63(25 Part B), 2889-2934.
Sui, X., Hooker, S. P., Lee, I.-M., Church, T. S., Colabianchi, N., Lee, C.-D., & Blair, S. N. (2008). A prospective study of cardiorespiratory fitness and risk of type 2 diabetes in women. Diabetes care, 31(3), 550-555.
Sutton-Tyrrell, K., Wildman, R. P., Matthews, K. A., Chae, C., Lasley, B. L., Brockwell, S. et al. (2005). Sex hormone–binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation, 111(10), 1242-1249.
Tabrizi, R., Saneei, P., Lankarani, K. B., Akbari, M., Kolahdooz, F., Esmaillzadeh, A., . . . Asemi, Z. (2018). The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Critical reviews in food science and nutrition, 1-9.
Talanian, J. L., Galloway, S. D., Heigenhauser, G. J., Bonen, A., & Spriet, L. L. (2007). Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. Journal of applied physiology, 102(4), 1439-1447.
Talanian, J. L., & Spriet, L. L. (2016). Low and moderate doses of caffeine late in exercise improve performance in trained cyclists. Applied Physiology, Nutrition, and Metabolism, 41(8), 850-855.
Thong, F. S., & Graham, T. E. (2002). Caffeine-induced impairment of glucose tolerance is abolished by β-adrenergic receptor blockade in humans. Journal of applied physiology, 92(6), 2347-2352.
Tjønna, A. E., Stølen, T. O., Bye, A., Volden, M., Slørdahl, S. A., Ødegård, R. et al. (2009). Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents. Clinical science, 116(4), 317-326.
Tofovic, S. P., Zacharia, L., Carcillo, J. A., & Jackson, E. K. (2001). Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in rats. Shock (Augusta, Ga.), 16(3), 196-202.
Topping, D. L., & Clifton, P. M. (2001). Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiological reviews, 81(3), 1031-1064.
Trapp, E. G., Chisholm, D. J., & Boutcher, S. H. (2007). Metabolic response of trained and untrained women during high-intensity intermittent cycle exercise. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 293(6), R2370-R2375.
Trapp, E. G., Chisholm, D. J., Freund, J., & Boutcher, S. H. (2008). The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. International journal of obesity, 32(4), 684.
Tremblay, A., Masson, E., Leduc, S., Houde, A., & Després, J.-P. (1988). Caffeine reduces spontaneous energy intake in men but not in women. Nutrition Research, 8(5), 553-558.
Tremellen, K., McPhee, N., Pearce, K., Benson, S., Schedlowski, M., & Engler, H. (2017). Endotoxin-initiated inflammation reduces testosterone production in men of reproductive age. American Journal of Physiology-Endocrinology And Metabolism, 314(3), E206-E213.
Trump, M. E., Heigenhauser, G., Putman, C., & Spriet, L. L. (1996). Importance of muscle phosphocreatine during intermittent maximal cycling. Journal of applied physiology, 80(5), 1574-1580.
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P. et al. (2001). Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New England Journal of Medicine, 344(18), 1343-1350.
Twells, L. K., Gregory, D. M., Reddigan, J., & Midodzi, W. K. (2014). Current and predicted prevalence of obesity in Canada: a trend analysis. CMAJ open, 2(1), E18.
Van Der Crabben, S. N., Blumer, R. M., Stegenga, M. E., Ackermans, M. T., Endert, E., Tanck, M. W. et al. (2009). Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans. The Journal of Clinical Endocrinology & Metabolism, 94(2), 463-468.
Visscher, T. L., & Seidell, J. C. (2001). The public health impact of obesity. Annual review of public health, 22(1), 355-375.
Wang, Y., & Xu, D. (2017). Effects of aerobic exercise on lipids and lipoproteins. Lipids in Health and Disease, 16(1), 132.
Waxman, A. (2004). WHO global strategy on diet, physical activity and health. Food and nutrition bulletin, 25(3), 292-302.
Wedick, N. M., Mantzoros, C. S., Ding, E. L., Brennan, A. M., Rosner, B., Rimm, E. B. et al. (2012). The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial. Nutrition journal, 11(1), 86.
Wellington, B. M., Leveritt, M. D., & Kelly, V. G. (2017). The effect of caffeine on repeat-high-intensity-effort performance in rugby league players. International journal of sports physiology and performance, 12(2), 206-210.
Welsh Jr, T. H., Bambino, T. H., & Hsueh, A. J. (1982). Mechanism of glucocorticoid-induced suppression of testicular androgen biosynthesis in vitro. Biology of Reproduction, 27(5), 1138-1146.
Westerterp-Plantenga, M. (2010). Green tea catechins, caffeine and body-weight regulation. Physiology & behavior, 100(1), 42-46.
Weston, K. S., Wisløff, U., & Coombes, J. S. (2014). High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med, 48(16), 1227-1234.
Wewege, M., Van Den Berg, R., Ward, R., & Keech, A. (2017). The effects of high‐intensity interval training vs. moderate‐intensity continuous training on body composition in overweight and obese adults: a systematic review and meta‐analysis. Obesity Reviews, 18(6), 635-646.
Wong, P.-l., Chaouachi, A., Chamari, K., Dellal, A., & Wisloff, U. (2010). Effect of preseason concurrent muscular strength and high-intensity interval training in professional soccer players. The Journal of Strength & Conditioning Research, 24(3), 653-660.
Wren, A., Small, C., Ward, H., Murphy, K., Dakin, C., Taheri, S. et al. (2000). The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology, 141(11), 4325-4328.
Wright, D. C., Hucker, K. A., Holloszy, J. O., & Han, D. H. (2004). Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions. Diabetes, 53(2), 330-335.
Xu, J., Mahowald, M. A., Ley, R. E., Lozupone, C. A., Hamady, M., Martens, E. C. et al. (2007). Evolution of symbiotic bacteria in the distal human intestine. PLoS biology, 5(7), e156.
Yoshioka, M., Doucet, E., Drapeau, V., Dionne, I., & Tremblay, A. (2001). Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. British Journal of Nutrition, 85(2), 203-211.
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